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Herein, we describe a rapid and transition metal-free conversion of fluoroform with paraformaldehyde into highly reactive potassium 2,2,2-trifluoroethoxide (CF\n                    <jats:sub>3<\/jats:sub>\n                    CH\n                    <jats:sub>2<\/jats:sub>\n                    OK) and demonstrate robust applications of this synthon in one-pot, two-stage 2,2,2-trifluoroethoxylations of both aromatic and aliphatic precursors. Moreover, we show that these transformations translate easily to fluoroform that has been labeled with either carbon-11 (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    \u2009=\u200920.4\u2009min) or fluorine-18 (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    \u2009=\u2009109.8\u2009min), so allowing the appendage of complex molecules with a no-carrier-added\n                    <jats:sup>11<\/jats:sup>\n                    C- or\n                    <jats:sup>18<\/jats:sup>\n                    F- 2,2,2-trifluoroethoxy group. This provides scope to create candidate PET tracers with radioactive and metabolically stable 2,2,2-trifluoroethoxy moieties. We also exemplify syntheses of isotopologues of potassium 2,2,2-trifluoroethoxide and show their utility for stable isotopic labeling which can be of further benefit for drug discovery and development.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-49975-7","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T12:01:55Z","timestamp":1720612915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Isotopologues of potassium 2,2,2-trifluoroethoxide for applications in positron emission tomography and beyond"],"prefix":"10.1038","volume":"15","author":[{"given":"Qunchao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8725","authenticated-orcid":false,"given":"Sanjay","family":"Telu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-347X","authenticated-orcid":false,"given":"Susovan","family":"Jana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-3560","authenticated-orcid":false,"given":"Cheryl L.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-2553","authenticated-orcid":false,"given":"Victor W.","family":"Pike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"49975_CR1","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1039\/D2NP00056C","volume":"40","author":"HP Li","year":"2023","unstructured":"Li, H. 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