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However, the direct deoxygenative coupling of aldehydes or ketones to construct C(sp<jats:sup>3<\/jats:sup>)\u2212C(sp<jats:sup>3<\/jats:sup>) bond remains a scientific challenge. Here we report a nickel\u2212catalyzed reductive homo-coupling of moisture- and air-stable hydrazones generated in-situ from naturally abundant aldehydes and ketones to construct challenging C(sp<jats:sup>3<\/jats:sup>)\u2212C(sp<jats:sup>3<\/jats:sup>) bond. This transformation has great functional group compatibility and can suit a broad substrate scope with innocuous H<jats:sub>2<\/jats:sub>O, N<jats:sub>2<\/jats:sub> and H<jats:sub>2<\/jats:sub> as the by-products. Furthermore, the application in several biological molecules and the transformation of PEEK model\u00a0demonstrate the generality, practicability, and applicability of this novel methodology.<\/jats:p>","DOI":"10.1038\/s41467-021-23971-7","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T10:03:09Z","timestamp":1623924189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["C(sp3)\u2212C(sp3) bond formation via nickel-catalyzed deoxygenative homo-coupling of aldehydes\/ketones mediated by hydrazine"],"prefix":"10.1038","volume":"12","author":[{"given":"Dawei","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-5450","authenticated-orcid":false,"given":"Chen-Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-111X","authenticated-orcid":false,"given":"Huiying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3859-8824","authenticated-orcid":false,"given":"Chao-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"23971_CR1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.chempr.2016.08.007","volume":"1","author":"C-J Li","year":"2016","unstructured":"Li, C.-J. 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