{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T04:46:29Z","timestamp":1794631589910,"version":"4.9.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16J06207"],"award-info":[{"award-number":["JP16J06207"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K15003"],"award-info":[{"award-number":["JP18K15003"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H02457"],"award-info":[{"award-number":["JP16H02457"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K15169"],"award-info":[{"award-number":["JP16K15169"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the developing cortex, postmigratory neurons accumulate in the cortical plate (CP) to properly differentiate consolidating subtype identities. Microglia, despite their extensive surveying activity, temporarily disappear from the midembryonic CP. However, the mechanism and significance of this absence are unknown. Here, we show that microglia bidirectionally migrate via attraction by CXCL12 released from the meninges and subventricular zone and thereby exit the midembryonic CP. Upon nonphysiological excessive exposure to microglia in vivo or in vitro, young postmigratory and in vitro-grown CP neurons showed abnormal differentiation with disturbed expression of the subtype-associated transcription factors and genes implicated in functional neuronal maturation. Notably, this effect is primarily attributed to interleukin 6 and type I interferon secreted by microglia. These results suggest that \u201csanctuarization\u201d from microglia in the midembryonic CP is required for neurons to appropriately fine-tune the expression of molecules needed for proper differentiation, thus securing the establishment of functional cortical circuit.<\/jats:p>","DOI":"10.1038\/s41467-020-15409-3","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T06:04:16Z","timestamp":1585807456000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Transient microglial absence assists postmigratory cortical neurons in proper differentiation"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-0121","authenticated-orcid":false,"given":"Yuki","family":"Hattori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Tsugawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-0325","authenticated-orcid":false,"given":"Shigenori","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-4590","authenticated-orcid":false,"given":"Hiroaki","family":"Wake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-3992","authenticated-orcid":false,"given":"Ayano","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-0241","authenticated-orcid":false,"given":"Takaki","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"15409_CR1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature25158","volume":"552","author":"C Venegas","year":"2017","unstructured":"Venegas, C. et al. Microglia-derived ASC specks cross-seed amyloid-\u03b2 in Alzheimer\u2019s disease. Nature 552, 355\u2013361 (2017).","journal-title":"Nature"},{"key":"15409_CR2","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41593-018-0100-x","volume":"21","author":"B Ajami","year":"2018","unstructured":"Ajami, B. et al. Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models. Nat. Neurosci. 21, 541\u2013551 (2018).","journal-title":"Nat. Neurosci."},{"key":"15409_CR3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41593-018-0083-7","volume":"21","author":"KJ Spiller","year":"2018","unstructured":"Spiller, K. J. et al. Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy. Nat. Neurosci. 21, 329\u2013340 (2018).","journal-title":"Nat. Neurosci."},{"key":"15409_CR4","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.neuron.2018.01.031","volume":"97","author":"Y Zhao","year":"2018","unstructured":"Zhao, Y. et al. TREM2 is a receptor for \u03b2-amyloid that mediates microglial function. Neuron 97, 1023\u20131031 (2018).","journal-title":"Neuron"},{"key":"15409_CR5","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","volume":"29","author":"H Wake","year":"2009","unstructured":"Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S. & Nabekura, J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci. 29, 3974\u20133980 (2009).","journal-title":"J. Neurosci."},{"key":"15409_CR6","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.1202529","volume":"333","author":"RC Paolicelli","year":"2011","unstructured":"Paolicelli, R. C. et al. Synaptic pruning by microglia is necessary for normal brain development. Science 333, 1456\u20131458 (2011).","journal-title":"Science"},{"key":"15409_CR7","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","volume":"155","author":"CN Parkhurst","year":"2014","unstructured":"Parkhurst, C. N. et al. Microglia promote learning-dependent synapse formation through BDNF. Cell 155, 1596\u20131609 (2014).","journal-title":"Cell"},{"key":"15409_CR8","doi-asserted-by":"publisher","first-page":"aad8670","DOI":"10.1126\/science.aad8670","volume":"353","author":"O Matcovitch-Natan","year":"2016","unstructured":"Matcovitch-Natan, O. et al. Microglia development follows a stepwise program to regulate brain homeostasis. Science 353, aad8670 (2016).","journal-title":"Science"},{"key":"15409_CR9","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1523\/JNEUROSCI.3441-12.2013","volume":"33","author":"CLP Cunningham","year":"2013","unstructured":"Cunningham, C. L. P., Mart\u00ednez-Cerde\u00f1o, V. & Noctor, S. C. Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J. Neurosci. 33, 4216\u20134233 (2013).","journal-title":"J. Neurosci."},{"key":"15409_CR10","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1093\/cercor\/bhy145","volume":"29","author":"N Barger","year":"2019","unstructured":"Barger, N. et al. Microglia: an intrinsic component of the proliferative zones in the fetal rhesus monkey (Macaca mulatta) cerebral cortex. Cereb. Cortex 29, 2782\u20132796 (2019).","journal-title":"Cereb. Cortex"},{"key":"15409_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6611","volume":"5","author":"B Arn\u00f2","year":"2014","unstructured":"Arn\u00f2, B. et al. Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex. Nat. Commun. 5, 5611 (2014).","journal-title":"Nat. Commun."},{"key":"15409_CR12","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/gtc.12632","volume":"23","author":"Y Hattori","year":"2018","unstructured":"Hattori, Y. & Miyata, T. Microglia extensively survey the developing cortex via the CXCL12\/CXCR4 system to help neural progenitors to acquire differentiated properties. Genes Cells 23, 915\u2013922 (2018).","journal-title":"Genes Cells"},{"key":"15409_CR13","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/glia.22421","volume":"61","author":"N Swinnen","year":"2013","unstructured":"Swinnen, N. et al. Complex invasion pattern of the cerebral cortex by microglial cells during development of the mouse embryo. Glia 61, 150\u2013163 (2013).","journal-title":"Glia"},{"key":"15409_CR14","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.celrep.2014.07.042","volume":"8","author":"P Squarzoni","year":"2014","unstructured":"Squarzoni, P. et al. Microglia modulate wiring of the embryonic forebrain. Cell Rep. 8, 1271\u20131279 (2014).","journal-title":"Cell Rep."},{"key":"15409_CR15","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nn.3358","volume":"16","author":"M Ueno","year":"2013","unstructured":"Ueno, M. et al. Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci. 16, 543\u2013551 (2013).","journal-title":"Nat. Neurosci."},{"key":"15409_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuron.2004.12.036","volume":"45","author":"P Arlotta","year":"2005","unstructured":"Arlotta, P. et al. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron 45, 207\u2013221 (2005).","journal-title":"Neuron"},{"key":"15409_CR17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nrn2151","volume":"8","author":"BJ Molyneaux","year":"2007","unstructured":"Molyneaux, B. J., Arlotta, P., Menezes, J. R. L. & Macklis, J. D. Neuronal subtype specification in the cerebral cortex. Nat. Rev. Neurosci. 8, 427\u2013437 (2007).","journal-title":"Nat. Rev. Neurosci."},{"key":"15409_CR18","doi-asserted-by":"publisher","first-page":"16021","DOI":"10.1073\/pnas.0806791105","volume":"105","author":"KY Kwan","year":"2008","unstructured":"Kwan, K. Y. et al. SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc. Natl Acad. Sci. USA 105, 16021\u201316026 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"15409_CR19","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.neuron.2007.12.023","volume":"57","author":"T Lai","year":"2008","unstructured":"Lai, T. et al. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron 57, 232\u2013247 (2008).","journal-title":"Neuron"},{"key":"15409_CR20","doi-asserted-by":"publisher","first-page":"e10907","DOI":"10.7554\/eLife.10907","volume":"5","author":"K Oishi","year":"2016","unstructured":"Oishi, K. et al. Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex. Elife 5, e10907 (2016).","journal-title":"Elife"},{"key":"15409_CR21","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","volume":"20","author":"S Jung","year":"2000","unstructured":"Jung, S. et al. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106\u20134114 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"15409_CR22","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/ni.3423","volume":"17","author":"T Goldmann","year":"2016","unstructured":"Goldmann, T. et al. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat. Immunol. 17, 797\u2013805 (2016).","journal-title":"Nat. Immunol."},{"key":"15409_CR23","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/nn1883","volume":"10","author":"HT Xu","year":"2007","unstructured":"Xu, H. T., Pan, F., Yang, G. & Gan, W. B. Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat. Neurosci. 10, 549\u2013551 (2007).","journal-title":"Nat. Neurosci."},{"key":"15409_CR24","doi-asserted-by":"publisher","first-page":"5805","DOI":"10.1523\/JNEUROSCI.23-13-05805.2003","volume":"23","author":"ES Ang Jr.","year":"2003","unstructured":"Ang, E. S. Jr., Haydar, T. F., Gluncic, V. & Rakic, P. Four-dimensional migratory coordinates of GABAergic interneurons in the developing mouse cortex. J. Neurosci. 23, 5805\u20135815 (2003).","journal-title":"J. Neurosci."},{"key":"15409_CR25","doi-asserted-by":"publisher","first-page":"16737","DOI":"10.1073\/pnas.1209166109","volume":"109","author":"M Yanagida","year":"2012","unstructured":"Yanagida, M., Miyoshi, R., Toyokuni, R., Zhu, Y. & Murakami, F. Dynamics of the leading process, nucleus, and Golgi apparatus of migrating cortical interneurons in living mouse embryos. Proc. Natl Acad. Sci. USA 109, 16737\u201316742 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"15409_CR26","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/31261","volume":"393","author":"K Tachibana","year":"1998","unstructured":"Tachibana, K. et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393, 591\u2013594 (1998).","journal-title":"Nature"},{"key":"15409_CR27","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nm0198-072","volume":"4","author":"GA Donzella","year":"1998","unstructured":"Donzella, G. A. et al. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nat. Med. 4, 72\u201377 (1998).","journal-title":"Nat. Med."},{"key":"15409_CR28","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.cell.2017.11.042","volume":"172","author":"MS Thion","year":"2018","unstructured":"Thion, M. S. et al. Microbiome influences prenatal and adult microglia in a sex-specific manner. Cell 172, 500\u2013516 (2018).","journal-title":"Cell"},{"key":"15409_CR29","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1126\/science.aad8361","volume":"351","author":"L Telley","year":"2016","unstructured":"Telley, L. et al. Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex. Science 351, 1443\u20131446 (2016).","journal-title":"Science"},{"key":"15409_CR30","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.neuron.2007.12.012","volume":"57","author":"EA Alcamo","year":"2008","unstructured":"Alcamo, E. A. et al. Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 57, 364\u2013377 (2008).","journal-title":"Neuron"},{"key":"15409_CR31","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.neuron.2007.12.028","volume":"57","author":"O Britanova","year":"2008","unstructured":"Britanova, O. et al. Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron 57, 378\u2013392 (2008).","journal-title":"Neuron"},{"key":"15409_CR32","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/cne.20322","volume":"479","author":"M Nieto","year":"2004","unstructured":"Nieto, M. et al. Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex. J. Comp. Neurol. 479, 168\u2013180 (2004).","journal-title":"J. Comp. Neurol."},{"key":"15409_CR33","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0896-6273(01)00211-2","volume":"29","author":"RF Hevner","year":"2001","unstructured":"Hevner, R. F. et al. Tbr1 regulates differentiation of the preplate and layer 6. Neuron 29, 353\u2013366 (2001).","journal-title":"Neuron"},{"key":"15409_CR34","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/dgd.12131","volume":"56","author":"T Kawaue","year":"2014","unstructured":"Kawaue, T. et al. Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain. Dev. Growth Differ. 56, 293\u2013304 (2014).","journal-title":"Dev. Growth Differ."},{"key":"15409_CR35","doi-asserted-by":"publisher","first-page":"E1738","DOI":"10.1073\/pnas.1525528113","volume":"113","author":"ML Bennett","year":"2016","unstructured":"Bennett, M. L. et al. New tools for studying microglia in the mouse and human CNS. Proc. Natl Acad. Sci. USA 113, E1738\u2013E1746 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"15409_CR36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nn.3599","volume":"17","author":"O Butovsky","year":"2014","unstructured":"Butovsky, O. et al. Identification of a unique TGF-b-dependent molecular and functional signature in microglia. Nat. Neurosci. 17, 131\u2013144 (2014).","journal-title":"Nat. Neurosci."},{"key":"15409_CR37","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1523\/JNEUROSCI.4651-07.2008","volume":"28","author":"G L\u00f3pez-Bendito","year":"2008","unstructured":"L\u00f3pez-Bendito, G. et al. Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons. J. Neurosci. 28, 1613\u20131624 (2008).","journal-title":"J. Neurosci."},{"key":"15409_CR38","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.bbamcr.2016.03.018","volume":"1863","author":"M Rothaug","year":"2016","unstructured":"Rothaug, M., Becker-Pauly, C. & Rose-John, S. The role of interleukin-6 signaling in nervous tissue. Biochim. Biophys. Acta 1863, 1218\u20131227 (2016).","journal-title":"Biochim. Biophys. Acta"},{"key":"15409_CR39","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.3389\/fimmu.2018.03047","volume":"9","author":"TH Mogensen","year":"2019","unstructured":"Mogensen, T. H. IRF and STAT transcription factors - from basic biology to roles in infection, protective immunity, and primary immunodeficiencies. Front. Immunol. 9, 3047 (2019).","journal-title":"Front. Immunol."},{"key":"15409_CR40","doi-asserted-by":"publisher","first-page":"3890","DOI":"10.1210\/endo.140.9.6983","volume":"140","author":"L Valli\u00e8res","year":"1999","unstructured":"Valli\u00e8res, L. et al. Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor. Endocrinology 140, 3890\u20133903 (1999).","journal-title":"Endocrinology"},{"key":"15409_CR41","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0896-6273(01)00566-9","volume":"33","author":"KL Whitford","year":"2002","unstructured":"Whitford, K. L. et al. Regulation of cortical dendrite development by Slit-Robo interactions. Neuron 33, 47\u201361 (2002).","journal-title":"Neuron"},{"key":"15409_CR42","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nn.3893","volume":"18","author":"C Delloye-Bourgeois","year":"2015","unstructured":"Delloye-Bourgeois, C. et al. PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat. Neurosci. 18, 36\u201345 (2015).","journal-title":"Nat. Neurosci."},{"key":"15409_CR43","doi-asserted-by":"publisher","first-page":"16356","DOI":"10.1523\/JNEUROSCI.3502-10.2010","volume":"30","author":"G Apostolova","year":"2010","unstructured":"Apostolova, G., Loy, B., Dorn, R. & Dechant, G. The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2. J. Neurosci. 30, 16356\u201316364 (2010).","journal-title":"J. Neurosci."},{"key":"15409_CR44","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1242\/dev.01912","volume":"132","author":"G Fan","year":"2005","unstructured":"Fan, G. et al. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development 132, 3345\u20133356 (2005).","journal-title":"Development"},{"key":"15409_CR45","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbi.2019.01.027","volume":"79","author":"X Kong","year":"2019","unstructured":"Kong, X. et al. JAK2\/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation\/methylation. Brain Behav. Immun. 79, 159\u2013173 (2019).","journal-title":"Brain Behav. Immun."},{"key":"15409_CR46","doi-asserted-by":"publisher","first-page":"e126663","DOI":"10.1172\/jci.insight.126663","volume":"4","author":"M Stefan-Lifshitz","year":"2019","unstructured":"Stefan-Lifshitz, M. et al. Epigenetic modulation of \u03b2 cells by interferon-\u03b1 via PNPT1\/mir-26a\/TET2 triggers autoimmune diabetes. JCI Insight 4, e126663 (2019).","journal-title":"JCI Insight"},{"key":"15409_CR47","doi-asserted-by":"publisher","first-page":"e1005338","DOI":"10.1371\/journal.ppat.1005338","volume":"11","author":"DN Kroetz","year":"2015","unstructured":"Kroetz, D. N. et al. Type I interferon induced epigenetic regulation of macrophages suppresses innate and adaptive immunity in acute respiratory viral infection. PloS Pathog. 11, e1005338 (2015).","journal-title":"PloS Pathog."},{"key":"15409_CR48","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1242\/dev.01173","volume":"131","author":"T Miyata","year":"2004","unstructured":"Miyata, T. et al. Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells. Development 131, 3133\u20133145 (2004).","journal-title":"Development"},{"key":"15409_CR49","doi-asserted-by":"publisher","first-page":"0312","DOI":"10.1523\/ENEURO.0312-18.2018","volume":"5","author":"Y Hattori","year":"2018","unstructured":"Hattori, Y. & Miyata, T. Embryonic neocortical microglia express Toll-like receptor 9 and respond to plasmid DNA injected into the ventricle: technical considerations regarding microglial distribution in electroporated brain walls. eNeuro 5, 0312\u201318.2018 (2018).","journal-title":"eNeuro"},{"key":"15409_CR50","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1242\/dev.022616","volume":"135","author":"A Kawaguchi","year":"2008","unstructured":"Kawaguchi, A. et al. Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis. Development 135, 3113\u20133124 (2008).","journal-title":"Development"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-020-15409-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-020-15409-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-020-15409-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T15:10:12Z","timestamp":1670253012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-020-15409-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,2]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["15409"],"URL":"https:\/\/doi.org\/10.1038\/s41467-020-15409-3","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,2]]},"assertion":[{"value":"27 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1631"}}