{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T15:40:37Z","timestamp":1794584437221,"version":"4.9.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22272041"],"award-info":[{"award-number":["22272041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of tumor-resident intracellular microbiota (TRIM) in carcinogenesis has sparked enormous interest. Nevertheless, the impact of TRIM-targeted antibacteria on tumor inhibition and immune regulation in the tumor microenvironment (TME) remains unexplored. Herein, we report long-term relapse-free survival by coordinating antibacteria with antitumor treatment, addressing the aggravated immunosuppression and tumor overgrowth induced by TRIM using breast and prostate cancer models. Combining Ag<jats:sup>+<\/jats:sup> release with a Fenton-like reaction and photothermal conversion, simultaneous bacteria killing and multimodal antitumor therapy are enabled by a single agent. Free of immune-stimulating drugs, the agent restores antitumor immune surveillance and activates immunological responses. Secondary inoculation and distal tumor analysis confirm lasting immunological memory and systemic immune responses. A relapse-free survival of &gt;700 days is achieved. This work unravels the crucial role of TRIM-targeted antibacteria in tumor inhibition and unlocks an unconventional route for immune regulation in TME and a complete cure for cancer.<\/jats:p>","DOI":"10.1038\/s41467-024-48662-x","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:02:06Z","timestamp":1715940126000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Long-term relapse-free survival enabled by integrating targeted antibacteria in antitumor treatment"],"prefix":"10.1038","volume":"15","author":[{"given":"Yuanlin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiancheng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaotong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-6981","authenticated-orcid":false,"given":"Ye","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-5604","authenticated-orcid":false,"given":"Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-1335","authenticated-orcid":false,"given":"Flemming","family":"Besenbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6027-0315","authenticated-orcid":false,"given":"Chunying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8820-9594","authenticated-orcid":false,"given":"Miao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"48662_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nature23889","volume":"550","author":"J Lloyd-Price","year":"2017","unstructured":"Lloyd-Price, J. et al. Strains, functions and dynamics in the expanded human microbiome project. Nature 550, 61\u201366 (2017).","journal-title":"Nature"},{"key":"48662_CR2","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.3390\/cancers12092672","volume":"12","author":"J Chakladar","year":"2020","unstructured":"Chakladar, J. et al. The pancreatic microbiome is associated with carcinogenesis and worse prognosis in males and smokers. Cancers 12, 2672 (2020).","journal-title":"Cancers"},{"key":"48662_CR3","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s13046-021-02128-w","volume":"40","author":"J Ma","year":"2021","unstructured":"Ma, J. et al. The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor? J. Exp. Clin. Cancer Res. 40, 327 (2021).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"48662_CR4","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.cell.2022.02.027","volume":"185","author":"A Fu","year":"2022","unstructured":"Fu, A. et al. Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer. Cell 185, 1356\u20131372 (2022).","journal-title":"Cell"},{"key":"48662_CR5","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","volume":"368","author":"D Nejman","year":"2020","unstructured":"Nejman, D. et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368, 973\u2013980 (2020).","journal-title":"Science"},{"key":"48662_CR6","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.aah5043","volume":"357","author":"LT Geller","year":"2017","unstructured":"Geller, L. T. et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science 357, 1156\u20131160 (2017).","journal-title":"Science"},{"key":"48662_CR7","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1038\/s41587-022-01628-0","volume":"41","author":"A Heinken","year":"2023","unstructured":"Heinken, A. et al. Genome-scale metabolic reconstruction of 7,300 human microorganisms for personalized medicine. Nat. Biotechnol. 41, 1320\u20131331 (2023).","journal-title":"Nat. Biotechnol."},{"key":"48662_CR8","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/nn.4606","volume":"20","author":"S Shen","year":"2017","unstructured":"Shen, S. et al. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat. Neurosci. 20, 1213\u20131216 (2017).","journal-title":"Nat. Neurosci."},{"key":"48662_CR9","doi-asserted-by":"publisher","first-page":"4166","DOI":"10.1172\/JCI72334","volume":"124","author":"CL Sears","year":"2014","unstructured":"Sears, C. L., Geis, A. L. & Housseau, F. Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis. J. Clin. Invest. 124, 4166\u20134172 (2014).","journal-title":"J. Clin. Invest."},{"key":"48662_CR10","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/s41571-023-00803-9","volume":"20","author":"RC Simpson","year":"2023","unstructured":"Simpson, R. C. et al. Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors. Nat. Rev. Clin. Oncol. 20, 697\u2013715 (2023).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"48662_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40439-y","volume":"14","author":"T Lang","year":"2023","unstructured":"Lang, T. et al. Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy. Nat. Commun. 14, 4746 (2023).","journal-title":"Nat. Commun."},{"key":"48662_CR12","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1158\/2159-8290.CD-17-1134","volume":"8","author":"S Pushalkar","year":"2018","unstructured":"Pushalkar, S. et al. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. 8, 403\u2013416 (2018).","journal-title":"Cancer Discov."},{"key":"48662_CR13","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrmicro2536","volume":"9","author":"BP Willing","year":"2011","unstructured":"Willing, B. P., Russell, S. L. & Finlay, B. B. Shifting the balance: antibiotic effects on host-microbiota mutualism. Nat. Rev. Microbiol. 9, 233\u2013243 (2011).","journal-title":"Nat. Rev. Microbiol."},{"key":"48662_CR14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.tcb.2014.11.006","volume":"25","author":"F Klemm","year":"2015","unstructured":"Klemm, F. & Joyce, J. A. Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol. 25, 198\u2013213 (2015).","journal-title":"Trends Cell Biol."},{"key":"48662_CR15","doi-asserted-by":"publisher","first-page":"e1568812","DOI":"10.1080\/2162402X.2019.1568812","volume":"8","author":"A Elkrief","year":"2019","unstructured":"Elkrief, A. et al. Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with immune checkpoint inhibitors. Oncoimmunology 8, e1568812 (2019).","journal-title":"Oncoimmunology"},{"key":"48662_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1126\/science.aan4236","volume":"359","author":"V Gopalakrishnan","year":"2018","unstructured":"Gopalakrishnan, V. et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359, 97\u2013103 (2018).","journal-title":"Science"},{"key":"48662_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25561-z","volume":"12","author":"X Qin","year":"2021","unstructured":"Qin, X. et al. Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy. Nat. Commun. 12, 5243 (2021).","journal-title":"Nat. Commun."},{"key":"48662_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19945-w","volume":"11","author":"H Zhou","year":"2020","unstructured":"Zhou, H. et al. Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy. Nat. Commun. 11, 6183 (2020).","journal-title":"Nat. Commun."},{"key":"48662_CR19","doi-asserted-by":"publisher","first-page":"107753","DOI":"10.1016\/j.pharmthera.2020.107753","volume":"221","author":"Y Xiao","year":"2021","unstructured":"Xiao, Y. & Yu, D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol. Ther. 221, 107753 (2021).","journal-title":"Pharmacol. Ther."},{"key":"48662_CR20","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/ni1102-991","volume":"3","author":"GP Dunn","year":"2002","unstructured":"Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J. & Schreiber, R. D. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3, 991\u2013998 (2002).","journal-title":"Nat. Immunol."},{"key":"48662_CR21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41565-018-0319-4","volume":"14","author":"Q Chen","year":"2019","unstructured":"Chen, Q. et al. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Nat. Nanotechnol. 14, 89\u201397 (2019).","journal-title":"Nat. Nanotechnol."},{"key":"48662_CR22","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/s41551-020-0599-5","volume":"4","author":"L Li","year":"2020","unstructured":"Li, L. et al. Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells. Nat. Biomed. Eng. 4, 1102\u20131116 (2020).","journal-title":"Nat. Biomed. Eng."},{"key":"48662_CR23","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrc.2017.51","volume":"17","author":"De","year":"2017","unstructured":"De, Palma, M., Biziato, D. & Petrova, T. V. Microenvironmental regulation of tumour angiogenesis. Nat. Rev. Cancer 17, 457\u2013474 (2017).","journal-title":"Nat. Rev. Cancer"},{"key":"48662_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03225-9","volume":"9","author":"D Chen","year":"2018","unstructured":"Chen, D. et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat. Commun. 9, 873 (2018).","journal-title":"Nat. Commun."},{"key":"48662_CR25","doi-asserted-by":"publisher","first-page":"e279","DOI":"10.1016\/S1470-2045(13)70567-9","volume":"15","author":"L Fan","year":"2014","unstructured":"Fan, L. et al. Breast cancer in China. Lancet Oncol. 15, e279\u2013e289 (2014).","journal-title":"Lancet Oncol."},{"key":"48662_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-017-0140-9","volume":"50","author":"M Akram","year":"2017","unstructured":"Akram, M., Iqbal, M., Daniyal, M. & Khan, A. U. Awareness and current knowledge of breast cancer. Biol. Res. 50, 33 (2017).","journal-title":"Biol. Res."},{"key":"48662_CR27","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1007\/s10552-020-01338-5","volume":"31","author":"E Klann","year":"2020","unstructured":"Klann, E. et al. Microbiota composition in bilateral healthy breast tissue and breast tumors. Cancer Causes Control 31, 1027\u20131038 (2020).","journal-title":"Cancer Causes Control"},{"key":"48662_CR28","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-med-080719-091604","volume":"72","author":"RT Lacet","year":"2021","unstructured":"Lacet, R. T., Bleich, R. M. & Arthur, J. C. Microbia effects on carcinogensis: Initiation, promotion, and progress. Annu. Rev. Med. 72, 243\u2013261 (2021).","journal-title":"Annu. Rev. Med."},{"key":"48662_CR29","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41551-021-00807-9","volume":"6","author":"D Zheng","year":"2022","unstructured":"Zheng, D. et al. Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma. Nat. Biomed. Eng. 6, 32\u201343 (2022).","journal-title":"Nat. Biomed. Eng."},{"key":"48662_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.msec.2014.05.007","volume":"42","author":"Z Liu","year":"2014","unstructured":"Liu, Z. et al. Synthesis of polyethylenimine (PEI) functionalized silver nanoparticles by a hydrothermal method and their antibacterial activity study. Mater. Sci. Eng. C 42, 31\u201337 (2014).","journal-title":"Mater. Sci. Eng. C"},{"key":"48662_CR31","doi-asserted-by":"publisher","first-page":"1907568","DOI":"10.1002\/adma.201907568","volume":"32","author":"S Gao","year":"2020","unstructured":"Gao, S. et al. Selenium-containing nanoparticles combine the NK cells mediated immunotherapy with radiotherapy and chemotherapy. Adv. Mater. 32, 1907568 (2020).","journal-title":"Adv. Mater."},{"key":"48662_CR32","doi-asserted-by":"publisher","first-page":"2104410","DOI":"10.1002\/adma.202104410","volume":"33","author":"R He","year":"2021","unstructured":"He, R. et al. Congener-induced sulfur-related metabolism interference therapy promoted by photothermal sensitization for combating bacteria. Adv. Mater. 33, 2104410 (2021).","journal-title":"Adv. Mater."},{"key":"48662_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120167","volume":"255","author":"Y Wang","year":"2020","unstructured":"Wang, Y. et al. Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy. Biomaterials 255, 120167 (2020).","journal-title":"Biomaterials"},{"key":"48662_CR34","doi-asserted-by":"publisher","first-page":"646","DOI":"10.3389\/fonc.2020.00646","volume":"10","author":"M Serra","year":"2020","unstructured":"Serra, M. et al. Understanding metal dynamics between cancer cells and macrophages: competition or synergism? Front. Oncol. 10, 646 (2020).","journal-title":"Front. Oncol."},{"key":"48662_CR35","doi-asserted-by":"publisher","first-page":"9060","DOI":"10.1039\/c3ta11254c","volume":"1","author":"W Teng","year":"2013","unstructured":"Teng, W., Li, X., Zhao, Q. & Chen, G. Fabrication of Ag\/Ag3PO4\/TiO2 heterostructure photoelectrodes for efficient decomposition of 2-chlorophenol under visible light irradiation. J. Mater. Chem. A 1, 9060\u20139068 (2013).","journal-title":"J. Mater. Chem. A"},{"key":"48662_CR36","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/anie.201804882","volume":"58","author":"X Duan","year":"2019","unstructured":"Duan, X., Chan, C. & Lin, W. Nanoparticle-mediated immunogenic cell death enables and potentiates cancer immunotherapy. Angew. Chem. Int. Ed. 58, 670\u2013680 (2019).","journal-title":"Angew. Chem. Int. Ed."},{"key":"48662_CR37","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/nm1523","volume":"13","author":"M Obeid","year":"2007","unstructured":"Obeid, M. et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat. Med. 13, 1050\u20131059 (2007).","journal-title":"Nat. Med."},{"key":"48662_CR38","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nrc3380","volume":"12","author":"DV Krysko","year":"2012","unstructured":"Krysko, D. V. et al. Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 12, 860\u2013875 (2012).","journal-title":"Nat. Rev. Cancer"},{"key":"48662_CR39","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9854904","volume":"2022","author":"K Zhao","year":"2022","unstructured":"Zhao, K. et al. lncRNA HITT inhibits lactate production by repressing PKM2 oligomerization to reduce tumor growth and macrophage polarization. Research 2022, 9854904 (2022).","journal-title":"Research"},{"key":"48662_CR40","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.intimp.2016.06.006","volume":"38","author":"R Pal","year":"2016","unstructured":"Pal, R. et al. Noble metal nanoparticle-induced oxidative stress modulates tumor associated macrophages (TAMs) from an M2 to M1 phenotype: an in vitro approach. Int. Immunopharmacol. 38, 332\u2013341 (2016).","journal-title":"Int. Immunopharmacol."},{"key":"48662_CR41","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.1158\/0008-5472.CAN-08-0206","volume":"68","author":"JS Nam","year":"2008","unstructured":"Nam, J. S. et al. Transforming growth factor \u03b2 subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res. 68, 3915\u20133923 (2008).","journal-title":"Cancer Res."},{"key":"48662_CR42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13045-020-01014-w","volume":"14","author":"S Liu","year":"2021","unstructured":"Liu, S. et al. NK cell-based cancer immunotherapy: from basic biology to clinical development. J. Hematol. Oncol. 14, 7 (2021).","journal-title":"J. Hematol. Oncol."},{"key":"48662_CR43","doi-asserted-by":"publisher","first-page":"101366","DOI":"10.1016\/j.xpro.2022.101366","volume":"3","author":"E Kim","year":"2022","unstructured":"Kim, E. et al. Isolation and analyses of lamina propria lymphocytes from mouse intestines. STAR Protoc. 3, 101366 (2022).","journal-title":"STAR Protoc."},{"key":"48662_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03210-2","volume":"9","author":"X Wu","year":"2018","unstructured":"Wu, X. et al. A randomized and open-label phase II trial reports the efficacy of neoadjuvant lobaplatin in breast cancer. Nat. Commun. 9, 832 (2018).","journal-title":"Nat. Commun."},{"key":"48662_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101162","volume":"39","author":"Q Tian","year":"2021","unstructured":"Tian, Q. et al. Recent advances in enhanced chemodynamic therapy strategies. Nano Today 39, 101162 (2021).","journal-title":"Nano Today"},{"key":"48662_CR46","doi-asserted-by":"publisher","first-page":"6153","DOI":"10.1002\/smll.201601936","volume":"12","author":"D Shen","year":"2016","unstructured":"Shen, D. et al. A silver(I)-estrogen nanocluster: GSH sensitivity and targeting suppression on HepG2 cell. Small 12, 6153\u20136159 (2016).","journal-title":"Small"},{"key":"48662_CR47","doi-asserted-by":"publisher","unstructured":"Tsang, G. Y. & Zhang, Y. Nanomaterials for light-mediated therapeutics in deep tissue. Chem. Soc. Rev. (2024). https:\/\/doi.org\/10.1039\/d3cs00862b.","DOI":"10.1039\/d3cs00862b"},{"key":"48662_CR48","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4338","volume":"19","author":"R Ransohoff","year":"2016","unstructured":"Ransohoff, R. A polarizing question: do M1 and M2 microglia exist? Nat. Neurosci. 19, 987\u2013991 (2016).","journal-title":"Nat. Neurosci."},{"key":"48662_CR49","doi-asserted-by":"publisher","first-page":"8977","DOI":"10.1021\/acsnano.8b02446","volume":"12","author":"YW Choo","year":"2018","unstructured":"Choo, Y. W. et al. M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors. ACS Nano 12, 8977\u20138993 (2018).","journal-title":"ACS Nano"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-48662-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-48662-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-48662-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T11:04:58Z","timestamp":1715943898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-48662-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["48662"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-48662-x","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]},"assertion":[{"value":"11 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4194"}}