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However, realizing fiber electronics for monitoring micro-physiological activities remains challenging due to the intrinsic variability and subtle amplitude of physiological signals, which differ among individuals and scenarios. Here, we propose a technical approach based on a dynamic stability model of sheath-core fibers, integrating a micro-flexure-sensitive fiber enabled by nanofiber buckling and an ion conduction mechanism. This scheme enhances the accuracy of the signal transmission process, resulting in improved sensitivity (detectable signal at ultra-low curvature of 0.1\u2009mm<jats:sup>\u22121<\/jats:sup>; flexure factor &gt;21.8% within a bending range of 10\u00b0.) and robustness of fiber under micro flexure. In addition, we also developed a scalable manufacturing process and ensured compatibility with modern weaving techniques. 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