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Whether MAIT cell development depends on this invariant TCR-\u03b1 chain is unclear. Here we generate\n                    <jats:italic>Traj33<\/jats:italic>\n                    -deficient mice and show that they are highly depleted of MAIT cells; however, a residual population remains and can respond to exogenous antigen in vitro or pulmonary\n                    <jats:italic>Legionella<\/jats:italic>\n                    challenge in vivo. These residual cells include some that express\n                    <jats:italic>Trav1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    TCRs with conservative\n                    <jats:italic>Traj<\/jats:italic>\n                    -gene substitutions, and others that express\n                    <jats:italic>Trav1<\/jats:italic>\n                    <jats:sup>-<\/jats:sup>\n                    TCRs with a broad range of\n                    <jats:italic>Traj<\/jats:italic>\n                    genes. We further report that human TRAV1-2\n                    <jats:sup>-<\/jats:sup>\n                    MR1-restricted T cells contain both MAIT-like and non-MAIT-like cells, as judged by their TCR repertoire, antigen reactivity and phenotypic features. These include a MAIT-like population that expresses a public, canonical TRAV36\n                    <jats:sup>+<\/jats:sup>\n                    TRBV28\n                    <jats:sup>+<\/jats:sup>\n                    TCR. Our findings highlight the TCR diversity and the resulting potential impact on antigen recognition by MR1-restricted T cells.\n                  <\/jats:p>","DOI":"10.1038\/s41467-019-10198-w","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T06:11:42Z","timestamp":1558419102000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Diverse MR1-restricted T cells in mice and humans"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3236-9609","authenticated-orcid":false,"given":"Hui-Fern","family":"Koay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Gherardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Seneviratna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-683X","authenticated-orcid":false,"given":"Zhenjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-8566","authenticated-orcid":false,"given":"David P.","family":"Fairlie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-815X","authenticated-orcid":false,"given":"James","family":"McCluskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Pellicci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Uldrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3009-5472","authenticated-orcid":false,"given":"Dale I.","family":"Godfrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"10198_CR1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/imcb.12022","volume":"96","author":"EW Meermeier","year":"2018","unstructured":"Meermeier, E. 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