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Here, we report invasive recordings from ten dystonia patients via deep brain stimulation electrodes that allow for parallel recordings of several basal ganglia nuclei, namely the striatum, external and internal pallidum, that all displayed activity in the low frequency band (3\u201312\u2009Hz). In addition to a correlation with low-frequency activity in the internal pallidum (R\u2009=\u20090.88,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001), we demonstrate that dystonic symptoms correlate specifically with low-frequency coupling between striatum and internal pallidum (R\u2009=\u20090.75,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.009). This points towards a pathophysiological role of the direct striato-pallidal pathway in dystonia that is conveyed via coupling in the enhanced low-frequency band. Our study provides a mechanistic insight into the pathophysiology of dystonia by revealing a link between symptom severity and frequency-specific coupling of distinct basal ganglia pathways.\n                  <\/jats:p>","DOI":"10.1038\/s41467-024-52814-4","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T22:01:59Z","timestamp":1727733719000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-8250","authenticated-orcid":false,"given":"Roxanne","family":"Lofredi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-208X","authenticated-orcid":false,"given":"Lucia K.","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-2470","authenticated-orcid":false,"given":"Ute","family":"Scheller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-9708","authenticated-orcid":false,"given":"Wolf-Julian","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-9064","authenticated-orcid":false,"given":"Joachim K.","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assel","family":"Saryyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd-Helge","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Faust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2984-5579","authenticated-orcid":false,"given":"Tilmann","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-9060","authenticated-orcid":false,"given":"Andrea A.","family":"K\u00fchn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"52814_CR1","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1002\/mds.25532","volume":"28","author":"A Quartarone","year":"2013","unstructured":"Quartarone, A. & Hallett, M. 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Prof. K\u00fchn reports personal fees from Medtronic, and Boston Scientific. Dr. Krause reports personal fees from Medtronic, Stadapharm and Abbvie. Prof. Krauss reports personal fees from Medtronic, personal fees from Boston Scientific. Dr. Schneider reports personal fees from Medtronic, personal fees from Boston Scientific, personal fees from Abbott. All personal fees are not linked to the here presented study results. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8475"}}