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Although a growing number of lncRNAs are now known to regulate neural cell development and function, relatively few lncRNAs have been shown to underlie animal behavior.\n                    <jats:italic>Pnky<\/jats:italic>\n                    is an evolutionarily conserved, neural lncRNA that regulates brain development. Using mouse genetic strategies, we show that\n                    <jats:italic>Pnky<\/jats:italic>\n                    has sex-specific roles in mouse behavior and that this lncRNA can underlie specific behavior by functioning in\n                    <jats:italic>trans<\/jats:italic>\n                    . Male\n                    <jats:italic>Pnky<\/jats:italic>\n                    -knockout mice have decreased context generalization in a paradigm of associative fear learning and memory. In female\n                    <jats:italic>Pnky<\/jats:italic>\n                    -knockout mice, there is an increase in the acoustic startle response, a behavior that is altered in affective disorders. Remarkably, expression of\n                    <jats:italic>Pnky<\/jats:italic>\n                    from a bacterial artificial chromosome transgene decreases the acoustic startle response in female\n                    <jats:italic>Pnky<\/jats:italic>\n                    -knockout mice, demonstrating that\n                    <jats:italic>Pnky<\/jats:italic>\n                    can modulate specific animal behavior by functioning in\n                    <jats:italic>trans<\/jats:italic>\n                    . More broadly, these studies illustrate how specific lncRNAs can underlie cognitive and mood disorders.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-50851-7","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:02:19Z","timestamp":1723460539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sex-specific role for the long noncoding RNA Pnky in mouse behavior"],"prefix":"10.1038","volume":"15","author":[{"given":"Parna","family":"Saha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0702-3120","authenticated-orcid":false,"given":"Rebecca E.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Simms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonseok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-3425","authenticated-orcid":false,"given":"Daniel A.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"50851_CR1","doi-asserted-by":"publisher","unstructured":"Rinn, J. 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