{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:02:33Z","timestamp":1792526553916,"version":"4.5.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-53814-0","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T18:02:45Z","timestamp":1730484165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice"],"prefix":"10.1038","volume":"15","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1543-5678","authenticated-orcid":false,"given":"Ju","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-6927","authenticated-orcid":false,"given":"Xinyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-1691","authenticated-orcid":false,"given":"Jianfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-888X","authenticated-orcid":false,"given":"Youcun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"53814_CR1","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1126\/science.1223490","volume":"336","author":"LV Hooper","year":"2012","unstructured":"Hooper, L. V., Littman, D. R. & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268\u20131273 (2012).","journal-title":"Science"},{"key":"53814_CR2","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.cell.2010.01.023","volume":"140","author":"WS Garrett","year":"2010","unstructured":"Garrett, W. S., Gordon, J. I. & Glimcher, L. H. Homeostasis and inflammation in the intestine. Cell 140, 859\u2013870 (2010).","journal-title":"Cell"},{"key":"53814_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/nrgastro.2014.153","volume":"12","author":"N Jain","year":"2015","unstructured":"Jain, N. & Walker, W. A. Diet and host-microbial crosstalk in postnatal intestinal immune homeostasis. Nat. Rev. Gastroenterol. Hepatol. 12, 14\u201325 (2015).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"53814_CR4","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nri1057","volume":"3","author":"AM Mowat","year":"2003","unstructured":"Mowat, A. M. Anatomical basis of tolerance and immunity to intestinal antigens. Nat. Rev. Immunol. 3, 331\u2013341 (2003).","journal-title":"Nat. Rev. Immunol."},{"key":"53814_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2017.07.004","volume":"30","author":"RM Rezende","year":"2017","unstructured":"Rezende, R. M. & Weiner, H. L. History and mechanisms of oral tolerance. Semin Immunol. 30, 3\u201311 (2017).","journal-title":"Semin Immunol."},{"key":"53814_CR6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12016-018-8680-5","volume":"55","author":"L Tordesillas","year":"2018","unstructured":"Tordesillas, L. & Berin, M. C. Mechanisms of oral tolerance. Clin. Rev. Allergy Immunol. 55, 107\u2013117 (2018).","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"53814_CR7","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/mi.2012.4","volume":"5","author":"O Pabst","year":"2012","unstructured":"Pabst, O. & Mowat, A. M. Oral tolerance to food protein. Mucosal Immunol. 5, 232\u2013239 (2012).","journal-title":"Mucosal Immunol."},{"key":"53814_CR8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nri3007","volume":"11","author":"H Cheroutre","year":"2011","unstructured":"Cheroutre, H., Lambolez, F. & Mucida, D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 11, 445\u2013456 (2011).","journal-title":"Nat. Rev. Immunol."},{"key":"53814_CR9","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.4049\/jimmunol.1701704","volume":"200","author":"L Van Kaer","year":"2018","unstructured":"Van Kaer, L. & Olivares-Villagomez, D. Development, homeostasis, and functions of intestinal intraepithelial lymphocytes. J. Immunol. 200, 2235\u20132244 (2018).","journal-title":"J. Immunol."},{"key":"53814_CR10","doi-asserted-by":"publisher","first-page":"R737","DOI":"10.1016\/j.cub.2017.05.073","volume":"27","author":"DP Hoytema van Konijnenburg","year":"2017","unstructured":"Hoytema van Konijnenburg, D. P. & Mucida, D. Intraepithelial lymphocytes. Curr. Biol. 27, R737\u2013R739 (2017).","journal-title":"Curr. Biol."},{"key":"53814_CR11","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.it.2017.11.003","volume":"39","author":"D Olivares-Villagomez","year":"2018","unstructured":"Olivares-Villagomez, D. & Van Kaer, L. Intestinal intraepithelial lymphocytes: sentinels of the mucosal barrier. Trends Immunol. 39, 264\u2013275 (2018).","journal-title":"Trends Immunol."},{"key":"53814_CR12","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/s41577-018-0013-7","volume":"18","author":"BD McDonald","year":"2018","unstructured":"McDonald, B. D., Jabri, B. & Bendelac, A. Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 18, 514\u2013525 (2018).","journal-title":"Nat. Rev. Immunol."},{"key":"53814_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.coi.2019.04.010","volume":"58","author":"R Ruscher","year":"2019","unstructured":"Ruscher, R. & Hogquist, K. A. Development, ontogeny, and maintenance of TCRalphabeta(+) CD8alphaalpha IEL. Curr. Opin. Immunol. 58, 83\u201388 (2019).","journal-title":"Curr. Opin. Immunol."},{"key":"53814_CR14","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s10620-015-4016-y","volume":"61","author":"Y Qiu","year":"2016","unstructured":"Qiu, Y., Peng, K., Liu, M., Xiao, W. & Yang, H. CD8alphaalpha TCRalphabeta intraepithelial lymphocytes in the mouse gut. Dig. Dis. Sci. 61, 1451\u20131460 (2016).","journal-title":"Dig. Dis. Sci."},{"key":"53814_CR15","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.cell.2012.04.037","volume":"149","author":"H Chung","year":"2012","unstructured":"Chung, H. et al. Gut immune maturation depends on colonization with a host-specific microbiota. Cell 149, 1578\u20131593 (2012).","journal-title":"Cell"},{"key":"53814_CR16","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1084\/jem.172.1.239","volume":"172","author":"A Bandeira","year":"1990","unstructured":"Bandeira, A. et al. Localization of gamma\/delta T cells to the intestinal epithelium is independent of normal microbial colonization. J. Exp. Med. 172, 239\u2013244 (1990).","journal-title":"J. Exp. Med."},{"key":"53814_CR17","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.immuni.2014.06.018","volume":"41","author":"CS Klose","year":"2014","unstructured":"Klose, C. S. et al. The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8alphaalpha(+) intraepithelial lymphocyte development. Immunity 41, 230\u2013243 (2014).","journal-title":"Immunity"},{"key":"53814_CR18","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2017.08.046","volume":"171","author":"DP Hoytema van Konijnenburg","year":"2017","unstructured":"Hoytema van Konijnenburg, D. P. et al. Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection. Cell 171, 783\u2013794.e713 (2017).","journal-title":"Cell"},{"key":"53814_CR19","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-065X.2006.00475.x","volume":"215","author":"J Kunisawa","year":"2007","unstructured":"Kunisawa, J., Takahashi, I. & Kiyono, H. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol. Rev. 215, 136\u2013153 (2007).","journal-title":"Immunol. Rev."},{"key":"53814_CR20","doi-asserted-by":"publisher","first-page":"5611","DOI":"10.4049\/jimmunol.154.11.5611","volume":"154","author":"KW Beagley","year":"1995","unstructured":"Beagley, K. W. et al. Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. J. Immunol. 154, 5611\u20135619 (1995).","journal-title":"J. Immunol."},{"key":"53814_CR21","doi-asserted-by":"publisher","first-page":"6180","DOI":"10.4049\/jimmunol.176.10.6180","volume":"176","author":"Q Yu","year":"2006","unstructured":"Yu, Q. et al. MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 alpha alpha TCR alpha beta and TCR gamma delta intestinal intraepithelial lymphocytes. J. Immunol. 176, 6180\u20136185 (2006).","journal-title":"J. Immunol."},{"key":"53814_CR22","first-page":"32","volume":"79","author":"Y Umesaki","year":"1993","unstructured":"Umesaki, Y., Setoyama, H., Matsumoto, S. & Okada, Y. Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus. Immunology 79, 32\u201337 (1993).","journal-title":"Immunology"},{"key":"53814_CR23","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.cell.2011.09.025","volume":"147","author":"Y Li","year":"2011","unstructured":"Li, Y. et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 147, 629\u2013640 (2011).","journal-title":"Cell"},{"key":"53814_CR24","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1038\/s41590-019-0513-z","volume":"20","author":"L Liu","year":"2019","unstructured":"Liu, L. et al. Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Nat. Immunol. 20, 1681\u20131691 (2019).","journal-title":"Nat. Immunol."},{"key":"53814_CR25","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.4049\/jimmunol.0900420","volume":"183","author":"LJ Ma","year":"2009","unstructured":"Ma, L. J., Acero, L. F., Zal, T. & Schluns, K. S. Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. J. Immunol. 183, 1044\u20131054 (2009).","journal-title":"J. Immunol."},{"key":"53814_CR26","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1073\/pnas.0307442101","volume":"101","author":"KS Schluns","year":"2004","unstructured":"Schluns, K. S. et al. Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression. Proc. Natl. Acad. Sci. USA 101, 5616\u20135621 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"53814_CR27","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1189\/jlb.0210071","volume":"88","author":"E Marchlik","year":"2010","unstructured":"Marchlik, E. et al. Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J. Leukoc. Biol. 88, 1171\u20131180 (2010).","journal-title":"J. Leukoc. Biol."},{"key":"53814_CR28","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.4049\/jimmunol.1103609","volume":"188","author":"SL Colpitts","year":"2012","unstructured":"Colpitts, S. L. et al. Cutting edge: the role of IFN-alpha receptor and MyD88 signaling in induction of IL-15 expression in vivo. J. Immunol. 188, 2483\u20132487 (2012).","journal-title":"J. Immunol."},{"key":"53814_CR29","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3389\/fimmu.2018.00711","volume":"9","author":"S Iurescia","year":"2018","unstructured":"Iurescia, S., Fioretti, D. & Rinaldi, M. Targeting cytosolic nucleic acid-sensing pathways for cancer immunotherapies. Front. Immunol. 9, 711 (2018).","journal-title":"Front. Immunol."},{"key":"53814_CR30","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1586\/erv.09.57","volume":"8","author":"S Koyama","year":"2009","unstructured":"Koyama, S. et al. Innate immune control of nucleic acid-based vaccine immunogenicity. Expert Rev. Vaccines 8, 1099\u20131107 (2009).","journal-title":"Expert Rev. Vaccines"},{"key":"53814_CR31","doi-asserted-by":"publisher","DOI":"10.1093\/immadv\/ltab017","volume":"1","author":"N Pinheiro-Rosa","year":"2021","unstructured":"Pinheiro-Rosa, N. et al. Oral tolerance as antigen-specific immunotherapy. Immunother. Adv. 1, ltab017 (2021).","journal-title":"Immunother. Adv."},{"key":"53814_CR32","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1016\/j.celrep.2016.05.047","volume":"15","author":"J Tan","year":"2016","unstructured":"Tan, J. et al. Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Rep. 15, 2809\u20132824 (2016).","journal-title":"Cell Rep."},{"key":"53814_CR33","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.coi.2019.06.001","volume":"60","author":"E Stephen-Victor","year":"2019","unstructured":"Stephen-Victor, E. & Chatila, T. A. Regulation of oral immune tolerance by the microbiome in food allergy. Curr. Opin. Immunol. 60, 141\u2013147 (2019).","journal-title":"Curr. Opin. Immunol."},{"key":"53814_CR34","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0165-2478(95)02451-4","volume":"48","author":"J Mengel","year":"1995","unstructured":"Mengel, J. et al. Anti-gamma delta T cell antibody blocks the induction and maintenance of oral tolerance to ovalbumin in mice. Immunol. Lett. 48, 97\u2013102 (1995).","journal-title":"Immunol. Lett."},{"key":"53814_CR35","doi-asserted-by":"publisher","first-page":"3610","DOI":"10.4049\/jimmunol.158.8.3610","volume":"158","author":"Y Ke","year":"1997","unstructured":"Ke, Y., Pearce, K., Lake, J. P., Ziegler, H. K. & Kapp, J. A. Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance. J. Immunol. 158, 3610\u20133618 (1997).","journal-title":"J. Immunol."},{"key":"53814_CR36","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1093\/intimm\/11.12.1907","volume":"11","author":"K Fujihashi","year":"1999","unstructured":"Fujihashi, K. et al. gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion. Int. Immunol. 11, 1907\u20131916 (1999).","journal-title":"Int. Immunol."},{"key":"53814_CR37","doi-asserted-by":"publisher","first-page":"6553","DOI":"10.4049\/jimmunol.176.11.6553","volume":"176","author":"NR Locke","year":"2006","unstructured":"Locke, N. R., Stankovic, S., Funda, D. P. & Harrison, L. C. TCR gamma delta intraepithelial lymphocytes are required for self-tolerance. J. Immunol. 176, 6553\u20136559 (2006).","journal-title":"J. Immunol."},{"key":"53814_CR38","doi-asserted-by":"publisher","first-page":"836","DOI":"10.2174\/156652409789105525","volume":"9","author":"G Gorfu","year":"2009","unstructured":"Gorfu, G., Rivera-Nieves, J. & Ley, K. Role of beta7 integrins in intestinal lymphocyte homing and retention. Curr. Mol. Med. 9, 836\u2013850 (2009).","journal-title":"Curr. Mol. Med."},{"key":"53814_CR39","doi-asserted-by":"crossref","unstructured":"Wang, Y. C. et al. Intestinal cell type-specific communication networks underlie homeostasis and response to Western diet. J. Exp. Med. 220, e20221437 (2023).","DOI":"10.1084\/jem.20221437"},{"key":"53814_CR40","doi-asserted-by":"publisher","first-page":"4230","DOI":"10.4049\/jimmunol.178.7.4230","volume":"178","author":"TL Denning","year":"2007","unstructured":"Denning, T. L. et al. Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J. Immunol. 178, 4230\u20134239 (2007).","journal-title":"J. Immunol."},{"key":"53814_CR41","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13075-020-2130-5","volume":"22","author":"A van Caam","year":"2020","unstructured":"van Caam, A. et al. TGFbeta-mediated expression of TGFbeta-activating integrins in SSc monocytes: disturbed activation of latent TGFbeta? Arthritis Res. Ther. 22, 42 (2020).","journal-title":"Arthritis Res. Ther."},{"key":"53814_CR42","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.4049\/jimmunol.1600244","volume":"197","author":"M Boucard-Jourdin","year":"2016","unstructured":"Boucard-Jourdin, M. et al. beta8 integrin expression and activation of TGF-beta by intestinal dendritic cells are determined by both tissue microenvironment and cell lineage. J. Immunol. 197, 1968\u20131978 (2016).","journal-title":"J. Immunol."},{"key":"53814_CR43","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.2353\/ajpath.2009.090393","volume":"175","author":"SL Nishimura","year":"2009","unstructured":"Nishimura, S. L. Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders. Am. J. Pathol. 175, 1362\u20131370 (2009).","journal-title":"Am. J. Pathol."},{"key":"53814_CR44","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4168\/aair.2017.9.2.107","volume":"9","author":"M Wawrzyniak","year":"2017","unstructured":"Wawrzyniak, M., O\u2019Mahony, L. & Akdis, M. Role of regulatory cells in oral tolerance. Allergy Asthma Immunol. Res. 9, 107\u2013115 (2017).","journal-title":"Allergy Asthma Immunol. Res."},{"key":"53814_CR45","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fimmu.2011.00025","volume":"2","author":"DT Ruane","year":"2011","unstructured":"Ruane, D. T. & Lavelle, E. C. The role of CD103(+) dendritic cells in the intestinal mucosal immune system. Front. Immunol. 2, 25 (2011).","journal-title":"Front. Immunol."},{"key":"53814_CR46","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.it.2011.06.003","volume":"32","author":"CL Scott","year":"2011","unstructured":"Scott, C. L., Aumeunier, A. M. & Mowat, A. M. Intestinal CD103+ dendritic cells: master regulators of tolerance? Trends Immunol. 32, 412\u2013419 (2011).","journal-title":"Trends Immunol."},{"key":"53814_CR47","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1038\/mi.2008.43","volume":"1","author":"KR Siddiqui","year":"2008","unstructured":"Siddiqui, K. R. & Powrie, F. CD103+ GALT DCs promote Foxp3+ regulatory T cells. Mucosal Immunol. 1, S34\u2013S38 (2008).","journal-title":"Mucosal Immunol."},{"key":"53814_CR48","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1053\/j.gastro.2011.06.076","volume":"141","author":"H Paidassi","year":"2011","unstructured":"Paidassi, H. et al. Preferential expression of integrin alphavbeta8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells. Gastroenterology 141, 1813\u20131820 (2011).","journal-title":"Gastroenterology"},{"key":"53814_CR49","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1053\/j.gastro.2011.06.057","volume":"141","author":"JJ Worthington","year":"2011","unstructured":"Worthington, J. J., Czajkowska, B. I., Melton, A. C. & Travis, M. A. Intestinal dendritic cells specialize to activate transforming growth factor-beta and induce Foxp3+ regulatory T cells via integrin alphavbeta8. Gastroenterology 141, 1802\u20131812 (2011).","journal-title":"Gastroenterology"},{"key":"53814_CR50","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s12026-017-8944-9","volume":"65","author":"GE Esebanmen","year":"2017","unstructured":"Esebanmen, G. E. & Langridge, W. H. R. The role of TGF-beta signaling in dendritic cell tolerance. Immunol. Res. 65, 987\u2013994 (2017).","journal-title":"Immunol. Res."},{"key":"53814_CR51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000351390","volume":"77","author":"FM Ruemmele","year":"2013","unstructured":"Ruemmele, F. M. & Garnier-Lengline, H. Transforming growth factor and intestinal inflammation: the role of nutrition. Nestle Nutr. Inst. Workshop Ser. 77, 91\u201398 (2013).","journal-title":"Nestle Nutr. Inst. Workshop Ser."},{"key":"53814_CR52","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1126\/science.aac5560","volume":"351","author":"KS Kim","year":"2016","unstructured":"Kim, K. S. et al. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science 351, 858\u2013863 (2016).","journal-title":"Science"},{"key":"53814_CR53","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1271\/bbb.64.1459","volume":"64","author":"S Nagafuchi","year":"2000","unstructured":"Nagafuchi, S. et al. Dietary nucleotides increase the proportion of a TCR gammadelta+ subset of intraepithelial lymphocytes (IEL) and IL-7 production by intestinal epithelial cells (IEC); implications for modification of cellular and molecular cross-talk between IEL and IEC by dietary nucleotides. Biosci. Biotechnol. Biochem. 64, 1459\u20131465 (2000).","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"53814_CR54","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1146\/annurev-micro-102215-095605","volume":"72","author":"X Tan","year":"2018","unstructured":"Tan, X., Sun, L., Chen, J. & Chen, Z. J. Detection of microbial infections through innate immune sensing of nucleic acids. Annu. Rev. Microbiol. 72, 447\u2013478 (2018).","journal-title":"Annu. Rev. Microbiol."},{"key":"53814_CR55","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1084\/jem.191.5.771","volume":"191","author":"MK Kennedy","year":"2000","unstructured":"Kennedy, M. K. et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191, 771\u2013780 (2000).","journal-title":"J. Exp. Med."},{"key":"53814_CR56","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1084\/jem.20011793","volume":"195","author":"P Poussier","year":"2002","unstructured":"Poussier, P., Ning, T., Banerjee, D. & Julius, M. A unique subset of self-specific intraintestinal T cells maintains gut integrity. J. Exp. Med. 195, 1491\u20131497 (2002).","journal-title":"J. Exp. Med."},{"key":"53814_CR57","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.4049\/jimmunol.173.2.1390","volume":"173","author":"K Inagaki-Ohara","year":"2004","unstructured":"Inagaki-Ohara, K. et al. Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J. Immunol. 173, 1390\u20131398 (2004).","journal-title":"J. Immunol."},{"key":"53814_CR58","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1017\/S000711450783296X","volume":"98","author":"P Gutierrez-Castrellon","year":"2007","unstructured":"Gutierrez-Castrellon, P. et al. Immune response to nucleotide-supplemented infant formulae: systematic review and meta-analysis. Br. J. Nutr. 98, S64\u2013S67 (2007).","journal-title":"Br. J. Nutr."},{"key":"53814_CR59","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1016\/j.celrep.2017.10.114","volume":"21","author":"J Ye","year":"2017","unstructured":"Ye, J. et al. The aryl hydrocarbon receptor preferentially marks and promotes gut regulatory T cells. Cell Rep. 21, 2277\u20132290 (2017).","journal-title":"Cell Rep."},{"key":"53814_CR60","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1126\/science.1145697","volume":"317","author":"D Mucida","year":"2007","unstructured":"Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256\u2013260 (2007).","journal-title":"Science"},{"key":"53814_CR61","first-page":"136","volume":"12","author":"B Prietl","year":"2010","unstructured":"Prietl, B. et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? Isr. Med. Assoc. J. 12, 136\u2013139 (2010).","journal-title":"Isr. Med. Assoc. J."},{"key":"53814_CR62","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/ijos.2014.48","volume":"6","author":"RQ Wu","year":"2014","unstructured":"Wu, R. Q., Zhang, D. F., Tu, E., Chen, Q. M. & Chen, W. The mucosal immune system in the oral cavity-an orchestra of T cell diversity. Int. J. oral. Sci. 6, 125\u2013132 (2014).","journal-title":"Int. J. oral. Sci."},{"key":"53814_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01478-1","volume":"11","author":"RM Rezende","year":"2023","unstructured":"Rezende, R. M. et al. Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance. Microbiome 11, 32 (2023).","journal-title":"Microbiome"},{"key":"53814_CR64","doi-asserted-by":"publisher","first-page":"849954","DOI":"10.3389\/fimmu.2022.849954","volume":"13","author":"F Rampoldi","year":"2022","unstructured":"Rampoldi, F. & Prinz, I. Three layers of intestinal gammadelta T cells talk different languages with the microbiota. Front. Immunol. 13, 849954 (2022).","journal-title":"Front. Immunol."},{"key":"53814_CR65","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","volume":"9","author":"O Adachi","year":"1998","unstructured":"Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143\u2013150 (1998).","journal-title":"Immunity"},{"key":"53814_CR66","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.cell.2019.07.044","volume":"178","author":"MB Dong","year":"2019","unstructured":"Dong, M. B. et al. Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells. Cell 178, 1189\u20131204 e1123 (2019).","journal-title":"Cell"},{"key":"53814_CR67","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8090","volume":"6","author":"M Swamy","year":"2015","unstructured":"Swamy, M. et al. Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance. Nat. Commun. 6, 7090 (2015).","journal-title":"Nat. Commun."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53814-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53814-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53814-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T19:03:48Z","timestamp":1730487828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53814-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,1]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["53814"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-53814-0","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,1]]},"assertion":[{"value":"26 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9461"}}