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During hypoxia, their body temperature (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>b<\/jats:sub>\n                    ) decreases via unknown mechanisms to conserve energy. In small mammals, non-shivering thermogenesis in brown adipose tissue (BAT) is critical to\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>b<\/jats:sub>\n                    regulation; therefore, we hypothesize that hypoxia decreases naked mole-rat BAT thermogenesis. To test this, we measure changes in\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>b<\/jats:sub>\n                    during normoxia and hypoxia (7% O\n                    <jats:sub>2<\/jats:sub>\n                    ; 1\u20133\u2009h). We report that interscapular thermogenesis is high in normoxia but ceases during hypoxia, and\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>b<\/jats:sub>\n                    decreases. Furthermore, in BAT from animals treated in hypoxia, UCP1 and mitochondrial complexes I-V protein expression\u00a0rapidly decrease, while mitochondria undergo fission, and apoptosis and mitophagy are inhibited. Finally, UCP1 expression decreases in hypoxia in three other social African mole-rat species, but not a solitary species. These findings suggest that the ability to rapidly down-regulate thermogenesis to conserve oxygen in hypoxia may have evolved preferentially in social species.\n                  <\/jats:p>","DOI":"10.1038\/s41467-021-27170-2","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T06:02:49Z","timestamp":1637647369000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-640X","authenticated-orcid":false,"given":"Hang","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaa","family":"Sebaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Malholtra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1922-8801","authenticated-orcid":false,"given":"Baptiste","family":"Lacoste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3155-3287","authenticated-orcid":false,"given":"Ziyad","family":"El Hankouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel C.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"van Jaarsveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-558X","authenticated-orcid":false,"given":"Daniel W.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-6760","authenticated-orcid":false,"given":"Glenn J.","family":"Tattersall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-5886","authenticated-orcid":false,"given":"Mary-Ellen","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-9555","authenticated-orcid":false,"given":"Matthew E.","family":"Pamenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"27170_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.cbpa.2014.10.029","volume":"186","author":"YA Dzal","year":"2015","unstructured":"Dzal, Y. 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