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Prolonged exposure to cAMP causes calmodulin-dependent feedback-adaptation of CNG channels and attenuates neural responses. On the other hand, the odour-source searching behaviour requires ORNs to be sensitive to odours when approaching targets. How ORNs accommodate these conflicting aspects of cAMP responses remains unknown. Here, we discover that olfactory marker protein (OMP) is a major cAMP buffer that maintains the sensitivity of ORNs. Upon the application of sensory stimuli, OMP directly captured and swiftly reduced freely available cAMP, which transiently uncoupled downstream CNG channel activity and prevented persistent depolarization. Under repetitive stimulation,<jats:italic>OMP<\/jats:italic><jats:sup><jats:italic>-\/-<\/jats:italic><\/jats:sup>ORNs were immediately silenced after burst firing due to sustained depolarization and inactivated firing machinery. Consequently,<jats:italic>OMP<\/jats:italic><jats:sup><jats:italic>-\/-<\/jats:italic><\/jats:sup>mice showed serious impairment in odour-source searching tasks. 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