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Here, we characterise the mechanism of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell invasion into BEC. CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells observed within BEC were large, eccentric, and expressed E-cadherin, CD103 and CD69. They were also not contained within secondary vesicles. Internalisation required cytoskeletal rearrangements which facilitated contact with BEC. Internalised CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells were observed in both non-cirrhotic and cirrhotic diseased liver tissues but enriched in PBC patients, both during active disease and at the time of transplantation. E-cadherin expression by CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells correlated with frequency of internalisation of these cells into BEC. E-cadherin\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells formed \u03b2-catenin-associated interactions with BEC, were larger than E-cadherin\n                    <jats:sup>-<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and invaded into BEC more frequently. Overall, we unveil a distinct cell-in-cell structure process in the liver detailing the invasion of E-cadherin\n                    <jats:sup>+<\/jats:sup>\n                    CD103\n                    <jats:sup>+<\/jats:sup>\n                    CD69\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells into BEC.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-44910-2","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:03:49Z","timestamp":1706515429000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-1339","authenticated-orcid":false,"given":"Scott P.","family":"Davies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-1333","authenticated-orcid":false,"given":"Vincenzo","family":"Ronca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace E.","family":"Wootton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-6676","authenticated-orcid":false,"given":"Natalia M.","family":"Krajewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6637-8952","authenticated-orcid":false,"given":"Amber G.","family":"Bozward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1531-9770","authenticated-orcid":false,"given":"R\u00e9mi","family":"Fiancette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8745-0578","authenticated-orcid":false,"given":"Daniel A.","family":"Patten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Yankouskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-0582","authenticated-orcid":false,"given":"Gary M.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3671-9380","authenticated-orcid":false,"given":"Sofia","family":"Pat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-0730","authenticated-orcid":false,"given":"Daniel C.","family":"Osei-Bordom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9682-9857","authenticated-orcid":false,"given":"Naomi","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-7412","authenticated-orcid":false,"given":"Liam M.","family":"Grover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-1264","authenticated-orcid":false,"given":"Christopher J.","family":"Weston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-6734","authenticated-orcid":false,"given":"Ye H.","family":"Oo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"44910_CR1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nri3608","volume":"14","author":"LW Peterson","year":"2014","unstructured":"Peterson, L. 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