{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:26:06Z","timestamp":1787761566684,"version":"build-2784847793"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-51065-7","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T14:04:41Z","timestamp":1722953081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-8554","authenticated-orcid":false,"given":"Eunhye","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7674-6085","authenticated-orcid":false,"given":"Jii","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-4487","authenticated-orcid":false,"given":"Gyuwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2580-0368","authenticated-orcid":false,"given":"Jiwoo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-3028","authenticated-orcid":false,"given":"Hyunsu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-5619","authenticated-orcid":false,"given":"Suk-Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-2327","authenticated-orcid":false,"given":"Chun Kee","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-4169","authenticated-orcid":false,"given":"Jaeyoung","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Kyung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"51065_CR1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1017\/S0317167100038464","volume":"23","author":"J Engel","year":"1996","unstructured":"Engel, J. Excitation and inhibition in epilepsy. Can. J. Neurol. Sci. 23, 167\u2013174 (1996).","journal-title":"Can. J. Neurol. Sci."},{"key":"51065_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep23176","volume":"6","author":"N Dehghani","year":"2016","unstructured":"Dehghani, N. et al. Dynamic balance of excitation and inhibition in human and monkey neocortex. Sci. Rep. 6, 1\u201312 (2016).","journal-title":"Sci. Rep."},{"key":"51065_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1001\/jamaneurol.2017.3949","volume":"75","author":"Z Chen","year":"2018","unstructured":"Chen, Z., Brodie, M. J., Liew, D. & Kwan, P. Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study. JAMA Neurol. 75, 279\u2013286 (2018).","journal-title":"JAMA Neurol."},{"key":"51065_CR4","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1056\/NEJMra1004418","volume":"365","author":"P Kwan","year":"2011","unstructured":"Kwan, P., Schachter, S. C. & Brodie, M. J. Drug-resistant epilepsy. N. Engl. J. Med. 365, 919\u2013926 (2011).","journal-title":"N. Engl. J. Med."},{"key":"51065_CR5","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1093\/brain\/awh312","volume":"127","author":"S Sisodiya","year":"2004","unstructured":"Sisodiya, S. Surgery for focal cortical dysplasia. Brain 127, 2383\u20132384 (2004).","journal-title":"Brain"},{"key":"51065_CR6","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1684\/epd.2010.0327","volume":"12","author":"L Tassi","year":"2010","unstructured":"Tassi, L. et al. Type I focal cortical dysplasia: surgical outcome is related to histopathology. Epileptic Disord. 12, 181\u2013191 (2010).","journal-title":"Epileptic Disord."},{"key":"51065_CR7","doi-asserted-by":"crossref","unstructured":"Bl\u00fcmcke, I. et al. (eds) The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc task force of the ILAE Diagnostic Methods Commission 1 (Wiley Online Library, 2011).","DOI":"10.1111\/j.1528-1167.2010.02777.x"},{"key":"51065_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.5334\/jbsr.2710","volume":"106","author":"S Marcelis","year":"2022","unstructured":"Marcelis, S., Bossche, S. V. & Dekeyzer, S. Not your everyday FCD: imaging findings of focal cortical dysplasia type 1. J. Belg. Soc. Radiol. 106, 39 (2022).","journal-title":"J. Belg. Soc. Radiol."},{"key":"51065_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fnmol.2014.00028","volume":"7","author":"N Takei","year":"2014","unstructured":"Takei, N. & Nawa, H. mTOR signaling and its roles in normal and abnormal brain development. Front. Mol. Neurosci. 7, 28 (2014).","journal-title":"Front. Mol. Neurosci."},{"key":"51065_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7082696","volume":"2017","author":"L Ryskalin","year":"2017","unstructured":"Ryskalin, L. et al. mTOR-dependent cell proliferation in the brain. Biomed. Res. Int. 2017, 7082696 (2017).","journal-title":"Biomed. Res. Int."},{"key":"51065_CR11","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1146\/annurev-pathol-052016-100138","volume":"12","author":"PH Iffland","year":"2017","unstructured":"Iffland, P. H. & Crino, P. B. Focal cortical dysplasia: gene mutations, cell signaling, and therapeutic implications. Annu. Rev. Pathol. 12, 547\u2013571 (2017).","journal-title":"Annu. Rev. Pathol."},{"key":"51065_CR12","doi-asserted-by":"publisher","first-page":"580357","DOI":"10.3389\/fnins.2020.580357","volume":"14","author":"J Jesus-Ribeiro","year":"2021","unstructured":"Jesus-Ribeiro, J. et al. Genomic and epigenetic advances in focal cortical dysplasia types I and II: a scoping review. Front. Neurosci. 14, 580357 (2021).","journal-title":"Front. Neurosci."},{"key":"51065_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.0013-9580.2005.461008.x","volume":"46","author":"CK Chung","year":"2005","unstructured":"Chung, C. K., Lee, S. K. & Kim, K. J. Surgical outcome of epilepsy caused by cortical dysplasia. Epilepsia 46, 25\u201329 (2005).","journal-title":"Epilepsia"},{"key":"51065_CR14","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/S1474-4422(20)30220-9","volume":"19","author":"H Lamberink","year":"2020","unstructured":"Lamberink, H., Otte, W., Blumcke, I. & Braun, K. Seizure outcome and drug-freedom related to histopathology up to 5 years after epilepsy surgery: a retrospective, multi-centre, longitudinal, cohort study. Lancet Neurol. 19, 748\u2013757 (2020).","journal-title":"Lancet Neurol."},{"key":"51065_CR15","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/nature01616","volume":"423","author":"Y Shu","year":"2003","unstructured":"Shu, Y., Hasenstaub, A. & McCormick, D. A. Turning on and off recurrent balanced cortical activity. Nature 423, 288\u2013293 (2003).","journal-title":"Nature"},{"key":"51065_CR16","doi-asserted-by":"publisher","first-page":"4535","DOI":"10.1523\/JNEUROSCI.5297-05.2006","volume":"26","author":"B Haider","year":"2006","unstructured":"Haider, B., Duque, A., Hasenstaub, A. R. & McCormick, D. A. Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition. J. Neurosci. 26, 4535\u20134545 (2006).","journal-title":"J. Neurosci."},{"key":"51065_CR17","doi-asserted-by":"publisher","first-page":"9649","DOI":"10.1523\/JNEUROSCI.2687-05.2005","volume":"25","author":"ME Calcagnotto","year":"2005","unstructured":"Calcagnotto, M. E., Paredes, M. F., Tihan, T., Barbaro, N. M. & Baraban, S. C. Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia. J. Neurosci. 25, 9649\u20139657 (2005).","journal-title":"J. Neurosci."},{"key":"51065_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.562811","volume":"14","author":"J Banerjee","year":"2020","unstructured":"Banerjee, J. et al. GABAA receptor-mediated epileptogenicity in focal cortical dysplasia (FCD) depends on age at epilepsy onset. Front. Cell. Neurosci. 14, 562811 (2020).","journal-title":"Front. Cell. Neurosci."},{"key":"51065_CR19","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1093\/cercor\/bhab350","volume":"32","author":"L Cheng","year":"2022","unstructured":"Cheng, L. et al. Mechanistic analysis of micro-neurocircuits underlying the epileptogenic zone in focal cortical dysplasia patients. Cereb. Cortex 32, 2216\u20132230 (2022).","journal-title":"Cereb. Cortex"},{"key":"51065_CR20","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1093\/cercor\/8.8.753","volume":"8","author":"G Rosen","year":"1998","unstructured":"Rosen, G., Jacobs, K. & Prince, D. Effects of neonatal freeze lesions on expression of parvalbumin in rat neocortex. Cereb. Cortex 8, 753\u2013761 (1998).","journal-title":"Cereb. Cortex"},{"key":"51065_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0920-1211(99)00035-2","volume":"37","author":"SN Roper","year":"1999","unstructured":"Roper, S. N., Eisenschenk, S. & King, M. A. Reduced density of parvalbumin-and calbindin D28k-immunoreactive neurons in experimental cortical dysplasia. Epilepsy Res. 37, 63\u201371 (1999).","journal-title":"Epilepsy Res."},{"key":"51065_CR22","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/epi.13405","volume":"57","author":"V Medici","year":"2016","unstructured":"Medici, V. et al. Different parvalbumin and GABA expression in human epileptogenic focal cortical dysplasia. Epilepsia 57, 1109\u20131119 (2016).","journal-title":"Epilepsia"},{"key":"51065_CR23","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/2661","volume":"4","author":"AR Brooks-Kayal","year":"1998","unstructured":"Brooks-Kayal, A. R., Shumate, M. D., Jin, H., Rikhter, T. Y. & Coulter, D. A. Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy. Nat. Med. 4, 1166\u20131172 (1998).","journal-title":"Nat. Med."},{"key":"51065_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1528-1157.1999.tb02065.x","volume":"40","author":"A Bragin","year":"1999","unstructured":"Bragin, A., Engel, J. Jr, Wilson, C. L., Fried, I. & Mathern, G. W. Hippocampal and entorhinal cortex high\u2010frequency oscillations (100\u2013500\u2009Hz) in human epileptic brain and in kainic acid\u2010treated rats with chronic seizures. Epilepsia 40, 127\u2013137 (1999).","journal-title":"Epilepsia"},{"key":"51065_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74306-3","volume":"10","author":"M Pail","year":"2020","unstructured":"Pail, M. et al. High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task. Sci. Rep. 10, 18147 (2020).","journal-title":"Sci. Rep."},{"key":"51065_CR26","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3389\/fneur.2019.00094","volume":"10","author":"A Thomschewski","year":"2019","unstructured":"Thomschewski, A., Hincapi\u00e9, A.-S. & Frauscher, B. Localization of the epileptogenic zone using high frequency oscillations. Front. Neurol. 10, 94 (2019).","journal-title":"Front. Neurol."},{"key":"51065_CR27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/ana.21847","volume":"67","author":"J Jacobs","year":"2010","unstructured":"Jacobs, J. et al. High\u2010frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery. Ann. Neurol. 67, 209\u2013220 (2010).","journal-title":"Ann. Neurol."},{"key":"51065_CR28","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1111\/epi.13829","volume":"58","author":"B Frauscher","year":"2017","unstructured":"Frauscher, B. et al. High\u2010frequency oscillations: the state of clinical research. Epilepsia 58, 1316\u20131329 (2017).","journal-title":"Epilepsia"},{"key":"51065_CR29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.eplepsyres.2017.06.010","volume":"135","author":"SA Hussain","year":"2017","unstructured":"Hussain, S. A. et al. Intraoperative fast ripples independently predict postsurgical epilepsy outcome: comparison with other electrocorticographic phenomena. Epilepsy Res. 135, 79\u201386 (2017).","journal-title":"Epilepsy Res."},{"key":"51065_CR30","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1111\/epi.13830","volume":"58","author":"P Jiruska","year":"2017","unstructured":"Jiruska, P. et al. Update on the mechanisms and roles of high\u2010frequency oscillations in seizures and epileptic disorders. Epilepsia 58, 1330\u20131339 (2017).","journal-title":"Epilepsia"},{"key":"51065_CR31","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.pneurobio.2012.02.005","volume":"98","author":"JG Jefferys","year":"2012","unstructured":"Jefferys, J. G. et al. Mechanisms of physiological and epileptic HFO generation. Prog. Neurobiol. 98, 250\u2013264 (2012).","journal-title":"Prog. Neurobiol."},{"key":"51065_CR32","doi-asserted-by":"publisher","first-page":"ENEURO.0024","DOI":"10.1523\/ENEURO.0024-15.2015","volume":"2","author":"CG Fink","year":"2015","unstructured":"Fink, C. G., Gliske, S., Catoni, N. & Stacey, W. C. Network mechanisms generating abnormal and normal hippocampal high-frequency oscillations: a computational analysis. eNeuro 2, ENEURO.0024\u201315.2015 (2015).","journal-title":"eNeuro"},{"key":"51065_CR33","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0920-1211(93)90083-J","volume":"16","author":"F Du","year":"1993","unstructured":"Du, F. et al. Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res. 16, 223\u2013233 (1993).","journal-title":"Epilepsy Res."},{"key":"51065_CR34","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00401-010-0686-x","volume":"120","author":"G Hadjivassiliou","year":"2010","unstructured":"Hadjivassiliou, G. et al. The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy. Acta Neuropathol. 120, 517\u2013528 (2010).","journal-title":"Acta Neuropathol."},{"key":"51065_CR35","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.neuron.2018.10.012","volume":"100","author":"BE Kalmbach","year":"2018","unstructured":"Kalmbach, B. E. et al. h-Channels contribute to divergent intrinsic membrane properties of supragranular pyramidal neurons in human versus mouse cerebral cortex. Neuron 100, 1194\u20131208. e1195 (2018).","journal-title":"Neuron"},{"key":"51065_CR36","doi-asserted-by":"crossref","unstructured":"Nunez, P. L. & Srinivasan, R. Electric fields of the brain: the neurophysics of EEG (Oxford University Press, 2006).","DOI":"10.1093\/acprof:oso\/9780195050387.001.0001"},{"key":"51065_CR37","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fninf.2013.00041","volume":"7","author":"H Lind\u00e9n","year":"2014","unstructured":"Lind\u00e9n, H. et al. LFPy: a tool for biophysical simulation of extracellular potentials generated by detailed model neurons. Front. Neuroinform. 7, 41 (2014).","journal-title":"Front. Neuroinform."},{"key":"51065_CR38","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nn.2727","volume":"14","author":"CA Anastassiou","year":"2011","unstructured":"Anastassiou, C. A., Perin, R., Markram, H. & Koch, C. Ephaptic coupling of cortical neurons. Nat. Neurosci. 14, 217\u2013223 (2011).","journal-title":"Nat. Neurosci."},{"key":"51065_CR39","doi-asserted-by":"publisher","first-page":"eabj5861","DOI":"10.1126\/science.abj5861","volume":"375","author":"L Campagnola","year":"2022","unstructured":"Campagnola, L. et al. Local connectivity and synaptic dynamics in mouse and human neocortex. Science 375, eabj5861 (2022).","journal-title":"Science"},{"key":"51065_CR40","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1523\/JNEUROSCI.17-11-04382.1997","volume":"17","author":"MV Tsodyks","year":"1997","unstructured":"Tsodyks, M. V., Skaggs, W. E., Sejnowski, T. J. & McNaughton, B. L. Paradoxical effects of external modulation of inhibitory interneurons. J. Neurosci. 17, 4382\u20134388 (1997).","journal-title":"J. Neurosci."},{"key":"51065_CR41","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1523\/JNEUROSCI.3455-12.2013","volume":"33","author":"D Hansel","year":"2013","unstructured":"Hansel, D. & Mato, G. Short-term plasticity explains irregular persistent activity in working memory tasks. J. Neurosci. 33, 133\u2013149 (2013).","journal-title":"J. Neurosci."},{"key":"51065_CR42","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/nn.3446","volume":"16","author":"CK Pfeffer","year":"2013","unstructured":"Pfeffer, C. K., Xue, M., He, M., Huang, Z. J. & Scanziani, M. Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat. Neurosci. 16, 1068\u20131076 (2013).","journal-title":"Nat. Neurosci."},{"key":"51065_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1046\/j.1535-7597.2001.00011.x","volume":"1","author":"SC Baraban","year":"2001","unstructured":"Baraban, S. C. Epileptogenesis in the dysplastic brain: a revival of familiar themes. Epilepsy Curr. 1, 6\u201311 (2001).","journal-title":"Epilepsy Curr."},{"key":"51065_CR44","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/epi.12650","volume":"55","author":"I Marin\u2010Valencia","year":"2014","unstructured":"Marin\u2010Valencia, I., Guerrini, R. & Gleeson, J. G. Pathogenetic mechanisms of focal cortical dysplasia. Epilepsia 55, 970\u2013978 (2014).","journal-title":"Epilepsia"},{"key":"51065_CR45","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/ana.26149","volume":"90","author":"HY Koh","year":"2021","unstructured":"Koh, H. Y. et al. Non-cell autonomous epileptogenesis in focal cortical dysplasia. Ann. Neurol. 90, 285\u2013299 (2021).","journal-title":"Ann. Neurol."},{"key":"51065_CR46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.clinph.2023.03.360","volume":"151","author":"R Janca","year":"2023","unstructured":"Janca, R. et al. Distinct patterns of interictal intracranial EEG in focal cortical dysplasia type I and II. Clin. Neurophysiol. 151, 10\u201317 (2023).","journal-title":"Clin. Neurophysiol."},{"key":"51065_CR47","doi-asserted-by":"publisher","first-page":"e222","DOI":"10.1371\/journal.pbio.0060222","volume":"6","author":"G Moln\u00e1r","year":"2008","unstructured":"Moln\u00e1r, G. et al. Complex events initiated by individual spikes in the human cerebral cortex. PLoS Biol. 6, e222 (2008).","journal-title":"PLoS Biol."},{"key":"51065_CR48","doi-asserted-by":"publisher","first-page":"17197","DOI":"10.1523\/JNEUROSCI.3158-13.2013","volume":"33","author":"MB Verhoog","year":"2013","unstructured":"Verhoog, M. B. et al. Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses. J. Neurosci. 33, 17197\u201317208 (2013).","journal-title":"J. Neurosci."},{"key":"51065_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12826","volume":"7","author":"MB Verhoog","year":"2016","unstructured":"Verhoog, M. B. et al. Layer-specific cholinergic control of human and mouse cortical synaptic plasticity. Nat. Commun. 7, 12826 (2016).","journal-title":"Nat. Commun."},{"key":"51065_CR50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18167","volume":"5","author":"G Moln\u00e1r","year":"2016","unstructured":"Moln\u00e1r, G. et al. Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles. Elife 5, e18167 (2016).","journal-title":"Elife"},{"key":"51065_CR51","doi-asserted-by":"publisher","first-page":"e2000237","DOI":"10.1371\/journal.pbio.2000237","volume":"14","author":"V Szegedi","year":"2016","unstructured":"Szegedi, V. et al. Plasticity in single axon glutamatergic connection to GABAergic interneurons regulates complex events in the human neocortex. PLoS Biol. 14, e2000237 (2016).","journal-title":"PLoS Biol."},{"key":"51065_CR52","doi-asserted-by":"publisher","first-page":"111787","DOI":"10.1016\/j.celrep.2022.111787","volume":"41","author":"G Testa-Silva","year":"2022","unstructured":"Testa-Silva, G. et al. High synaptic threshold for dendritic nmda spike generation in human layer 2\/3 pyramidal neurons. Cell Rep. 41, 111787 (2022).","journal-title":"Cell Rep."},{"key":"51065_CR53","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1093\/cercor\/bhac246","volume":"33","author":"S Hunt","year":"2023","unstructured":"Hunt, S. et al. Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex. Cereb. Cortex 33, 2857\u20132878 (2023).","journal-title":"Cereb. Cortex"},{"key":"51065_CR54","doi-asserted-by":"publisher","unstructured":"Yoon, J. Geometrical determinant of nonlinear synaptic integration in human cortical pyramidal neurons. Preprint at https:\/\/doi.org\/10.1101\/2024.07.14.601255 (2024).","DOI":"10.1101\/2024.07.14.601255"},{"key":"51065_CR55","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.brainres.2005.06.015","volume":"1052","author":"JJ Hutsler","year":"2005","unstructured":"Hutsler, J. J., Lee, D.-G. & Porter, K. K. Comparative analysis of cortical layering and supragranular layer enlargement in rodent carnivore and primate species. Brain Res. 1052, 71\u201381 (2005).","journal-title":"Brain Res."},{"key":"51065_CR56","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.tins.2018.06.003","volume":"41","author":"A Goulas","year":"2018","unstructured":"Goulas, A., Zilles, K. & Hilgetag, C. C. Cortical gradients and laminar projections in mammals. Trends Neurosci. 41, 775\u2013788 (2018).","journal-title":"Trends Neurosci."},{"key":"51065_CR57","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.tics.2022.08.012","volume":"26","author":"A Galakhova","year":"2022","unstructured":"Galakhova, A. et al. Evolution of cortical neurons supporting human cognition. Trends Cogn. Sci. 26, 909\u2013922 (2022).","journal-title":"Trends Cogn. Sci."},{"key":"51065_CR58","doi-asserted-by":"publisher","first-page":"1238406","DOI":"10.1126\/science.1238406","volume":"342","author":"NT Markov","year":"2013","unstructured":"Markov, N. T. et al. Cortical high-density counterstream architectures. Science 342, 1238406 (2013).","journal-title":"Science"},{"key":"51065_CR59","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/bs.pbr.2016.04.012","volume":"226","author":"X Jiang","year":"2016","unstructured":"Jiang, X., Lachance, M. & Rossignol, E. Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy. Prog. Brain Res. 226, 81\u2013126 (2016).","journal-title":"Prog. Brain Res."},{"key":"51065_CR60","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nrn3155","volume":"13","author":"O Mar\u00edn","year":"2012","unstructured":"Mar\u00edn, O. Interneuron dysfunction in psychiatric disorders. Nat. Rev. Neurosci. 13, 107\u2013120 (2012).","journal-title":"Nat. Rev. Neurosci."},{"key":"51065_CR61","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nn.3947","volume":"18","author":"K Staley","year":"2015","unstructured":"Staley, K. Molecular mechanisms of epilepsy. Nat. Neurosci. 18, 367\u2013372 (2015).","journal-title":"Nat. Neurosci."},{"key":"51065_CR62","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo0924","volume":"377","author":"S Loomba","year":"2022","unstructured":"Loomba, S. et al. Connectomic comparison of mouse and human cortex. Science 377, eabo0924 (2022).","journal-title":"Science"},{"key":"51065_CR63","doi-asserted-by":"publisher","first-page":"ENEURO.0260","DOI":"10.1523\/ENEURO.0260-17.2017","volume":"4","author":"V Szegedi","year":"2017","unstructured":"Szegedi, V. et al. High-precision fast-spiking basket cell discharges during complex events in the human neocortex. eNeuro 4, ENEURO.0260\u201317.2017 (2017).","journal-title":"eNeuro"},{"key":"51065_CR64","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn1831","volume":"10","author":"TW Groemer","year":"2007","unstructured":"Groemer, T. W. & Klingauf, J. Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool. Nat. Neurosci. 10, 145\u2013147 (2007).","journal-title":"Nat. Neurosci."},{"key":"51065_CR65","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1038\/nn.2695","volume":"13","author":"Y Hua","year":"2010","unstructured":"Hua, Y., Sinha, R., Martineau, M., Kahms, M. & Klingauf, J. A common origin of synaptic vesicles undergoing evoked and spontaneous fusion. Nat. Neurosci. 13, 1451\u20131453 (2010).","journal-title":"Nat. Neurosci."},{"key":"51065_CR66","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1016\/j.neuron.2022.05.007","volume":"110","author":"JE Chung","year":"2022","unstructured":"Chung, J. E. et al. High-density single-unit human cortical recordings using the neuropixels probe. Neuron 110, 2409\u20132421 (2022).","journal-title":"Neuron"},{"key":"51065_CR67","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fphar.2011.00002","volume":"2","author":"F Miceli","year":"2011","unstructured":"Miceli, F. et al. The voltage-sensing domain of Kv7. 2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants. Front. Pharmacol. 2, 2 (2011).","journal-title":"Front. Pharmacol."},{"key":"51065_CR68","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1523\/JNEUROSCI.4423-14.2015","volume":"35","author":"F Miceli","year":"2015","unstructured":"Miceli, F. et al. Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7. 2 and Kv7. 3 potassium channel subunits. J. Neurosci. 35, 3782\u20133793 (2015).","journal-title":"J. Neurosci."},{"key":"51065_CR69","unstructured":"French, J. A. et al. Efficacy and Safety of XEN1101, a novel potassium channel opener, in adults with focal epilepsy: a phase 2b randomized clinical trial. JAMA Neurol. 80, 1145\u20131154 (2023)."},{"key":"51065_CR70","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41582-023-00926-8","volume":"20","author":"L Kiani","year":"2024","unstructured":"Kiani, L. Gene therapy for seizures in focal cortical dysplasia. Nat. Rev. Neurol. 20, 63 (2024).","journal-title":"Nat. Rev. Neurol."},{"key":"51065_CR71","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.tins.2007.05.003","volume":"30","author":"EO Mann","year":"2007","unstructured":"Mann, E. O. & Paulsen, O. Role of GABAergic inhibition in hippocampal network oscillations. Trends Neurosci. 30, 343\u2013349 (2007).","journal-title":"Trends Neurosci."},{"key":"51065_CR72","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/378075a0","volume":"378","author":"S Cobb","year":"1995","unstructured":"Cobb, S., Buhl, E. H., Halasy, K., Paulsen, O. & Somogyi, P. Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons. Nature 378, 75\u201378 (1995).","journal-title":"Nature"},{"key":"51065_CR73","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nrn2044","volume":"8","author":"M Bartos","year":"2007","unstructured":"Bartos, M., Vida, I. & Jonas, P. Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks. Nat. Rev. Neurosci. 8, 45\u201356 (2007).","journal-title":"Nat. Rev. Neurosci."},{"key":"51065_CR74","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fncir.2015.00006","volume":"9","author":"T Kuki","year":"2015","unstructured":"Kuki, T. et al. Contribution of parvalbumin and somatostatin-expressing GABAergic neurons to slow oscillations and the balance in beta-gamma oscillations across cortical layers. Front. Neural Circuits 9, 6 (2015).","journal-title":"Front. Neural Circuits"},{"key":"51065_CR75","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nature01374","volume":"421","author":"T Klausberger","year":"2003","unstructured":"Klausberger, T. et al. Brain-state-and cell-type-specific firing of hippocampal interneurons in vivo. Nature 421, 844\u2013848 (2003).","journal-title":"Nature"},{"key":"51065_CR76","doi-asserted-by":"publisher","first-page":"9782","DOI":"10.1523\/JNEUROSCI.3269-05.2005","volume":"25","author":"T Klausberger","year":"2005","unstructured":"Klausberger, T. et al. Complementary roles of cholecystokinin-and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. J. Neurosci. 25, 9782\u20139793 (2005).","journal-title":"J. Neurosci."},{"key":"51065_CR77","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1212\/WNL.0b013e31829c002f","volume":"81","author":"EE Benarroch","year":"2013","unstructured":"Benarroch, E. E. Neocortical interneurons: functional diversity and clinical correlations. Neurology 81, 273\u2013280 (2013).","journal-title":"Neurology"},{"key":"51065_CR78","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.conb.2014.07.020","volume":"31","author":"AI Guly\u00e1s","year":"2015","unstructured":"Guly\u00e1s, A. I. & Freund, T. T. Generation of physiological and pathological high frequency oscillations: the role of perisomatic inhibition in sharp-wave ripple and interictal spike generation. Curr. Opin. Neurobiol. 31, 26\u201332 (2015).","journal-title":"Curr. Opin. Neurobiol."},{"key":"51065_CR79","doi-asserted-by":"publisher","first-page":"9544","DOI":"10.1523\/JNEUROSCI.5117-14.2015","volume":"35","author":"M Sessolo","year":"2015","unstructured":"Sessolo, M. et al. Parvalbumin-positive inhibitory interneurons oppose propagation but favor generation of focal epileptiform activity. J. Neurosci. 35, 9544\u20139557 (2015).","journal-title":"J. Neurosci."},{"key":"51065_CR80","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1113\/jphysiol.2012.238154","volume":"591","author":"M Cammarota","year":"2013","unstructured":"Cammarota, M., Losi, G., Chiavegato, A., Zonta, M. & Carmignoto, G. Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy. J. Physiol. 591, 807\u2013822 (2013).","journal-title":"J. Physiol."},{"key":"51065_CR81","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/epi.13370","volume":"57","author":"M de Curtis","year":"2016","unstructured":"de Curtis, M. & Avoli, M. GABAergic networks jump-start focal seizures. Epilepsia 57, 679\u2013687 (2016).","journal-title":"Epilepsia"},{"key":"51065_CR82","doi-asserted-by":"publisher","first-page":"4839","DOI":"10.1093\/cercor\/bhv188","volume":"25","author":"H Mohan","year":"2015","unstructured":"Mohan, H. et al. Dendritic and axonal architecture of individual pyramidal neurons across layers of adult human neocortex. Cereb. Cortex 25, 4839\u20134853 (2015).","journal-title":"Cereb. Cortex"},{"key":"51065_CR83","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1111\/epi.12728","volume":"55","author":"Y Sato","year":"2014","unstructured":"Sato, Y. et al. Preictal surrender of post\u2013spike slow waves to spike\u2010related high\u2010frequency oscillations (80\u2013200\u2009Hz) is associated with seizure initiation. Epilepsia 55, 1399\u20131405 (2014).","journal-title":"Epilepsia"},{"key":"51065_CR84","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/WNP.0000000000000150","volume":"32","author":"LM de la Prida","year":"2015","unstructured":"de la Prida, L. M., Staba, R. J. & Dian, J. A. Conundrums of high-frequency oscillations (80\u2013800\u2009Hz) in the epileptic brain. J. Clin. Neurophysiol. 32, 207 (2015).","journal-title":"J. Clin. Neurophysiol."},{"key":"51065_CR85","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1152\/jn.2002.88.4.1743","volume":"88","author":"RJ Staba","year":"2002","unstructured":"Staba, R. J., Wilson, C. L., Bragin, A., Fried, I. & Engel Jr, J. Quantitative analysis of high-frequency oscillations (80\u2013500\u2009Hz) recorded in human epileptic hippocampus and entorhinal cortex. J. Neurophysiol. 88, 1743\u20131752 (2002).","journal-title":"J. Neurophysiol."},{"key":"51065_CR86","doi-asserted-by":"publisher","first-page":"e0158276","DOI":"10.1371\/journal.pone.0158276","volume":"11","author":"M Navarrete","year":"2016","unstructured":"Navarrete, M., Alvarado-Rojas, C., Le Van Quyen, M. & Valderrama, M. RIPPLELAB: a comprehensive application for the detection, analysis and classification of high frequency oscillations in electroencephalographic signals. PLoS one 11, e0158276 (2016).","journal-title":"PLoS one"},{"key":"51065_CR87","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.clinph.2006.12.019","volume":"118","author":"AB Gardner","year":"2007","unstructured":"Gardner, A. B., Worrell, G. A., Marsh, E., Dlugos, D. & Litt, B. Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings. Clin. Neurophysiol. 118, 1134\u20131143 (2007).","journal-title":"Clin. Neurophysiol."},{"key":"51065_CR88","unstructured":"Paxinos, G. & Watson, C. The rat brain in stereotaxic coordinates (Elsevier, 2006)."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-51065-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-51065-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-51065-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T18:02:36Z","timestamp":1723226556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-51065-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":88,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["51065"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-51065-7","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]},"assertion":[{"value":"11 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors report no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6683"}}