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Its application to asymmetric catalysis, however, has been scarcely explored. Herein, we disclose our effort toward this goal by incorporation of dual asymmetric photocatalysis by a chiral nickel catalyst and a commercially available organophotocatalyst with a radical relay strategy through sulfur dioxide insertion. Such design leads to the development of three-component asymmetric sulfonylation involving direct functionalization of cycloalkanes, alkanes, toluene derivatives or ethers. The photochemical reaction of a C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )-H precursor, a SO\n                    <jats:sub>2<\/jats:sub>\n                    surrogate and a common \u03b1,\u03b2-unsaturated carbonyl compound proceeds smoothly under mild conditions, delivering a wide range of biologically interesting \u03b1-C chiral sulfones with high regio- and enantioselectivity (&gt;50 examples, up to &gt;50:1 rr and 95% ee). This method is applicable to late-stage functionalization of bioactive molecules, and provides an appealing access to enantioenriched compounds starting from the abundant hydrocarbon compounds.\n                  <\/jats:p>","DOI":"10.1038\/s41467-021-22690-3","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T06:16:55Z","timestamp":1619072215000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Photocatalytic three-component asymmetric sulfonylation via direct C(sp3)-H functionalization"],"prefix":"10.1038","volume":"12","author":[{"given":"Shi","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-6880","authenticated-orcid":false,"given":"Lei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"22690_CR1","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.2174\/1568026615666150915111741","volume":"16","author":"M Feng","year":"2016","unstructured":"Feng, M., Tang, B., Liang, S. 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