{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T15:42:35Z","timestamp":1794584555352,"version":"4.9.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000093","name":"U.S. Department of Health & Human Services | NIH | Center for Information Technology","doi-asserted-by":"publisher","award":["1R21CA223969-01A1"],"award-info":[{"award-number":["1R21CA223969-01A1"]}],"id":[{"id":"10.13039\/100000093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"EC | Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["720834"],"award-info":[{"award-number":["720834"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"EC | Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["720834"],"award-info":[{"award-number":["720834"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004770","name":"Universit\u00e0 degli Studi di Parma","doi-asserted-by":"publisher","award":["FIL_2018_Miragoli"],"award-info":[{"award-number":["FIL_2018_Miragoli"]}],"id":[{"id":"10.13039\/501100004770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial infarction causes 7.3 million deaths worldwide, mostly for fibrillation that electrically originates from the damaged areas of the left ventricle. Conventional cardiac bypass graft and percutaneous coronary interventions allow reperfusion of the downstream tissue but do not counteract the bioelectrical alteration originated from the infarct area. Genetic, cellular, and tissue engineering therapies are promising avenues but require days\/months for permitting proper functional tissue regeneration. Here we engineered biocompatible silicon carbide semiconductive nanowires that synthetically couple, via membrane nanobridge formations, isolated beating cardiomyocytes over distance, restoring physiological cell-cell conductance, thereby permitting the synchronization of bioelectrical activity in otherwise uncoupled cells. Local in-situ multiple injections of nanowires in the left ventricular infarcted regions allow rapid reinstatement of impulse propagation across damaged areas and recover electrogram parameters and conduction velocity. Here we propose this nanomedical intervention as a strategy for reducing ventricular arrhythmia after acute myocardial infarction.<\/jats:p>","DOI":"10.1038\/s41467-021-27637-2","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T11:03:42Z","timestamp":1641812622000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires"],"prefix":"10.1038","volume":"13","author":[{"given":"Paola","family":"Lagonegro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-8410","authenticated-orcid":false,"given":"Stefano","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-3221","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Salvarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-2458","authenticated-orcid":false,"given":"Francesco Paolo","family":"Lo Muzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Rozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-8009","authenticated-orcid":false,"given":"Jessica","family":"Modica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5214-7624","authenticated-orcid":false,"given":"Franca","family":"Bigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-6031","authenticated-orcid":false,"given":"Martina","family":"Quaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9828-6371","authenticated-orcid":false,"given":"Giancarlo","family":"Salviati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Pinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Alinovi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-6114","authenticated-orcid":false,"given":"Daniele","family":"Catalucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3675-9196","authenticated-orcid":false,"given":"Francesca","family":"D\u2019Autilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Gazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0481-6843","authenticated-orcid":false,"given":"Gianluigi","family":"Condorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-2542","authenticated-orcid":false,"given":"Francesca","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-4368","authenticated-orcid":false,"given":"Michele","family":"Miragoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"27637_CR1","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1093\/eurheartj\/eht453","volume":"35","author":"W Bougouin","year":"2014","unstructured":"Bougouin, W. et al. Incidence of sudden cardiac death after ventricular fibrillation complicating acute myocardial infarction: a 5-year cause-of-death analysis of the FAST-MI 2005 registry. Eur. Heart J. 35, 116\u2013122 (2014).","journal-title":"Eur. Heart J."},{"key":"27637_CR2","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1161\/CIRCULATIONAHA.116.026075","volume":"135","author":"MP Rao","year":"2017","unstructured":"Rao, M. P. et al. Sudden cardiac death in patients with ischemic heart failure undergoing coronary artery bypass grafting: results from the STICH randomized clinical trial (Surgical Treatment for Ischemic Heart Failure). Circulation 135, 1136\u20131144 (2017).","journal-title":"Circulation"},{"key":"27637_CR3","first-page":"e350","volume":"117","author":"AE Epstein","year":"2008","unstructured":"Epstein, A. E. et al. ACC\/AHA\/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC\/AHA\/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117, e350\u2013e408 (2008).","journal-title":"Circulation"},{"key":"27637_CR4","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1161\/01.CIR.88.3.915","volume":"88","author":"JM de Bakker","year":"1993","unstructured":"de Bakker, J. M. et al. Slow conduction in the infarcted human heart. \u2018Zigzag\u2019 course of activation. Circulation 88, 915\u2013926 (1993).","journal-title":"Circulation"},{"key":"27637_CR5","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0008-6363(99)00013-9","volume":"42","author":"JM Pinto","year":"1999","unstructured":"Pinto, J. M. & Boyden, P. A. Electrical remodeling in ischemia and infarction. Cardiovasc. Res. 42, 284\u2013297 (1999).","journal-title":"Cardiovasc. Res."},{"key":"27637_CR6","first-page":"e210","volume":"138","author":"SM Al-Khatib","year":"2018","unstructured":"Al-Khatib, S. M. et al. 2017 AHA\/ACC\/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation 138, e210\u2013e271 (2018).","journal-title":"Circulation"},{"key":"27637_CR7","doi-asserted-by":"publisher","first-page":"7045245","DOI":"10.1155\/2018\/7045245","volume":"2018","author":"Z Chen","year":"2018","unstructured":"Chen, Z., Chen, L., Zeng, C. & Wang, W. E. Functionally improved mesenchymal stem cells to better treat myocardial infarction. Stem Cells Int. 2018, 7045245 (2018).","journal-title":"Stem Cells Int."},{"key":"27637_CR8","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1161\/CIRCRESAHA.118.311587","volume":"123","author":"K Ishikawa","year":"2018","unstructured":"Ishikawa, K., Weber, T. & Hajjar, R. J. Human cardiac gene therapy. Circ. Res. 123, 601\u2013613 (2018).","journal-title":"Circ. Res."},{"key":"27637_CR9","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/cvr\/cvx070","volume":"113","author":"C Perrino","year":"2017","unstructured":"Perrino, C. et al. Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovasc. Res. 113, 725\u2013736 (2017).","journal-title":"Cardiovasc. Res."},{"key":"27637_CR10","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/cvr\/cvz010","volume":"115","author":"R Madonna","year":"2019","unstructured":"Madonna, R. et al. ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure. Cardiovasc. Res. 115, 488\u2013500 (2019).","journal-title":"Cardiovasc. Res."},{"key":"27637_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/bmb\/ldn026","volume":"87","author":"H Jawad","year":"2008","unstructured":"Jawad, H., Lyon, A. R., Harding, S. E., Ali, N. N. & Boccaccini, A. R. Myocardial tissue engineering. Br. Med. Bull. 87, 31\u201347 (2008).","journal-title":"Br. Med. Bull."},{"key":"27637_CR12","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1161\/CIRCRESAHA.116.310277","volume":"120","author":"L Gao","year":"2017","unstructured":"Gao, L. et al. Myocardial tissue engineering with cells derived from human-induced pluripotent stem cells and a native-like, high-resolution, 3-dimensionally printed scaffold. Circ. Res. 120, 1318\u20131325 (2017).","journal-title":"Circ. Res."},{"key":"27637_CR13","doi-asserted-by":"publisher","first-page":"eaan6205","DOI":"10.1126\/scitranslmed.aan6205","volume":"10","author":"M Miragoli","year":"2018","unstructured":"Miragoli, M. et al. Inhalation of peptide-loaded nanoparticles improves heart failure. Sci. Transl. Med. 10, eaan6205 (2018).","journal-title":"Sci. Transl. Med."},{"key":"27637_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41569-018-0073-1","volume":"16","author":"R Duivenvoorden","year":"2019","unstructured":"Duivenvoorden, R. et al. Nanoimmunotherapy to treat ischaemic heart disease. Nat. Rev. Cardiol. 16, 21\u201332 (2019).","journal-title":"Nat. Rev. Cardiol."},{"key":"27637_CR15","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1126\/scitranslmed.3005101","volume":"6","author":"WJ Mulder","year":"2014","unstructured":"Mulder, W. J., Jaffer, F. A., Fayad, Z. A. & Nahrendorf, M. Imaging and nanomedicine in inflammatory atherosclerosis. Sci. Transl. Med. 6, 239\u2013231 (2014).","journal-title":"Sci. Transl. Med."},{"key":"27637_CR16","doi-asserted-by":"publisher","first-page":"e006920","DOI":"10.1161\/CIRCEP.118.006920","volume":"12","author":"DM Pedrotty","year":"2019","unstructured":"Pedrotty, D. M. et al. Three-dimensional printed biopatches with conductive ink facilitate cardiac conduction when applied to disrupted myocardium. Circ. Arrhythmia Electrophysiol. 12, e006920 (2019).","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"27637_CR17","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/nbt0708-774","volume":"26","author":"K Kostarelos","year":"2008","unstructured":"Kostarelos, K. The long and short of carbon nanotube toxicity. Nat. Biotechnol. 26, 774\u2013776 (2008).","journal-title":"Nat. Biotechnol."},{"key":"27637_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33144-0","volume":"8","author":"S Saravanan","year":"2018","unstructured":"Saravanan, S. et al. Graphene oxide-gold nanosheets containing chitosan scaffold improves ventricular contractility and function after implantation into infarcted heart. Sci. Rep. 8, 15069 (2018).","journal-title":"Sci. Rep."},{"key":"27637_CR19","doi-asserted-by":"publisher","first-page":"265702","DOI":"10.1088\/1361-6528\/ab0d5d","volume":"30","author":"S Nakata","year":"2019","unstructured":"Nakata, S. et al. Strain engineering of core-shell silicon carbide nanowires for mechanical and piezoresistive characterizations. Nanotechnology. 30, 265702 (2019).","journal-title":"Nanotechnology"},{"key":"27637_CR20","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.msec.2016.12.096","volume":"73","author":"P Lagonegro","year":"2017","unstructured":"Lagonegro, P. et al. A cytotoxicity study of silicon oxycarbide nanowires as cell scaffold for biomedical applications. Mater. Sci. Eng. C Mater. Biol. Appl. 73, 465\u2013471 (2017).","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"27637_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9671","volume":"6","author":"Y Connor","year":"2015","unstructured":"Connor, Y. et al. Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype. Nat. Commun. 6, 8671 (2015).","journal-title":"Nat. Commun."},{"key":"27637_CR22","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.yjmcc.2018.05.002","volume":"119","author":"C Houston","year":"2018","unstructured":"Houston, C. et al. Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line. J. Mol. Cell. Cardiol. 119, 155\u2013164 (2018).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"27637_CR23","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1161\/01.RES.0000089258.40661.0C","volume":"93","author":"G Gaudesius","year":"2003","unstructured":"Gaudesius, G., Miragoli, M., Thomas, S. P. & Rohr, S. Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circ. Res. 93, 421\u2013428 (2003).","journal-title":"Circ. Res."},{"key":"27637_CR24","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1161\/01.RES.0000214537.44195.a3","volume":"98","author":"M Miragoli","year":"2006","unstructured":"Miragoli, M., Gaudesius, G. & Rohr, S. Electrotonic modulation of cardiac impulse conduction by myofibroblasts. Circ. Res. 98, 801\u2013810 (2006).","journal-title":"Circ. Res."},{"key":"27637_CR25","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/978-1-62703-505-7_20","volume":"1037","author":"EG Strungs","year":"2013","unstructured":"Strungs, E. G. et al. Cryoinjury models of the adult and neonatal mouse heart for studies of scarring and regeneration. Methods Mol. Biol. 1037, 343\u2013353 (2013).","journal-title":"Methods Mol. Biol."},{"key":"27637_CR26","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1161\/CIRCRESAHA.117.312354","volume":"122","author":"J Tang","year":"2018","unstructured":"Tang, J. et al. Genetic fate mapping defines the vascular potential of endocardial cells in the adult heart. Circ. Res. 122, 984\u2013993 (2018).","journal-title":"Circ. Res."},{"key":"27637_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-019-0311-7","volume":"16","author":"S Rossi","year":"2019","unstructured":"Rossi, S. et al. Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats. Part. Fibre Toxicol. 16, 25 (2019).","journal-title":"Part. Fibre Toxicol."},{"key":"27637_CR28","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1126\/science.1128640","volume":"313","author":"F Patolsky","year":"2006","unstructured":"Patolsky, F. et al. Detection, stimulation, and inhibition of neuronal signals with high-density nanowire transistor arrays. Science 313, 1100\u20131104 (2006).","journal-title":"Science"},{"key":"27637_CR29","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/s41565-017-0041-7","volume":"13","author":"R Parameswaran","year":"2018","unstructured":"Parameswaran, R. et al. Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires. Nat. Nanotechnol. 13, 260\u2013266 (2018).","journal-title":"Nat. Nanotechnol."},{"key":"27637_CR30","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1073\/pnas.1000450107","volume":"107","author":"C Xie","year":"2010","unstructured":"Xie, C. & Cui, Y. Nanowire platform for mapping neural circuits. Proc. Natl Acad. Sci. USA 107, 4489\u20134490 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"27637_CR31","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.nantod.2013.05.001","volume":"8","author":"X Duan","year":"2013","unstructured":"Duan, X., Fu, T. M., Liu, J. & Lieber, C. M. Nanoelectronics-biology frontier: from nanoscopic probes for action potential recording in live cells to three-dimensional cyborg tissues. Nano Today 8, 351\u2013373 (2013).","journal-title":"Nano Today"},{"key":"27637_CR32","doi-asserted-by":"publisher","first-page":"22531","DOI":"10.1073\/pnas.1913651116","volume":"116","author":"MY Rotenberg","year":"2019","unstructured":"Rotenberg, M. Y. et al. Living myofibroblast-silicon composites for probing electrical coupling in cardiac systems. Proc. Natl Acad. Sci. USA 116, 22531\u201322539 (2019).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"27637_CR33","doi-asserted-by":"publisher","first-page":"10453","DOI":"10.1096\/fj.201802740RR","volume":"33","author":"F Schultz","year":"2019","unstructured":"Schultz, F. et al. Cardiomyocyte-myofibroblast contact dynamism is modulated by connexin-43. FASEB J. 33, 10453\u201310468 (2019).","journal-title":"FASEB J."},{"key":"27637_CR34","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1161\/CIRCRESAHA.107.160549","volume":"101","author":"M Miragoli","year":"2007","unstructured":"Miragoli, M., Salvarani, N. & Rohr, S. Myofibroblasts induce ectopic activity in cardiac tissue. Circ. Res. 101, 755\u2013758 (2007).","journal-title":"Circ. Res."},{"key":"27637_CR35","doi-asserted-by":"publisher","first-page":"e1601039","DOI":"10.1126\/sciadv.1601039","volume":"2","author":"JF Zimmerman","year":"2016","unstructured":"Zimmerman, J. F. et al. Cellular uptake and dynamics of unlabeled freestanding silicon nanowires. Sci. Adv. 2, e1601039 (2016).","journal-title":"Sci. Adv."},{"key":"27637_CR36","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.biomaterials.2018.06.027","volume":"179","author":"F Chen","year":"2018","unstructured":"Chen, F. et al. Cellular toxicity of silicon carbide nanomaterials as a function of morphology. Biomaterials 179, 60\u201370 (2018).","journal-title":"Biomaterials"},{"key":"27637_CR37","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1021\/nl501255m","volume":"14","author":"A Cacchioli","year":"2014","unstructured":"Cacchioli, A. et al. Cytocompatibility and cellular internalization mechanisms of SiC\/SiO2 nanowires. Nano Lett. 14, 4368\u20134375 (2014).","journal-title":"Nano Lett."},{"key":"27637_CR38","doi-asserted-by":"publisher","first-page":"14852","DOI":"10.1073\/pnas.1611184114","volume":"113","author":"TA Quinn","year":"2016","unstructured":"Quinn, T. A. et al. Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics. Proc. Natl Acad. Sci. USA 113, 14852\u201314857 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"27637_CR39","doi-asserted-by":"publisher","first-page":"015012","DOI":"10.1088\/1758-5090\/8\/1\/015012","volume":"8","author":"H Yang","year":"2016","unstructured":"Yang, H. et al. Biochip-based study of unidirectional mitochondrial transfer from stem cells to myocytes via tunneling nanotubes. Biofabrication 8, 015012 (2016).","journal-title":"Biofabrication"},{"key":"27637_CR40","doi-asserted-by":"publisher","first-page":"e90266","DOI":"10.1371\/journal.pone.0090266","volume":"9","author":"P Dias","year":"2014","unstructured":"Dias, P. et al. Characterisation of connexin expression and electrophysiological properties in stable clones of the HL-1 myocyte cell line. PLoS ONE 9, e90266 (2014).","journal-title":"PLoS ONE"},{"key":"27637_CR41","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1161\/01.RES.63.1.72","volume":"63","author":"R Weingart","year":"1988","unstructured":"Weingart, R. & Maurer, P. Action potential transfer in cell pairs isolated from adult rat and guinea pig ventricles. Circ. Res. 63, 72\u201380 (1988).","journal-title":"Circ. Res."},{"key":"27637_CR42","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0006-3495(96)79569-3","volume":"70","author":"R Wilders","year":"1996","unstructured":"Wilders, R. et al. Action potential conduction between a ventricular cell model and an isolated ventricular cell. Biophys. J. 70, 281\u2013295 (1996).","journal-title":"Biophys. J."},{"key":"27637_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/eurheartj\/6.suppl_D.85","volume":"6","author":"S Ahnve","year":"1985","unstructured":"Ahnve, S. QT interval prolongation in acute myocardial infarction. Eur. Heart J. 6, 85\u201395 (1985).","journal-title":"Eur. Heart J."},{"key":"27637_CR44","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1161\/CIRCULATIONAHA.117.030142","volume":"137","author":"JR Giudicessi","year":"2018","unstructured":"Giudicessi, J. R., Roden, D. M., Wilde, A. A. M. & Ackerman, M. J. Classification and reporting of potentially proarrhythmic common genetic variation in long QT syndrome genetic testing. Circulation 137, 619\u2013630 (2018).","journal-title":"Circulation"},{"key":"27637_CR45","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/eci.12670","volume":"46","author":"R Ieva","year":"2016","unstructured":"Ieva, R. et al. Prolonged QT and myocardium recovery after primary PCI: a cMRI study. Eur. J. Clin. Invest. 46, 873\u2013879 (2016).","journal-title":"Eur. J. Clin. Invest."},{"key":"27637_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48710-3","volume":"9","author":"JE Azarov","year":"2019","unstructured":"Azarov, J. E., Ovechkin, A. O., Vaykshnorayte, M. A., Demidova, M. M. & Platonov, P. G. Prolongation of the activation time in ischemic myocardium is associated with J-wave generation in ECG and ventricular fibrillation. Sci. Rep. 9, 12202 (2019).","journal-title":"Sci. Rep."},{"key":"27637_CR47","doi-asserted-by":"crossref","unstructured":"Whittaker, P., Kloner, R. A. & Przyklenk, K. Intramyocardial injections and protection against myocardial ischemia. An attempt to examine the cardioprotective actions of adenosine. Circulation 93, 2043\u20132057 (1996).","DOI":"10.1161\/01.CIR.93.11.2043"},{"key":"27637_CR48","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1161\/CIRCRESAHA.110.235747","volume":"108","author":"MP O\u2019Quinn","year":"2011","unstructured":"O\u2019Quinn, M. P., Palatinus, J. A., Harris, B. S., Hewett, K. W. & Gourdie, R. G. A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury. Circ. Res. 108, 704\u2013715 (2011).","journal-title":"Circ. Res."},{"key":"27637_CR49","doi-asserted-by":"publisher","first-page":"394006","DOI":"10.1088\/0022-3727\/47\/39\/394006","volume":"47","author":"F Fabbri","year":"2014","unstructured":"Fabbri, F. et al. 3C\u2013SiC nanowires luminescent enhancement by coating with a conformal oxides layer. J. Phys. D Appl. Phys. 47, 394006 (2014).","journal-title":"J. Phys. D Appl. Phys."},{"key":"27637_CR50","unstructured":"Rossi, F. et al. in Silicon Carbide Biotechnology 2nd edn, Ch. 10. (Elsevier, 2016)."},{"key":"27637_CR51","doi-asserted-by":"publisher","first-page":"345702","DOI":"10.1088\/0957-4484\/21\/34\/345702","volume":"21","author":"F Fabbri","year":"2010","unstructured":"Fabbri, F. et al. Enhancement of the core near-band-edge emission induced by an amorphous shell in coaxial one-dimensional nanostructure: the case of SiC\/SiO2 core\/shell self-organized nanowires. Nanotechnology 21, 345702 (2010).","journal-title":"Nanotechnology"},{"key":"27637_CR52","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.yjmcc.2015.08.001","volume":"87","author":"V Meraviglia","year":"2015","unstructured":"Meraviglia, V. et al. Acetylation mediates Cx43 reduction caused by electrical stimulation. J. Mol. Cell. Cardiol. 87, 54\u201364 (2015).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"27637_CR53","doi-asserted-by":"publisher","first-page":"891","DOI":"10.2217\/nnm.16.26","volume":"11","author":"V Di Mauro","year":"2016","unstructured":"Di Mauro, V. et al. Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs. Nanomedicine 11, 891\u2013906 (2016).","journal-title":"Nanomedicine"},{"key":"27637_CR54","doi-asserted-by":"publisher","first-page":"12033","DOI":"10.1073\/pnas.1712612114","volume":"114","author":"I Gesmundo","year":"2017","unstructured":"Gesmundo, I. et al. Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure. Proc. Natl Acad. Sci. USA 114, 12033\u201312038 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"27637_CR55","doi-asserted-by":"publisher","first-page":"e004567","DOI":"10.1161\/CIRCEP.116.004567","volume":"10","author":"N Salvarani","year":"2017","unstructured":"Salvarani, N. et al. TGF-beta1 (Transforming Growth Factor-beta1) plays a pivotal role in cardiac myofibroblast arrhythmogenicity. Circ. Arrhythmia Electrophysiol. 10, e004567 (2017).","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"27637_CR56","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.pbiomolbio.2019.05.003","volume":"154","author":"FP Lo Muzio","year":"2019","unstructured":"Lo Muzio, F. P. et al. In-situ optical assessment of rat epicardial kinematic parameters reveals frequency-dependent mechanic heterogeneity related to gender. Prog. Biophys. Mol. Biol. 154, 94\u2013101 (2019).","journal-title":"Prog. Biophys. Mol. Biol."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-021-27637-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-021-27637-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-021-27637-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T15:30:46Z","timestamp":1669303846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-021-27637-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["27637"],"URL":"https:\/\/doi.org\/10.1038\/s41467-021-27637-2","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"11 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6"}}