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Herein we provide a theoretical treatment for this phenomenon, presenting an effective spin-Hamiltonian for helical molecules like DNA and density functional theory (DFT) results on amino acids that confirm the dependence of J-couplings on the choice of enantiomer. The connection between nuclear spin dynamics and chirality could offer insights for molecular sensing and quantum information sciences. These results establish NMR as a potential tool for chiral discrimination without external agents.<\/jats:p>","DOI":"10.1038\/s41467-024-49966-8","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T06:02:47Z","timestamp":1724738567000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Enantiospecificity in NMR enabled by chirality-induced spin selectivity"],"prefix":"10.1038","volume":"15","author":[{"given":"T.","family":"Georgiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-7560","authenticated-orcid":false,"given":"J. 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