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One antifungal class used to treat\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    infections is the fungistatic echinocandins, semisynthetic drugs derived from naturally occurring fungal lipopeptides. By inhibiting beta-1,3-glucan synthesis, echinocandins cause both fungistatic stunting of hyphal growth and repeated fungicidal lysis of apical tip compartments. Here, we uncover an endogenous mechanism of echinocandin tolerance in\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    whereby the inducible oxylipin signal 5,8-diHODE confers protection against tip lysis via the transcription factor ZfpA. Treatment of\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    with echinocandins induces 5,8-diHODE synthesis by the fungal oxygenase PpoA in a ZfpA dependent manner resulting in a positive feedback loop. This protective 5,8-diHODE\/ZfpA signaling relay is conserved among diverse isolates of\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    and in two other\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    pathogens. Our findings reveal an oxylipin-directed growth program\u2014possibly arisen through natural encounters with native echinocandin producing fungi\u2014that enables echinocandin tolerance in pathogenic aspergilli.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-48231-2","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T11:01:34Z","timestamp":1714820494000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["An oxylipin signal confers protection against antifungal echinocandins in pathogenic aspergilli"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0953-4029","authenticated-orcid":false,"given":"Dante G.","family":"Calise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9081-7992","authenticated-orcid":false,"given":"Sung Chul","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Woo","family":"Bok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2986-350X","authenticated-orcid":false,"given":"Gustavo H.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-9473","authenticated-orcid":false,"given":"Nancy P.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"48231_CR1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1136\/thoraxjnl-2014-206291","volume":"70","author":"C Kosmidis","year":"2015","unstructured":"Kosmidis, C. & Denning, D. 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