{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:05:34Z","timestamp":1793401534461,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The removal of highly toxic, ultra-dilute contaminants of concern has been a primary challenge for clean water technologies. Chromium and arsenic are among the most prevalent heavy metal pollutants in urban and agricultural waters, with current separation processes having severe limitations due to lack of molecular selectivity. Here, we report redox-active metallopolymer electrodes for the selective electrochemical removal of chromium and arsenic. An uptake greater than 100\u2009mg Cr\/g adsorbent can be achieved electrochemically, with a 99% reversible working capacity, with the bound chromium ions released in the less harmful trivalent form. Furthermore, we study the metallopolymer response during electrochemical modulation by in\u00a0situ transmission electron microscopy. The underlying mechanisms for molecular selectivity are investigated through electronic structure calculations, indicating a strong charge transfer to the heavy metal oxyanions. Finally, chromium and arsenic are remediated efficiently at concentrations as low as 100 ppb, in the presence of over 200-fold excess competing salts.<\/jats:p>","DOI":"10.1038\/s41467-018-07159-0","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T11:25:05Z","timestamp":1541157905000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":305,"title":["Electrochemically-mediated selective capture of heavy metal chromium and arsenic oxyanions from water"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7794-290X","authenticated-orcid":false,"given":"Xiao","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Kushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7841-8058","authenticated-orcid":false,"given":"Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-245X","authenticated-orcid":false,"given":"T. Alan","family":"Hatton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"7159_CR1","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.1200488","volume":"333","author":"M Elimelech","year":"2011","unstructured":"Elimelech, M. & Phillip, W. A. The future of seawater desalination: energy, technology, and the environment. Science 333, 712\u2013717 (2011).","journal-title":"Science"},{"key":"7159_CR2","doi-asserted-by":"publisher","first-page":"e47877","DOI":"10.1371\/journal.pone.0047877","volume":"7","author":"P Sharma","year":"2012","unstructured":"Sharma, P. et al. Groundwater contaminated with hexavalent chromium [Cr (VI)]: a health survey and clinical examination of community inhabitants (Kanpur, India). PLoS ONE 7, e47877 (2012).","journal-title":"PLoS ONE"},{"key":"7159_CR3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/S0043-1354(00)00279-7","volume":"35","author":"Y Nakano","year":"2001","unstructured":"Nakano, Y., Takeshita, K. & Tsutsumi, T. Adsorption mechanism of hexavalent chromium by redox within condensed-tannin gel. Water Res. 35, 496\u2013500 (2001).","journal-title":"Water Res."},{"key":"7159_CR4","doi-asserted-by":"publisher","first-page":"6549","DOI":"10.1021\/ie050321p","volume":"44","author":"P Rana-Madaria","year":"2005","unstructured":"Rana-Madaria, P., Nagarajan, M., Rajagopal, C. & Garg, B. S. Removal of chromium from aqueous solutions by treatment with carbon aerogel electrodes using response surface methodology. Ind. Eng. Chem. Res. 44, 6549\u20136559 (2005).","journal-title":"Ind. Eng. Chem. Res."},{"key":"7159_CR5","unstructured":"National Research Council. Alternatives for Ground Water Cleanup (National Acadmies of Sciences, Washington, 1994)."},{"key":"7159_CR6","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1021\/es960836v","volume":"31","author":"RR Patterson","year":"1997","unstructured":"Patterson, R. R., Fendorf, S. & Fendorf, M. Reduction of hexavalent chromium by amorphous iron sulfide. Environ. Sci. Technol. 31, 2039\u20132044 (1997).","journal-title":"Environ. Sci. Technol."},{"key":"7159_CR7","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.chemosphere.2016.11.158","volume":"170","author":"M Kikuchi","year":"2017","unstructured":"Kikuchi, M., Syudo, A., Hukumori, M., Naito, C. & Sawai, J. Changes in aquatic toxicity of potassium dichromate as a function of water quality parameters. Chemosphere 170, 113\u2013117 (2017).","journal-title":"Chemosphere"},{"key":"7159_CR8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/bmb\/ldg032","volume":"68","author":"L Jarup","year":"2003","unstructured":"Jarup, L. Hazards of heavy metal contamination. Br. Med. Bull. 68, 167\u2013182 (2003).","journal-title":"Br. Med. Bull."},{"key":"7159_CR9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0039-9140(02)00268-0","volume":"58","author":"BK Mandal","year":"2002","unstructured":"Mandal, B. K. & Suzuki, K. T. Arsenic round the world: a review. Talanta 58, 201\u2013235 (2002).","journal-title":"Talanta"},{"key":"7159_CR10","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1021\/es030309t","volume":"37","author":"S Dixit","year":"2003","unstructured":"Dixit, S. & Hering, J. G. Comparison of arsenic(V) and arsenic(III) sorption onto iron oxide minerals: implications for arsenic mobility. Environ. Sci. Technol. 37, 4182\u20134189 (2003).","journal-title":"Environ. Sci. Technol."},{"key":"7159_CR11","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1021\/ie800814h","volume":"48","author":"GL Huang","year":"2009","unstructured":"Huang, G. L., Zhang, H. Y., Shi, J. X. & Langrish, T. A. G. Adsorption of chromium(VI) from aqueous solutions using cross-linked magnetic chitosan beads. Ind. Eng. Chem. Res. 48, 2646\u20132651 (2009).","journal-title":"Ind. Eng. Chem. Res."},{"key":"7159_CR12","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jhazmat.2010.08.052","volume":"184","author":"S Recillas","year":"2010","unstructured":"Recillas, S. et al. Chromium VI adsorption on cerium oxide nanoparticles and morphology changes during the process. J. Hazard. Mater. 184, 425\u2013431 (2010).","journal-title":"J. Hazard. Mater."},{"key":"7159_CR13","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.cej.2017.03.144","volume":"322","author":"C Santhosh","year":"2017","unstructured":"Santhosh, C. et al. Magnetic SiO2 @CoFe2O4 nanoparticles decorated on graphene oxide as efficient adsorbents for the removal of anionic pollutants from water. Chem. Eng. J. 322, 472\u2013487 (2017).","journal-title":"Chem. Eng. J."},{"key":"7159_CR14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0304-3894(01)00291-6","volume":"87","author":"S Rengaraj","year":"2001","unstructured":"Rengaraj, S., Yeon, K.-H. & Moon, S.-H. Removal of chromium from water and wastewater by ion exchange resins. J. Hazard. Mater. 87, 273\u2013287 (2001).","journal-title":"J. Hazard. Mater."},{"key":"7159_CR15","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nature16185","volume":"529","author":"A Alsbaiee","year":"2016","unstructured":"Alsbaiee, A. et al. Rapid removal of organic micropollutants from water by a porous beta-cyclodextrin polymer. Nature 529, 190\u2013U146 (2016).","journal-title":"Nature"},{"key":"7159_CR16","doi-asserted-by":"publisher","first-page":"5326","DOI":"10.1021\/acs.est.6b06181","volume":"51","author":"S Ahualli","year":"2017","unstructured":"Ahualli, S., Iglesias, G. R., Fernandez, M. M., Jimenez, M. L. & Delgado, A. V. Use of soft electrodes in capacitive deionization of solutions. Environ. Sci. Technol. 51, 5326\u20135333 (2017).","journal-title":"Environ. Sci. Technol."},{"key":"7159_CR17","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1021\/acs.estlett.7b00392","volume":"4","author":"T Kim","year":"2017","unstructured":"Kim, T., Gorski, C. A. & Logan, B. E. Low energy desalination using battery electrode deionization. Environ. Sci. Technol. Lett. 4, 444\u2013449 (2017).","journal-title":"Environ. Sci. Technol. Lett."},{"key":"7159_CR18","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1039\/C4EE02378A","volume":"7","author":"J Lee","year":"2014","unstructured":"Lee, J., Kim, S., Kim, C. & Yoon, J. Hybrid capacitive deionization to enhance the desalination performance of capacitive techniques. Energy Environ. Sci. 7, 3683\u20133689 (2014).","journal-title":"Energy Environ. Sci."},{"key":"7159_CR19","doi-asserted-by":"publisher","first-page":"9520","DOI":"10.1039\/c2ee21737f","volume":"5","author":"R Zhao","year":"2012","unstructured":"Zhao, R., Biesheuvel, P. M. & van der Wal, A. Energy consumption and constant current operation in membrane capacitive deionization. Energy Environ. Sci. 5, 9520\u20139527 (2012).","journal-title":"Energy Environ. Sci."},{"key":"7159_CR20","doi-asserted-by":"publisher","first-page":"23570","DOI":"10.1039\/C7CP02822A","volume":"19","author":"X Su","year":"2017","unstructured":"Su, X. & Hatton, T. A. Electrosorption at functional interfaces: from molecular-level interactions to electrochemical cell design. Phys. Chem. Chem. Phys. 19, 23570\u201323584 (2017).","journal-title":"Phys. Chem. Chem. Phys."},{"key":"7159_CR21","doi-asserted-by":"publisher","first-page":"15205","DOI":"10.1039\/C4RA14447C","volume":"5","author":"Y Liu","year":"2015","unstructured":"Liu, Y. et al. Review on carbon-based composite materials for capacitive deionization. RSC Adv. 5, 15205\u201315225 (2015).","journal-title":"RSC Adv."},{"key":"7159_CR22","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1039\/C5EE00519A","volume":"8","author":"ME Suss","year":"2015","unstructured":"Suss, M. E. et al. Water desalination via capacitive deionization: what is it and what can we expect from it? Energy Environ. Sci. 8, 2296\u20132319 (2015).","journal-title":"Energy Environ. Sci."},{"key":"7159_CR23","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.1002\/adfm.201600079","volume":"26","author":"X Su","year":"2016","unstructured":"Su, X., Kulik, H. J., Jamison, T. F. & Hatton, T. A. Anion-selective redox electrodes: electrochemically mediated separation with heterogeneous organometallic interfaces. Adv. Funct. Mater. 26, 3394\u20133404 (2016).","journal-title":"Adv. Funct. Mater."},{"key":"7159_CR24","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1039\/C7EE00066A","volume":"10","author":"X Su","year":"2017","unstructured":"Su, X. et al. Asymmetric Faradaic systems for selective electrochemical separations. Energy Environ. Sci. 10, 1272\u20131283 (2017).","journal-title":"Energy Environ. Sci."},{"key":"7159_CR25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.cis.2016.09.001","volume":"244","author":"X Su","year":"2017","unstructured":"Su, X. & Hatton, T. A. Redox-electrodes for selective electrochemical separations. Adv. Colloid Interface Sci. 244, 6\u201320 (2017).","journal-title":"Adv. Colloid Interface Sci."},{"key":"7159_CR26","doi-asserted-by":"publisher","first-page":"9626","DOI":"10.1021\/la401440w","volume":"29","author":"X Mao","year":"2013","unstructured":"Mao, X., Rutledge, G. C. & Hatton, T. A. Polyvinylferrocene for noncovalent dispersion and redox-controlled precipitation of carbon nanotubes in nonaqueous media. Langmuir 29, 9626\u20139634 (2013).","journal-title":"Langmuir"},{"key":"7159_CR27","doi-asserted-by":"publisher","first-page":"4528","DOI":"10.1016\/j.watres.2005.05.051","volume":"39","author":"J Hu","year":"2005","unstructured":"Hu, J., Chen, G. & Lo, I. M. C. Removal and recovery of Cr(VI) from wastewater by maghemite nanoparticles. Water Res. 39, 4528\u20134536 (2005).","journal-title":"Water Res."},{"key":"7159_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1021\/ef9601374","volume":"11","author":"JC Farmer","year":"1997","unstructured":"Farmer, J. C. et al. Electrosorption of chromium ions on carbon aerogel electrodes as a means of remediating ground water. Energy Fuels 11, 337\u2013347 (1997).","journal-title":"Energy Fuels"},{"key":"7159_CR29","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1021\/es061721m","volume":"41","author":"BA Manning","year":"2007","unstructured":"Manning, B. A., Kiser, J. R., Kwon, H. & Kanel, S. R. Spectroscopic investigation of Cr(III)- and Cr(VI)-treated nanoscale zerovalent iron. Environ. Sci. Technol. 41, 586\u2013592 (2007).","journal-title":"Environ. Sci. Technol."},{"key":"7159_CR30","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1021\/es950618m","volume":"30","author":"SE Fendorf","year":"1996","unstructured":"Fendorf, S. E. & Li, G. C. Kinetics of chromate reduction by ferrous iron. Environ. Sci. Technol. 30, 1614\u20131617 (1996).","journal-title":"Environ. Sci. Technol."},{"key":"7159_CR31","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s10800-005-9074-y","volume":"36","author":"I Frenzel","year":"2005","unstructured":"Frenzel, I., Holdik, H., Barmashenko, V., Stamatialis, D. F. & Wessling, M. Electrochemical reduction of dilute chromate solutions on carbon felt electrodes. J. Appl. Electrochem. 36, 323\u2013332 (2005).","journal-title":"J. Appl. Electrochem."},{"key":"7159_CR32","doi-asserted-by":"publisher","first-page":"084204","DOI":"10.1088\/0953-8984\/21\/8\/084204","volume":"21","author":"W Tang","year":"2009","unstructured":"Tang, W., Sanville, E. & Henkelman, G. A grid-based Bader analysis algorithm without lattice bias. J. Phys. Condens. Matter 21, 084204 (2009).","journal-title":"J. Phys. Condens. Matter"},{"key":"7159_CR33","doi-asserted-by":"publisher","first-page":"8260","DOI":"10.1021\/acs.nanolett.5b03812","volume":"15","author":"A Kushima","year":"2015","unstructured":"Kushima, A. et al. Charging\/discharging nanomorphology asymmetry and rate-dependent capacity degradation in Li-oxygen battery. Nano Lett. 15, 8260\u20138265 (2015).","journal-title":"Nano Lett."},{"key":"7159_CR34","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.nanoen.2016.12.001","volume":"32","author":"A Kushima","year":"2017","unstructured":"Kushima, A. et al. Liquid cell transmission electron microscopy observation of lithium metal growth and dissolution: root growth, dead lithium and lithium flotsams. Nano Energy 32, 271\u2013279 (2017).","journal-title":"Nano Energy"},{"key":"7159_CR35","doi-asserted-by":"publisher","first-page":"4005","DOI":"10.1021\/nl501415b","volume":"14","author":"JJ Niu","year":"2014","unstructured":"Niu, J. J. et al. In situ observation of random solid solution zone in LiFePO4 electrode. Nano Lett. 14, 4005\u20134010 (2014).","journal-title":"Nano Lett."},{"key":"7159_CR36","doi-asserted-by":"publisher","first-page":"L24","DOI":"10.1149\/1.1838269","volume":"145","author":"S Bruckenstein","year":"1998","unstructured":"Bruckenstein, S., Fensore, A. T. & Hillman, A. R. Time-resolved mono-anion, di-anion, and solvent transfers into a poly(vinylferrocene)-modified electrode. J. Electrochem. Soc. 145, L24\u2013L26 (1998).","journal-title":"J. Electrochem. Soc."},{"key":"7159_CR37","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0022-0728(00)00190-X","volume":"488","author":"I Jureviciute","year":"2000","unstructured":"Jureviciute, I., Bruckenstein, S. & Hillman, A. R. Counter-ion specific effects on charge and solvent trapping in poly(vinylferrocene) films. J. Electroanal. Chem. 488, 73\u201381 (2000).","journal-title":"J. Electroanal. Chem."},{"key":"7159_CR38","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0022-0728(83)80616-0","volume":"158","author":"S Nakahama","year":"1983","unstructured":"Nakahama, S. & Murray, R. W. The effect of composition of a ferrocene-containing redox polymer on the electrochemistry of its thin-film coatings on electrodes. J. Electroanal. Chem. 158, 303\u2013322 (1983).","journal-title":"J. Electroanal. Chem."},{"key":"7159_CR39","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1149\/1.2113837","volume":"132","author":"CM Carlin","year":"1985","unstructured":"Carlin, C. M., Kepley, L. J. & Bard, A. J. Polymer-films on electrodes. 16. In situ ellipsometric measurements of polybipyrazine, polyaniline and polyvinylferrocene films. J. Electrochem. Soc. 132, 353\u2013359 (1985).","journal-title":"J. Electrochem. Soc."},{"key":"7159_CR40","unstructured":"Bard, A. J. & Faulkner, L. R. Electrochemical Methods: Fundamentals and Applications 2nd edn (Wiley, New York, 2000)."},{"key":"7159_CR41","doi-asserted-by":"publisher","first-page":"4093","DOI":"10.1021\/la803234e","volume":"25","author":"A Glidle","year":"2009","unstructured":"Glidle, A. et al. Use of neutron reflectivity to measure the dynamics of solvation and structural changes in polyvinylferrocene films during electrochemically controlled redox cycling. Langmuir 25, 4093\u20134103 (2009).","journal-title":"Langmuir"},{"key":"7159_CR42","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1246\/bcsj.64.2887","volume":"64","author":"M Mizunuma","year":"1991","unstructured":"Mizunuma, M., Ohsaka, T., Miyamoto, H. & Oyama, N. Investigation of ion and solvent transport accompanying redox reactions of polyvinylferrocene films using an in situ electrochemical quartz crystal microbalance technique. Bull. Chem. Soc. Jpn. 64, 2887\u20132893 (1991).","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"7159_CR43","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1039\/a706092k","volume":"94","author":"EM Pater","year":"1998","unstructured":"Pater, E. M., Bruckenstein, S. & Hillman, A. R. Film mass and volume changes accompanying redox-driven solvent and salt transfer during redox switching of polyvinylferrocene films. J. Chem. Soc. Faraday Trans. 94, 1097\u20131103 (1998).","journal-title":"J. Chem. Soc. Faraday Trans."},{"key":"7159_CR44","doi-asserted-by":"publisher","first-page":"11169","DOI":"10.1103\/PhysRevB.54.11169","volume":"54","author":"G Kresse","year":"1996","unstructured":"Kresse, G. & Furthmuller, J. Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. Phys. Rev. B 54, 11169\u201311186 (1996).","journal-title":"Phys. Rev. B"},{"key":"7159_CR45","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1103\/PhysRevB.59.1758","volume":"59","author":"G Kresse","year":"1999","unstructured":"Kresse, G. & Joubert, D. From ultrasoft pseudopotentials to the projector augmented-wave method. Phys. Rev. B 59, 1758\u20131775 (1999).","journal-title":"Phys. Rev. B"},{"key":"7159_CR46","doi-asserted-by":"publisher","first-page":"154104","DOI":"10.1063\/1.3382344","volume":"132","author":"S Grimme","year":"2010","unstructured":"Grimme, S., Antony, J., Ehrlich, S. & Krieg, H. A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. J. Chem. Phys. 132, 154104 (2010).","journal-title":"J. Chem. Phys."},{"key":"7159_CR47","doi-asserted-by":"publisher","first-page":"084106","DOI":"10.1063\/1.4865107","volume":"140","author":"K Mathew","year":"2014","unstructured":"Mathew, K., Sundararaman, R., Letchworth-Weaver, K., Arias, T. A. & Hennig, R. G. Implicit solvation model for density-functional study of nanocrystal surfaces and reaction pathways. J. Chem. Phys. 140, 084106 (2014).","journal-title":"J. Chem. Phys."},{"key":"7159_CR48","doi-asserted-by":"publisher","first-page":"245402","DOI":"10.1103\/PhysRevB.87.245402","volume":"87","author":"M Fishman","year":"2013","unstructured":"Fishman, M., Zhuang, H. L. L., Mathew, K., Dirschka, W. & Hennig, R. G. Accuracy of exchange-correlation functionals and effect of solvation on the surface energy of copper. Phys. Rev. B 87, 245402 (2013).","journal-title":"Phys. Rev. B"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-018-07159-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-018-07159-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-018-07159-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T15:06:39Z","timestamp":1671548799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-018-07159-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["7159"],"URL":"https:\/\/doi.org\/10.1038\/s41467-018-07159-0","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,8]]},"assertion":[{"value":"1 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4701"}}