{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:21:39Z","timestamp":1787800899414,"version":"build-2784847793"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000060","name":"U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI143839"],"award-info":[{"award-number":["AI143839"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM134974-5749"],"award-info":[{"award-number":["P20GM134974-5749"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ike Muslow Predoctoral Fellowship from LSU Health Shreveport to AAW"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-52184-x","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T07:02:13Z","timestamp":1725778933000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Iron-depleting nutritional immunity controls extracellular bacterial replication in Legionella pneumophila infections"],"prefix":"10.1038","volume":"15","author":[{"given":"Ascenci\u00f3n","family":"Torres-Escobar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda D.","family":"Ju\u00e1rez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Circu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Latimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-6802","authenticated-orcid":false,"given":"Ana-Maria","family":"Dragoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-7595","authenticated-orcid":false,"given":"Stanimir S.","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"52184_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3389\/fcimb.2017.00477","volume":"7","author":"DK Boamah","year":"2017","unstructured":"Boamah, D. K., Zhou, G., Ensminger, A. W. & O\u2019Connor, T. J. From Many Hosts, One Accidental Pathogen: The Diverse Protozoan Hosts of Legionella. Front. Cell Infect. Microbiol. 7, 477 (2017).","journal-title":"Front. Cell Infect. Microbiol."},{"key":"52184_CR2","doi-asserted-by":"publisher","unstructured":"Gomez-Valero, L. & Buchrieser, C. Genome dynamics in Legionella: the basis of versatility and adaptation to intracellular replication. Cold Spring Harb. Perspect. Med. 3, https:\/\/doi.org\/10.1101\/cshperspect.a009993 (2013).","DOI":"10.1101\/cshperspect.a009993"},{"key":"52184_CR3","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3201\/eid2701.190676","volume":"27","author":"SA Collier","year":"2021","unstructured":"Collier, S. A. et al. Estimate of Burden and Direct Healthcare Cost of Infectious Waterborne Disease in the United States. Emerg. Infect. Dis. 27, 140\u2013149 (2021).","journal-title":"Emerg. Infect. Dis."},{"key":"52184_CR4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0140-6736(15)60078-2","volume":"387","author":"BA Cunha","year":"2016","unstructured":"Cunha, B. A., Burillo, A. & Bouza, E. Legionnaires\u2019 disease. Lancet 387, 376\u2013385 (2016).","journal-title":"Lancet"},{"key":"52184_CR5","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/S1473-3099(14)70713-3","volume":"14","author":"N Phin","year":"2014","unstructured":"Phin, N. et al. Epidemiology and clinical management of Legionnaires\u2019 disease. Lancet Infect. Dis. 14, 1011\u20131021 (2014).","journal-title":"Lancet Infect. Dis."},{"key":"52184_CR6","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1017\/S0950268813003440","volume":"142","author":"J Ambrose","year":"2014","unstructured":"Ambrose, J. et al. Large outbreak of Legionnaires\u2019 disease and Pontiac fever at a military base. Epidemiol. Infect. 142, 2336\u20132346 (2014).","journal-title":"Epidemiol. Infect."},{"key":"52184_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1086\/338060","volume":"185","author":"AL Benin","year":"2002","unstructured":"Benin, A. L. et al. An outbreak of travel-associated Legionnaires disease and Pontiac fever: the need for enhanced surveillance of travel-associated legionellosis in the United States. J. Infect. Dis. 185, 237\u2013243 (2002).","journal-title":"J. Infect. Dis."},{"key":"52184_CR8","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1086\/510387","volume":"44","author":"LJ Burnsed","year":"2007","unstructured":"Burnsed, L. J. et al. A large, travel-associated outbreak of legionellosis among hotel guests: utility of the urine antigen assay in confirming Pontiac fever. Clin. Infect. Dis. 44, 222\u2013228 (2007).","journal-title":"Clin. Infect. Dis."},{"key":"52184_CR9","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3109\/00365548.2010.509331","volume":"42","author":"SM Euser","year":"2010","unstructured":"Euser, S. M., Pelgrim, M. & den Boer, J. W. Legionnaires\u2019 disease and Pontiac fever after using a private outdoor whirlpool spa. Scand. J. Infect. Dis. 42, 910\u2013916 (2010).","journal-title":"Scand. J. Infect. Dis."},{"key":"52184_CR10","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1001\/archinte.1982.00340160125024","volume":"142","author":"JC Girod","year":"1982","unstructured":"Girod, J. C. et al. Pneumonic and nonpneumonic forms of legionellosis. The result of a common-source exposure to Legionella pneumophila. Arch. Intern. Med. 142, 545\u2013547 (1982).","journal-title":"Arch. Intern. Med."},{"key":"52184_CR11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1017\/S0950268800048767","volume":"107","author":"DA Hunt","year":"1991","unstructured":"Hunt, D. A. et al. An outbreak of Legionnaires\u2019 disease in Gloucester. Epidemiol. Infect. 107, 133\u2013141 (1991).","journal-title":"Epidemiol. Infect."},{"key":"52184_CR12","doi-asserted-by":"publisher","first-page":"ofv164","DOI":"10.1093\/ofid\/ofv164","volume":"2","author":"SS Smith","year":"2015","unstructured":"Smith, S. S. et al. Legionellosis Outbreak Associated With a Hotel Fountain. Open Forum Infect. Dis. 2, ofv164 (2015).","journal-title":"Open Forum Infect. Dis."},{"key":"52184_CR13","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1001\/archinte.1993.00410220113013","volume":"153","author":"DL Thomas","year":"1993","unstructured":"Thomas, D. L., Mundy, L. M. & Tucker, P. C. Hot tub legionellosis. Legionnaires\u2019 disease and Pontiac fever after a point-source exposure to Legionella pneumophila. Arch. Intern. Med. 153, 2597\u20132599 (1993).","journal-title":"Arch. Intern. Med."},{"key":"52184_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/path.1711400202","volume":"140","author":"A Baskerville","year":"1983","unstructured":"Baskerville, A., Dowsett, A. B., Fitzgeorge, R. B., Hambleton, P. & Broster, M. Ultrastructure of pulmonary alveoli and macrophages in experimental Legionnaires\u2019 disease. J. Pathol. 140, 77\u201390 (1983).","journal-title":"J. Pathol."},{"key":"52184_CR15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/ajcp\/71.1.43","volume":"71","author":"FW Chandler","year":"1979","unstructured":"Chandler, F. W., Blackmon, J. A., Hicklin, M. D., Cole, R. M. & Callaway, C. S. Ultrastructure of the agent of Legionnaires\u2019 disease in the human lung. Am. J. Clin. Pathol. 71, 43\u201350 (1979).","journal-title":"Am. J. Clin. Pathol."},{"key":"52184_CR16","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1093\/infdis\/148.5.823","volume":"148","author":"GS Davis","year":"1983","unstructured":"Davis, G. S., Winn, W. C. Jr., Gump, D. W. & Beaty, H. N. The kinetics of early inflammatory events during experimental pneumonia due to Legionella pneumophila in guinea pigs. J. Infect. Dis. 148, 823\u2013835 (1983).","journal-title":"J. Infect. Dis."},{"key":"52184_CR17","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1172\/JCI111493","volume":"74","author":"TW Nash","year":"1984","unstructured":"Nash, T. W., Libby, D. M. & Horwitz, M. A. Interaction between the legionnaires\u2019 disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone. J. Clin. Invest. 74, 771\u2013782 (1984).","journal-title":"J. Clin. Invest."},{"key":"52184_CR18","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0046-8177(81)80021-4","volume":"12","author":"WC Winn Jr.","year":"1981","unstructured":"Winn, W. C. Jr. & Myerowitz, R. L. The pathology of the Legionella pneumonias. A review of 74 cases and the literature. Hum. Pathol. 12, 401\u2013422 (1981).","journal-title":"Hum. Pathol."},{"key":"52184_CR19","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1084\/jem.158.4.1319","volume":"158","author":"MA Horwitz","year":"1983","unstructured":"Horwitz, M. A. Formation of a novel phagosome by the Legionnaires\u2019 disease bacterium (Legionella pneumophila) in human monocytes. J. Exp. Med. 158, 1319\u20131331 (1983).","journal-title":"J. Exp. Med."},{"key":"52184_CR20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1462-5822.2008.01251.x","volume":"11","author":"SS Ivanov","year":"2009","unstructured":"Ivanov, S. S. & Roy, C. R. Modulation of ubiquitin dynamics and suppression of DALIS formation by the Legionella pneumophila Dot\/Icm system. Cell Microbiol. 11, 261\u2013278 (2009).","journal-title":"Cell Microbiol."},{"key":"52184_CR21","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1128\/iai.63.9.3609-3620.1995","volume":"63","author":"MS Swanson","year":"1995","unstructured":"Swanson, M. S. & Isberg, R. R. Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect. Immun. 63, 3609\u20133620 (1995).","journal-title":"Infect. Immun."},{"key":"52184_CR22","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1242\/jcs.114.24.4637","volume":"114","author":"LG Tilney","year":"2001","unstructured":"Tilney, L. G., Harb, O. S., Connelly, P. S., Robinson, C. G. & Roy, C. R. How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. J. Cell Sci. 114, 4637\u20134650 (2001).","journal-title":"J. Cell Sci."},{"key":"52184_CR23","doi-asserted-by":"publisher","first-page":"3931","DOI":"10.1083\/jcb.201701095","volume":"216","author":"E Cornejo","year":"2017","unstructured":"Cornejo, E., Schlaermann, P. & Mukherjee, S. How to rewire the host cell: A home improvement guide for intracellular bacteria. J. Cell Biol. 216, 3931\u20133948 (2017).","journal-title":"J. Cell Biol."},{"key":"52184_CR24","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.tim.2016.02.003","volume":"24","author":"N Personnic","year":"2016","unstructured":"Personnic, N., Barlocher, K., Finsel, I. & Hilbi, H. Subversion of Retrograde Trafficking by Translocated Pathogen Effectors. Trends Microbiol. 24, 450\u2013462 (2016).","journal-title":"Trends Microbiol."},{"key":"52184_CR25","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1046\/j.1365-2958.1998.00841.x","volume":"28","author":"CR Roy","year":"1998","unstructured":"Roy, C. R., Berger, K. H. & Isberg, R. R. Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake. Mol. Microbiol. 28, 663\u2013674 (1998).","journal-title":"Mol. Microbiol."},{"key":"52184_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1128\/iai.51.1.31-36.1986","volume":"51","author":"JA Elliott","year":"1986","unstructured":"Elliott, J. A. & Winn, W. C. Jr. Treatment of alveolar macrophages with cytochalasin D inhibits uptake and subsequent growth of Legionella pneumophila. Infect. Immun. 51, 31\u201336 (1986).","journal-title":"Infect. Immun."},{"key":"52184_CR27","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1172\/JCI109874","volume":"66","author":"MA Horwitz","year":"1980","unstructured":"Horwitz, M. A. & Silverstein, S. C. Legionnaires\u2019 disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes. J. Clin. Invest. 66, 441\u2013450 (1980).","journal-title":"J. Clin. Invest."},{"key":"52184_CR28","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1128\/IAI.66.3.950-958.1998","volume":"66","author":"HL Andrews","year":"1998","unstructured":"Andrews, H. L., Vogel, J. P. & Isberg, R. R. Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway. Infect. Immun. 66, 950\u2013958 (1998).","journal-title":"Infect. Immun."},{"key":"52184_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1365-2958.1993.tb01092.x","volume":"7","author":"KH Berger","year":"1993","unstructured":"Berger, K. H. & Isberg, R. R. Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol. Microbiol. 7, 7\u201319 (1993).","journal-title":"Mol. Microbiol."},{"key":"52184_CR30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/j.1365-2958.1994.tb01316.x","volume":"14","author":"BC Brand","year":"1994","unstructured":"Brand, B. C., Sadosky, A. B. & Shuman, H. A. The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages. Mol. Microbiol. 14, 797\u2013808 (1994).","journal-title":"Mol. Microbiol."},{"key":"52184_CR31","doi-asserted-by":"publisher","first-page":"9607","DOI":"10.1073\/pnas.89.20.9607","volume":"89","author":"A Marra","year":"1992","unstructured":"Marra, A., Blander, S. J., Horwitz, M. A. & Shuman, H. A. Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc. Natl Acad. Sci. USA 89, 9607\u20139611 (1992).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52184_CR32","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/j.1365-2958.1994.tb01317.x","volume":"14","author":"KH Berger","year":"1994","unstructured":"Berger, K. H., Merriam, J. J. & Isberg, R. R. Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene. Mol. Microbiol. 14, 809\u2013822 (1994).","journal-title":"Mol. Microbiol."},{"key":"52184_CR33","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1128\/IAI.67.5.2117-2124.1999","volume":"67","author":"G Segal","year":"1999","unstructured":"Segal, G. & Shuman, H. A. Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages. Infect. Immun. 67, 2117\u20132124 (1999).","journal-title":"Infect. Immun."},{"key":"52184_CR34","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1128\/IAI.68.5.2939-2947.2000","volume":"68","author":"JM Solomon","year":"2000","unstructured":"Solomon, J. M., Rupper, A., Cardelli, J. A. & Isberg, R. R. Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions. Infect. Immun. 68, 2939\u20132947 (2000).","journal-title":"Infect. Immun."},{"key":"52184_CR35","first-page":"235","volume":"23","author":"A Akinsulore","year":"2015","unstructured":"Akinsulore, A., Owojuyigbe, A. M., Faponle, A. F. & Fatoye, F. O. Assessment of Preoperative and Postoperative Anxiety among Elective Major Surgery Patients in a Tertiary Hospital in Nigeria. Middle East J. Anaesthesiol. 23, 235\u2013240 (2015).","journal-title":"Middle East J. Anaesthesiol."},{"key":"52184_CR36","doi-asserted-by":"publisher","first-page":"3868","DOI":"10.1002\/1873-3468.12326","volume":"590","author":"W Eisenreich","year":"2016","unstructured":"Eisenreich, W. & Heuner, K. The life stage-specific pathometabolism of Legionella pneumophila. FEBS Lett. 590, 3868\u20133886 (2016).","journal-title":"FEBS Lett."},{"key":"52184_CR37","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1128\/jcm.11.3.286-291.1980","volume":"11","author":"JR George","year":"1980","unstructured":"George, J. R., Pine, L., Reeves, M. W. & Harrell, W. K. Amino acid requirements of Legionella pneumophila. J. Clin. Microbiol. 11, 286\u2013291 (1980).","journal-title":"J. Clin. Microbiol."},{"key":"52184_CR38","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1128\/jcm.9.5.615-626.1979","volume":"9","author":"L Pine","year":"1979","unstructured":"Pine, L., George, J. R., Reeves, M. W. & Harrell, W. K. Development of a chemically defined liquid medium for growth of Legionella pneumophila. J. Clin. Microbiol. 9, 615\u2013626 (1979).","journal-title":"J. Clin. Microbiol."},{"key":"52184_CR39","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1128\/jcm.13.5.865-869.1981","volume":"13","author":"MJ Tesh","year":"1981","unstructured":"Tesh, M. J. & Miller, R. D. Amino acid requirements for Legionella pneumophila growth. J. Clin. Microbiol. 13, 865\u2013869 (1981).","journal-title":"J. Clin. Microbiol."},{"key":"52184_CR40","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1172\/JCI110923","volume":"71","author":"MA Horwitz","year":"1983","unstructured":"Horwitz, M. A. Cell-mediated immunity in Legionnaires\u2019 disease. J. Clin. Invest. 71, 1686\u20131697 (1983).","journal-title":"J. Clin. Invest."},{"key":"52184_CR41","doi-asserted-by":"publisher","first-page":"7344","DOI":"10.1128\/JB.186.21.7344-7352.2004","volume":"186","author":"SA Coleman","year":"2004","unstructured":"Coleman, S. A., Fischer, E. R., Howe, D., Mead, D. J. & Heinzen, R. A. Temporal analysis of Coxiella burnetii morphological differentiation. J. Bacteriol. 186, 7344\u20137352 (2004).","journal-title":"J. Bacteriol."},{"key":"52184_CR42","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrmicro.2016.30","volume":"14","author":"C Elwell","year":"2016","unstructured":"Elwell, C., Mirrashidi, K. & Engel, J. Chlamydia cell biology and pathogenesis. Nat. Rev. Microbiol. 14, 385\u2013400 (2016).","journal-title":"Nat. Rev. Microbiol."},{"key":"52184_CR43","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.3389\/fmicb.2019.02329","volume":"10","author":"A Gitsels","year":"2019","unstructured":"Gitsels, A., Sanders, N. & Vanrompay, D. Chlamydial Infection From Outside to Inside. Front. Microbiol. 10, 2329 (2019).","journal-title":"Front. Microbiol."},{"key":"52184_CR44","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0966-842X(99)01475-4","volume":"7","author":"RA Heinzen","year":"1999","unstructured":"Heinzen, R. A., Hackstadt, T. & Samuel, J. E. Developmental biology of Coxiella burnettii. Trends Microbiol. 7, 149\u2013154 (1999).","journal-title":"Trends Microbiol."},{"key":"52184_CR45","doi-asserted-by":"publisher","first-page":"4018","DOI":"10.1128\/IAI.00527-09","volume":"77","author":"MJ Troese","year":"2009","unstructured":"Troese, M. J. & Carlyon, J. A. Anaplasma phagocytophilum dense-cored organisms mediate cellular adherence through recognition of human P-selectin glycoprotein ligand 1. Infect. Immun. 77, 4018\u20134027 (2009).","journal-title":"Infect. Immun."},{"key":"52184_CR46","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1111\/j.1462-5822.2006.00812.x","volume":"9","author":"JZ Zhang","year":"2007","unstructured":"Zhang, J. Z., Popov, V. L., Gao, S., Walker, D. H. & Yu, X. J. The developmental cycle of Ehrlichia chaffeensis in vertebrate cells. Cell Microbiol. 9, 610\u2013618 (2007).","journal-title":"Cell Microbiol."},{"key":"52184_CR47","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1128\/IAI.72.5.2468-2476.2004","volume":"72","author":"MA Bachman","year":"2004","unstructured":"Bachman, M. A. & Swanson, M. S. Genetic evidence that Legionella pneumophila RpoS modulates expression of the transmission phenotype in both the exponential phase and the stationary phase. Infect. Immun. 72, 2468\u20132476 (2004).","journal-title":"Infect. Immun."},{"key":"52184_CR48","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1128\/IAI.66.7.3029-3034.1998","volume":"66","author":"B Byrne","year":"1998","unstructured":"Byrne, B. & Swanson, M. S. Expression of Legionella pneumophila virulence traits in response to growth conditions. Infect. Immun. 66, 3029\u20133034 (1998).","journal-title":"Infect. Immun."},{"key":"52184_CR49","doi-asserted-by":"publisher","first-page":"6273","DOI":"10.1128\/IAI.70.11.6273-6283.2002","volume":"70","author":"RA Garduno","year":"2002","unstructured":"Garduno, R. A., Garduno, E., Hiltz, M. & Hoffman, P. S. Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase forms. Infect. Immun. 70, 6273\u20136283 (2002).","journal-title":"Infect. Immun."},{"key":"52184_CR50","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1046\/j.1365-2958.2002.02884.x","volume":"44","author":"BK Hammer","year":"2002","unstructured":"Hammer, B. K., Tateda, E. S. & Swanson, M. S. A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila. Mol. Microbiol. 44, 107\u2013118 (2002).","journal-title":"Mol. Microbiol."},{"key":"52184_CR51","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-2958.2004.04129.x","volume":"53","author":"AB Molofsky","year":"2004","unstructured":"Molofsky, A. B. & Swanson, M. S. Differentiate to thrive: lessons from the Legionella pneumophila life cycle. Mol. Microbiol. 53, 29\u201340 (2004).","journal-title":"Mol. Microbiol."},{"key":"52184_CR52","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.4049\/jimmunol.137.8.2662","volume":"137","author":"N Bhardwaj","year":"1986","unstructured":"Bhardwaj, N., Nash, T. W. & Horwitz, M. A. Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila. J. Immunol. 137, 2662\u20132669 (1986).","journal-title":"J. Immunol."},{"key":"52184_CR53","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.4049\/jimmunol.140.11.3978","volume":"140","author":"TW Nash","year":"1988","unstructured":"Nash, T. W., Libby, D. M. & Horwitz, M. A. IFN-gamma-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila. J. Immunol. 140, 3978\u20133981 (1988).","journal-title":"J. Immunol."},{"key":"52184_CR54","doi-asserted-by":"publisher","unstructured":"Price, J. V. et al. IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. mBio 10, https:\/\/doi.org\/10.1128\/mBio.02629-19 (2019).","DOI":"10.1128\/mBio.02629-19"},{"key":"52184_CR55","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1099\/0022-1317-51-3-225","volume":"51","author":"Y Shinozawa","year":"2002","unstructured":"Shinozawa, Y. et al. Role of interferon-gamma in inflammatory responses in murine respiratory infection with Legionella pneumophila. J. Med. Microbiol. 51, 225\u2013230 (2002).","journal-title":"J. Med. Microbiol."},{"key":"52184_CR56","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.4049\/jimmunol.176.10.6162","volume":"176","author":"R Sporri","year":"2006","unstructured":"Sporri, R., Joller, N., Albers, U., Hilbi, H. & Oxenius, A. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection. J. Immunol. 176, 6162\u20136171 (2006).","journal-title":"J. Immunol."},{"key":"52184_CR57","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01707-23","volume":"14","author":"AR Bass","year":"2023","unstructured":"Bass, A. R. et al. Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation. mBio 14, e0170723 (2023).","journal-title":"mBio"},{"key":"52184_CR58","doi-asserted-by":"publisher","first-page":"E1698","DOI":"10.1073\/pnas.1615771114","volume":"114","author":"EM Feeley","year":"2017","unstructured":"Feeley, E. M. et al. Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. Proc. Natl Acad. Sci. USA 114, E1698\u2013E1706 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52184_CR59","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1111\/j.1462-5822.2011.01646.x","volume":"13","author":"J Lippmann","year":"2011","unstructured":"Lippmann, J. et al. Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice. Cell Microbiol. 13, 1668\u20131682 (2011).","journal-title":"Cell Microbiol."},{"key":"52184_CR60","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.celrep.2018.06.012","volume":"24","author":"BC Liu","year":"2018","unstructured":"Liu, B. C. et al. Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses. Cell Rep. 24, 155\u2013168.e155 (2018).","journal-title":"Cell Rep."},{"key":"52184_CR61","doi-asserted-by":"publisher","first-page":"e1005408","DOI":"10.1371\/journal.ppat.1005408","volume":"12","author":"J Naujoks","year":"2016","unstructured":"Naujoks, J. et al. IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid. PLoS Pathog. 12, e1005408 (2016).","journal-title":"PLoS Pathog."},{"key":"52184_CR62","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1073\/pnas.1321700111","volume":"111","author":"DM Pilla","year":"2014","unstructured":"Pilla, D. M. et al. Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc. Natl Acad. Sci. USA 111, 6046\u20136051 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52184_CR63","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/thorax.58.1.63","volume":"58","author":"KD Lettinga","year":"2003","unstructured":"Lettinga, K. D. et al. Reduced interferon-gamma release in patients recovered from Legionnaires\u2019 disease. Thorax 58, 63\u201367 (2003).","journal-title":"Thorax"},{"key":"52184_CR64","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41579-022-00745-6","volume":"20","author":"CC Murdoch","year":"2022","unstructured":"Murdoch, C. C. & Skaar, E. P. Nutritional immunity: the battle for nutrient metals at the host-pathogen interface. Nat. Rev. Microbiol. 20, 657\u2013670 (2022).","journal-title":"Nat. Rev. Microbiol."},{"key":"52184_CR65","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1126\/science.184.4140.952","volume":"184","author":"ED Weinberg","year":"1974","unstructured":"Weinberg, E. D. Iron and susceptibility to infectious disease. Science 184, 952\u2013956 (1974).","journal-title":"Science"},{"key":"52184_CR66","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1001\/jama.1975.03240130021018","volume":"231","author":"ED Weinberg","year":"1975","unstructured":"Weinberg, E. D. Nutritional immunity. Host\u2019s attempt to withold iron from microbial invaders. JAMA 231, 39\u201341 (1975).","journal-title":"JAMA"},{"key":"52184_CR67","doi-asserted-by":"publisher","unstructured":"Neves, J., Haider, T., Gassmann, M. & Muckenthaler, M. U. Iron Homeostasis in the Lungs-A Balance between Health and Disease. Pharmaceuticals 12, https:\/\/doi.org\/10.3390\/ph12010005 (2019)","DOI":"10.3390\/ph12010005"},{"key":"52184_CR68","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1086\/323203","volume":"184","author":"IT Gangaidzo","year":"2001","unstructured":"Gangaidzo, I. T. et al. Association of pulmonary tuberculosis with increased dietary iron. J. Infect. Dis. 184, 936\u2013939 (2001).","journal-title":"J. Infect. Dis."},{"key":"52184_CR69","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.coi.2009.01.011","volume":"21","author":"T Ganz","year":"2009","unstructured":"Ganz, T. Iron in innate immunity: starve the invaders. Curr. Opin. Immunol. 21, 63\u201367 (2009).","journal-title":"Curr. Opin. Immunol."},{"key":"52184_CR70","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.ijid.2007.04.007","volume":"11","author":"FA Khan","year":"2007","unstructured":"Khan, F. A., Fisher, M. A. & Khakoo, R. A. Association of hemochromatosis with infectious diseases: expanding spectrum. Int. J. Infect. Dis. 11, 482\u2013487 (2007).","journal-title":"Int. J. Infect. Dis."},{"key":"52184_CR71","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0140-6736(06)67962-2","volume":"367","author":"S Sazawal","year":"2006","unstructured":"Sazawal, S. et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 367, 133\u2013143 (2006).","journal-title":"Lancet"},{"key":"52184_CR72","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/emph\/eox010","volume":"2017","author":"K Wander","year":"2017","unstructured":"Wander, K., Shell-Duncan, B. & Brindle, E. Lower incidence of respiratory infections among iron-deficient children in Kilimanjaro, Tanzania. Evol. Med. Public Health 2017, 109\u2013119 (2017).","journal-title":"Evol. Med. Public Health"},{"key":"52184_CR73","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/35001596","volume":"403","author":"A Donovan","year":"2000","unstructured":"Donovan, A. et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403, 776\u2013781 (2000).","journal-title":"Nature"},{"key":"52184_CR74","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","volume":"1","author":"A Donovan","year":"2005","unstructured":"Donovan, A. et al. The iron exporter ferroportin\/Slc40a1 is essential for iron homeostasis. Cell Metab. 1, 191\u2013200 (2005).","journal-title":"Cell Metab."},{"key":"52184_CR75","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","volume":"13","author":"JE Cassat","year":"2013","unstructured":"Cassat, J. E. & Skaar, E. P. Iron in infection and immunity. Cell Host Microbe 13, 509\u2013519 (2013).","journal-title":"Cell Host Microbe"},{"key":"52184_CR76","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1172\/JCI114038","volume":"83","author":"TF Byrd","year":"1989","unstructured":"Byrd, T. F. & Horwitz, M. A. Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. J. Clin. Invest 83, 1457\u20131465 (1989).","journal-title":"J. Clin. Invest"},{"key":"52184_CR77","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1172\/JCI115409","volume":"88","author":"TF Byrd","year":"1991","unstructured":"Byrd, T. F. & Horwitz, M. A. Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila. J. Clin. Invest. 88, 1103\u20131112 (1991).","journal-title":"J. Clin. Invest."},{"key":"52184_CR78","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1371\/journal.ppat.0020018","volume":"2","author":"T Ren","year":"2006","unstructured":"Ren, T., Zamboni, D. S., Roy, C. R., Dietrich, W. F. & Vance, R. E. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog. 2, e18 (2006).","journal-title":"PLoS Pathog."},{"key":"52184_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15698\/mic2023.01.789","volume":"10","author":"E Ondari","year":"2023","unstructured":"Ondari, E., Wilkins, A., Latimer, B., Dragoi, A. M. & Ivanov, S. S. Cellular cholesterol licenses Legionella pneumophila intracellular replication in macrophages. Micro Cell 10, 1\u201317 (2023).","journal-title":"Micro Cell"},{"key":"52184_CR80","doi-asserted-by":"publisher","unstructured":"Wilkins, A. A. et al. The intracellular growth of the vacuolar pathogen Legionella pneumophila is dependent on the acyl chain composition of host membranes. Front. Bacteriol. 3, https:\/\/doi.org\/10.3389\/fbrio.2024.1322138 (2024)","DOI":"10.3389\/fbrio.2024.1322138"},{"key":"52184_CR81","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1749-6632.1996.tb52975.x","volume":"797","author":"JP Vogel","year":"1996","unstructured":"Vogel, J. P., Roy, C. & Isberg, R. R. Use of salt to isolate Legionella pneumophila mutants unable to replicate in macrophages. Ann. N. Y. Acad. Sci. 797, 271\u2013272 (1996).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"52184_CR82","doi-asserted-by":"publisher","first-page":"11804","DOI":"10.1073\/pnas.1404506111","volume":"111","author":"T Kubori","year":"2014","unstructured":"Kubori, T. et al. Native structure of a type IV secretion system core complex essential for Legionella pathogenesis. Proc. Natl Acad. Sci. USA 111, 11804\u201311809 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52184_CR83","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/j.1365-2958.2006.05446.x","volume":"62","author":"CD Vincent","year":"2006","unstructured":"Vincent, C. D. et al. Identification of the core transmembrane complex of the Legionella Dot\/Icm type IV secretion system. Mol. Microbiol. 62, 1278\u20131291 (2006).","journal-title":"Mol. Microbiol."},{"key":"52184_CR84","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/s41564-018-0165-z","volume":"3","author":"D Chetrit","year":"2018","unstructured":"Chetrit, D., Hu, B., Christie, P. J., Roy, C. R. & Liu, J. A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel. Nat. Microbiol. 3, 678\u2013686 (2018).","journal-title":"Nat. Microbiol."},{"key":"52184_CR85","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1128\/JB.186.6.1658-1666.2004","volume":"186","author":"JA Sexton","year":"2004","unstructured":"Sexton, J. A. et al. The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. J. Bacteriol. 186, 1658\u20131666 (2004).","journal-title":"J. Bacteriol."},{"key":"52184_CR86","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1574-695X.1999.tb01372.x","volume":"26","author":"K Izu","year":"1999","unstructured":"Izu, K. et al. Grouping of 20 reference strains of Legionella species by the growth ability within mouse and guinea pig macrophages. FEMS Immunol. Med. Microbiol. 26, 61\u201368 (1999).","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"52184_CR87","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1073\/pnas.1121286109","volume":"109","author":"EA Creasey","year":"2012","unstructured":"Creasey, E. A. & Isberg, R. R. The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc. Natl Acad. Sci. USA 109, 3481\u20133486 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52184_CR88","doi-asserted-by":"publisher","first-page":"E5208","DOI":"10.1073\/pnas.1511389112","volume":"112","author":"DT Isaac","year":"2015","unstructured":"Isaac, D. T., Laguna, R. K., Valtz, N. & Isberg, R. R. MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth. Proc. Natl Acad. Sci. USA 112, E5208\u2013E5217 (2015).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52184_CR89","doi-asserted-by":"publisher","first-page":"109894","DOI":"10.1016\/j.celrep.2021.109894","volume":"37","author":"WY Choi","year":"2021","unstructured":"Choi, W. Y. et al. SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase. Cell Rep. 37, 109894 (2021).","journal-title":"Cell Rep."},{"key":"52184_CR90","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.1021\/acs.biochem.9b00658","volume":"58","author":"SS Abeyrathna","year":"2019","unstructured":"Abeyrathna, S. S. et al. IroT\/MavN Is a Legionella Transmembrane Fe(II) Transporter: Metal Selectivity and Translocation Kinetics Revealed by in Vitro Real-Time Transport. Biochemistry 58, 4337\u20134342 (2019).","journal-title":"Biochemistry"},{"key":"52184_CR91","doi-asserted-by":"publisher","first-page":"17775","DOI":"10.1073\/pnas.1902806116","volume":"116","author":"ET Christenson","year":"2019","unstructured":"Christenson, E. T. et al. The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter. Proc. Natl Acad. Sci. USA 116, 17775\u201317785 (2019).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52184_CR92","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1128\/AEM.00684-06","volume":"72","author":"F Ewann","year":"2006","unstructured":"Ewann, F. & Hoffman, P. S. Cysteine metabolism in Legionella pneumophila: characterization of an L-cystine-utilizing mutant. Appl. Environ. Microbiol. 72, 3993\u20134000 (2006).","journal-title":"Appl. Environ. Microbiol."},{"key":"52184_CR93","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1128\/jcm.13.4.688-695.1981","volume":"13","author":"MW Reeves","year":"1981","unstructured":"Reeves, M. W., Pine, L., Hutner, S. H., George, J. R. & Harrell, W. K. Metal requirements of Legionella pneumophila. J. Clin. Microbiol. 13, 688\u2013695 (1981).","journal-title":"J. Clin. Microbiol."},{"key":"52184_CR94","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1002\/eji.200838439","volume":"38","author":"P Castellani","year":"2008","unstructured":"Castellani, P., Angelini, G., Delfino, L., Matucci, A. & Rubartelli, A. The thiol redox state of lymphoid organs is modified by immunization: role of different immune cell populations. Eur. J. Immunol. 38, 2419\u20132425 (2008).","journal-title":"Eur. J. Immunol."},{"key":"52184_CR95","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/0008-8749(90)90184-S","volume":"129","author":"H Gmunder","year":"1990","unstructured":"Gmunder, H., Eck, H. P., Benninghoff, B., Roth, S. & Droge, W. Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine. Cell Immunol. 129, 32\u201346 (1990).","journal-title":"Cell Immunol."},{"key":"52184_CR96","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1099\/jmm.0.46386-0","volume":"55","author":"JJ Bullen","year":"2006","unstructured":"Bullen, J. J., Rogers, H. J., Spalding, P. B. & Ward, C. G. Natural resistance, iron and infection: a challenge for clinical medicine. J. Med. Microbiol. 55, 251\u2013258 (2006).","journal-title":"J. Med. Microbiol."},{"key":"52184_CR97","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1093\/ajcp\/81.6.748","volume":"81","author":"RL Hunter","year":"1984","unstructured":"Hunter, R. L., Bennett, B., Towns, M. & Vogler, W. R. Transferrin in disease II: defects in the regulation of transferrin saturation with iron contribute to susceptibility to infection. Am. J. Clin. Pathol. 81, 748\u2013753 (1984).","journal-title":"Am. J. Clin. Pathol."},{"key":"52184_CR98","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/nri3863","volume":"15","author":"T Ganz","year":"2015","unstructured":"Ganz, T. & Nemeth, E. Iron homeostasis in host defence and inflammation. Nat. Rev. Immunol. 15, 500\u2013510 (2015).","journal-title":"Nat. Rev. Immunol."},{"key":"52184_CR99","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00424-017-1944-8","volume":"469","author":"M Nairz","year":"2017","unstructured":"Nairz, M., Theurl, I., Swirski, F. K. & Weiss, G. Pumping iron\u201d-how macrophages handle iron at the systemic, microenvironmental, and cellular levels. Pflug. Arch. 469, 397\u2013418 (2017).","journal-title":"Pflug. Arch."},{"key":"52184_CR100","doi-asserted-by":"publisher","unstructured":"Winn, N. C., Volk, K. M. & Hasty, A. H. Regulation of tissue iron homeostasis: the macrophage \u201cferrostat\u201d. JCI Insight 5, https:\/\/doi.org\/10.1172\/jci.insight.132964 (2020).","DOI":"10.1172\/jci.insight.132964"},{"key":"52184_CR101","doi-asserted-by":"publisher","first-page":"1015711","DOI":"10.3389\/fmed.2023.1015711","volume":"10","author":"JB Parker","year":"2023","unstructured":"Parker, J. B. et al. Chelating the valley of death: Deferoxamine\u2019s path from bench to wound clinic. Front. Med. 10, 1015711 (2023).","journal-title":"Front. Med."},{"key":"52184_CR102","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1159\/000194213","volume":"39","author":"S Szabo","year":"1980","unstructured":"Szabo, S., Barbu, Z., Lakatos, L., Laszlo, I. & Szabo, A. Local production of proteins in normal human bronchial secretion. Respiration 39, 172\u2013178 (1980).","journal-title":"Respiration"},{"key":"52184_CR103","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1084\/jem.154.5.1618","volume":"154","author":"MA Horwitz","year":"1981","unstructured":"Horwitz, M. A. & Silverstein, S. C. Activated human monocytes inhibit the intracellular multiplication of Legionnaires\u2019 disease bacteria. J. Exp. Med. 154, 1618\u20131635 (1981).","journal-title":"J. Exp. Med."},{"key":"52184_CR104","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1183\/09031936.93.05070804","volume":"5","author":"JL Corhay","year":"1992","unstructured":"Corhay, J. L. et al. Iron content in human alveolar macrophages. Eur. Respir. J. 5, 804\u2013809 (1992).","journal-title":"Eur. Respir. J."},{"key":"52184_CR105","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1164\/rccm.200802-334OC","volume":"178","author":"AJ Ghio","year":"2008","unstructured":"Ghio, A. J. et al. Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect. Am. J. Respir. Crit. Care Med. 178, 1130\u20131138 (2008).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"52184_CR106","first-page":"611","volume":"111","author":"SE McGowan","year":"1988","unstructured":"McGowan, S. E. & Henley, S. A. Iron and ferritin contents and distribution in human alveolar macrophages. J. Lab. Clin. Med. 111, 611\u2013617 (1988).","journal-title":"J. Lab. Clin. Med."},{"key":"52184_CR107","first-page":"493","volume":"117","author":"AB Thompson","year":"1991","unstructured":"Thompson, A. B., Bohling, T., Heires, A., Linder, J. & Rennard, S. I. Lower respiratory tract iron burden is increased in association with cigarette smoking. J. Lab Clin. Med. 117, 493\u2013499 (1991).","journal-title":"J. Lab Clin. Med."},{"key":"52184_CR108","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1164\/ajrccm\/145.2_Pt_1.311","volume":"145","author":"LJ Wesselius","year":"1992","unstructured":"Wesselius, L. J., Flowers, C. H. & Skikne, B. S. Alveolar macrophage content of isoferritins and transferrin. Comparison of nonsmokers and smokers with and without chronic airflow obstruction. Am. Rev. Respir. Dis. 145, 311\u2013316 (1992).","journal-title":"Am. Rev. Respir. Dis."},{"key":"52184_CR109","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1164\/ajrccm.150.3.8087339","volume":"150","author":"LJ Wesselius","year":"1994","unstructured":"Wesselius, L. J., Nelson, M. E. & Skikne, B. S. Increased release of ferritin and iron by iron-loaded alveolar macrophages in cigarette smokers. Am. J. Respir. Crit. Care Med. 150, 690\u2013695 (1994).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"52184_CR110","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0022-2143(97)90161-X","volume":"129","author":"AJ Ghio","year":"1997","unstructured":"Ghio, A. J., Pritchard, R. J., Dittrich, K. L. & Samet, J. M. Non-heme (Fe3+) in the lung increases with age in both humans and rats. J. Lab. Clin. Med. 129, 53\u201361 (1997).","journal-title":"J. Lab. Clin. Med."},{"key":"52184_CR111","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/jlb.45.1.29","volume":"45","author":"JM Carlin","year":"1989","unstructured":"Carlin, J. M., Borden, E. C., Sondel, P. M. & Byrne, G. I. Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes. J. Leukoc. Biol. 45, 29\u201334 (1989).","journal-title":"J. Leukoc. Biol."},{"key":"52184_CR112","doi-asserted-by":"publisher","first-page":"15623","DOI":"10.1073\/pnas.95.26.15623","volume":"95","author":"SD Der","year":"1998","unstructured":"Der, S. D., Zhou, A., Williams, B. R. & Silverman, R. H. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc. Natl Acad. Sci. USA 95, 15623\u201315628 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52184_CR113","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1046\/j.1365-2958.1996.406943.x","volume":"19","author":"SM Loosmore","year":"1996","unstructured":"Loosmore, S. M. et al. Cloning and expression of the Haemophilus influenzae transferrin receptor genes. Mol. Microbiol. 19, 575\u2013586 (1996).","journal-title":"Mol. Microbiol."},{"key":"52184_CR114","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1128\/iai.62.9.3850-3858.1994","volume":"62","author":"B Modun","year":"1994","unstructured":"Modun, B., Kendall, D. & Williams, P. Staphylococci express a receptor for human transferrin: identification of a 42-kilodalton cell wall transferrin-binding protein. Infect. Immun. 62, 3850\u20133858 (1994).","journal-title":"Infect. Immun."},{"key":"52184_CR115","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nature10823","volume":"483","author":"N Noinaj","year":"2012","unstructured":"Noinaj, N. et al. Structural basis for iron piracy by pathogenic Neisseria. Nature 483, 53\u201358 (2012).","journal-title":"Nature"},{"key":"52184_CR116","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12931-018-0743-x","volume":"19","author":"LG Vargas Buonfiglio","year":"2018","unstructured":"Vargas Buonfiglio, L. G. et al. Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance. Respir. Res. 19, 42 (2018).","journal-title":"Respir. Res."},{"key":"52184_CR117","doi-asserted-by":"publisher","first-page":"e0240949","DOI":"10.1371\/journal.pone.0240949","volume":"15","author":"R Abreu","year":"2020","unstructured":"Abreu, R., Essler, L., Giri, P. & Quinn, F. Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication. PLoS One 15, e0240949 (2020).","journal-title":"PLoS One"},{"key":"52184_CR118","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1128\/AEM.00070-06","volume":"72","author":"R Temmerman","year":"2006","unstructured":"Temmerman, R., Vervaeren, H., Noseda, B., Boon, N. & Verstraete, W. Necrotrophic growth of Legionella pneumophila. Appl. Environ. Microbiol. 72, 4323\u20134328 (2006).","journal-title":"Appl. Environ. Microbiol."},{"key":"52184_CR119","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1128\/IAI.02049-05","volume":"74","author":"KA Archer","year":"2006","unstructured":"Archer, K. A. & Roy, C. R. MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires\u2019 disease. Infect. Immun. 74, 3325\u20133333 (2006).","journal-title":"Infect. Immun."},{"key":"52184_CR120","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1183\/09031936.00076911","volume":"39","author":"C Chidiac","year":"2012","unstructured":"Chidiac, C. et al. Factors associated with hospital mortality in community-acquired legionellosis in France. Eur. Respir. J. 39, 963\u2013970 (2012).","journal-title":"Eur. Respir. J."},{"key":"52184_CR121","doi-asserted-by":"publisher","unstructured":"Kostic, A. et al. The Different Clinical Courses of Legionnaires\u2019 Disease in Newborns from the Same Maternity Hospital. Medicina 58, https:\/\/doi.org\/10.3390\/medicina58091150 (2022)","DOI":"10.3390\/medicina58091150"},{"key":"52184_CR122","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4104\/pcrj.2010.00014","volume":"19","author":"ML Levy","year":"2010","unstructured":"Levy, M. L. et al. Primary care summary of the British Thoracic Society Guidelines for the management of community acquired pneumonia in adults: 2009 update. Endorsed by the Royal College of General Practitioners and the Primary Care Respiratory Society UK. Prim. Care Respir. J. 19, 21\u201327 (2010).","journal-title":"Prim. Care Respir. J."},{"key":"52184_CR123","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27478-z","volume":"12","author":"BA Wee","year":"2021","unstructured":"Wee, B. A. et al. Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing. Nat. Commun. 12, 7165 (2021).","journal-title":"Nat. Commun."},{"key":"52184_CR124","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1128\/jcm.10.4.437-441.1979","volume":"10","author":"JC Feeley","year":"1979","unstructured":"Feeley, J. C. et al. Charcoal-yeast extract agar: primary isolation medium for Legionella pneumophila. J. Clin. Microbiol 10, 437\u2013441 (1979).","journal-title":"J. Clin. Microbiol"},{"key":"52184_CR125","doi-asserted-by":"publisher","unstructured":"Wilkins, A. A. et al. The intracellular growth of the vacuolar pathogen Legionella pneumophila is dependent on the acyl chain composition of host membranes. bioRxiv. https:\/\/doi.org\/10.1101\/2023.11.19.567753, (2023).","DOI":"10.1101\/2023.11.19.567753"},{"key":"52184_CR126","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1128\/iai.65.6.2497-2501.1997","volume":"65","author":"JJ Merriam","year":"1997","unstructured":"Merriam, J. J., Mathur, R., Maxfield-Boumil, R. & Isberg, R. R. Analysis of the Legionella pneumophila fliI gene: intracellular growth of a defined mutant defective for flagellum biosynthesis. Infect. Immun. 65, 2497\u20132501 (1997).","journal-title":"Infect. Immun."},{"key":"52184_CR127","doi-asserted-by":"publisher","first-page":"e1006088","DOI":"10.1371\/journal.ppat.1006088","volume":"12","author":"CF Abshire","year":"2016","unstructured":"Abshire, C. F., Dragoi, A. M., Roy, C. R. & Ivanov, S. S. MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis. PLoS Pathog. 12, e1006088 (2016).","journal-title":"PLoS Pathog."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52184-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52184-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52184-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T08:01:58Z","timestamp":1725782518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52184-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,8]]},"references-count":127,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["52184"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-52184-x","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,8]]},"assertion":[{"value":"2 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7848"}}