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Insecticide-based management has led to the evolution of insecticide resistance in both species, though the genetic architecture and geographical spread of resistance remains incompletely understood. This study investigates partial selective sweeps at resistance genes on two chromosomes and characterises their spread across populations. Sweeps at the voltage-sensitive sodium channel (\n                    <jats:italic>VSSC<\/jats:italic>\n                    ) gene on chromosome 3 correspond to one resistance-associated nucleotide substitution in\n                    <jats:italic>Ae. albopictus<\/jats:italic>\n                    and three in\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    , including two substitutions at the same nucleotide position (F1534C) that have evolved and spread independently. In\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    , we also identify partial sweeps at a second locus on chromosome 2. This locus contains 15 glutathione S-transferase (\n                    <jats:italic>GST<\/jats:italic>\n                    ) epsilon class genes with significant copy number variation among populations and where three distinct genetic backgrounds have spread across the Indo-Pacific region, the Americas, and Australia. Local geographical patterns and linkage networks indicate\n                    <jats:italic>VSSC<\/jats:italic>\n                    and\n                    <jats:italic>GST<\/jats:italic>\n                    backgrounds probably spread at different times and interact locally with different genes to produce resistance phenotypes. These findings highlight the rapid global spread of resistance and are evidence for the critical importance of\n                    <jats:italic>GST<\/jats:italic>\n                    genes in resistance evolution.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-49792-y","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T09:09:41Z","timestamp":1721812181000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4695-075X","authenticated-orcid":false,"given":"Thomas L.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Endersby-Harshman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R. 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