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Herein, we disclose a copper(I)-NHC complex catalyzed asymmetric 1,6-conjugate allylation of 2,2-dimethyl-6-alkenyl-4<jats:italic>H<\/jats:italic>-1,3-dioxin-4-ones. The phenolic hydroxyl group in NHC ligands is found to be pivotal to obtain the desired products. Both aryl group and alkyl group at \u03b4-position are well tolerated with the corresponding products generated in moderate to high yields and high enantioselectivity. Moreover, both 2-substituted and 3-substituted allylboronates serve as acceptable allylation reagents. At last, the synthetic utility of the products is demonstrated in several transformations by means of the versatile terminal olefin and dioxinone groups.<\/jats:p>","DOI":"10.1038\/s41467-020-19293-9","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T11:03:14Z","timestamp":1604055794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Copper(I)-catalyzed asymmetric 1,6-conjugate allylation"],"prefix":"10.1038","volume":"11","author":[{"given":"Chang-Yun","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Zhou","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-0664","authenticated-orcid":false,"given":"Ping","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-5198","authenticated-orcid":false,"given":"Liang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"19293_CR1","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1021\/cr0683515","volume":"108","author":"A Alexakis","year":"2008","unstructured":"Alexakis, A., B\u00e4ckvall, J. 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