{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:16:41Z","timestamp":1793852201479,"version":"4.6.1"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL148184-01"],"award-info":[{"award-number":["R01HL148184-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01AI12492093"],"award-info":[{"award-number":["R01AI12492093"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["CFF"],"award-info":[{"award-number":["CFF"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-53994-9","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T05:02:58Z","timestamp":1732770178000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-3232","authenticated-orcid":false,"given":"Minyoung Kevin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingquan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6963-9780","authenticated-orcid":false,"given":"Arne","family":"Echterhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Pennetzdorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niaz","family":"Banaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8969-6232","authenticated-orcid":false,"given":"Elizabeth B.","family":"Burgener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Milla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2499-9448","authenticated-orcid":false,"given":"Paul L.","family":"Bollyky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"53994_CR1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"Antimicrobial Resistance, C.","year":"2022","unstructured":"Antimicrobial Resistance, C. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399, 629\u2013655 (2022).","journal-title":"Lancet"},{"key":"53994_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev-med-080219-122208","volume":"73","author":"GF Hatfull","year":"2022","unstructured":"Hatfull, G. F., Dedrick, R. M. & Schooley, R. T. Phage therapy for antibiotic-resistant bacterial infections. Annu Rev. Med. 73, 197\u2013211 (2022).","journal-title":"Annu Rev. Med."},{"key":"53994_CR3","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/s41564-024-01705-x","volume":"9","author":"JP Pirnay","year":"2024","unstructured":"Pirnay, J. P. et al. Personalized bacteriophage therapy outcomes for 100 consecutive cases: a multicentre, multinational, retrospective observational study. Nat. Microbiol. 9, 1434\u20131453 (2024).","journal-title":"Nat. Microbiol."},{"key":"53994_CR4","doi-asserted-by":"publisher","first-page":"e208","DOI":"10.1016\/S1473-3099(21)00612-5","volume":"22","author":"S Uyttebroek","year":"2022","unstructured":"Uyttebroek, S. et al. Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review. Lancet Infect Dis. 22, e208\u2013e220 (2022).","journal-title":"Lancet Infect Dis"},{"key":"53994_CR5","doi-asserted-by":"publisher","unstructured":"Schooley, R. T. et al. Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection. Antimicrob Agents Chemother 61 https:\/\/doi.org\/10.1128\/AAC.00954-17 (2017).","DOI":"10.1128\/AAC.00954-17"},{"key":"53994_CR6","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1093\/cid\/ciaa705","volume":"73","author":"EJ Cano","year":"2021","unstructured":"Cano, E. J. et al. Phage Therapy for Limb-threatening Prosthetic Knee Klebsiella pneumoniae Infection: Case Report and In Vitro Characterization of Anti-biofilm Activity. Clin. Infect Dis. 73, e144\u2013e151 (2021).","journal-title":"Clin. Infect Dis."},{"key":"53994_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1709-y","volume":"21","author":"S Jennes","year":"2017","unstructured":"Jennes, S. et al. Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury-a case report. Crit Care 21, 129 (2017).","journal-title":"Crit Care"},{"key":"53994_CR8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S1473-3099(18)30482-1","volume":"19","author":"P Jault","year":"2019","unstructured":"Jault, P. et al. Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1\/2 trial. Lancet Infect Dis. 19, 35\u201345 (2019).","journal-title":"Lancet Infect Dis."},{"key":"53994_CR9","doi-asserted-by":"publisher","unstructured":"Gorski, A., Borysowski, J. & Miedzybrodzki, R. Phage therapy: Towards a successful clinical trial. Antibiotics (Basel) 9, https:\/\/doi.org\/10.3390\/antibiotics9110827 (2020).","DOI":"10.3390\/antibiotics9110827"},{"key":"53994_CR10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S1473-3099(20)30330-3","volume":"21","author":"L Leitner","year":"2021","unstructured":"Leitner, L. et al. Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial. Lancet Infect Dis. 21, 427\u2013436 (2021).","journal-title":"Lancet Infect Dis."},{"key":"53994_CR11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.tim.2018.08.006","volume":"27","author":"PA de Jonge","year":"2019","unstructured":"de Jonge, P. A., Nobrega, F. L., Brouns, S. J. J. & Dutilh, B. E. Molecular and evolutionary determinants of bacteriophage host range. Trends Microbiol. 27, 51\u201363 (2019).","journal-title":"Trends Microbiol."},{"key":"53994_CR12","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.chom.2015.07.006","volume":"18","author":"P Jorth","year":"2015","unstructured":"Jorth, P. et al. Regional isolation drives bacterial diversification within cystic fibrosis lungs. Cell Host Microbe 18, 307\u2013319 (2015).","journal-title":"Cell Host Microbe"},{"key":"53994_CR13","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s10096-016-2621-0","volume":"35","author":"DH Limoli","year":"2016","unstructured":"Limoli, D. H. et al. Staphylococcus aureus and Pseudomonas aeruginosa co-infection is associated with cystic fibrosis-related diabetes and poor clinical outcomes. Eur J Clin. Microbiol. Infect. Dis. 35, 947\u2013953 (2016).","journal-title":"Eur J Clin. Microbiol. Infect. Dis."},{"key":"53994_CR14","doi-asserted-by":"publisher","unstructured":"Oechslin, F. Resistance development to bacteriophages occurring during bacteriophage therapy. Viruses 10, https:\/\/doi.org\/10.3390\/v10070351 (2018).","DOI":"10.3390\/v10070351"},{"key":"53994_CR15","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1016\/j.cell.2023.02.029","volume":"186","author":"A Stokar-Avihail","year":"2023","unstructured":"Stokar-Avihail, A. et al. Discovery of phage determinants that confer sensitivity to bacterial immune systems. Cell 186, 1863\u20131876 e1816 (2023).","journal-title":"Cell"},{"key":"53994_CR16","doi-asserted-by":"publisher","unstructured":"Egido, J. E., Costa, A. R., Aparicio-Maldonado, C., Haas, P. J. & Brouns, S. J. J. Mechanisms and clinical importance of bacteriophage resistance. FEMS Microbiol. Rev. 46, https:\/\/doi.org\/10.1093\/femsre\/fuab048 (2022).","DOI":"10.1093\/femsre\/fuab048"},{"key":"53994_CR17","doi-asserted-by":"publisher","first-page":"e555","DOI":"10.1016\/S2666-5247(21)00127-0","volume":"2","author":"D Gelman","year":"2021","unstructured":"Gelman, D. et al. Clinical phage microbiology: a suggested framework and recommendations for the in vitro matching steps of phage therapy. Lancet Microbe 2, e555\u2013e563 (2021).","journal-title":"Lancet Microbe"},{"key":"53994_CR18","doi-asserted-by":"publisher","first-page":"e00362","DOI":"10.1128\/mBio.00362-12","volume":"4","author":"NM Hoyland-Kroghsbo","year":"2013","unstructured":"Hoyland-Kroghsbo, N. M., Maerkedahl, R. B. & Svenningsen, S. L. A quorum-sensing-induced bacteriophage defense mechanism. mBio. 4, e00362\u201300312 (2013).","journal-title":"mBio."},{"key":"53994_CR19","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41586-018-0767-x","volume":"564","author":"S Kronheim","year":"2018","unstructured":"Kronheim, S. et al. A chemical defence against phage infection. Nature 564, 283\u2013286 (2018).","journal-title":"Nature"},{"key":"53994_CR20","doi-asserted-by":"publisher","unstructured":"Glonti, T. & Pirnay, J. P. In Vitro Techniques and Measurements of Phage Characteristics That Are Important for Phage Therapy Success. Viruses 14, https:\/\/doi.org\/10.3390\/v14071490 (2022).","DOI":"10.3390\/v14071490"},{"key":"53994_CR21","doi-asserted-by":"publisher","unstructured":"Abedon, S. T., Danis-Wlodarczyk, K. M. & Wozniak, D. J. Phage cocktail development for bacteriophage therapy: Toward improving spectrum of activity breadth and depth. Pharmaceuticals (Basel) 14, https:\/\/doi.org\/10.3390\/ph14101019 (2021).","DOI":"10.3390\/ph14101019"},{"key":"53994_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.564532","volume":"12","author":"F Molina","year":"2021","unstructured":"Molina, F. et al. A new pipeline for designing phage cocktails based on phage-bacteria infection networks. Front Microbiol. 12, 564532 (2021).","journal-title":"Front Microbiol."},{"key":"53994_CR23","doi-asserted-by":"publisher","first-page":"e590","DOI":"10.7717\/peerj.590","volume":"2","author":"M Schmerer","year":"2014","unstructured":"Schmerer, M., Molineux, I. J. & Bull, J. J. Synergy as a rationale for phage therapy using phage cocktails. PeerJ 2, e590 (2014).","journal-title":"PeerJ"},{"key":"53994_CR24","doi-asserted-by":"publisher","first-page":"5646","DOI":"10.1128\/AEM.00757-12","volume":"78","author":"AR Hall","year":"2012","unstructured":"Hall, A. R., De Vos, D., Friman, V. P., Pirnay, J. P. & Buckling, A. Effects of sequential and simultaneous applications of bacteriophages on populations of Pseudomonas aeruginosa in vitro and in wax moth larvae. Appl. Environ. Microbiol. 78, 5646\u20135652 (2012).","journal-title":"Appl. Environ. Microbiol."},{"key":"53994_CR25","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-1-4939-7395-8_9","volume":"1693","author":"M Merabishvili","year":"2018","unstructured":"Merabishvili, M., Pirnay, J. P. & De Vos, D. Guidelines to compose an ideal bacteriophage cocktail. Methods Mol. Biol. 1693, 99\u2013110 (2018).","journal-title":"Methods Mol. Biol."},{"key":"53994_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.613529","volume":"12","author":"MEK Haines","year":"2021","unstructured":"Haines, M. E. K. et al. Analysis of selection methods to develop novel phage therapy cocktails against antimicrobial resistant clinical isolates of bacteria. Front Microbiol. 12, 613529 (2021).","journal-title":"Front Microbiol."},{"key":"53994_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fcimb.2019.00022","volume":"9","author":"TL Tagliaferri","year":"2019","unstructured":"Tagliaferri, T. L., Jansen, M. & Horz, H. P. Fighting pathogenic bacteria on two fronts: Phages and antibiotics as combined strategy. Front Cell Infect. Microbiol. 9, 22 (2019).","journal-title":"Front Cell Infect. Microbiol."},{"key":"53994_CR28","doi-asserted-by":"publisher","unstructured":"Gu Liu, C. et al. Phage-antibiotic synergy is driven by a unique combination of antibacterial mechanism of action and stoichiometry. mBio. 11, https:\/\/doi.org\/10.1128\/mBio.01462-20 (2020).","DOI":"10.1128\/mBio.01462-20"},{"key":"53994_CR29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12929-022-00806-1","volume":"29","author":"M Lusiak-Szelachowska","year":"2022","unstructured":"Lusiak-Szelachowska, M. et al. Bacteriophages and antibiotic interactions in clinical practice: what we have learned so far. J Biomed Sci. 29, 23 (2022).","journal-title":"J Biomed Sci."},{"key":"53994_CR30","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.coviro.2021.12.011","volume":"52","author":"C Lood","year":"2022","unstructured":"Lood, C., Haas, P. J., van Noort, V. & Lavigne, R. Shopping for phages? Unpacking design rules for therapeutic phage cocktails. Curr Opin Virol 52, 236\u2013243 (2022).","journal-title":"Curr Opin Virol"},{"key":"53994_CR31","doi-asserted-by":"publisher","first-page":"e114785","DOI":"10.1371\/journal.pone.0114785","volume":"9","author":"JA Hammerl","year":"2014","unstructured":"Hammerl, J. A. et al. Reduction of Campylobacter jejuni in broiler chicken by successive application of group II and group III phages. PLoS One 9, e114785 (2014).","journal-title":"PLoS One"},{"key":"53994_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.105186","volume":"142","author":"M Menor-Flores","year":"2022","unstructured":"Menor-Flores, M., Vega-Rodriguez, M. A. & Molina, F. Computational design of phage cocktails based on phage-bacteria infection networks. Comput Biol. Med. 142, 105186 (2022).","journal-title":"Comput Biol. Med."},{"key":"53994_CR33","doi-asserted-by":"publisher","first-page":"e31698","DOI":"10.1371\/journal.pone.0031698","volume":"7","author":"J Gu","year":"2012","unstructured":"Gu, J. et al. A method for generation phage cocktail with great therapeutic potential. PLoS One 7, e31698 (2012).","journal-title":"PLoS One"},{"key":"53994_CR34","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3389\/fmicb.2020.00327","volume":"11","author":"Y Yang","year":"2020","unstructured":"Yang, Y. et al. Development of a Bacteriophage Cocktail to Constrain the Emergence of Phage-Resistant Pseudomonas aeruginosa. Front Microbiol. 11, 327 (2020).","journal-title":"Front Microbiol."},{"key":"53994_CR35","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s00253-003-1438-9","volume":"64","author":"Y Tanji","year":"2004","unstructured":"Tanji, Y. et al. Toward rational control of Escherichia coli O157:H7 by a phage cocktail. Appl. Microbiol. Biotechnol. 64, 270\u2013274 (2004).","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"53994_CR36","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.copbio.2020.10.002","volume":"68","author":"FL Gordillo Altamirano","year":"2021","unstructured":"Gordillo Altamirano, F. L. & Barr, J. J. Unlocking the next generation of phage therapy: the key is in the receptors. Curr Opin Biotechnol 68, 115\u2013123 (2021).","journal-title":"Curr Opin Biotechnol"},{"key":"53994_CR37","doi-asserted-by":"publisher","first-page":"e2006057","DOI":"10.1371\/journal.pbio.2006057","volume":"16","author":"RCT Wright","year":"2018","unstructured":"Wright, R. C. T., Friman, V. P., Smith, M. C. M. & Brockhurst, M. A. Cross-resistance is modular in bacteria-phage interactions. PLoS Biol. 16, e2006057 (2018).","journal-title":"PLoS Biol"},{"key":"53994_CR38","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1128\/AAC.01028-06","volume":"51","author":"CS McVay","year":"2007","unstructured":"McVay, C. S., Velasquez, M. & Fralick, J. A. Phage therapy of Pseudomonas aeruginosa infection in a mouse burn wound model. Antimicrob Agents Chemother 51, 1934\u20131938 (2007).","journal-title":"Antimicrob Agents Chemother"},{"key":"53994_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-12-122","volume":"12","author":"E Morales","year":"2012","unstructured":"Morales, E. et al. Hospital costs of nosocomial multi-drug resistant Pseudomonas aeruginosa acquisition. BMC Health Serv Res 12, 122 (2012).","journal-title":"BMC Health Serv Res"},{"key":"53994_CR40","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/j.1469-0691.2012.03914.x","volume":"19","author":"BY Lee","year":"2013","unstructured":"Lee, B. Y. et al. The economic burden of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). Clin. Microbiol. Infect. 19, 528\u2013536 (2013).","journal-title":"Clin. Microbiol. Infect."},{"key":"53994_CR41","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/s42003-020-01127-5","volume":"3","author":"J Beal","year":"2020","unstructured":"Beal, J. et al. Robust estimation of bacterial cell count from optical density. Commun Biol. 3, 512 (2020).","journal-title":"Commun Biol."},{"key":"53994_CR42","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1128\/JB.01184-12","volume":"194","author":"KC Cady","year":"2012","unstructured":"Cady, K. C., Bondy-Denomy, J., Heussler, G. E. & Davidson, A. R. & O\u2019Toole, G. A. The CRISPR\/Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phages. J Bacteriol 194, 5728\u20135738 (2012).","journal-title":"J Bacteriol"},{"key":"53994_CR43","doi-asserted-by":"publisher","unstructured":"Xie, Y., Wahab, L. & Gill, J. J. Development and validation of a microtiter plate-based assay for determination of bacteriophage host range and virulence. Viruses 10 https:\/\/doi.org\/10.3390\/v10040189 (2018).","DOI":"10.3390\/v10040189"},{"key":"53994_CR44","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.chom.2021.11.014","volume":"30","author":"T Dimitriu","year":"2022","unstructured":"Dimitriu, T. et al. Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition. Cell Host Microbe 30, 31\u201340.e35 (2022).","journal-title":"Cell Host Microbe"},{"key":"53994_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45785-z","volume":"15","author":"EA Ashworth","year":"2024","unstructured":"Ashworth, E. A. et al. Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo. Nat. Commun. 15, 1547 (2024).","journal-title":"Nat. Commun."},{"key":"53994_CR46","doi-asserted-by":"publisher","unstructured":"Chan, B. K. et al Personalized Inhaled Bacteriophage Therapy Decreases Multidrug-Resistant Pseudomonas aeruginosa. medRxiv https:\/\/doi.org\/10.1101\/2023.01.23.22283996 (2023).","DOI":"10.1101\/2023.01.23.22283996"},{"key":"53994_CR47","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.coviro.2011.06.009","volume":"1","author":"GF Hatfull","year":"2011","unstructured":"Hatfull, G. F. & Hendrix, R. W. Bacteriophages and their genomes. Curr. Opin Virol 1, 298\u2013303 (2011).","journal-title":"Curr. Opin Virol"},{"key":"53994_CR48","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-micro-092611-150055","volume":"66","author":"LL Burrows","year":"2012","unstructured":"Burrows, L. L. Pseudomonas aeruginosa twitching motility: type IV pili in action. Annu Rev. Microbiol. 66, 493\u2013520 (2012).","journal-title":"Annu Rev. Microbiol."},{"key":"53994_CR49","doi-asserted-by":"publisher","unstructured":"Bouteiller, M. et al. Pseudomonas flagella: Generalities and specificities. Int J Mol Sci. 22, https:\/\/doi.org\/10.3390\/ijms22073337 (2021).","DOI":"10.3390\/ijms22073337"},{"key":"53994_CR50","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3389\/fmicb.2017.01229","volume":"8","author":"DP Pires","year":"2017","unstructured":"Pires, D. P. et al. A genotypic analysis of five P. aeruginosa strains after biofilm infection by phages targeting different cell surface receptors. Front Microbiol. 8, 1229 (2017).","journal-title":"Front Microbiol."},{"key":"53994_CR51","doi-asserted-by":"publisher","first-page":"18670","DOI":"10.1073\/pnas.2001888117","volume":"117","author":"KE Kortright","year":"2020","unstructured":"Kortright, K. E., Chan, B. K. & Turner, P. E. High-throughput discovery of phage receptors using transposon insertion sequencing of bacteria. Proc Natl Acad Sci. USA 117, 18670\u201318679 (2020).","journal-title":"Proc Natl Acad Sci. USA"},{"key":"53994_CR52","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.cub.2015.02.074","volume":"25","author":"A Siryaporn","year":"2015","unstructured":"Siryaporn, A., Kim, M. K., Shen, Y., Stone, H. A. & Gitai, Z. Colonization, competition, and dispersal of pathogens in fluid flow networks. Curr. Biol. 25, 1201\u20131207 (2015).","journal-title":"Curr. Biol."},{"key":"53994_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/srep26717","volume":"6","author":"BK Chan","year":"2016","unstructured":"Chan, B. K. et al. Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa. Sci. Rep. 6, 26717 (2016).","journal-title":"Sci. Rep"},{"key":"53994_CR54","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fmicb.2016.00252","volume":"7","author":"X Pan","year":"2016","unstructured":"Pan, X. et al. Genetic evidence for O-specific antigen as receptor of Pseudomonas aeruginosa phage K8 and Its genomic analysis. Front Microbiol. 7, 252 (2016).","journal-title":"Front Microbiol."},{"key":"53994_CR55","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1111\/j.1462-2920.2009.02030.x","volume":"11","author":"PJ Ceyssens","year":"2009","unstructured":"Ceyssens, P. J. et al. Comparative analysis of the widespread and conserved PB1-like viruses infecting Pseudomonas aeruginosa. Environ Microbiol. 11, 2874\u20132883 (2009).","journal-title":"Environ Microbiol."},{"key":"53994_CR56","doi-asserted-by":"publisher","unstructured":"Davis, C. M., McCutcheon, J. G. & Dennis, J. J. Aztreonam lysine increases the activity of phages E79 and phiKZ against Pseudomonas aeruginosa PAO1. Microorganisms 9, https:\/\/doi.org\/10.3390\/microorganisms9010152 (2021).","DOI":"10.3390\/microorganisms9010152"},{"key":"53994_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.80","volume":"2","author":"MK Kim","year":"2017","unstructured":"Kim, M. K. et al. Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development. Nat Microbiol. 2, 17080 (2017).","journal-title":"Nat Microbiol."},{"key":"53994_CR58","doi-asserted-by":"publisher","unstructured":"Sweere, J. M. et al. Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection. Science 363, https:\/\/doi.org\/10.1126\/science.aat9691 (2019).","DOI":"10.1126\/science.aat9691"},{"key":"53994_CR59","doi-asserted-by":"publisher","unstructured":"Chen, Q. et al. Bacteriophage and bacterial susceptibility, resistance, and tolerance to antibiotics. Pharmaceutics 14, https:\/\/doi.org\/10.3390\/pharmaceutics14071425 (2022).","DOI":"10.3390\/pharmaceutics14071425"},{"key":"53994_CR60","doi-asserted-by":"publisher","first-page":"e1219440","DOI":"10.1080\/21597081.2016.1219440","volume":"6","author":"LA Estrella","year":"2016","unstructured":"Estrella, L. A. et al. Characterization of novel Staphylococcus aureus lytic phage and defining their combinatorial virulence using the OmniLog(R) system. Bacteriophage 6, e1219440 (2016).","journal-title":"Bacteriophage"},{"key":"53994_CR61","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1128\/JVI.02763-12","volume":"87","author":"K Vandersteegen","year":"2013","unstructured":"Vandersteegen, K. et al. Romulus and Remus, two phage isolates representing a distinct clade within the Twortlikevirus genus, display suitable properties for phage therapy applications. J Virol 87, 3237\u20133247 (2013).","journal-title":"J Virol"},{"key":"53994_CR62","doi-asserted-by":"publisher","first-page":"5763","DOI":"10.1128\/AEM.01385-16","volume":"82","author":"I Takeuchi","year":"2016","unstructured":"Takeuchi, I. et al. The Presence of Two Receptor-Binding Proteins Contributes to the Wide Host Range of Staphylococcal Twort-Like Phages. Appl. Environ. Microbiol. 82, 5763\u20135774 (2016).","journal-title":"Appl. Environ. Microbiol."},{"key":"53994_CR63","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/emph\/eoy005","volume":"2018","author":"BK Chan","year":"2018","unstructured":"Chan, B. K. et al. Phage treatment of an aortic graft infected with Pseudomonas aeruginosa. Evol Med Public Health 2018, 60\u201366 (2018).","journal-title":"Evol Med Public Health"},{"key":"53994_CR64","doi-asserted-by":"publisher","first-page":"a007161","DOI":"10.1101\/cshperspect.a007161","volume":"2","author":"EJ Arts","year":"2012","unstructured":"Arts, E. J. & Hazuda, D. J. HIV-1 antiretroviral drug therapy. Cold Spring Harb Perspect Med 2, a007161 (2012).","journal-title":"Cold Spring Harb Perspect Med"},{"key":"53994_CR65","doi-asserted-by":"publisher","first-page":"10384","DOI":"10.1128\/JVI.00801-12","volume":"86","author":"D Schwarzer","year":"2012","unstructured":"Schwarzer, D. et al. A multivalent adsorption apparatus explains the broad host range of phage phi92: a comprehensive genomic and structural analysis. J Virol 86, 10384\u201310398 (2012).","journal-title":"J Virol"},{"key":"53994_CR66","first-page":"55","volume":"4","author":"GBN Fungo","year":"2023","unstructured":"Fungo, G. B. N. et al. Two Is Better Than One\u201d: The Multifactorial Nature of Phage-Antibiotic Combinatorial Treatments Against ESKAPE-Induced Infections. Phage (New Rochelle) 4, 55\u201367 (2023).","journal-title":"Phage (New Rochelle)"},{"key":"53994_CR67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216084120","volume":"120","author":"BJ Pons","year":"2023","unstructured":"Pons, B. J., Dimitriu, T., Westra, E. R. & van Houte, S. Antibiotics that affect translation can antagonize phage infectivity by interfering with the deployment of counter-defenses. Proc Natl Acad Sci. USA 120, e2216084120 (2023).","journal-title":"Proc Natl Acad Sci. USA"},{"key":"53994_CR68","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.cell.2019.09.015","volume":"179","author":"K Yehl","year":"2019","unstructured":"Yehl, K. et al. Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis. Cell 179, 459\u2013469.e459 (2019).","journal-title":"Cell"},{"key":"53994_CR69","doi-asserted-by":"publisher","first-page":"e956","DOI":"10.1016\/S2666-5247(22)00288-9","volume":"3","author":"SA Gomez-Ochoa","year":"2022","unstructured":"Gomez-Ochoa, S. A. et al. Efficacy of phage therapy in preclinical models of bacterial infection: a systematic review and meta-analysis. Lancet Microbe 3, e956\u2013e968 (2022).","journal-title":"Lancet Microbe"},{"key":"53994_CR70","doi-asserted-by":"publisher","unstructured":"Visnapuu, A., Van der Gucht, M., Wagemans, J. & Lavigne, R. Deconstructing the Phage-Bacterial Biofilm Interaction as a Basis to Establish New Antibiofilm Strategies. Viruses 14, https:\/\/doi.org\/10.3390\/v14051057 (2022).","DOI":"10.3390\/v14051057"},{"key":"53994_CR71","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl5576","volume":"10","author":"Q Chen","year":"2024","unstructured":"Chen, Q. et al. Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding. Sci. Adv. 10, eadl5576 (2024).","journal-title":"Sci. Adv."},{"key":"53994_CR72","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1146\/annurev.micro.54.1.799","volume":"54","author":"IN Wang","year":"2000","unstructured":"Wang, I. N., Smith, D. L. & Young, R. Holins: the protein clocks of bacteriophage infections. Annu Rev. Microbiol. 54, 799\u2013825 (2000).","journal-title":"Annu Rev. Microbiol."},{"key":"53994_CR73","doi-asserted-by":"publisher","unstructured":"Jakociune, D. & Moodley, A. A rapid bacteriophage DNA extraction method. Methods Protoc 1, https:\/\/doi.org\/10.3390\/mps1030027 (2018).","DOI":"10.3390\/mps1030027"},{"key":"53994_CR74","doi-asserted-by":"publisher","first-page":"E9411","DOI":"10.1073\/pnas.1814023115","volume":"115","author":"S Mukherjee","year":"2018","unstructured":"Mukherjee, S. et al. The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa. Proc Natl Acad Sci. USA 115, E9411\u2013E9418 (2018).","journal-title":"Proc Natl Acad Sci. USA"},{"key":"53994_CR75","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/978-1-4939-0473-0_31","volume":"1149","author":"JS Lam","year":"2014","unstructured":"Lam, J. S., Anderson, E. M. & Hao, Y. LPS quantitation procedures. Methods Mol. Biol. 1149, 375\u2013402 (2014).","journal-title":"Methods Mol. Biol."},{"key":"53994_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2015.5","volume":"1","author":"MK Kim","year":"2016","unstructured":"Kim, M. K., Ingremeau, F., Zhao, A., Bassler, B. L. & Stone, H. A. Local and global consequences of flow on bacterial quorum sensing. Nat. Microbiol. 1, 15005 (2016).","journal-title":"Nat. Microbiol."},{"key":"53994_CR77","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41564-020-00817-4","volume":"6","author":"R Hartmann","year":"2021","unstructured":"Hartmann, R. et al. Quantitative image analysis of microbial communities with BiofilmQ. Nat. Microbiol. 6, 151\u2013156 (2021).","journal-title":"Nat. Microbiol."},{"key":"53994_CR78","doi-asserted-by":"publisher","unstructured":"O\u2019Toole, G. A. Microtiter dish biofilm formation assay. J Vis Exp https:\/\/doi.org\/10.3791\/2437 (2011).","DOI":"10.3791\/2437"},{"key":"53994_CR79","doi-asserted-by":"publisher","first-page":"e1010746","DOI":"10.1371\/journal.pcbi.1010746","volume":"18","author":"QJ Leclerc","year":"2022","unstructured":"Leclerc, Q. J., Lindsay, J. A. & Knight, G. M. Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: Killers and drivers of resistance evolution. PLoS Comput Biol. 18, e1010746 (2022).","journal-title":"PLoS Comput Biol."},{"key":"53994_CR80","doi-asserted-by":"crossref","unstructured":"Yadav, B., Wennerberg, K., Aittokallio, T. & Tang, J. Searching for drug synergy in complex dose-response landscapes using an interaction potency model. Comput Struct Biotechnol J 13, 504-513 (2015).","DOI":"10.1016\/j.csbj.2015.09.001"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53994-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53994-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53994-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T06:07:43Z","timestamp":1732774063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-53994-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":80,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["53994"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-53994-9","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"30 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9987"}}