{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T07:05:27Z","timestamp":1794380727528,"version":"4.9.0"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-52025-x","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:02:47Z","timestamp":1725879767000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes"],"prefix":"10.1038","volume":"15","author":[{"given":"Kurt","family":"Farrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-6620","authenticated-orcid":false,"given":"Jack","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-9874","authenticated-orcid":false,"given":"Timothy","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-5440","authenticated-orcid":false,"given":"Yuk Yee","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2248-6403","authenticated-orcid":false,"given":"Pavel P.","family":"Kuksa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishakha","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-1181","authenticated-orcid":false,"given":"Wan-Ping","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-5420","authenticated-orcid":false,"given":"Amanda B.","family":"Kuzma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-2187","authenticated-orcid":false,"given":"Otto","family":"Valladares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Cantwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashvin","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"De Sanctis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Christie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robina","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrishtee","family":"Kandoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Whitney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Krassner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadley","family":"Ressler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SoongHo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Dangoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A.","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Casella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth H.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3892-6733","authenticated-orcid":false,"given":"Melissa J.","family":"Nirenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-8268","authenticated-orcid":false,"given":"Alan E.","family":"Renton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bergan","family":"Babrowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-5704","authenticated-orcid":false,"given":"Towfique","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-6187","authenticated-orcid":false,"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence I.","family":"Golbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-3774","authenticated-orcid":false,"given":"Huw R.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Revesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-6995","authenticated-orcid":false,"given":"Tom T.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-8881","authenticated-orcid":false,"given":"Zane","family":"Jaunmuktane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Y.","family":"Mok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-0863","authenticated-orcid":false,"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-7917","authenticated-orcid":false,"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-756X","authenticated-orcid":false,"given":"Owen A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-San","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-2472","authenticated-orcid":false,"given":"Alison","family":"Goate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Schellenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-3450","authenticated-orcid":false,"given":"Daniel H.","family":"Geschwind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PSP Genetics Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Hopfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Roeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Herms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Troakes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslau","family":"Compta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"van Swieten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fairlie","family":"Hinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justo Garc\u00eda","family":"de Yebenes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-293X","authenticated-orcid":false,"given":"John F.","family":"Crary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-2942","authenticated-orcid":false,"given":"Adam","family":"Naj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"52025_CR1","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12792","volume":"48","author":"GG Kovacs","year":"2022","unstructured":"Kovacs, G. G., Ghetti, B. & Goedert, M. Classification of diseases with accumulation of Tau protein. Neuropathol. Appl. Neurobiol. 48, e12792 (2022).","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"52025_CR2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41582-021-00541-5","volume":"17","author":"M Stamelou","year":"2021","unstructured":"Stamelou, M. et al. Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies. Nat. Rev. Neurol. 17, 601\u2013620 (2021).","journal-title":"Nat. Rev. Neurol."},{"key":"52025_CR3","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/brain\/124.7.1438","volume":"124","author":"U Nath","year":"2001","unstructured":"Nath, U. et al. The prevalence of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) in the UK. Brain 124, 1438\u20131449 (2001).","journal-title":"Brain"},{"key":"52025_CR4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/NRL.0b013e31815cffc9","volume":"14","author":"M Lubarsky","year":"2008","unstructured":"Lubarsky, M. & Juncos, J. L. Progressive supranuclear palsy: a current review. Neurologist 14, 79\u201388 (2008).","journal-title":"Neurologist"},{"key":"52025_CR5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.parkreldis.2011.02.017","volume":"17","author":"VGH Evidente","year":"2011","unstructured":"Evidente, V. G. H. et al. Neuropathological findings of PSP in the elderly without clinical PSP: Possible incidental PSP? Parkinsonism Relat. D. 17, 365\u2013371 (2011).","journal-title":"Parkinsonism Relat. D."},{"key":"52025_CR6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1212\/WNL.0b013e3181a92bcc","volume":"73","author":"L Donker Kaat","year":"2009","unstructured":"Donker Kaat, L. et al. Familial aggregation of parkinsonism in progressive supranuclear palsy. Neurology 73, 98\u2013105 (2009).","journal-title":"Neurology"},{"key":"52025_CR7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1212\/WNL.56.1.25","volume":"56","author":"KB Baker","year":"2001","unstructured":"Baker, K. B. & Montgomery, E. B. Jr. Performance on the PD test battery by relatives of patients with progressive supranuclear palsy. Neurology 56, 25\u201330 (2001).","journal-title":"Neurology"},{"key":"52025_CR8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ng.859","volume":"43","author":"GU Hoglinger","year":"2011","unstructured":"Hoglinger, G. U. et al. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat. Genet. 43, 699\u2013705 (2011).","journal-title":"Nat. Genet."},{"key":"52025_CR9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1474-4422(20)30394-X","volume":"20","author":"E Jabbari","year":"2021","unstructured":"Jabbari, E. et al. Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study. Lancet Neurol. 20, 107\u2013116 (2021).","journal-title":"Lancet Neurol."},{"key":"52025_CR10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13024-018-0270-8","volume":"13","author":"JA Chen","year":"2018","unstructured":"Chen, J. A. et al. Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases. Mol. Neurodegener. 13, 41 (2018).","journal-title":"Mol. Neurodegener."},{"key":"52025_CR11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-018-0267-3","volume":"13","author":"MY Sanchez-Contreras","year":"2018","unstructured":"Sanchez-Contreras, M. Y. et al. Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci. Mol. Neurodegener. 13, 37 (2018).","journal-title":"Mol. Neurodegener."},{"key":"52025_CR12","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3389\/fneur.2019.01125","volume":"10","author":"A Shoeibi","year":"2019","unstructured":"Shoeibi, A., Olfati, N. & Litvan, I. Frontrunner in Translation: Progressive Supranuclear Palsy. Front Neurol. 10, 1125 (2019).","journal-title":"Front Neurol."},{"key":"52025_CR13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","volume":"43","author":"AC Naj","year":"2011","unstructured":"Naj, A. C. et al. Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease. Nat. Genet. 43, 436\u2013441 (2011).","journal-title":"Nat. Genet."},{"key":"52025_CR14","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.3404","volume":"47","author":"HK Finucane","year":"2015","unstructured":"Finucane, H. K. et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet. 47, 1228\u20131235 (2015).","journal-title":"Nat. Genet."},{"key":"52025_CR15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291\u2013295 (2015).","journal-title":"Nat. Genet."},{"key":"52025_CR16","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.aay0793","volume":"366","author":"A Nott","year":"2019","unstructured":"Nott, A. et al. Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science 366, 1134\u20131139 (2019).","journal-title":"Science"},{"key":"52025_CR17","doi-asserted-by":"publisher","unstructured":"Lambert, J. C., Ramirez, A., Grenier-Boley, B. & Bellenguez, C. Step by step: towards a better understanding of the genetic architecture of Alzheimer\u2019s disease. Mol. Psychiatry https:\/\/doi.org\/10.1038\/s41380-023-02076-1 (2023).","DOI":"10.1038\/s41380-023-02076-1"},{"key":"52025_CR18","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","volume":"51","author":"BW Kunkle","year":"2019","unstructured":"Kunkle, B. W. et al. Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing. Nat. Genet. 51, 414\u2013430 (2019).","journal-title":"Nat. Genet."},{"key":"52025_CR19","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","volume":"18","author":"MA Nalls","year":"2019","unstructured":"Nalls, M. A. et al. Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies. Lancet Neurol. 18, 1091\u20131102 (2019).","journal-title":"Lancet Neurol."},{"key":"52025_CR20","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/bioinformatics\/btw018","volume":"32","author":"C Benner","year":"2016","unstructured":"Benner, C. et al. FINEMAP: efficient variable selection using summary data from genome-wide association studies. Bioinformatics 32, 1493\u20131501 (2016).","journal-title":"Bioinformatics"},{"key":"52025_CR21","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/s41588-020-00735-5","volume":"52","author":"O Weissbrod","year":"2020","unstructured":"Weissbrod, O. et al. Functionally informed fine-mapping and polygenic localization of complex trait heritability. Nat. Genet. 52, 1355\u20131363 (2020).","journal-title":"Nat. Genet."},{"key":"52025_CR22","doi-asserted-by":"crossref","DOI":"10.1126\/science.abi8654","volume":"377","author":"YA Cooper","year":"2022","unstructured":"Cooper, Y. A. et al. Functional regulatory variants implicate distinct transcriptional networks in dementia. Science 377, eabi8654 (2022).","journal-title":"Science"},{"key":"52025_CR23","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/s41593-022-01128-z","volume":"25","author":"J Bryois","year":"2022","unstructured":"Bryois, J. et al. Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders. Nat. Neurosci. 25, 1104\u20131112 (2022).","journal-title":"Nat. Neurosci."},{"key":"52025_CR24","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ng.3367","volume":"47","author":"ER Gamazon","year":"2015","unstructured":"Gamazon, E. R. et al. A gene-based association method for mapping traits using reference transcriptome data. Nat. Genet. 47, 1091\u20131098 (2015).","journal-title":"Nat. Genet."},{"key":"52025_CR25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","volume":"48","author":"A Gusev","year":"2016","unstructured":"Gusev, A. et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat. Genet. 48, 245\u2013252 (2016).","journal-title":"Nat. Genet."},{"key":"52025_CR26","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/s41588-018-0238-1","volume":"50","author":"T Raj","year":"2018","unstructured":"Raj, T. et al. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer\u2019s disease susceptibility. Nat. Genet. 50, 1584\u20131592 (2018).","journal-title":"Nat. Genet."},{"key":"52025_CR27","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-021-00890-2","volume":"13","author":"J Gockley","year":"2021","unstructured":"Gockley, J. et al. Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer\u2019s disease. Genome Med. 13, 76 (2021).","journal-title":"Genome Med."},{"key":"52025_CR28","doi-asserted-by":"crossref","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"C Giambartolomei","year":"2014","unstructured":"Giambartolomei, C. et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 10, e1004383 (2014).","journal-title":"PLoS Genet."},{"key":"52025_CR29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-0716-1158-6_6","volume":"2254","author":"A Amlie-Wolf","year":"2021","unstructured":"Amlie-Wolf, A. et al. Using INFERNO to Infer the Molecular Mechanisms Underlying Noncoding Genetic Associations. Methods Mol. Biol. 2254, 73\u201391 (2021).","journal-title":"Methods Mol. Biol."},{"key":"52025_CR30","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1093\/bioinformatics\/btaa246","volume":"36","author":"PP Kuksa","year":"2020","unstructured":"Kuksa, P. P. et al. SparkINFERNO: a scalable high-throughput pipeline for inferring molecular mechanisms of non-coding genetic variants. Bioinformatics 36, 3879\u20133881 (2020).","journal-title":"Bioinformatics"},{"key":"52025_CR31","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2016.89","volume":"3","author":"M Allen","year":"2016","unstructured":"Allen, M. et al. Human whole genome genotype and transcriptome data for Alzheimer\u2019s and other neurodegenerative diseases. Sci. Data 3, 160089 (2016).","journal-title":"Sci. Data"},{"key":"52025_CR32","doi-asserted-by":"crossref","unstructured":"Ressler, H. W. et al. MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy. Acta Neuropathol. Commun. 12, 135 (2024).","DOI":"10.1186\/s40478-024-01839-3"},{"key":"52025_CR33","doi-asserted-by":"publisher","unstructured":"Nachun, D. et al. Systems-level analysis of peripheral blood gene expression in dementia patients reveals an innate immune response shared across multiple disorders. bioRxiv, 2019.2012.2013.875112 https:\/\/doi.org\/10.1101\/2019.12.13.875112 (2019).","DOI":"10.1101\/2019.12.13.875112"},{"key":"52025_CR34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ng.3448","volume":"48","author":"LG Fritsche","year":"2016","unstructured":"Fritsche, L. G. et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat. Genet. 48, 134\u2013143 (2016).","journal-title":"Nat. Genet."},{"key":"52025_CR35","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.neuron.2015.08.020","volume":"87","author":"Y Zhao","year":"2015","unstructured":"Zhao, Y. et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron 87, 963\u2013975 (2015).","journal-title":"Neuron"},{"key":"52025_CR36","doi-asserted-by":"publisher","unstructured":"Silva, M. C. & Haggarty, S. J. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. Int. J. Mol. Sci. 21 https:\/\/doi.org\/10.3390\/ijms21238948 (2020).","DOI":"10.3390\/ijms21238948"},{"key":"52025_CR37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-022-00524-0","volume":"17","author":"LK Wareham","year":"2022","unstructured":"Wareham, L. K. et al. Solving neurodegeneration: common mechanisms and strategies for new treatments. Mol. Neurodegener. 17, 23 (2022).","journal-title":"Mol. Neurodegener."},{"key":"52025_CR38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000440840","volume":"16","author":"P Tacik","year":"2016","unstructured":"Tacik, P., Sanchez-Contreras, M., Rademakers, R., Dickson, D. W. & Wszolek, Z. K. Genetic Disorders with Tau Pathology: A Review of the Literature and Report of Two Patients with Tauopathy and Positive Family Histories. Neurodegener. Dis. 16, 12\u201321 (2016).","journal-title":"Neurodegener. Dis."},{"key":"52025_CR39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104511","volume":"90","author":"SJ Andrews","year":"2023","unstructured":"Andrews, S. J. et al. The complex genetic architecture of Alzheimer\u2019s disease: novel insights and future directions. EBioMedicine 90, 104511 (2023).","journal-title":"EBioMedicine"},{"key":"52025_CR40","unstructured":"Salloway, S. P. et al. Advancing combination therapy for Alzheimer\u2019s disease. Alzheimers Dement (NY) 6, e12073 (2020)."},{"key":"52025_CR41","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41588-021-00973-1","volume":"53","author":"W van Rheenen","year":"2021","unstructured":"van Rheenen, W. et al. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat. Genet. 53, 1636\u20131648 (2021).","journal-title":"Nat. Genet."},{"key":"52025_CR42","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnins.2014.00252","volume":"8","author":"EB Moloney","year":"2014","unstructured":"Moloney, E. B., de Winter, F. & Verhaagen, J. ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease. Front Neurosci. 8, 252 (2014).","journal-title":"Front Neurosci."},{"key":"52025_CR43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature16549","volume":"530","author":"A Sekar","year":"2016","unstructured":"Sekar, A. et al. Schizophrenia risk from complex variation of complement component 4. Nature 530, 177\u2013183 (2016).","journal-title":"Nature"},{"key":"52025_CR44","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41593-020-00763-8","volume":"24","author":"M Yilmaz","year":"2021","unstructured":"Yilmaz, M. et al. Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. Nat. Neurosci. 24, 214\u2013224 (2021).","journal-title":"Nat. Neurosci."},{"key":"52025_CR45","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/j.1471-4159.2008.05558.x","volume":"106","author":"J Zhou","year":"2008","unstructured":"Zhou, J., Fonseca, M. I., Pisalyaput, K. & Tenner, A. J. Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer\u2019s disease. J. Neurochem 106, 2080\u20132092 (2008).","journal-title":"J. Neurochem"},{"key":"52025_CR46","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1600-0404.1994.tb01631.x","volume":"89","author":"T Yamada","year":"1994","unstructured":"Yamada, T., Moroo, I., Koguchi, Y., Asahina, M. & Hirayama, K. Increased concentration of C4d complement protein in the cerebrospinal fluids in progressive supranuclear palsy. Acta Neurol. Scand. 89, 42\u201346 (1994).","journal-title":"Acta Neurol. Scand."},{"key":"52025_CR47","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/jnnp.57.7.859","volume":"57","author":"Y Tsuboi","year":"1994","unstructured":"Tsuboi, Y. & Yamada, T. Increased concentration of C4d complement protein in CSF in amyotrophic lateral sclerosis. J. Neurol. Neurosurg. Psychiatry 57, 859\u2013861 (1994).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"52025_CR48","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2023.105313","volume":"108","author":"S Khosousi","year":"2023","unstructured":"Khosousi, S. et al. Complement system changes in blood in Parkinson\u2019s disease and progressive Supranuclear Palsy\/Corticobasal Syndrome. Parkinsonism Relat. Disord. 108, 105313 (2023).","journal-title":"Parkinsonism Relat. Disord."},{"key":"52025_CR49","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.neuron.2018.12.003","volume":"100","author":"C Davies","year":"2018","unstructured":"Davies, C. & Spires-Jones, T. L. Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies. Neuron 100, 1267\u20131269 (2018).","journal-title":"Neuron"},{"key":"52025_CR50","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroscience.2022.05.022","volume":"518","author":"D Gallo","year":"2023","unstructured":"Gallo, D., Ruiz, A. & Sanchez-Juan, P. Genetic Architecture of Primary Tauopathies. Neuroscience 518, 27\u201337 (2023).","journal-title":"Neuroscience"},{"key":"52025_CR51","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/ng.3622","volume":"48","author":"W van Rheenen","year":"2016","unstructured":"van Rheenen, W. et al. Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nat. Genet. 48, 1043\u20131048 (2016).","journal-title":"Nat. Genet."},{"key":"52025_CR52","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8247","volume":"6","author":"N Kouri","year":"2015","unstructured":"Kouri, N. et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nat. Commun. 6, 7247 (2015).","journal-title":"Nat. Commun."},{"key":"52025_CR53","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00401-018-1900-5","volume":"136","author":"M Allen","year":"2018","unstructured":"Allen, M. et al. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy. Acta Neuropathol. 136, 709\u2013727 (2018).","journal-title":"Acta Neuropathol."},{"key":"52025_CR54","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nri1980","volume":"6","author":"JL Stow","year":"2006","unstructured":"Stow, J. L., Manderson, A. P. & Murray, R. Z. SNAREing immunity: the role of SNAREs in the immune system. Nat. Rev. Immunol. 6, 919\u2013929 (2006).","journal-title":"Nat. Rev. Immunol."},{"key":"52025_CR55","first-page":"1514 e1511","volume":"35","author":"R Ferrari","year":"2014","unstructured":"Ferrari, R. et al. Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy. Neurobiol. Aging 35, 1514 e1511\u20131512 (2014).","journal-title":"Neurobiol. Aging"},{"key":"52025_CR56","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/path.3969","volume":"226","author":"DA Nijholt","year":"2012","unstructured":"Nijholt, D. A., van Haastert, E. S., Rozemuller, A. J., Scheper, W. & Hoozemans, J. J. The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J. Pathol. 226, 693\u2013702 (2012).","journal-title":"J. Pathol."},{"key":"52025_CR57","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/jnen\/nlz110","volume":"79","author":"BM Verheijen","year":"2020","unstructured":"Verheijen, B. M. et al. Activation of the Unfolded Protein Response and Proteostasis Disturbance in Parkinsonism-Dementia of Guam. J. Neuropathol. Exp. Neurol. 79, 34\u201345 (2020).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"52025_CR58","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3233\/ADR-210050","volume":"5","author":"AP Pitera","year":"2021","unstructured":"Pitera, A. P. et al. Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies. J. Alzheimers Dis. Rep. 5, 855\u2013869 (2021).","journal-title":"J. Alzheimers Dis. Rep."},{"key":"52025_CR59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuint.2014.04.010","volume":"74","author":"R Nakazato","year":"2014","unstructured":"Nakazato, R. et al. Constitutive and functional expression of runt-related transcription factor-2 by microglial cells. Neurochem Int. 74, 24\u201335 (2014).","journal-title":"Neurochem Int."},{"key":"52025_CR60","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1002\/jcp.24988","volume":"230","author":"R Nakazato","year":"2015","unstructured":"Nakazato, R. et al. Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-beta Signaling Pathway in Microglial BV-2 Cells Exposed to ATP. J. Cell Physiol. 230, 2510\u20132521 (2015).","journal-title":"J. Cell Physiol."},{"key":"52025_CR61","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jemt.10377","volume":"61","author":"AL Bronckers","year":"2003","unstructured":"Bronckers, A. L., Sasaguri, K. & Engelse, M. A. Transcription and immunolocalization of Runx2\/Cbfa1\/Pebp2alphaA in developing rodent and human craniofacial tissues: further evidence suggesting osteoclasts phagocytose osteocytes. Microsc Res. Tech. 61, 540\u2013548 (2003).","journal-title":"Microsc Res. Tech."},{"key":"52025_CR62","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-022-04436-3","volume":"603","author":"AL Brown","year":"2022","unstructured":"Brown, A. L. et al. TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. Nature 603, 131\u2013137 (2022).","journal-title":"Nature"},{"key":"52025_CR63","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/mp.2016.35","volume":"22","author":"T Roostaei","year":"2017","unstructured":"Roostaei, T. et al. Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer\u2019s disease. Mol. Psychiatry 22, 287\u2013295 (2017).","journal-title":"Mol. Psychiatry"},{"key":"52025_CR64","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/mds.28011","volume":"35","author":"M Jecmenica Lukic","year":"2020","unstructured":"Jecmenica Lukic, M. et al. Copathology in Progressive Supranuclear Palsy: Does It Matter? Mov. Disord. 35, 984\u2013993 (2020).","journal-title":"Mov. Disord."},{"key":"52025_CR65","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00401-021-02379-z","volume":"143","author":"K Farrell","year":"2022","unstructured":"Farrell, K. et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 143, 33\u201353 (2022).","journal-title":"Acta Neuropathol."},{"key":"52025_CR66","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price, A. L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904\u2013909 (2006).","journal-title":"Nat. Genet."},{"key":"52025_CR67","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","volume":"2","author":"N Patterson","year":"2006","unstructured":"Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).","journal-title":"PLoS Genet."},{"key":"52025_CR68","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","volume":"48","author":"S Das","year":"2016","unstructured":"Das, S. et al. Next-generation genotype imputation service and methods. Nat. Genet. 48, 1284\u20131287 (2016).","journal-title":"Nat. Genet."},{"key":"52025_CR69","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-021-03205-y","volume":"590","author":"D Taliun","year":"2021","unstructured":"Taliun, D. et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature 590, 290\u2013299 (2021).","journal-title":"Nature"},{"key":"52025_CR70","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3679","volume":"48","author":"PR Loh","year":"2016","unstructured":"Loh, P. R. et al. Reference-based phasing using the Haplotype Reference Consortium panel. Nat. Genet. 48, 1443\u20131448 (2016).","journal-title":"Nat. Genet."},{"key":"52025_CR71","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/bioinformatics\/btu704","volume":"31","author":"C Fuchsberger","year":"2015","unstructured":"Fuchsberger, C., Abecasis, G. R. & Hinds, D. A. minimac2: faster genotype imputation. Bioinformatics 31, 782\u2013784 (2015).","journal-title":"Bioinformatics"},{"key":"52025_CR72","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng2088","volume":"39","author":"J Marchini","year":"2007","unstructured":"Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39, 906\u2013913 (2007).","journal-title":"Nat. Genet."},{"key":"52025_CR73","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","volume":"369","author":"GT Consortium","year":"2020","unstructured":"Consortium, G. T. The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science 369, 1318\u20131330 (2020).","journal-title":"Science"},{"key":"52025_CR74","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature24277","volume":"550","author":"GT Consortium","year":"2017","unstructured":"Consortium, G. T. et al. Genetic effects on gene expression across human tissues. Nature 550, 204\u2013213 (2017).","journal-title":"Nature"},{"key":"52025_CR75","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/bioinformatics\/btr509","volume":"27","author":"H Li","year":"2011","unstructured":"Li, H. A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Bioinformatics 27, 2987\u20132993 (2011).","journal-title":"Bioinformatics"},{"key":"52025_CR76","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/ng.3954","volume":"49","author":"S Gazal","year":"2017","unstructured":"Gazal, S. et al. Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection. Nat. Genet. 49, 1421\u20131427 (2017).","journal-title":"Nat. Genet."},{"key":"52025_CR77","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1097\/00005650-198812000-00011","volume":"26","author":"JE Anderson","year":"1988","unstructured":"Anderson, J. E. & Willan, A. R. Estimating the size of family practice populations. Quadratic Odds Estimation. Med. Care 26, 1228\u20131233 (1988).","journal-title":"Med. Care"},{"key":"52025_CR78","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"C Genomes Project","year":"2015","unstructured":"Genomes Project, C. et al. A global reference for human genetic variation. Nature 526, 68\u201374 (2015).","journal-title":"Nature"},{"key":"52025_CR79","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fgene.2020.00157","volume":"11","author":"TA Myers","year":"2020","unstructured":"Myers, T. A., Chanock, S. J. & Machiela, M. J. LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations. Front Genet. 11, 157 (2020).","journal-title":"Front Genet."},{"key":"52025_CR80","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1093\/nar\/gky686","volume":"46","author":"A Amlie-Wolf","year":"2018","unstructured":"Amlie-Wolf, A. et al. INFERNO: inferring the molecular mechanisms of noncoding genetic variants. Nucleic Acids Res. 46, 8740\u20138753 (2018).","journal-title":"Nucleic Acids Res."},{"key":"52025_CR81","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ajhg.2018.07.015","volume":"103","author":"BL Browning","year":"2018","unstructured":"Browning, B. L., Zhou, Y. & Browning, S. R. A One-Penny Imputed Genome from Next-Generation Reference Panels. Am. J. Hum. Genet. 103, 338\u2013348 (2018).","journal-title":"Am. J. Hum. Genet."},{"key":"52025_CR82","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114\u20132120 (2014).","journal-title":"Bioinformatics"},{"key":"52025_CR83","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15\u201321 (2013).","journal-title":"Bioinformatics"},{"key":"52025_CR84","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Smyth, G. K. & Shi, W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30, 923\u2013930 (2014).","journal-title":"Bioinformatics"},{"key":"52025_CR85","volume":"12","author":"B Li","year":"2011","unstructured":"Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinforma. 12, 323 (2011).","journal-title":"BMC Bioinforma."},{"key":"52025_CR86","volume":"15","author":"CW Law","year":"2014","unstructured":"Law, C. W., Chen, Y., Shi, W. & Smyth, G. K. voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol. 15, R29 (2014).","journal-title":"Genome Biol."},{"key":"52025_CR87","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-016-1323-z","volume":"17","author":"GE Hoffman","year":"2016","unstructured":"Hoffman, G. E. & Schadt, E. E. variancePartition: interpreting drivers of variation in complex gene expression studies. BMC Bioinforma. 17, 483 (2016).","journal-title":"BMC Bioinforma."},{"key":"52025_CR88","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/bioinformatics\/btp053","volume":"25","author":"DJ McCarthy","year":"2009","unstructured":"McCarthy, D. J. & Smyth, G. K. Testing significance relative to a fold-change threshold is a TREAT. Bioinformatics 25, 765\u2013771 (2009).","journal-title":"Bioinformatics"},{"key":"52025_CR89","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.20022","volume":"58","author":"E Meijering","year":"2004","unstructured":"Meijering, E. et al. Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytom. A 58, 167\u2013176 (2004).","journal-title":"Cytom. A"},{"key":"52025_CR90","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676\u2013682 (2012).","journal-title":"Nat. Methods"}],"updated-by":[{"DOI":"10.1038\/s41467-024-53617-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000}}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52025-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52025-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52025-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:03:21Z","timestamp":1731564201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52025-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":90,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["52025"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-52025-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.09.565552","asserted-by":"object"}]},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]},"assertion":[{"value":"15 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41467-024-53617-3","URL":"https:\/\/doi.org\/10.1038\/s41467-024-53617-3","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"There are no competing interests to the work published here, but in full transparency the following authors wish to disclose their industry relations. A.M.G. is an SAB member for Genentech and Muna Therapeutics. H.M. consultants for Roche, Aprinoia, AI Therapeutics, and Amylyx and is a co-applicant on a patent application PCT\/GB2012\/052140. L.G. consults for AI Therapeutics, Amylyx, Apellis, Aprinoia, Ferrer, Mitochon, Mitsubishi Tanabe, P3Lab, Roche, Springer, Switch, UCB, and Woolsey G.C. is currently employed by Regeneron. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7880"}}