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To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA. It has been proposed that cohesin is protected from WAPL by SORORIN. However, in vivo evidence for this antagonism is missing and SORORIN is only known to exist in vertebrates and insects. It is therefore unknown how important and widespread SORORIN\u2019s functions are. Here we report the identification of SORORIN orthologs in\n                    <jats:italic>Schizosaccharomyces pombe<\/jats:italic>\n                    (Sor1) and\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    (AtSORORIN).\n                    <jats:italic>sor1\u0394<\/jats:italic>\n                    mutants display cohesion defects, which are partially alleviated by\n                    <jats:italic>wpl1\u0394<\/jats:italic>\n                    .\n                    <jats:italic>Atsororin<\/jats:italic>\n                    mutant plants display dwarfism, tissue specific cohesion defects and chromosome mis-segregation. Furthermore,\n                    <jats:italic>Atsororin<\/jats:italic>\n                    mutant plants are sterile and separate sister chromatids prematurely at anaphase I. The somatic, but not the meiotic deficiencies can be alleviated by loss of WAPL. These results provide in vivo evidence for SORORIN antagonizing WAPL, reveal that SORORIN is present in organisms beyond the animal kingdom and indicate that it has acquired tissue specific functions in plants.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-49178-0","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T13:02:26Z","timestamp":1717419746000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sororin is an evolutionary conserved antagonist of WAPL"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8170-6552","authenticated-orcid":false,"given":"Ignacio","family":"Prus\u00e9n Mota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Galova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-2747","authenticated-orcid":false,"given":"Alexander","family":"Schleiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-8870","authenticated-orcid":false,"given":"Tan-Trung","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Kovacikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Farias Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Litos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2989-8374","authenticated-orcid":false,"given":"Juraj","family":"Gregan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-3195","authenticated-orcid":false,"given":"Jan-Michael","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0909-3587","authenticated-orcid":false,"given":"Peter","family":"Schl\u00f6gelhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"49178_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/gtc.12652","volume":"24","author":"KI Ishiguro","year":"2019","unstructured":"Ishiguro, K. 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