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Our knowledge of variations in the genomic loci encoding\u00a0immunoglobulin genes is incomplete, resulting in conflicting\n                    <jats:italic>VDJ<\/jats:italic>\n                    gene assignments and biased genotype and haplotype inference. Haplotypes can be inferred using\n                    <jats:italic>IGHJ6<\/jats:italic>\n                    heterozygosity, observed in one third of the people. Here, we propose a robust novel method for determining\n                    <jats:italic>VDJ<\/jats:italic>\n                    haplotypes by adapting a Bayesian framework. Our method extends haplotype inference to\n                    <jats:italic>IGHD<\/jats:italic>\n                    - and\n                    <jats:italic>IGHV<\/jats:italic>\n                    -based analysis, enabling inference of deletions and copy number variations in the entire population. To test this method, we generated a multi-individual data set of naive B-cell repertoires, and found allele usage bias, as well as a mosaic, tiled pattern of deleted\n                    <jats:italic>IGHD<\/jats:italic>\n                    and\n                    <jats:italic>IGHV<\/jats:italic>\n                    genes. The inferred haplotypes may have clinical implications for genetic disease predispositions. Our findings expand the knowledge that can be extracted from antibody repertoire sequencing data.\n                  <\/jats:p>","DOI":"10.1038\/s41467-019-08489-3","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T06:05:41Z","timestamp":1549519541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping"],"prefix":"10.1038","volume":"10","author":[{"given":"Moriah","family":"Gidoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omri","family":"Snir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Peres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pazit","family":"Polak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8343-2842","authenticated-orcid":false,"given":"Ida","family":"Lindeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Mikocziova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas Kumar","family":"Sarna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E. 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