{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:46:59Z","timestamp":1784735219479,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PID2019-110344RB-I00, PID2022-143298OB-I00"],"award-info":[{"award-number":["PID2019-110344RB-I00, PID2022-143298OB-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-52725-4","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T10:02:04Z","timestamp":1728640924000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An automated network-based tool to search for metabolic vulnerabilities in cancer"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3769-5419","authenticated-orcid":false,"given":"Luis V.","family":"Valc\u00e1rcel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5786-5273","authenticated-orcid":false,"given":"Edurne","family":"San Jos\u00e9-En\u00e9riz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Ordo\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8961-4513","authenticated-orcid":false,"given":"I\u00f1igo","family":"Apaolaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-6616","authenticated-orcid":false,"given":"Danel","family":"Olaverri-Mendizabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4324-3371","authenticated-orcid":false,"given":"Naroa","family":"Barrena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Valc\u00e1rcel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Garate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9183-4857","authenticated-orcid":false,"given":"Jes\u00fas","family":"San Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pineda-Lucena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-9560","authenticated-orcid":false,"given":"Xabier","family":"Agirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-8790","authenticated-orcid":false,"given":"Felipe","family":"Pr\u00f3sper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-3105","authenticated-orcid":false,"given":"Francisco J.","family":"Planes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"52725_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scisignal.aaz1482","volume":"13","author":"JL Robinson","year":"2020","unstructured":"Robinson, J. L. et al. An atlas of human metabolism. Sci. Signal. 13, 1\u201312 (2020).","journal-title":"Sci. Signal."},{"key":"52725_CR2","doi-asserted-by":"publisher","first-page":"e1393","DOI":"10.1002\/wsbm.1393","volume":"9","author":"DJ Cook","year":"2017","unstructured":"Cook, D. J. & Nielsen, J. Genome-scale metabolic models applied to human health and disease. Wiley Interdiscip. Rev. Syst. Biol. Med. 9, e1393 (2017).","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"52725_CR3","first-page":"237","volume":"0","author":"NE Lewis","year":"2013","unstructured":"Lewis, N. E. & Abdel-Haleem, A. M. The evolution of genome-scale models of cancer metabolism. Front. Physiol. 0, 237 (2013).","journal-title":"Front. Physiol."},{"key":"52725_CR4","first-page":"382","volume":"0","author":"P Ghaffari","year":"2015","unstructured":"Ghaffari, P., Mardinoglu, A. & Nielsen, J. Cancer metabolism: a modeling perspective. Front. Physiol. 0, 382 (2015).","journal-title":"Front. Physiol."},{"key":"52725_CR5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nrmicro2737","volume":"10","author":"NE Lewis","year":"2012","unstructured":"Lewis, N. E., Nagarajan, H. & Palsson, B. O. Constraining the metabolic genotype\u2013phenotype relationship using a phylogeny of in silico methods. Nat. Rev. Microbiol. 10, 291\u2013305 (2012).","journal-title":"Nat. Rev. Microbiol."},{"key":"52725_CR6","doi-asserted-by":"publisher","first-page":"e0154583","DOI":"10.1371\/journal.pone.0154583","volume":"11","author":"L Tobalina","year":"2016","unstructured":"Tobalina, L., Pey, J., Rezola, A. & Planes, F. J. Assessment of FBA based gene essentiality analysis in cancer with a fast context-specific network reconstruction method. PLoS ONE 11, e0154583 (2016).","journal-title":"PLoS ONE"},{"key":"52725_CR7","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/msb.2011.35","volume":"7","author":"O Folger","year":"2011","unstructured":"Folger, O. et al. Predicting selective drug targets in cancer through metabolic networks. Mol. Syst. Biol. 7, 501 (2011).","journal-title":"Mol. Syst. Biol."},{"key":"52725_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-00555-y","volume":"8","author":"I Apaolaza","year":"2017","unstructured":"Apaolaza, I. et al. An in-silico approach to predict and exploit synthetic lethality in cancer metabolism. Nat. Commun. 8, 1\u20139 (2017).","journal-title":"Nat. Commun."},{"key":"52725_CR9","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1093\/bioinformatics\/bty656","volume":"35","author":"I Apaolaza","year":"2019","unstructured":"Apaolaza, I., Valcarcel, L. V. & Planes, F. J. GMCS: fast computation of genetic minimal cut sets in large networks. Bioinformatics 35, 535\u2013537 (2019).","journal-title":"Bioinformatics"},{"key":"52725_CR10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/nbt.2488","volume":"31","author":"I Thiele","year":"2013","unstructured":"Thiele, I. et al. A community-driven global reconstruction of human metabolism. Nat. Biotechnol. 31, 419\u2013425 (2013).","journal-title":"Nat. Biotechnol."},{"key":"52725_CR11","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1038\/ng.3984","volume":"49","author":"RM Meyers","year":"2017","unstructured":"Meyers, R. M. et al. Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nat. Genet. 49, 1779\u20131784 (2017).","journal-title":"Nat. Genet."},{"key":"52725_CR12","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","volume":"569","author":"M Ghandi","year":"2019","unstructured":"Ghandi, M. et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569, 503\u2013508 (2019).","journal-title":"Nature"},{"key":"52725_CR13","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/msb.145122","volume":"10","author":"R Agren","year":"2014","unstructured":"Agren, R. et al. Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol. Syst. Biol. 10, 721 (2014).","journal-title":"Mol. Syst. Biol."},{"key":"52725_CR14","doi-asserted-by":"publisher","first-page":"aaf1420","DOI":"10.1126\/science.aaf1420","volume":"353","author":"M Costanzo","year":"2016","unstructured":"Costanzo, M. et al. A global genetic interaction network maps a wiring diagram of cellular function. Science 353, aaf1420 (2016).","journal-title":"Science"},{"key":"52725_CR15","doi-asserted-by":"publisher","first-page":"D938","DOI":"10.1093\/nar\/gkt1204","volume":"42","author":"MN McCall","year":"2014","unstructured":"McCall, M. N. et al. The Gene Expression Barcode 3.0: improved data processing and mining tools. Nucleic Acids Res. 42, D938\u2013D943 (2014).","journal-title":"Nucleic Acids Res."},{"key":"52725_CR16","doi-asserted-by":"publisher","first-page":"e1007185","DOI":"10.1371\/journal.pcbi.1007185","volume":"15","author":"A Richelle","year":"2019","unstructured":"Richelle, A., Joshi, C. & Lewis, N. E. Assessing key decisions for transcriptomic data integration in biochemical networks. PLoS Comput. Biol. 15, e1007185 (2019).","journal-title":"PLoS Comput. Biol."},{"key":"52725_CR17","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/s41587-020-0437-z","volume":"38","author":"T Gonatopoulos-Pournatzis","year":"2020","unstructured":"Gonatopoulos-Pournatzis, T. et al. Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform. Nat. Biotechnol. 38, 638\u2013648 (2020).","journal-title":"Nat. Biotechnol."},{"key":"52725_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21478-9","volume":"12","author":"NA Thompson","year":"2021","unstructured":"Thompson, N. A. et al. Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Nat. Commun. 12, 1302 (2021).","journal-title":"Nat. Commun."},{"key":"52725_CR19","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.cels.2021.08.006","volume":"12","author":"B De Kegel","year":"2021","unstructured":"De Kegel, B., Quinn, N., Thompson, N. A., Adams, D. J. & Ryan, C. J. Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines. Cell Syst. 12, 1144\u20131159.e6 (2021).","journal-title":"Cell Syst."},{"key":"52725_CR20","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature11331","volume":"488","author":"FL Muller","year":"2012","unstructured":"Muller, F. L. et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature 488, 337\u2013342 (2012).","journal-title":"Nature"},{"key":"52725_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08679-z","volume":"10","author":"X Agirre","year":"2019","unstructured":"Agirre, X. et al. Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response. Nat. Commun. 10, 821 (2019).","journal-title":"Nat. Commun."},{"key":"52725_CR22","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1101\/gr.265520.120","volume":"30","author":"R Ordo\u00f1ez","year":"2020","unstructured":"Ordo\u00f1ez, R. et al. Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma. Genome Res. 30, 1217\u20131227 (2020).","journal-title":"Genome Res."},{"key":"52725_CR23","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/s41375-021-01147-y","volume":"35","author":"A Carrasco-Leon","year":"2021","unstructured":"Carrasco-Leon, A. et al. Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma. Leukemia 35, 1438\u20131450 (2021).","journal-title":"Leukemia"},{"key":"52725_CR24","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/nature13386","volume":"510","author":"E Martin","year":"2014","unstructured":"Martin, E. et al. CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation. Nature 510, 288\u2013292 (2014).","journal-title":"Nature"},{"key":"52725_CR25","doi-asserted-by":"publisher","first-page":"e2107968118","DOI":"10.1073\/pnas.2107968118","volume":"118","author":"EM Lynch","year":"2021","unstructured":"Lynch, E. M. et al. Structural basis for isoform-specific inhibition of human CTPS1. Proc. Natl Acad. Sci. USA 118, e2107968118 (2021).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52725_CR26","doi-asserted-by":"publisher","first-page":"6014","DOI":"10.1182\/blood-2022-159449","volume":"140","author":"D Chiron","year":"2022","unstructured":"Chiron, D. et al. STP938, a selective CTPS1 inhibitor, shows single agent activity and synergy with BCL2 inhibition in preclinical models of mantle cell lymphoma. Blood 140, 6014\u20136015 (2022).","journal-title":"Blood"},{"key":"52725_CR27","doi-asserted-by":"publisher","unstructured":"Rao, Y. et al. Targeting CTP synthetase 1 to restore interferon induction and impede nucleotide synthesis in SARS-CoV-2 infection. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2021.02.05.429959 (2021).","DOI":"10.1101\/2021.02.05.429959"},{"key":"52725_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-01677-z","volume":"8","author":"JL Wu","year":"2017","unstructured":"Wu, J. L. et al. O-GlcNAcylation is required for B cell homeostasis and antibody responses. Nat. Commun. 8, 1\u201310 (2017).","journal-title":"Nat. Commun."},{"key":"52725_CR29","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/ng0797-260","volume":"16","author":"M Chesi","year":"1997","unstructured":"Chesi, M. et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat. Genet. 16, 260\u2013264 (1997).","journal-title":"Nat. Genet."},{"key":"52725_CR30","doi-asserted-by":"publisher","first-page":"e71","DOI":"10.1093\/nar\/gkv1507","volume":"44","author":"A Colaprico","year":"2016","unstructured":"Colaprico, A. et al. TCGAbiolinks: an R\/Bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res. 44, e71\u2013e71 (2016).","journal-title":"Nucleic Acids Res."},{"key":"52725_CR31","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1111\/jcmm.14114","volume":"23","author":"C Piao","year":"2019","unstructured":"Piao, C. et al. Inhibition of stearoyl CoA desaturase-1 activity suppresses tumour progression and improves prognosis in human bladder cancer. J. Cell. Mol. Med. 23, 2064\u20132076 (2019).","journal-title":"J. Cell. Mol. Med."},{"key":"52725_CR32","doi-asserted-by":"publisher","first-page":"5287","DOI":"10.1158\/0008-5472.CAN-05-1489","volume":"66","author":"V Chaje\u0300s","year":"2006","unstructured":"Chaje\u0300s, V., Cambot, M., Moreau, K., Lenoir, G. M. & Joulin, V. Acetyl-CoA carboxylase \u03b1 is essential to breast cancer cell survival. Cancer Res. 66, 5287\u20135294 (2006).","journal-title":"Cancer Res."},{"key":"52725_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31725-2","volume":"13","author":"S Li","year":"2022","unstructured":"Li, S. et al. Acetyl-CoA-carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function. Nat. Commun. 13, 3998 (2022).","journal-title":"Nat. Commun."},{"key":"52725_CR34","doi-asserted-by":"publisher","first-page":"e1002518","DOI":"10.1371\/journal.pcbi.1002518","volume":"8","author":"R Agren","year":"2012","unstructured":"Agren, R. et al. Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT. PLoS Comput. Biol. 8, e1002518 (2012).","journal-title":"PLoS Comput. Biol."},{"key":"52725_CR35","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1007\/s11306-015-0819-2","volume":"11","author":"D Dikicioglu","year":"2015","unstructured":"Dikicioglu, D., K\u0131rdar, B. & Oliver, S. G. Biomass composition: the \u201celephant in the room\u201d of metabolic modelling. Metabolomics 11, 1690\u20131701 (2015).","journal-title":"Metabolomics"},{"key":"52725_CR36","doi-asserted-by":"publisher","first-page":"e1006971","DOI":"10.1371\/journal.pcbi.1006971","volume":"15","author":"JC Lachance","year":"2019","unstructured":"Lachance, J. C. et al. BOFdat: generating biomass objective functions for genome-scale metabolic models from experimental data. PLoS Comput. Biol. 15, e1006971 (2019).","journal-title":"PLoS Comput. Biol."},{"key":"52725_CR37","doi-asserted-by":"publisher","first-page":"103110","DOI":"10.1016\/j.isci.2021.103110","volume":"24","author":"M Moscard\u00f3 Garc\u00eda","year":"2021","unstructured":"Moscard\u00f3 Garc\u00eda, M., Pacheco, M., Bintener, T., Presta, L. & Sauter, T. Importance of the biomass formulation for cancer metabolic modeling and drug prediction. iScience 24, 103110 (2021).","journal-title":"iScience"},{"key":"52725_CR38","doi-asserted-by":"publisher","first-page":"481","DOI":"10.3389\/fphys.2012.00481","volume":"3","author":"CE Hern\u00e1ndez Pati\u00f1o","year":"2013","unstructured":"Hern\u00e1ndez Pati\u00f1o, C. E., Jaime-Mu\u00f1oz, G. & Resendis-Antonio, O. Systems biology of cancer: moving toward the integrative study of the metabolic alterations in cancer cells. Front. Physiol. 3, 481 (2013).","journal-title":"Front. Physiol."},{"key":"52725_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep41241","volume":"7","author":"DC Zielinski","year":"2017","unstructured":"Zielinski, D. C. et al. Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. Sci. Rep. 7, 1\u201314 (2017).","journal-title":"Sci. Rep."},{"key":"52725_CR40","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646\u2013674 (2011).","journal-title":"Cell"},{"key":"52725_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-14067-8","volume":"7","author":"J Pey","year":"2017","unstructured":"Pey, J. et al. In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer. Sci. Rep. 7, 1\u201310 (2017).","journal-title":"Sci. Rep."},{"key":"52725_CR42","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1073\/pnas.0610772104","volume":"104","author":"NC Duarte","year":"2007","unstructured":"Duarte, N. C. et al. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc. Natl Acad. Sci. USA 104, 1777\u20131782 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"52725_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11306-016-1051-4","volume":"12","author":"N Swainston","year":"2016","unstructured":"Swainston, N. et al. Recon 2.2: from reconstruction to model of human metabolism. Metabolomics 12, 1\u20137 (2016).","journal-title":"Metabolomics"},{"key":"52725_CR44","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nbt.1614","volume":"28","author":"JD Orth","year":"2010","unstructured":"Orth, J. D., Thiele, I. & Palsson, B. \u00d8. What is flux balance analysis? Nat. Biotechnol. 28, 245\u2013248 (2010).","journal-title":"Nat. Biotechnol."},{"key":"52725_CR45","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/s41596-018-0098-2","volume":"14","author":"L Heirendt","year":"2019","unstructured":"Heirendt, L. et al. Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0. Nat. Protoc. 14, 639\u2013702 (2019).","journal-title":"Nat. Protoc."},{"key":"52725_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pcbi.1006541","volume":"14","author":"H Wang","year":"2018","unstructured":"Wang, H. et al. RAVEN 2.0: a versatile toolbox for metabolic network reconstruction and a case study on Streptomyces coelicolor. PLoS Comput. Biol. 14, 1\u201317 (2018).","journal-title":"PLoS Comput. Biol."},{"key":"52725_CR47","unstructured":"R Core Team. R: a language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2021). https:\/\/www.R-project.org\/."},{"key":"52725_CR48","unstructured":"Chang, W. et al. shiny: web application framework for R (2021). https:\/\/shiny.rstudio.com\/, https:\/\/shiny.posit.co"},{"key":"52725_CR49","doi-asserted-by":"publisher","unstructured":"Valcarcel, L. V. et al. Scripts and code for \u2018gmctool: automated network-based tool to search for metabolic vulnerabilities in cancer\u2019. Zenodo https:\/\/doi.org\/10.5281\/zenodo.13285245 (2024).","DOI":"10.5281\/zenodo.13285245"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52725-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52725-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52725-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T12:02:58Z","timestamp":1730721778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-52725-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,11]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["52725"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-52725-4","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,11]]},"assertion":[{"value":"22 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8685"}}