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A need to develop novel therapies specifically targeting fundamental metastasis processes remains urgent. Here, we demonstrate that\n                    <jats:italic>Salmonella<\/jats:italic>\n                    YB1, an engineered oxygen-sensitive strain, potently inhibits metastasis of a broad range of cancers. This process requires both IFN-\u03b3 and NK cells, as the absence of IFN-\u03b3 greatly reduces, whilst depletion of NK cells in vivo completely abolishes, the anti-metastatic ability of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    . Mechanistically, we find that IFN-\u03b3 is mainly produced by NK cells during early\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection, and in turn, IFN-\u03b3 promotes the accumulation, activation, and cytotoxicity of NK cells, which kill the metastatic cancer cells thus achieving an anti-metastatic effect. Our findings highlight the significance of a self-regulatory feedback loop of NK cells in inhibiting metastasis, pointing a possible approach to develop anti-metastatic therapies by harnessing the power of NK cells.\n                  <\/jats:p>","DOI":"10.1038\/s41467-021-22755-3","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T06:04:15Z","timestamp":1620194655000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["IFN-\u03b3-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella"],"prefix":"10.1038","volume":"12","author":[{"given":"Qiubin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-7222","authenticated-orcid":false,"given":"Li","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-7454","authenticated-orcid":false,"given":"Xian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-7226","authenticated-orcid":false,"given":"Jingchu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-359X","authenticated-orcid":false,"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-1126","authenticated-orcid":false,"given":"S. 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