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Here, genome-wide association study (GWAS) analyses based on 456,327 UK Biobank (UKB) individuals identify 8 independent and significant loci for PUD at, or near, genes\n                    <jats:italic>MUC1<\/jats:italic>\n                    ,\n                    <jats:italic>MUC6, FUT2<\/jats:italic>\n                    ,\n                    <jats:italic>PSCA<\/jats:italic>\n                    ,\n                    <jats:italic>ABO<\/jats:italic>\n                    ,\n                    <jats:italic>CDX2, GAST<\/jats:italic>\n                    and\n                    <jats:italic>CCKBR<\/jats:italic>\n                    . There are previously established roles in susceptibility to\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection, response to counteract infection-related damage, gastric acid secretion or gastrointestinal motility for these genes. Only two associations have been previously reported for duodenal ulcer, here replicated trans-ancestrally. The results highlight the role of host genetic susceptibility to infection. Post-GWAS analyses for PUD, GORD, IBS and IBD add insights into relationships between these gastrointestinal diseases and their relationships with depression, a commonly comorbid disorder.\n                  <\/jats:p>","DOI":"10.1038\/s41467-021-21280-7","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T11:05:34Z","timestamp":1613819134000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":187,"title":["GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-1526","authenticated-orcid":false,"given":"Yeda","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8296-1742","authenticated-orcid":false,"given":"Graham K.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enda M.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-6772","authenticated-orcid":false,"given":"Julia","family":"Sidorenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2143-8760","authenticated-orcid":false,"given":"Peter M.","family":"Visscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-3357","authenticated-orcid":false,"given":"Naomi R.","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"21280_CR1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","volume":"156","author":"AF Peery","year":"2019","unstructured":"Peery, A. 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