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Here, we use optogenetic tools to investigate the functional plasticity of the glutamatergic reticulospinal drive of the medullary reticular formation after a lateral thoracic hemisection in female mice. Sites evoking stronger excitatory descending drive in intact conditions are the most impaired after injury, whereas those associated with a weaker drive are potentiated. After lesion, pro- and anti-locomotor activities (that is, initiation\/acceleration versus stop\/deceleration) are overall preserved. Activating the descending reticulospinal drive improves stepping ability on a flat surface of chronically impaired injured mice, and its priming enhances recovery of skilled locomotion on a horizontal ladder. This study highlights the resilience and capacity for reorganization of the glutamatergic reticulospinal command after injury, along with its suitability as a therapeutical target to promote functional recovery.<\/jats:p>","DOI":"10.1038\/s41467-024-45300-4","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T08:03:00Z","timestamp":1708416180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3260-2029","authenticated-orcid":false,"given":"Maxime","family":"Lemieux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-3414","authenticated-orcid":false,"given":"Frederic","family":"Bretzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"45300_CR1","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/s41593-022-01196-1","volume":"25","author":"MA Anderson","year":"2022","unstructured":"Anderson, M. 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