{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:26:31Z","timestamp":1794014791500,"version":"4.8.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The mechanisms initiating late immune responses to an allograft are poorly understood. Here we show, via transcriptome analysis of serial protocol biopsies from kidney transplants, that the initial responses to kidney injury correlate with a late B lymphocyte signature relating to renal dysfunction and fibrosis. With a potential link between dysfunctional repair and immunoreactivity, we investigate the immunological consequences of dysfunctional repair examining chronic disease in mouse kidneys 18 months after a bilateral ischemia\/reperfusion injury event. In the absence of foreign antigens, a sustained immune response involving both innate and adaptive immune systems accompanies a transition to chronic kidney damage. At late stages, B lymphocytes exhibite an antigen-driven proliferation, selection and maturation into broadly-reacting antibody-secreting cells. These findings reveal a previously unappreciated role for dysfunctional tissue repair in local immunomodulation that may have particular relevance to transplant-associated immunobiology.<\/jats:p>","DOI":"10.1038\/s41467-019-09092-2","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T07:02:58Z","timestamp":1552287778000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation"],"prefix":"10.1038","volume":"10","author":[{"given":"Pietro E.","family":"Cipp\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-3623","authenticated-orcid":false,"given":"Bo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Naesens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"9092_CR1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","volume":"356","author":"SA Eming","year":"2017","unstructured":"Eming, S. A., Wynn, T. A. & Martin, P. Inflammation and metabolism in tissue repair and regeneration. Science 356, 1026\u20131030 (2017).","journal-title":"Science"},{"key":"9092_CR2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrneph.2014.180","volume":"11","author":"HR Jang","year":"2015","unstructured":"Jang, H. R. & Rabb, H. Immune cells in experimental acute kidney injury. Nat. Rev. Nephrol. 11, 88\u2013101 (2015).","journal-title":"Nat. Rev. Nephrol."},{"key":"9092_CR3","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/nm.3284","volume":"19","author":"Y Zouggari","year":"2013","unstructured":"Zouggari, Y. et al. B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. Nat. Med. 19, 1273\u20131280 (2013).","journal-title":"Nat. Med."},{"key":"9092_CR4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jaut.2009.02.021","volume":"32","author":"J Chen","year":"2009","unstructured":"Chen, J., Crispin, J. C., Tedder, T. F., Dalle Lucca, J. & Tsokos, G. C. B cells contribute to ischemia\/reperfusion-mediated tissue injury. J. Autoimmun. 32, 195\u2013200 (2009).","journal-title":"J. Autoimmun."},{"key":"9092_CR5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1681\/ASN.2009020182","volume":"21","author":"HR Jang","year":"2010","unstructured":"Jang, H. R. et al. B cells limit repair after ischemic acute kidney injury. J. Am. Soc. Nephrol. 21, 654\u2013665 (2010).","journal-title":"J. Am. Soc. Nephrol."},{"key":"9092_CR6","doi-asserted-by":"crossref","first-page":"280rv282","DOI":"10.1126\/scitranslmed.aaa6853","volume":"7","author":"C McDonald-Hyman","year":"2015","unstructured":"McDonald-Hyman, C., Turka, L. A. & Blazar, B. R. Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Sci. Transl. Med. 7, 280rv282 (2015).","journal-title":"Sci. Transl. Med."},{"key":"9092_CR7","doi-asserted-by":"crossref","unstructured":"Dai, H. et al. Donor SIRP\u03b1 polymorphism modulates the innate immune response to allogeneic grafts. Sci. Immunol. 2, eaam6202 (2017).","DOI":"10.1126\/sciimmunol.aam6202"},{"key":"9092_CR8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nm.2376","volume":"17","author":"S Celli","year":"2011","unstructured":"Celli, S., Albert, M. L. & Bousso, P. Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy. Nat. Med. 17, 744\u2013749 (2011).","journal-title":"Nat. Med."},{"key":"9092_CR9","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1056\/NEJMon043418","volume":"351","author":"MH Sayegh","year":"2004","unstructured":"Sayegh, M. H. & Carpenter, C. B. Transplantation 50 years later\u2014progress, challenges, and promises. N. Engl. J. Med. 351, 2761\u20132766 (2004).","journal-title":"N. Engl. J. Med."},{"key":"9092_CR10","doi-asserted-by":"crossref","unstructured":"Eskandary, F. et al. A randomized trial of bortezomib in late antibody-mediated kidney transplant rejection. J. Am. Soc. Nephrol. 29, 591\u2013605 (2018).","DOI":"10.1681\/ASN.2017070818"},{"key":"9092_CR11","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1172\/JCI90597","volume":"127","author":"NM Valenzuela","year":"2017","unstructured":"Valenzuela, N. M. & Reed, E. F. Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies. J. Clin. Invest. 127, 2492\u20132504 (2017).","journal-title":"J. Clin. Invest."},{"key":"9092_CR12","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/S0140-6736(17)31283-7","volume":"389","author":"T Wekerle","year":"2017","unstructured":"Wekerle, T., Segev, D., Lechler, R. & Oberbauer, R. Strategies for long-term preservation of kidney graft function. Lancet 389, 2152\u20132162 (2017).","journal-title":"Lancet"},{"key":"9092_CR13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJM200003023420901","volume":"342","author":"S Hariharan","year":"2000","unstructured":"Hariharan, S. et al. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N. Engl. J. Med. 342, 605\u2013612 (2000).","journal-title":"N. Engl. J. Med."},{"key":"9092_CR14","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1600-6143.2004.00515.x","volume":"4","author":"HU Meier-Kriesche","year":"2004","unstructured":"Meier-Kriesche, H. U., Schold, J. D. & Kaplan, B. Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies? Am. J. Transplant. 4, 1289\u20131295 (2004).","journal-title":"Am. J. Transplant."},{"key":"9092_CR15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nri1702","volume":"5","author":"RB Colvin","year":"2005","unstructured":"Colvin, R. B. & Smith, R. N. Antibody-mediated organ-allograft rejection. Nat. Rev. Immunol. 5, 807\u2013817 (2005).","journal-title":"Nat. Rev. Immunol."},{"key":"9092_CR16","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/ajt.14669","volume":"18","author":"AS Chong","year":"2018","unstructured":"Chong, A. S. & Ansari, M. J. Heterogeneity of memory B cells. Am. J. Transplant. 18, 779\u2013784 (2018).","journal-title":"Am. J. Transplant."},{"key":"9092_CR17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1681\/ASN.2017121296","volume":"29","author":"K Budde","year":"2018","unstructured":"Budde, K. & Durr, M. Any progress in the treatment of antibody-mediated rejection? J. Am. Soc. Nephrol. 29, 350\u2013352 (2018).","journal-title":"J. Am. Soc. Nephrol."},{"key":"9092_CR18","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/j.1600-6143.2008.02232.x","volume":"8","author":"G Einecke","year":"2008","unstructured":"Einecke, G. et al. Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts. Am. J. Transplant. 8, 1434\u20131443 (2008).","journal-title":"Am. J. Transplant."},{"key":"9092_CR19","doi-asserted-by":"crossref","first-page":"e85323","DOI":"10.1172\/jci.insight.85323","volume":"1","author":"JM Venner","year":"2016","unstructured":"Venner, J. M., Famulski, K. S., Reeve, J., Chang, J. & Halloran, P. F. Relationships among injury, fibrosis, and time in human kidney transplants. JCI Insight 1, e85323 (2016).","journal-title":"JCI Insight"},{"key":"9092_CR20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","volume":"11","author":"DA Ferenbach","year":"2015","unstructured":"Ferenbach, D. A. & Bonventre, J. V. Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD. Nat. Rev. Nephrol. 11, 264\u2013276 (2015).","journal-title":"Nat. Rev. Nephrol."},{"key":"9092_CR21","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/nm.4419","volume":"23","author":"D Lagares","year":"2017","unstructured":"Lagares, D. et al. ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis. Nat. Med. 23, 1405\u20131415 (2017).","journal-title":"Nat. Med."},{"key":"9092_CR22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/ajt.14107","volume":"17","author":"A Loupy","year":"2017","unstructured":"Loupy, A. et al. The Banff 2015 kidney meeting report: current challenges in rejection classification and prospects for adopting molecular pathology. Am. J. Transplant. 17, 28\u201341 (2017).","journal-title":"Am. J. Transplant."},{"key":"9092_CR23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1681\/ASN.2014111108","volume":"27","author":"T Chiba","year":"2016","unstructured":"Chiba, T. et al. Retinoic acid signaling coordinates macrophage-dependent injury and repair after AKI. J. Am. Soc. Nephrol. 27, 495\u2013508 (2016).","journal-title":"J. Am. Soc. Nephrol."},{"key":"9092_CR24","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.celrep.2015.07.034","volume":"12","author":"S Kumar","year":"2015","unstructured":"Kumar, S. et al. Sox9 activation highlights a cellular pathway of renal repair in the acutely injured mammalian kidney. Cell Rep. 12, 1325\u20131338 (2015).","journal-title":"Cell Rep."},{"key":"9092_CR25","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1111\/ajt.13728","volume":"16","author":"BD Modena","year":"2016","unstructured":"Modena, B. D. et al. Gene expression in biopsies of acute rejection and interstitial fibrosis\/tubular atrophy reveals highly shared mechanisms that correlate with worse long-term outcomes. Am. J. Transplant. 16, 1982\u20131998 (2016).","journal-title":"Am. J. Transplant."},{"key":"9092_CR26","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1681\/ASN.2011090887","volume":"23","author":"KS Famulski","year":"2012","unstructured":"Famulski, K. S. et al. Molecular phenotypes of acute kidney injury in kidney transplants. J. Am. Soc. Nephrol. 23, 948\u2013958 (2012).","journal-title":"J. Am. Soc. Nephrol."},{"key":"9092_CR27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.pathmechdis.3.121806.151508","volume":"3","author":"LD Cornell","year":"2008","unstructured":"Cornell, L. D., Smith, R. N. & Colvin, R. B. Kidney transplantation: mechanisms of rejection and acceptance. Annu. Rev. Pathol. 3, 189\u2013220 (2008).","journal-title":"Annu. Rev. Pathol."},{"key":"9092_CR28","doi-asserted-by":"crossref","unstructured":"Liu, J. et al. Molecular characterization of the transition from acute to chronic kidney injury following ischemia\/reperfusion. JCI Insight 2, 94716 (2017).","DOI":"10.1172\/jci.insight.94716"},{"key":"9092_CR29","volume":"7","author":"Z Chen","year":"2017","unstructured":"Chen, Z. et al. Inference of immune cell composition on the expression profiles of mouse tissue. Sci. Rep. 7, 40508 (2017).","journal-title":"Sci. Rep."},{"key":"9092_CR30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman, A. M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods 12, 453\u2013457 (2015).","journal-title":"Nat. Methods"},{"key":"9092_CR31","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.cell.2017.07.026","volume":"170","author":"SE Degn","year":"2017","unstructured":"Degn, S. E. et al. Clonal evolution of autoreactive germinal centers. Cell 170, 913\u2013926 (2017).","journal-title":"Cell"},{"key":"9092_CR32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cell.2010.10.032","volume":"143","author":"GD Victora","year":"2010","unstructured":"Victora, G. D. et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143, 592\u2013605 (2010).","journal-title":"Cell"},{"key":"9092_CR33","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/sj.ki.5002734","volume":"73","author":"S Segerer","year":"2008","unstructured":"Segerer, S. & Schlondorff, D. B cells and tertiary lymphoid organs in renal inflammation. Kidney Int. 73, 533\u2013537 (2008).","journal-title":"Kidney Int."},{"key":"9092_CR34","first-page":"430","volume":"7","author":"E Corsiero","year":"2016","unstructured":"Corsiero, E., Nerviani, A., Bombardieri, M. & Pitzalis, C. Ectopic lymphoid structures: powerhouse of autoimmunity. Front. Immunol. 7, 430 (2016).","journal-title":"Front. Immunol."},{"key":"9092_CR35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cell.2012.05.032","volume":"150","author":"NJ Krautler","year":"2012","unstructured":"Krautler, N. J. et al. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell 150, 194\u2013206 (2012).","journal-title":"Cell"},{"key":"9092_CR36","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1172\/JCI72126","volume":"124","author":"J Liu","year":"2014","unstructured":"Liu, J. et al. Cell-specific translational profiling in acute kidney injury. J. Clin. Invest. 124, 1242\u20131254 (2014).","journal-title":"J. Clin. Invest."},{"key":"9092_CR37","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1681\/ASN.2013101143","volume":"25","author":"I Grgic","year":"2014","unstructured":"Grgic, I. et al. Translational profiles of medullary myofibroblasts during kidney fibrosis. J. Am. Soc. Nephrol. 25, 1979\u20131990 (2014).","journal-title":"J. Am. Soc. Nephrol."},{"key":"9092_CR38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.immuni.2014.07.010","volume":"41","author":"S Mayans","year":"2014","unstructured":"Mayans, S. et al. \u03b1\u03b2T cell receptors expressed by CD4(\u2212)CD8\u03b1\u03b2(\u2212) intraepithelial T cells drive their fate into a unique lineage with unusual MHC reactivities. Immunity 41, 207\u2013218 (2014).","journal-title":"Immunity"},{"key":"9092_CR39","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1681\/ASN.2014121214","volume":"27","author":"MN Martina","year":"2016","unstructured":"Martina, M. N. et al. Double-negative \u03b1\u03b2 T cells are early responders to AKI and are found in human kidney. J. Am. Soc. Nephrol. 27, 1113\u20131123 (2016).","journal-title":"J. Am. Soc. Nephrol."},{"key":"9092_CR40","doi-asserted-by":"crossref","unstructured":"Park, J. et al. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science 360, 758\u2013763 (2018).","DOI":"10.1126\/science.aar2131"},{"key":"9092_CR41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-1-4939-1212-4_4","volume":"1193","author":"I Ludwig-Portugall","year":"2014","unstructured":"Ludwig-Portugall, I. & Kurts, C. T cell isolation from mouse kidneys. Methods Mol. Biol. 1193, 27\u201335 (2014).","journal-title":"Methods Mol. Biol."},{"key":"9092_CR42","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.191.7.1149","volume":"191","author":"LJ McHeyzer-Williams","year":"2000","unstructured":"McHeyzer-Williams, L. J., Cool, M. & McHeyzer-Williams, M. G. Antigen-specific B cell memory: expression and replenishment of a novel b220(\u2212) memory b cell compartment. J. Exp. Med. 191, 1149\u20131166 (2000).","journal-title":"J. Exp. Med."},{"key":"9092_CR43","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.4049\/jimmunol.167.4.2361","volume":"167","author":"E Arce","year":"2001","unstructured":"Arce, E. et al. Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus. J. Immunol. 167, 2361\u20132369 (2001).","journal-title":"J. Immunol."},{"key":"9092_CR44","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1681\/ASN.2010050515","volume":"22","author":"M Espeli","year":"2011","unstructured":"Espeli, M. et al. Local renal autoantibody production in lupus nephritis. J. Am. Soc. Nephrol. 22, 296\u2013305 (2011).","journal-title":"J. Am. Soc. Nephrol."},{"key":"9092_CR45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.autrev.2005.09.006","volume":"5","author":"SD Fleming","year":"2006","unstructured":"Fleming, S. D. & Tsokos, G. C. Complement, natural antibodies, autoantibodies and tissue injury. Autoimmun. Rev. 5, 89\u201392 (2006).","journal-title":"Autoimmun. Rev."},{"key":"9092_CR46","doi-asserted-by":"crossref","first-page":"e22365","DOI":"10.1371\/journal.pone.0022365","volume":"6","author":"R Arnaout","year":"2011","unstructured":"Arnaout, R. et al. High-resolution description of antibody heavy-chain repertoires in humans. PLoS ONE 6, e22365 (2011).","journal-title":"PLoS One"},{"key":"9092_CR47","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3680","volume":"4","author":"CS Carlson","year":"2013","unstructured":"Carlson, C. S. et al. Using synthetic templates to design an unbiased multiplex PCR assay. Nat. Commun. 4, 2680 (2013).","journal-title":"Nat. Commun."},{"key":"9092_CR48","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1215173","volume":"335","author":"PJ Rauch","year":"2012","unstructured":"Rauch, P. J. et al. Innate response activator B cells protect against microbial sepsis. Science 335, 597\u2013601 (2012).","journal-title":"Science"},{"key":"9092_CR49","doi-asserted-by":"crossref","unstructured":"Cippa, P. E. et al. Transcriptional trajectories of human kidney injury progression. JCI Insight 3, 123151 (2018).","DOI":"10.1172\/jci.insight.123151"},{"key":"9092_CR50","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ni.3790","volume":"18","author":"MG Netea","year":"2017","unstructured":"Netea, M. G. et al. A guiding map for inflammation. Nat. Immunol. 18, 826\u2013831 (2017).","journal-title":"Nat. Immunol."},{"key":"9092_CR51","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.116.308030","volume":"119","author":"SA Dick","year":"2016","unstructured":"Dick, S. A. & Epelman, S. Chronic heart failure and inflammation: what do we really know? Circ. Res. 119, 159\u2013176 (2016).","journal-title":"Circ. Res."},{"key":"9092_CR52","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","volume":"17","author":"C Iadecola","year":"2011","unstructured":"Iadecola, C. & Anrather, J. The immunology of stroke: from mechanisms to translation. Nat. Med. 17, 796\u2013808 (2011).","journal-title":"Nat. Med."},{"key":"9092_CR53","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1073\/pnas.1621457114","volume":"114","author":"X Li","year":"2017","unstructured":"Li, X. et al. Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease. Proc. Natl Acad. Sci. U.S.A. 114, 7089\u20137094 (2017).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"9092_CR54","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1097\/TP.0b013e3181d72091","volume":"89","author":"F Porcheray","year":"2010","unstructured":"Porcheray, F. et al. Chronic humoral rejection of human kidney allografts associates with broad autoantibody responses. Transplantation 89, 1239\u20131246 (2010).","journal-title":"Transplantation"},{"key":"9092_CR55","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/MOT.0000000000000329","volume":"21","author":"A Sicard","year":"2016","unstructured":"Sicard, A., Chen, C. C., Morelon, E. & Thaunat, O. Alloimmune-induced intragraft lymphoid neogenesis promotes B-cell tolerance breakdown that accelerates chronic rejection. Curr. Opin. Organ Transplant. 21, 368\u2013374 (2016).","journal-title":"Curr. Opin. Organ Transplant."},{"key":"9092_CR56","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ki.2011.317","volume":"81","author":"O Thaunat","year":"2012","unstructured":"Thaunat, O. et al. A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection. Kidney Int. 81, 207\u2013219 (2012).","journal-title":"Kidney Int."},{"key":"9092_CR57","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1681\/ASN.2004121130","volume":"16","author":"M Hourmant","year":"2005","unstructured":"Hourmant, M. et al. Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation. J. Am. Soc. Nephrol. 16, 2804\u20132812 (2005).","journal-title":"J. Am. Soc. Nephrol."},{"key":"9092_CR58","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(16)30826-1","volume":"388","author":"PJ O\u2019Connell","year":"2016","unstructured":"O\u2019Connell, P. J. et al. Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study. Lancet 388, 983\u2013993 (2016).","journal-title":"Lancet"},{"key":"9092_CR59","doi-asserted-by":"crossref","first-page":"e87680","DOI":"10.1172\/jci.insight.87680","volume":"1","author":"Y Sato","year":"2016","unstructured":"Sato, Y. et al. Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney. JCI Insight 1, e87680 (2016).","journal-title":"JCI Insight"},{"key":"9092_CR60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41586-018-0047-9","volume":"557","author":"D Nasralla","year":"2018","unstructured":"Nasralla, D. et al. A randomized trial of normothermic preservation in liver transplantation. Nature 557, 50\u201356 (2018).","journal-title":"Nature"},{"key":"9092_CR61","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/ki.2011.31","volume":"79","author":"D Schock-Kusch","year":"2011","unstructured":"Schock-Kusch, D. et al. Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves. Kidney Int. 79, 1254\u20131258 (2011).","journal-title":"Kidney Int."},{"key":"9092_CR62","doi-asserted-by":"crossref","unstructured":"Herrera Perez, Z., Weinfurter, S. & Gretz, N. Transcutaneous assessment of renal function in conscious rodents. J. Vis. Exp. e53767 (2016).","DOI":"10.3791\/53767"},{"key":"9092_CR63","doi-asserted-by":"crossref","first-page":"e71519","DOI":"10.1371\/journal.pone.0071519","volume":"8","author":"D Schock-Kusch","year":"2013","unstructured":"Schock-Kusch, D. et al. Reliability of transcutaneous measurement of renal function in various strains of conscious mice. PLoS ONE 8, e71519 (2013).","journal-title":"PLoS One"},{"key":"9092_CR64","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/biostatistics\/kxm030","volume":"9","author":"MD Robinson","year":"2008","unstructured":"Robinson, M. D. & Smyth, G. K. Small-sample estimation of negative binomial dispersion, with applications to SAGE data. Biostatistics 9, 321\u2013332 (2008).","journal-title":"Biostatistics"},{"key":"9092_CR65","volume":"19","author":"Q Zhu","year":"2018","unstructured":"Zhu, Q. et al. PIVOT: platform for interactive analysis and visualization of transcriptomics data. BMC Bioinformatics 19, 6 (2018).","journal-title":"BMC Bioinformatics"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-019-09092-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-019-09092-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-019-09092-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T16:23:22Z","timestamp":1671207802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-019-09092-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,11]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["9092"],"URL":"https:\/\/doi.org\/10.1038\/s41467-019-09092-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/343012","asserted-by":"object"}]},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,11]]},"assertion":[{"value":"5 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1157"}}