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However, general approaches towards carboxylation of carbonyl compounds with CO<jats:sub>2<\/jats:sub>remain scarce. Herein, we report a strategy for visible-light photoredox-catalyzed umpolung carboxylation of diverse carbonyl compounds with CO<jats:sub>2<\/jats:sub>by using Lewis acidic chlorosilanes as activating\/protecting groups. This strategy is general and practical to generate valuable \u03b1-hydroxycarboxylic acids. It works well for challenging alkyl aryl ketones and aryl aldehydes, as well as for \u03b1-ketoamides and \u03b1-ketoesters, the latter two of which have never been successfully applied in umpolung carboxylations with CO<jats:sub>2<\/jats:sub>(to the best of our knowledge). This reaction features high selectivity, broad substrate scope, good functional group tolerance, mild reaction conditions and facile derivations of products to bioactive compounds, including oxypheonium, mepenzolate bromide, benactyzine, and tiotropium. Moreover, the formation of carbon radicals and carbanions as well as the key role of chlorosilanes are supported by control experiments.<\/jats:p>","DOI":"10.1038\/s41467-021-23447-8","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T10:15:03Z","timestamp":1622715303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2"],"prefix":"10.1038","volume":"12","author":[{"given":"Guang-Mei","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Long","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Shun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-4863","authenticated-orcid":false,"given":"Jason J.","family":"Chruma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5888-1494","authenticated-orcid":false,"given":"Da-Gang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"23447_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/anie.197902393","volume":"18","author":"D Seebach","year":"1979","unstructured":"Seebach, D. 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