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We used a set of magnetic resonance imaging (MRI) metrics derived from structural and diffusion MRI data in\n                    <jats:italic>N<\/jats:italic>\n                    =48,040 UK Biobank participants to evaluate age-related differences in brain asymmetry. Most regional grey and white matter metrics presented asymmetry, which were higher later in life. Informed by these results, we conducted\n                    <jats:italic>hemispheric brain age<\/jats:italic>\n                    (HBA) predictions from left\/right multimodal MRI metrics. HBA was concordant to conventional brain age predictions, using metrics from both hemispheres, but offers a supplemental general marker of brain asymmetry when setting left\/right HBA into relationship with each other. In contrast to WM brain asymmetries, left\/right discrepancies in HBA are lower at higher ages. Our findings outline various sex-specific differences, particularly important for brain age estimates, and the value of further investigating the role of brain asymmetries in brain ageing and disease development.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-45282-3","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T02:03:25Z","timestamp":1706753005000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Brain asymmetries from mid- to late life and hemispheric brain age"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8113-2560","authenticated-orcid":false,"given":"Max","family":"Korbmacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-9304","authenticated-orcid":false,"given":"Dani","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Marie G.","family":"de Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Eikefjord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvid","family":"Lundervold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-3568","authenticated-orcid":false,"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-956X","authenticated-orcid":false,"given":"Lars T.","family":"Westlye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-6774","authenticated-orcid":false,"given":"Ivan I.","family":"Maximov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"45282_CR1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/hbm.26076","volume":"44","author":"N Nazlee","year":"2023","unstructured":"Nazlee, N., Waiter, G. 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