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Herein, a unified protocol for a variety of intermolecular Heck-type functionalizations of C\n                    <jats:sub>\n                      <jats:italic>sp2<\/jats:italic>\n                    <\/jats:sub>\n                    -H bond of alkenes has been developed by thianthrenation. The reaction features metal-free and operationally simple conditions for exclusive\n                    <jats:italic>cine<\/jats:italic>\n                    -selective C-H functionalization of aliphatic and aryl alkenes to forge C-C, C-N, C-P, and C-S bonds at room temperature, providing a general protocol for intermolecular Heck-type reaction of alkenes with nucleophiles (Nu = sulfinates, cyanides, amines, amides). Alkenes undergo\n                    <jats:italic>cine<\/jats:italic>\n                    -sulfonylation, cyanation, amination to afford alkenyl sulfones, alkenyl nitriles and enamines.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-44746-w","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T10:02:08Z","timestamp":1705312928000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Unified metal-free intermolecular Heck-type sulfonylation, cyanation, amination, amidation of alkenes by thianthrenation"],"prefix":"10.1038","volume":"15","author":[{"given":"Ming-Shang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Wu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-2634","authenticated-orcid":false,"given":"Wei","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"44746_CR1","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1021\/cr00038a011","volume":"95","author":"SD Rychnovsky","year":"1995","unstructured":"Rychnovsky, S. 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