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An example is the analysis of intracranial EEG (iEEG) from epilepsy patients for the detection of High Frequency Oscillations (HFO), which are a biomarker for epileptogenic brain tissue. Mixed-signal neuromorphic circuits offer the possibility of building compact and low-power neural network processing systems that can analyze data on-line in real-time. Here we present a neuromorphic system that combines a neural recording headstage with a spiking neural network (SNN) processing core on the same die for processing iEEG, and show how it can reliably detect HFO, thereby achieving state-of-the-art accuracy, sensitivity, and specificity. This is a first feasibility study towards identifying relevant features in iEEG in real-time using mixed-signal neuromorphic computing technologies.<\/jats:p>","DOI":"10.1038\/s41467-021-23342-2","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T06:02:59Z","timestamp":1621922579000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["An electronic neuromorphic system for real-time detection of high frequency oscillations (HFO) in intracranial EEG"],"prefix":"10.1038","volume":"12","author":[{"given":"Mohammadali","family":"Sharifshazileh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4807-5223","authenticated-orcid":false,"given":"Karla","family":"Burelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-381X","authenticated-orcid":false,"given":"Johannes","family":"Sarnthein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-1689","authenticated-orcid":false,"given":"Giacomo","family":"Indiveri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"23342_CR1","doi-asserted-by":"crossref","unstructured":"Editoral-team. 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