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Here we report lineage M1\n                    <jats:sub>UK<\/jats:sub>\n                    to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1\n                    <jats:sub>global<\/jats:sub>\n                    strains, invasive M1\n                    <jats:sub>UK<\/jats:sub>\n                    strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes\n                    <jats:italic>covRS<\/jats:italic>\n                    . The emergence of M1\n                    <jats:sub>UK<\/jats:sub>\n                    is dated to 2008. Following a bottleneck coinciding with the COVID-19 pandemic, three emergent M1\n                    <jats:sub>UK<\/jats:sub>\n                    clades underwent rapid nationwide expansion, despite lack of detection in previous years. All M1\n                    <jats:sub>UK<\/jats:sub>\n                    isolates thus-far sequenced globally have a phylogenetic origin in the UK, with dispersal of the new clades in Europe. While waning immunity may promote streptococcal epidemics, the genetic features of M1\n                    <jats:sub>UK<\/jats:sub>\n                    point to a fitness advantage in pathogenicity, and a striking ability to persist through population bottlenecks.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-47929-7","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T06:01:59Z","timestamp":1715320919000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes"],"prefix":"10.1038","volume":"15","author":[{"given":"Ana","family":"Vieira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8354-7647","authenticated-orcid":false,"given":"Yu","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-5943","authenticated-orcid":false,"given":"Ho Kwong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Papangeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin K.","family":"Huse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy C.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-5070","authenticated-orcid":false,"given":"Valerie W. 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