{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:00:03Z","timestamp":1791824403718,"version":"4.3.4"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-50866-0","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T17:03:07Z","timestamp":1723136587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Light-responsive adipose-hypothalamus axis controls metabolic regulation"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2837-8246","authenticated-orcid":false,"given":"Tadataka","family":"Tsuji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Tolstikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-1393","authenticated-orcid":false,"given":"Tian Lian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7589-071X","authenticated-orcid":false,"given":"Meghan","family":"Halpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niven R.","family":"Narain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King-Wai","family":"Yau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0746-0854","authenticated-orcid":false,"given":"Matthew D.","family":"Lynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Kiebish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2053-9559","authenticated-orcid":false,"given":"Yu-Hua","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"50866_CR1","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","volume":"390","author":"GCoD Collaborators","year":"2017","unstructured":"Collaborators, G. Co. D. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390, 1151\u20131210 (2017).","journal-title":"Lancet"},{"key":"50866_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1614362","volume":"377","author":"GO Collaborators","year":"2017","unstructured":"Collaborators, G. O. Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N. Engl. J. Med 377, 13\u201327 (2017).","journal-title":"N. Engl. J. Med"},{"key":"50866_CR3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.cmet.2017.12.002","volume":"27","author":"RK Zwick","year":"2018","unstructured":"Zwick, R. K., Guerrero-Juarez, C. F., Horsley, V. & Plikus, M. V. Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metab. 27, 68\u201383 (2018).","journal-title":"Cell Metab."},{"key":"50866_CR4","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1172\/JCI129187","volume":"129","author":"CR Kahn","year":"2019","unstructured":"Kahn, C. R., Wang, G. & Lee, K. Y. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J. Clin. Invest 129, 3990\u20134000 (2019).","journal-title":"J. Clin. Invest"},{"key":"50866_CR5","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1056\/NEJMra2032804","volume":"386","author":"AM Cypess","year":"2022","unstructured":"Cypess, A. M. Reassessing Human Adipose Tissue. N. Engl. J. Med 386, 768\u2013779 (2022).","journal-title":"N. Engl. J. Med"},{"key":"50866_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11154-021-09640-6","volume":"23","author":"A Gavalda-Navarro","year":"2022","unstructured":"Gavalda-Navarro, A., Villarroya, J., Cereijo, R., Giralt, M. & Villarroya, F. The endocrine role of brown adipose tissue: An update on actors and actions. Rev. Endocr. Metab. Disord. 23, 31\u201341 (2022).","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"50866_CR7","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1016\/j.cell.2021.02.012","volume":"184","author":"NJ Pillon","year":"2021","unstructured":"Pillon, N. J., Loos, R. J. F., Marshall, S. M. & Zierath, J. R. Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care. Cell 184, 1530\u20131544 (2021).","journal-title":"Cell"},{"key":"50866_CR8","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.bbabio.2013.09.003","volume":"1837","author":"M Koyanagi","year":"2014","unstructured":"Koyanagi, M. & Terakita, A. Diversity of animal opsin-based pigments and their optogenetic potential. Biochim Biophys. Acta 1837, 710\u2013716 (2014).","journal-title":"Biochim Biophys. Acta"},{"key":"50866_CR9","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.celrep.2019.12.043","volume":"30","author":"G Nayak","year":"2020","unstructured":"Nayak, G. et al. Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell Rep. 30, 672\u2013686.e678 (2020).","journal-title":"Cell Rep."},{"key":"50866_CR10","doi-asserted-by":"publisher","first-page":"e3000630","DOI":"10.1371\/journal.pbio.3000630","volume":"18","author":"M Sato","year":"2020","unstructured":"Sato, M. et al. Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes. PLoS Biol. 18, e3000630 (2020).","journal-title":"PLoS Biol."},{"key":"50866_CR11","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/s42255-023-00868-x","volume":"5","author":"G Mishra","year":"2023","unstructured":"Mishra, G. & Townsend, K. L. The metabolic and functional roles of sensory nerves in adipose tissues. Nat. Metab. 5, 1461\u20131474 (2023).","journal-title":"Nat. Metab."},{"key":"50866_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41574-019-0165-y","volume":"15","author":"A Guilherme","year":"2019","unstructured":"Guilherme, A., Henriques, F., Bedard, A. H. & Czech, M. P. Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus. Nat. Rev. Endocrinol. 15, 207\u2013225 (2019).","journal-title":"Nat. Rev. Endocrinol."},{"key":"50866_CR13","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41586-020-2683-0","volume":"585","author":"KX Zhang","year":"2020","unstructured":"Zhang, K. X. et al. Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Nature 585, 420\u2013425 (2020).","journal-title":"Nature"},{"key":"50866_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11154-021-09687-5","volume":"23","author":"C Pico","year":"2022","unstructured":"Pico, C., Palou, M., Pomar, C. A., Rodriguez, A. M. & Palou, A. Leptin as a key regulator of the adipose organ. Rev. Endocr. Metab. Disord. 23, 13\u201330 (2022).","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"50866_CR15","doi-asserted-by":"publisher","first-page":"2570S","DOI":"10.1093\/jn\/nxaa079","volume":"150","author":"ME Brosnan","year":"2020","unstructured":"Brosnan, M. E. & Brosnan, J. T. Histidine Metabolism and Function. J. Nutr. 150, 2570S\u20132575S (2020).","journal-title":"J. Nutr."},{"key":"50866_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1177\/153537020222700111","volume":"227","author":"H Yoshimatsu","year":"2002","unstructured":"Yoshimatsu, H., Chiba, S., Tajima, D., Akehi, Y. & Sakata, T. Histidine suppresses food intake through its conversion into neuronal histamine. Exp. Biol. Med (Maywood) 227, 63\u201368 (2002).","journal-title":"Exp. Biol. Med (Maywood)"},{"key":"50866_CR17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neulet.2003.10.052","volume":"362","author":"T Yasuda","year":"2004","unstructured":"Yasuda, T. et al. L-histidine stimulates sympathetic nerve activity to brown adipose tissue in rats. Neurosci. Lett. 362, 71\u201374 (2004).","journal-title":"Neurosci. Lett."},{"key":"50866_CR18","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1046\/j.1365-2362.2002.00972.x","volume":"32","author":"H Yoshimatsu","year":"2002","unstructured":"Yoshimatsu, H. et al. Histidine induces lipolysis through sympathetic nerve in white adipose tissue. Eur. J. Clin. Invest 32, 236\u2013241 (2002).","journal-title":"Eur. J. Clin. Invest"},{"key":"50866_CR19","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.cell.2008.08.040","volume":"135","author":"JB Regard","year":"2008","unstructured":"Regard, J. B., Sato, I. T. & Coughlin, S. R. Anatomical profiling of G protein-coupled receptor expression. Cell 135, 561\u2013571 (2008).","journal-title":"Cell"},{"key":"50866_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/1745-7580-4-5","volume":"4","author":"JE Lattin","year":"2008","unstructured":"Lattin, J. E. et al. Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res 4, 5 (2008).","journal-title":"Immunome Res"},{"key":"50866_CR21","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","volume":"603","author":"MP Emont","year":"2022","unstructured":"Emont, M. P. et al. A single-cell atlas of human and mouse white adipose tissue. Nature 603, 926\u2013933 (2022).","journal-title":"Nature"},{"key":"50866_CR22","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.neuron.2016.12.031","volume":"93","author":"G Shin","year":"2017","unstructured":"Shin, G. et al. Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics. Neuron 93, 509\u2013521.e503 (2017).","journal-title":"Neuron"},{"key":"50866_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/978-1-0716-2087-8_9","volume":"2448","author":"K Ikeda","year":"2022","unstructured":"Ikeda, K., Tajima, K., Tanabe, Y., Poon, A. S. Y. & Kajimura, S. Activation of UCP1-Independent Ca(2+) Cycling Thermogenesis by Wireless Optogenetics. Methods Mol. Biol. 2448, 131\u2013139 (2022).","journal-title":"Methods Mol. Biol."},{"key":"50866_CR24","doi-asserted-by":"publisher","first-page":"4998","DOI":"10.1073\/pnas.1219416110","volume":"110","author":"M Koyanagi","year":"2013","unstructured":"Koyanagi, M., Takada, E., Nagata, T., Tsukamoto, H. & Terakita, A. Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue. Proc. Natl Acad. Sci. USA 110, 4998\u20135003 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"50866_CR25","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/353655a0","volume":"353","author":"GH Jacobs","year":"1991","unstructured":"Jacobs, G. H., Neitz, J. & Deegan, J. F. 2nd. Retinal receptors in rodents maximally sensitive to ultraviolet light. Nature 353, 655\u2013656 (1991).","journal-title":"Nature"},{"key":"50866_CR26","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.visres.2004.01.016","volume":"44","author":"GH Jacobs","year":"2004","unstructured":"Jacobs, G. H., Williams, G. A. & Fenwick, J. A. Influence of cone pigment coexpression on spectral sensitivity and color vision in the mouse. Vis. Res 44, 1615\u20131622 (2004).","journal-title":"Vis. Res"},{"key":"50866_CR27","doi-asserted-by":"publisher","first-page":"13093","DOI":"10.1073\/pnas.1516259112","volume":"112","author":"ED Buhr","year":"2015","unstructured":"Buhr, E. D. et al. Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proc. Natl Acad. Sci. USA 112, 13093\u201313098 (2015).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"50866_CR28","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1046\/j.1432-1033.2003.03834.x","volume":"270","author":"C Rodriguez-Caso","year":"2003","unstructured":"Rodriguez-Caso, C. et al. Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability. Eur. J. Biochem 270, 4376\u20134387 (2003).","journal-title":"Eur. J. Biochem"},{"key":"50866_CR29","doi-asserted-by":"publisher","first-page":"4306","DOI":"10.1210\/en.2003-0222","volume":"144","author":"AK Fulop","year":"2003","unstructured":"Fulop, A. K. et al. Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene. Endocrinology 144, 4306\u20134314 (2003).","journal-title":"Endocrinology"},{"key":"50866_CR30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nm.3056","volume":"19","author":"CW Liew","year":"2013","unstructured":"Liew, C. W. et al. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat. Med 19, 217\u2013226 (2013).","journal-title":"Nat. Med"},{"key":"50866_CR31","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1210\/en.2017-00212","volume":"158","author":"KL Townsend","year":"2017","unstructured":"Townsend, K. L. et al. Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A. Endocrinology 158, 4233\u20134245 (2017).","journal-title":"Endocrinology"},{"key":"50866_CR32","doi-asserted-by":"publisher","unstructured":"Blaszkiewicz, M., Willows, J. W., Johnson, C. P. & Townsend, K. L. The Importance of Peripheral Nerves in Adipose Tissue for the Regulation of Energy Balance. Biology (Basel) 8, https:\/\/doi.org\/10.3390\/biology8010010 (2019).","DOI":"10.3390\/biology8010010"},{"key":"50866_CR33","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00125-009-1496-3","volume":"53","author":"T McLaughlin","year":"2010","unstructured":"McLaughlin, T. et al. Inflammation in subcutaneous adipose tissue: relationship to adipose cell size. Diabetologia 53, 369\u2013377 (2010).","journal-title":"Diabetologia"},{"key":"50866_CR34","doi-asserted-by":"publisher","first-page":"R284","DOI":"10.1152\/ajpregu.00257.2017","volume":"315","author":"KG Stenkula","year":"2018","unstructured":"Stenkula, K. G. & Erlanson-Albertsson, C. Adipose cell size: importance in health and disease. Am. J. Physiol. Regul. Integr. Comp. Physiol. 315, R284\u2013R295 (2018).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"50866_CR35","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.cell.2022.12.024","volume":"186","author":"JJ Meng","year":"2023","unstructured":"Meng, J. J. et al. Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis. Cell 186, 398\u2013412.e317 (2023).","journal-title":"Cell"},{"key":"50866_CR36","doi-asserted-by":"publisher","first-page":"e2017337","DOI":"10.1001\/jamanetworkopen.2020.17337","volume":"3","author":"MG Figueiro Longo","year":"2020","unstructured":"Figueiro Longo, M. G. et al. Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients With Moderate Traumatic Brain Injury: A Randomized Clinical Trial. JAMA Netw. Open 3, e2017337 (2020).","journal-title":"JAMA Netw. Open"},{"key":"50866_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16689-4","volume":"7","author":"K Ondrusova","year":"2017","unstructured":"Ondrusova, K. et al. Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin\/TRPC channel axis. Sci. Rep. 7, 16332 (2017).","journal-title":"Sci. Rep."},{"key":"50866_CR38","doi-asserted-by":"publisher","first-page":"e0161215","DOI":"10.1371\/journal.pone.0161215","volume":"11","author":"T Sugihara","year":"2016","unstructured":"Sugihara, T., Nagata, T., Mason, B., Koyanagi, M. & Terakita, A. Absorption Characteristics of Vertebrate Non-Visual Opsin, Opn3. PLoS One 11, e0161215 (2016).","journal-title":"PLoS One"},{"key":"50866_CR39","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2337\/DC11-1577","volume":"35","author":"SJ Mihalik","year":"2012","unstructured":"Mihalik, S. J. et al. Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation. Diabetes Care 35, 605\u2013611 (2012).","journal-title":"Diabetes Care"},{"key":"50866_CR40","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00125-018-4619-x","volume":"61","author":"P Welsh","year":"2018","unstructured":"Welsh, P. et al. Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial. Diabetologia 61, 1581\u20131591 (2018).","journal-title":"Diabetologia"},{"key":"50866_CR41","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s00726-020-02877-6","volume":"52","author":"MC Piro","year":"2020","unstructured":"Piro, M. C. et al. Free-amino acid metabolic profiling of visceral adipose tissue from obese subjects. Amino Acids 52, 1125\u20131137 (2020).","journal-title":"Amino Acids"},{"key":"50866_CR42","doi-asserted-by":"publisher","unstructured":"Moro, J., Tome, D., Schmidely, P., Demersay, T. C. & Azzout-Marniche, D. Histidine: A Systematic Review on Metabolism and Physiological Effects in Human and Different Animal Species. Nutrients 12, https:\/\/doi.org\/10.3390\/nu12051414 (2020).","DOI":"10.3390\/nu12051414"},{"key":"50866_CR43","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2188\/jea.JE20150044","volume":"26","author":"M Iwasaki","year":"2016","unstructured":"Iwasaki, M. et al. Validity of a Self-Administered Food-Frequency Questionnaire for Assessing Amino Acid Intake in Japan: Comparison With Intake From 4-Day Weighed Dietary Records and Plasma Levels. J. Epidemiol. 26, 36\u201344 (2016).","journal-title":"J. Epidemiol."},{"key":"50866_CR44","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/ejcn.2015.144","volume":"70","author":"JA Schmidt","year":"2016","unstructured":"Schmidt, J. A. et al. Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. Eur. J. Clin. Nutr. 70, 306\u2013312 (2016).","journal-title":"Eur. J. Clin. Nutr."},{"key":"50866_CR45","doi-asserted-by":"publisher","unstructured":"Li, Y. C. et al. Relationships of Dietary Histidine and Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study. Nutrients 8, https:\/\/doi.org\/10.3390\/nu8070420 (2016).","DOI":"10.3390\/nu8070420"},{"key":"50866_CR46","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1002\/oby.21434","volume":"24","author":"B de Courten","year":"2016","unstructured":"de Courten, B. et al. Effects of carnosine supplementation on glucose metabolism: Pilot clinical trial. Obes. (Silver Spring) 24, 1027\u20131034 (2016).","journal-title":"Obes. (Silver Spring)"},{"key":"50866_CR47","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41586-019-1011-z","volume":"568","author":"R Yan","year":"2019","unstructured":"Yan, R., Zhao, X., Lei, J. & Zhou, Q. Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature 568, 127\u2013130 (2019).","journal-title":"Nature"},{"key":"50866_CR48","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s11095-020-02826-8","volume":"37","author":"E Puris","year":"2020","unstructured":"Puris, E., Gynther, M., Auriola, S. & Huttunen, K. M. L-Type amino acid transporter 1 as a target for drug delivery. Pharm. Res 37, 88 (2020).","journal-title":"Pharm. Res"},{"key":"50866_CR49","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrn1034","volume":"4","author":"H Haas","year":"2003","unstructured":"Haas, H. & Panula, P. The role of histamine and the tuberomamillary nucleus in the nervous system. Nat. Rev. Neurosci. 4, 121\u2013130 (2003).","journal-title":"Nat. Rev. Neurosci."},{"key":"50866_CR50","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1073\/pnas.81.8.2572","volume":"81","author":"P Panula","year":"1984","unstructured":"Panula, P., Yang, H. Y. & Costa, E. Histamine-containing neurons in the rat hypothalamus. Proc. Natl Acad. Sci. USA 81, 2572\u20132576 (1984).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"50866_CR51","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0301-0082(00)00039-3","volume":"63","author":"RE Brown","year":"2001","unstructured":"Brown, R. E., Stevens, D. R. & Haas, H. L. The physiology of brain histamine. Prog. Neurobiol. 63, 637\u2013672 (2001).","journal-title":"Prog. Neurobiol."},{"key":"50866_CR52","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0166-4328(01)00225-X","volume":"124","author":"T Morimoto","year":"2001","unstructured":"Morimoto, T., Yamamoto, Y. & Yamatodani, A. Brain histamine and feeding behavior. Behav. Brain Res 124, 145\u2013150 (2001).","journal-title":"Behav. Brain Res"},{"key":"50866_CR53","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1177\/153537020222700309","volume":"227","author":"K Tsuda","year":"2002","unstructured":"Tsuda, K. et al. Hypothalamic histamine neurons activate lipolysis in rat adipose tissue. Exp. Biol. Med (Maywood) 227, 208\u2013213 (2002).","journal-title":"Exp. Biol. Med (Maywood)"},{"key":"50866_CR54","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.3945\/jn.114.196105","volume":"144","author":"T Yoshikawa","year":"2014","unstructured":"Yoshikawa, T. et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J. Nutr. 144, 1637\u20131641 (2014).","journal-title":"J. Nutr."},{"key":"50866_CR55","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/eye.2015.261","volume":"30","author":"JB O\u2019Hagan","year":"2016","unstructured":"O\u2019Hagan, J. B., Khazova, M. & Price, L. L. Low-energy light bulbs, computers, tablets and the blue light hazard. Eye (Lond.) 30, 230\u2013233 (2016).","journal-title":"Eye (Lond.)"},{"key":"50866_CR56","doi-asserted-by":"publisher","first-page":"4276","DOI":"10.3390\/en13164276","volume":"13","author":"DB Moyano","year":"2020","unstructured":"Moyano, D. B., Sola, Y. & Gonz\u00e1lez-Lezcano, R. A. Blue-light levels emitted from portable electronic devices compared to sunlight. Energies 13, 4276 (2020).","journal-title":"Energies"},{"key":"50866_CR57","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202302241","volume":"19","author":"X Shang","year":"2023","unstructured":"Shang, X., Ling, W., Chen, Y., Li, C. & Huang, X. Construction of a Flexible Optogenetic Device for Multisite and Multiregional Optical Stimulation Through Flexible micro-LED Displays on the Cerebral Cortex. Small 19, e2302241 (2023).","journal-title":"Small"},{"key":"50866_CR58","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201796","volume":"12","author":"JH Lee","year":"2023","unstructured":"Lee, J. H. et al. Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition. Adv. Health. Mater. 12, e2201796 (2023).","journal-title":"Adv. Health. Mater."},{"key":"50866_CR59","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/B978-0-12-411619-1.00011-2","volume":"537","author":"CH Vaughan","year":"2014","unstructured":"Vaughan, C. H., Zarebidaki, E., Ehlen, J. C. & Bartness, T. J. Analysis and measurement of the sympathetic and sensory innervation of white and brown adipose tissue. Methods Enzymol. 537, 199\u2013225 (2014).","journal-title":"Methods Enzymol."},{"key":"50866_CR60","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/nature07221","volume":"454","author":"YH Tseng","year":"2008","unstructured":"Tseng, Y. H. et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000\u20131004 (2008).","journal-title":"Nature"},{"key":"50866_CR61","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/nm.3881","volume":"21","author":"R Xue","year":"2015","unstructured":"Xue, R. et al. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat. Med 21, 760\u2013768 (2015).","journal-title":"Nat. Med"},{"key":"50866_CR62","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-4939-6820-6_8","volume":"1566","author":"F Shamsi","year":"2017","unstructured":"Shamsi, F. & Tseng, Y. H. Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines. Methods Mol. Biol. 1566, 77\u201385 (2017).","journal-title":"Methods Mol. Biol."},{"key":"50866_CR63","first-page":"46","volume":"46","author":"NA Johnston","year":"2007","unstructured":"Johnston, N. A. et al. Strategies for refinement of abdominal device implantation in mice: strain, carboxymethylcellulose, thermal support, and atipamezole. J. Am. Assoc. Lab Anim. Sci. 46, 46\u201353 (2007).","journal-title":"J. Am. Assoc. Lab Anim. Sci."},{"key":"50866_CR64","doi-asserted-by":"publisher","first-page":"e114019","DOI":"10.1371\/journal.pone.0114019","volume":"9","author":"V Tolstikov","year":"2014","unstructured":"Tolstikov, V., Nikolayev, A., Dong, S., Zhao, G. & Kuo, M. S. Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells. PLoS One 9, e114019 (2014).","journal-title":"PLoS One"},{"key":"50866_CR65","doi-asserted-by":"publisher","unstructured":"Drolet, J. et al. Integrated Metabolomics Assessment of Human Dried Blood Spots and Urine Strips. Metabolites 7 https:\/\/doi.org\/10.3390\/metabo7030035 (2017).","DOI":"10.3390\/metabo7030035"},{"key":"50866_CR66","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.2337\/db18-0462","volume":"67","author":"AS Baskin","year":"2018","unstructured":"Baskin, A. S. et al. Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a beta3-Adrenergic Receptor Agonist. Diabetes 67, 2113\u20132125 (2018).","journal-title":"Diabetes"},{"key":"50866_CR67","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-02185-y","volume":"18","author":"MA Kiebish","year":"2020","unstructured":"Kiebish, M. A. et al. Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer. J. Transl. Med 18, 10 (2020).","journal-title":"J. Transl. Med"},{"key":"50866_CR68","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1093\/brain\/awab320","volume":"145","author":"A Ntranos","year":"2022","unstructured":"Ntranos, A. et al. Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma. Brain 145, 569\u2013583 (2022).","journal-title":"Brain"},{"key":"50866_CR69","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/978-1-61737-985-7_13","volume":"708","author":"S Bajad","year":"2011","unstructured":"Bajad, S. & Shulaev, V. LC-MS-based metabolomics. Methods Mol. Biol. 708, 213\u2013228 (2011).","journal-title":"Methods Mol. Biol."},{"key":"50866_CR70","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1038\/nprot.2011.335","volume":"6","author":"WB Dunn","year":"2011","unstructured":"Dunn, W. B. et al. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat. Protoc. 6, 1060\u20131083 (2011).","journal-title":"Nat. Protoc."},{"key":"50866_CR71","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nprot.2012.024","volume":"7","author":"M Yuan","year":"2012","unstructured":"Yuan, M., Breitkopf, S. B., Yang, X. & Asara, J. M. A positive\/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue. Nat. Protoc. 7, 872\u2013881 (2012).","journal-title":"Nat. Protoc."},{"key":"50866_CR72","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nprot.2012.135","volume":"8","author":"EJ Want","year":"2013","unstructured":"Want, E. J. et al. Global metabolic profiling of animal and human tissues via UPLC-MS. Nat. Protoc. 8, 17\u201332 (2013).","journal-title":"Nat. Protoc."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-50866-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-50866-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-50866-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T18:13:41Z","timestamp":1723140821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-50866-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["50866"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-50866-0","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"assertion":[{"value":"16 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare the following competing interests: V.T., M.A.K., and N.R.N. are employees of BPGbio. The remaining authors declare no other competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6768"}}