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The identification of Aplp1 and the interplay with Lag3 for \u03b1-syn PFF induced pathology deepens our insight about molecular mechanisms of cell-to-cell transmission of pathologic \u03b1-syn and provides additional targets for therapeutic strategies aimed at preventing neurodegeneration in Parkinson\u2019s disease and related \u03b1-synucleinopathies.<\/jats:p>","DOI":"10.1038\/s41467-024-49016-3","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T18:02:39Z","timestamp":1717178559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Aplp1 interacts with Lag3 to facilitate transmission of pathologic 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Patents relate to the LAG3 aspects of this manuscript (Fig.\u00a0, Supplementary Figs. 5, 6, and 9 are as follows: US Provisional Patent Application #60\/451,039 (St Jude # SJ-02-0027)). Title: Regulating T-Cell Homeostasis. Priority date: February 28, 2003. Pardoll D, Vignali DAA, Powell J, Drake C, Huang C-T, Workman CJ. US Provisional Patent Application #60\/482,143 (St Jude # SJ-03-0012 \/ JH # Dm-4255). Title: Modulating Regulatory T-Cell Activity via CD223. Filed: June 24, 2003. Combined and published September 16, 2004, as International Application No. WO 2004\/078928 entitled \u2018T-Cell Regulation\u2019. European Patent Application No: 07021595.9; publication no: 1897548, Feb 13, 2008. Pending U.S. application for \u201cT-cell Regulation\u201d published Oct. 26, 2006, as Pub. No. 2006\/0240024 and corresponding foreign applications pending in Canada and Japan. Patents granted in US (8551481 - issued 10\/8\/2013; 9005629 - issued 04\/14\/2015; 10787513 - issued 09\/29\/2020; 10934354 - issued 03\/02\/2021), Australia (2004217526; issued \u2013 8\/12\/2010), Europe (1897548; issued \u2013 08\/14\/2013), Japan (6758259; issued 09\/03\/2020), and Hong Kong (1114339; issued 11\/22\/2013). Additional applications pending in Canada (1), Europe (2), Japan (2), and the U.S. (1). The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4663"}}