{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:59:44Z","timestamp":1791896384315,"version":"4.3.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC U23A20454"],"award-info":[{"award-number":["NSFC U23A20454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82372873"],"award-info":[{"award-number":["NSFC 82372873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81972404"],"award-info":[{"award-number":["NSFC 81972404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82472909"],"award-info":[{"award-number":["NSFC 82472909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-53233-1","type":"journal-article","created":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:02:57Z","timestamp":1729382577000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"Kai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benxia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genyu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglei","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0124-9433","authenticated-orcid":false,"given":"Wei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Qiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-5527","authenticated-orcid":false,"given":"Helen He","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,20]]},"reference":[{"key":"53233_CR1","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1039\/C7MT90039B","volume":"9","author":"V Abbate","year":"2017","unstructured":"Abbate, V. & Hider, R. Iron in biology. Metallomics Integr. Biometal Sci. 9, 1467\u20131469 (2017).","journal-title":"Metallomics Integr. Biometal Sci."},{"key":"53233_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11002-5","volume":"10","author":"Y Jiang","year":"2019","unstructured":"Jiang, Y. et al. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat. Commun. 10, 2935 (2019).","journal-title":"Nat. Commun."},{"key":"53233_CR3","doi-asserted-by":"publisher","unstructured":"Gao, X. et al. Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus. The J. Clin. Investig. 132, https:\/\/doi.org\/10.1172\/jci152345 (2022).","DOI":"10.1172\/jci152345"},{"key":"53233_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/cells11010020","volume":"11","author":"F Koinis","year":"2021","unstructured":"Koinis, F. et al. Myeloid-derived suppressor cells in prostate cancer: present knowledge and future perspectives. Cells 11, 20 (2021).","journal-title":"Cells"},{"key":"53233_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8580043","volume":"2022","author":"C Han","year":"2022","unstructured":"Han, C. et al. The roles of tumor-associated macrophages in prostate cancer. J. Oncol. 2022, 8580043 (2022).","journal-title":"J. Oncol."},{"key":"53233_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.862416","volume":"12","author":"I Siemi\u0144ska","year":"2022","unstructured":"Siemi\u0144ska, I. & Baran, J. Myeloid-derived suppressor cells as key players and promising therapy targets in prostate cancer. Front. Oncol. 12, 862416 (2022).","journal-title":"Front. Oncol."},{"key":"53233_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1001297","volume":"13","author":"W Wu","year":"2022","unstructured":"Wu, W. et al. Immune microenvironment infiltration landscape and immune-related subtypes in prostate cancer. Front. Immunol. 13, 1001297 (2022).","journal-title":"Front. Immunol."},{"key":"53233_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1055826","volume":"13","author":"C Qin","year":"2022","unstructured":"Qin, C., Wang, J., Du, Y. & Xu, T. Immunosuppressive environment in response to androgen deprivation treatment in prostate cancer. Front. Endocrinol. 13, 1055826 (2022).","journal-title":"Front. Endocrinol."},{"key":"53233_CR9","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1158\/0008-5472.CAN-23-2260","volume":"83","author":"X Li","year":"2023","unstructured":"Li, X. & Mu, P. The critical interplay of CAF plasticity and resistance in prostate cancer. Cancer Res. 83, 2990\u20132992 (2023).","journal-title":"Cancer Res."},{"key":"53233_CR10","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1158\/0008-5472.CAN-21-4141","volume":"82","author":"L Jenkins","year":"2022","unstructured":"Jenkins, L. et al. Cancer-associated fibroblasts suppress CD8+ T-cell infiltration and confer resistance to immune-checkpoint blockade. Cancer Res. 82, 2904\u20132917 (2022).","journal-title":"Cancer Res."},{"key":"53233_CR11","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1158\/1535-7163.MCT-20-0620","volume":"20","author":"D Li","year":"2021","unstructured":"Li, D. et al. T cell-mediated antitumor immunity cooperatively induced By TGF\u03b2R1 antagonism and gemcitabine counteracts reformation of the stromal barrier in pancreatic cancer. Mol. Cancer Ther. 20, 1926\u20131940 (2021).","journal-title":"Mol. Cancer Ther."},{"key":"53233_CR12","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","volume":"9","author":"E Elyada","year":"2019","unstructured":"Elyada, E. et al. Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov. 9, 1102\u20131123 (2019).","journal-title":"Cancer Discov."},{"key":"53233_CR13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S1535-6108(03)00197-1","volume":"4","author":"K Ellwood-Yen","year":"2003","unstructured":"Ellwood-Yen, K. et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 4, 223\u2013238 (2003).","journal-title":"Cancer Cell"},{"key":"53233_CR14","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1002\/pros.23206","volume":"76","author":"L Ellis","year":"2016","unstructured":"Ellis, L. et al. Generation of a C57BL\/6 MYC-driven mouse model and cell line of prostate cancer. Prostate 76, 1192\u20131202 (2016).","journal-title":"Prostate"},{"key":"53233_CR15","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1084\/jem.20162024","volume":"214","author":"D Ohlund","year":"2017","unstructured":"Ohlund, D. et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J. Exp. Med. 214, 579\u2013596 (2017).","journal-title":"J. Exp. Med."},{"key":"53233_CR16","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","volume":"184","author":"S Cheng","year":"2021","unstructured":"Cheng, S. et al. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell 184, 792\u2013809.e723 (2021).","journal-title":"Cell"},{"key":"53233_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01165-x","volume":"19","author":"H Yang","year":"2020","unstructured":"Yang, H. et al. CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis. Mol. Cancer 19, 41 (2020).","journal-title":"Mol. Cancer"},{"key":"53233_CR18","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.ccell.2019.02.009","volume":"35","author":"L Cassetta","year":"2019","unstructured":"Cassetta, L. et al. Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets. Cancer Cell 35, 588\u2013602.e510 (2019).","journal-title":"Cancer Cell"},{"key":"53233_CR19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1136\/gutjnl-2015-310514","volume":"66","author":"X Li","year":"2017","unstructured":"Li, X. et al. Targeting of tumour-infiltrating macrophages via CCL2\/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma. Gut 66, 157\u2013167 (2017).","journal-title":"Gut"},{"key":"53233_CR20","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.3892\/ijo.2016.3680","volume":"49","author":"J Ding","year":"2016","unstructured":"Ding, J. et al. CSF1 is involved in breast cancer progression through inducing monocyte differentiation and homing. Int. J. Oncol. 49, 2064\u20132074 (2016).","journal-title":"Int. J. Oncol."},{"key":"53233_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215598","volume":"532","author":"X Zhou","year":"2022","unstructured":"Zhou, X. et al. PMN-MDSCs accumulation induced by CXCL1 promotes CD8(+) T cells exhaustion in gastric cancer. Cancer Lett. 532, 215598 (2022).","journal-title":"Cancer Lett."},{"key":"53233_CR22","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1038\/onc.2016.367","volume":"36","author":"H Zhang","year":"2017","unstructured":"Zhang, H. et al. CXCL2\/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer. Oncogene 36, 2095\u20132104 (2017).","journal-title":"Oncogene"},{"key":"53233_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using CellChat. Nat. Commun. 12, 1088 (2021).","journal-title":"Nat. Commun."},{"key":"53233_CR24","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1089\/ars.2016.6735","volume":"27","author":"G Li Volti","year":"2017","unstructured":"Li Volti, G. et al. The heme oxygenase system in hematological malignancies. Antioxid. redox Signal. 27, 363\u2013377 (2017).","journal-title":"Antioxid. redox Signal."},{"key":"53233_CR25","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","volume":"116","author":"X Fang","year":"2019","unstructured":"Fang, X. et al. Ferroptosis as a target for protection against cardiomyopathy. Proc. Natl Acad. Sci. USA 116, 2672\u20132680 (2019).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"53233_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13056","volume":"54","author":"K Liu","year":"2021","unstructured":"Liu, K. et al. A novel mouse model for liver metastasis of prostate cancer reveals dynamic tumour-immune cell communication. Cell Prolif. 54, e13056 (2021).","journal-title":"Cell Prolif."},{"key":"53233_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41573-018-0004-1","volume":"18","author":"X Chen","year":"2019","unstructured":"Chen, X. & Song, E. Turning foes to friends: targeting cancer-associated fibroblasts. Nat. Rev. Drug Discov. 18, 99\u2013115 (2019).","journal-title":"Nat. Rev. Drug Discov."},{"key":"53233_CR28","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s43018-022-00411-z","volume":"3","author":"D Lavie","year":"2022","unstructured":"Lavie, D., Ben-Shmuel, A., Erez, N. & Scherz-Shouval, R. Cancer-associated fibroblasts in the single-cell era. Nat. Cancer 3, 793\u2013807 (2022).","journal-title":"Nat. Cancer"},{"key":"53233_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41556-020-00613-6","volume":"23","author":"S Chen","year":"2021","unstructured":"Chen, S. et al. Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. Nat. Cell Biol. 23, 87\u201398 (2021).","journal-title":"Nat. Cell Biol."},{"key":"53233_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/978-1-4939-3578-9_6","volume":"1418","author":"Z Wang","year":"2016","unstructured":"Wang, Z., Jensen, M. A. & Zenklusen, J. C. A practical guide to the cancer genome atlas (TCGA). Methods Mol. Biol. 1418, 111\u2013141 (2016).","journal-title":"Methods Mol. Biol."},{"key":"53233_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35832-6","volume":"14","author":"CJ Hanley","year":"2023","unstructured":"Hanley, C. J. et al. Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer. Nat. Commun. 14, 387 (2023).","journal-title":"Nat. Commun."},{"key":"53233_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109165","volume":"35","author":"S Olalekan","year":"2021","unstructured":"Olalekan, S., Xie, B., Back, R., Eckart, H. & Basu, A. Characterizing the tumor microenvironment of metastatic ovarian cancer by single-cell transcriptomics. Cell Rep. 35, 109165 (2021).","journal-title":"Cell Rep."},{"key":"53233_CR33","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.ccell.2021.03.012","volume":"39","author":"S Affo","year":"2021","unstructured":"Affo, S. et al. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell 39, 866\u2013882 e811 (2021).","journal-title":"Cancer Cell"},{"key":"53233_CR34","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1158\/0008-5472.CAN-22-2316","volume":"83","author":"S Schworer","year":"2023","unstructured":"Schworer, S. et al. Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines. Cancer Res. 83, 1596\u20131610 (2023).","journal-title":"Cancer Res."},{"key":"53233_CR35","first-page":"e133929","volume":"5","author":"E Alaluf","year":"2020","unstructured":"Alaluf, E. et al. Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages. JCI Insight 5, e133929 (2020).","journal-title":"JCI Insight"},{"key":"53233_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-022-00434-2","volume":"11","author":"AM Mello","year":"2022","unstructured":"Mello, A. M. et al. Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer. Oncogenesis 11, 56 (2022).","journal-title":"Oncogenesis"},{"key":"53233_CR37","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1158\/0008-5472.CAN-23-0523","volume":"83","author":"NR Fuentes","year":"2023","unstructured":"Fuentes, N. R. & Taniguchi, C. M. Turning down oxygen to turn up inflammation in CAFs. Cancer Res. 83, 1560\u20131562 (2023).","journal-title":"Cancer Res."},{"key":"53233_CR38","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1038\/s42255-023-00928-2","volume":"5","author":"M Maus","year":"2023","unstructured":"Maus, M. et al. Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype. Nat. Metab. 5, 2111\u20132130 (2023).","journal-title":"Nat. Metab."},{"key":"53233_CR39","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ccell.2020.06.005","volume":"38","author":"Z Zhang","year":"2020","unstructured":"Zhang, Z. et al. Tumor microenvironment-derived NRG1 promotes antiandrogen resistance in prostate cancer. Cancer Cell 38, 279\u2013296.e279 (2020).","journal-title":"Cancer Cell"},{"key":"53233_CR40","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.ccell.2023.05.016","volume":"41","author":"H Wang","year":"2023","unstructured":"Wang, H. et al. Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer. Cancer Cell 41, 1345\u20131362.e1349 (2023).","journal-title":"Cancer Cell"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53233-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53233-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53233-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T05:15:10Z","timestamp":1729746910000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53233-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,20]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["53233"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-53233-1","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,20]]},"assertion":[{"value":"5 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9050"}}