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However, the probiotic bacterium\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    Nissle 1917 (or \u201cNissle\u201d) exhibits appreciable growth in zinc-limited media even when these transporters are deleted. Here, we show that Nissle utilizes the siderophore yersiniabactin as a zincophore, enabling Nissle to grow in zinc-limited media, to tolerate calprotectin-mediated zinc sequestration, and to thrive in the inflamed gut. We also show that yersiniabactin\u2019s affinity for iron or zinc changes in a pH-dependent manner, with increased relative zinc binding as the pH increases. Thus, our results indicate that siderophore metal affinity can be influenced by the local environment and reveal a mechanism of zinc acquisition available to commensal and pathogenic\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1038\/s41467-021-27297-2","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T06:04:42Z","timestamp":1638338682000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-1090","authenticated-orcid":false,"given":"Judith","family":"Behnsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allegra T.","family":"Aron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivekanandan","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-3769","authenticated-orcid":false,"given":"William","family":"Santus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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