{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:23:40Z","timestamp":1793917420002,"version":"4.8.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273973"],"award-info":[{"award-number":["82273973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-55047-7","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:19:13Z","timestamp":1736759953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia"],"prefix":"10.1038","volume":"16","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Churan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-1195","authenticated-orcid":false,"given":"Jiong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-0946","authenticated-orcid":false,"given":"Ya-Zhen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-2134","authenticated-orcid":false,"given":"Kankan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-0436","authenticated-orcid":false,"given":"Hong-Hu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5634-6308","authenticated-orcid":false,"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"55047_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0609.1996.tb00483.x","volume":"57","author":"I Olsson","year":"1996","unstructured":"Olsson, I., Bergh, G., Ehinger, M. & Gullberg, U. Cell differentiation in acute myeloid leukemia. Eur. J. Haematol. 57, 1\u201316 (1996).","journal-title":"Eur. J. Haematol."},{"key":"55047_CR2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/s41416-019-0456-z","volume":"120","author":"X Chen","year":"2019","unstructured":"Chen, X. et al. A novel NPM1-RARG-NPM1 chimeric fusion in acute myeloid leukaemia resembling acute promyelocytic leukaemia but resistant to all-trans retinoic acid and arsenic trioxide. Br. J. Cancer 120, 1023\u20131025 (2019).","journal-title":"Br. J. Cancer"},{"key":"55047_CR3","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1056\/NEJMoa2024534","volume":"384","author":"EJ Duncavage","year":"2021","unstructured":"Duncavage, E. J. et al. Genome sequencing as an alternative to cytogenetic analysis in myeloid cancers. N. Engl. J. Med. 384, 924\u2013935 (2021).","journal-title":"N. Engl. J. Med."},{"key":"55047_CR4","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1182\/blood-2010-06-291658","volume":"117","author":"E Such","year":"2011","unstructured":"Such, E. et al. A novel NUP98\/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia. Blood 117, 242\u2013245 (2011).","journal-title":"Blood"},{"key":"55047_CR5","unstructured":"Zhu H. et al. A global study for acute myeloid leukemia with RARG rearrangement. Blood Adv. 7, 2972\u20132982 (2023)."},{"key":"55047_CR6","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1038\/leu.2017.167","volume":"31","author":"JS Ha","year":"2017","unstructured":"Ha, J. S. et al. Identification of a novel PML-RARG fusion in acute promyelocytic leukemia. Leukemia 31, 1992\u20131995 (2017).","journal-title":"Leukemia"},{"key":"55047_CR7","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1182\/blood-2017-11-818716","volume":"131","author":"T Liu","year":"2018","unstructured":"Liu, T. et al. Identification of novel recurrent CPSF6-RARG fusions in acute myeloid leukemia resembling acute promyelocytic leukemia. Blood 131, 1870\u20131873 (2018).","journal-title":"Blood"},{"key":"55047_CR8","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1182\/bloodadvances.2017014183","volume":"2","author":"CA Miller","year":"2018","unstructured":"Miller, C. A. et al. A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion. Blood Adv. 2, 1295\u20131299 (2018).","journal-title":"Blood Adv."},{"key":"55047_CR9","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1038\/s41375-018-0095-z","volume":"32","author":"YZ Qin","year":"2018","unstructured":"Qin, Y. Z., Huang, X. J. & Zhu, H. H. Identification of a novel CPSF6-RARG fusion transcript in acute myeloid leukemia resembling acute promyelocytic leukemia. Leukemia 32, 2285\u20132287 (2018).","journal-title":"Leukemia"},{"key":"55047_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.leukres.2018.12.009","volume":"77","author":"H Luo","year":"2019","unstructured":"Luo, H. et al. A novel entity of acute myeloid leukaemia with recurrent RARG-rearrangement resembling acute promyelocytic leukaemia. Leuk. Res. 77, 14\u201316 (2019).","journal-title":"Leuk. Res."},{"key":"55047_CR11","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1080\/10428194.2018.1553302","volume":"60","author":"X Zhang","year":"2019","unstructured":"Zhang, X. et al. RARgamma-rearrangements resemble acute promyelocytic leukemia and benefit from 3 + 7 regimen. Leuk. Lymphoma 60, 1831\u20131834 (2019).","journal-title":"Leuk. Lymphoma"},{"key":"55047_CR12","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/s41375-018-0338-z","volume":"33","author":"J Zhao","year":"2019","unstructured":"Zhao, J. et al. The genetics and clinical characteristics of children morphologically diagnosed as acute promyelocytic leukemia. Leukemia 33, 1387\u20131399 (2019).","journal-title":"Leukemia"},{"key":"55047_CR13","doi-asserted-by":"publisher","first-page":"e376","DOI":"10.3324\/haematol.2019.244715","volume":"105","author":"Z Su","year":"2020","unstructured":"Su, Z. et al. Novel reciprocal fusion genes involving HNRNPC and RARG in acute promyelocytic leukemia lacking RARA rearrangement. Haematologica 105, e376\u2013e378 (2020).","journal-title":"Haematologica"},{"key":"55047_CR14","doi-asserted-by":"publisher","first-page":"10559","DOI":"10.2147\/OTT.S273172","volume":"13","author":"S Tao","year":"2020","unstructured":"Tao, S. et al. Acute myeloid leukemia with NUP98-RARG gene fusion similar to acute promyelocytic leukemia: case report and literature review. Onco Targets Ther. 13, 10559\u201310566 (2020).","journal-title":"Onco Targets Ther."},{"key":"55047_CR15","doi-asserted-by":"publisher","first-page":"e22488","DOI":"10.1097\/MD.0000000000022488","volume":"99","author":"W Wei","year":"2020","unstructured":"Wei, W. et al. Alkaloid-based regimen is beneficial for acute myeloid leukemia resembling acute promyelocytic leukemia with NUP98\/RARG fusion and RUNX1 mutation: a case report. Medicine 99, e22488 (2020).","journal-title":"Medicine"},{"key":"55047_CR16","doi-asserted-by":"publisher","DOI":"10.1177\/2040620720976984","volume":"12","author":"X Han","year":"2021","unstructured":"Han, X. et al. Acute myeloid leukemia with CPSF6-RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration. Ther. Adv. Hematol. 12, 2040620720976984 (2021).","journal-title":"Ther. Adv. Hematol."},{"key":"55047_CR17","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1038\/leu.2014.334","volume":"29","author":"JJ Qiu","year":"2015","unstructured":"Qiu, J. J. et al. Critical role of retinoid\/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia. Leukemia 29, 1153\u20131162 (2015).","journal-title":"Leukemia"},{"key":"55047_CR18","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nrc2943","volume":"10","author":"H de The","year":"2010","unstructured":"de The, H. & Chen, Z. Acute promyelocytic leukaemia: novel insights into the mechanisms of cure. Nat. Rev. Cancer 10, 775\u2013783 (2010).","journal-title":"Nat. Rev. Cancer"},{"key":"55047_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2014.12.003","volume":"41","author":"A di Masi","year":"2015","unstructured":"di Masi, A. et al. Retinoic acid receptors: from molecular mechanisms to cancer therapy. Mol. Asp. Med. 41, 1\u2013115 (2015).","journal-title":"Mol. Asp. Med."},{"key":"55047_CR20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1385\/SCR:1:3:197","volume":"1","author":"S Sell","year":"2005","unstructured":"Sell, S. Leukemia: stem cells, maturation arrest, and differentiation therapy. Stem Cell Rev. 1, 197\u2013205 (2005).","journal-title":"Stem Cell Rev."},{"key":"55047_CR21","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fmolb.2019.00114","volume":"6","author":"MR Conserva","year":"2019","unstructured":"Conserva, M. R. et al. RARG gene dysregulation in acute myeloid leukemia. Front. Mol. Biosci. 6, 114 (2019).","journal-title":"Front. Mol. Biosci."},{"key":"55047_CR22","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1093\/emboj\/20.8.1897","volume":"20","author":"EllisenLW Carlesso","year":"2001","unstructured":"Carlesso, EllisenL. W., Cheng, N., Scadden, T. & Haber, D. T. DA. The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells. EMBO J. 20, 1897\u20131909 (2001).","journal-title":"EMBO J."},{"key":"55047_CR23","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.molcel.2014.12.023","volume":"57","author":"Y Wang","year":"2015","unstructured":"Wang, Y. et al. WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol. Cell 57, 662\u2013673 (2015).","journal-title":"Mol. Cell"},{"key":"55047_CR24","doi-asserted-by":"crossref","unstructured":"Sarma, N. J., Takeda, A. & Yaseen, N. R. Colony forming cell (CFC) assay for human hematopoietic cells. J. Vis. Exp. 46, 2195 (2010).","DOI":"10.3791\/2195-v"},{"key":"55047_CR25","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/leu.2010.42","volume":"24","author":"ER Yassin","year":"2010","unstructured":"Yassin, E. R., Abdul-Nabi, A. M., Takeda, A. & Yaseen, N. R. Effects of the NUP98-DDX10 oncogene on primary human CD34+ cells: role of a conserved helicase motif. Leukemia 24, 1001\u20131011 (2010).","journal-title":"Leukemia"},{"key":"55047_CR26","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1182\/blood-2002-05-1374","volume":"101","author":"BT Truong","year":"2003","unstructured":"Truong, B. T. et al. CCAAT\/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood 101, 1141\u20131148 (2003).","journal-title":"Blood"},{"key":"55047_CR27","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ccr.2009.12.045","volume":"17","author":"K Wang","year":"2010","unstructured":"Wang, K. et al. PML\/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell 17, 186\u2013197 (2010).","journal-title":"Cancer Cell"},{"key":"55047_CR28","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1182\/blood-2011-12-395350","volume":"119","author":"Z Hu","year":"2012","unstructured":"Hu, Z. & Saunthararajah, Y. CEBPE activation in PML-RARA cells by arsenic. Blood 119, 2177\u20132179 (2012).","journal-title":"Blood"},{"key":"55047_CR29","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1038\/onc.2013.224","volume":"33","author":"XW Yang","year":"2014","unstructured":"Yang, X. W. et al. Coordinated regulation of the immunoproteasome subunits by PML\/RARalpha and PU.1 in acute promyelocytic leukemia. Oncogene 33, 2700\u20132708 (2014).","journal-title":"Oncogene"},{"key":"55047_CR30","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1182\/blood.2020005698","volume":"137","author":"Y Tan","year":"2021","unstructured":"Tan, Y. et al. A PML\/RARalpha direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia. Blood 137, 1503\u20131516 (2021).","journal-title":"Blood"},{"key":"55047_CR31","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ccr.2006.01.005","volume":"9","author":"C Kwok","year":"2006","unstructured":"Kwok, C., Zeisig, B. B., Dong, S. & So, C. W. Forced homo-oligomerization of RARalpha leads to transformation of primary hematopoietic cells. Cancer Cell 9, 95\u2013108 (2006).","journal-title":"Cancer Cell"},{"key":"55047_CR32","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1073\/pnas.0810558106","volume":"106","author":"C Kwok","year":"2009","unstructured":"Kwok, C., Zeisig, B. B., Qiu, J., Dong, S. & So, C. W. Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes. Proc. Natl Acad. Sci. USA 106, 2853\u20132858 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"55047_CR33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ccr.2007.06.004","volume":"12","author":"J Zhu","year":"2007","unstructured":"Zhu, J. et al. RXR is an essential component of the oncogenic PML\/RARA complex in vivo. Cancer Cell 12, 23\u201335 (2007).","journal-title":"Cancer Cell"},{"key":"55047_CR34","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1182\/blood-2009-07-232652","volume":"115","author":"JJ Qiu","year":"2010","unstructured":"Qiu, J. J. et al. Leukemic transformation by the APL fusion protein PRKAR1A-RARalpha critically depends on recruitment of RXRalpha. Blood 115, 643\u2013652 (2010).","journal-title":"Blood"},{"key":"55047_CR35","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1016\/j.molcel.2021.05.008","volume":"81","author":"D Di Marcantonio","year":"2021","unstructured":"Di Marcantonio, D. et al. ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia. Mol. Cell 81, 2752\u20132764.e2756 (2021).","journal-title":"Mol. Cell"},{"key":"55047_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188569","volume":"1876","author":"L Zhang","year":"2021","unstructured":"Zhang, L., Lu, Z. & Zhao, X. Targeting Bcl-2 for cancer therapy. Biochim. Biophys. Acta Rev. Cancer 1876, 188569 (2021).","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"55047_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00425-3","volume":"11","author":"H Kantarjian","year":"2021","unstructured":"Kantarjian, H. et al. Acute myeloid leukemia: current progress and future directions. Blood Cancer J. 11, 41 (2021).","journal-title":"Blood Cancer J."},{"key":"55047_CR38","doi-asserted-by":"crossref","unstructured":"Geoffroy M. C., de The H. Classic and variants APLs, as viewed from a therapy response. Cancers 12, 967 (2020).","DOI":"10.3390\/cancers12040967"},{"key":"55047_CR39","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1182\/blood.2020010100","volume":"137","author":"MC Geoffroy","year":"2021","unstructured":"Geoffroy, M. C., Esnault, C. & de, TheH. Retinoids in hematology: a timely revival? Blood 137, 2429\u20132437 (2021).","journal-title":"Blood"},{"key":"55047_CR40","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1182\/blood.V94.2.793","volume":"94","author":"C Du","year":"1999","unstructured":"Du, C., Redner, R. L., Cooke, M. P. & Lavau, C. Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes. Blood 94, 793\u2013802 (1999).","journal-title":"Blood"},{"key":"55047_CR41","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.cell.2007.05.014","volume":"129","author":"CR Walkley","year":"2007","unstructured":"Walkley, C. R. et al. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell 129, 1097\u20131110 (2007).","journal-title":"Cell"},{"key":"55047_CR42","doi-asserted-by":"publisher","first-page":"16121","DOI":"10.1073\/pnas.1305937110","volume":"110","author":"G Ghiaur","year":"2013","unstructured":"Ghiaur, G. et al. Regulation of human hematopoietic stem cell self-renewal by the microenvironment\u2019s control of retinoic acid signaling. Proc. Natl Acad. Sci. USA 110, 16121\u201316126 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"55047_CR43","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1182\/blood.V91.8.2961.2961_2961_2968","volume":"91","author":"L King-Underwood","year":"1998","unstructured":"King-Underwood, L. & Pritchard-Jones, K. Wilms\u2019 tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood 91, 2961\u20132968 (1998).","journal-title":"Blood"},{"key":"55047_CR44","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1182\/blood-2008-12-192039","volume":"114","author":"V Tosello","year":"2009","unstructured":"Tosello, V. et al. WT1 mutations in T-ALL. Blood 114, 1038\u20131045 (2009).","journal-title":"Blood"},{"key":"55047_CR45","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/leu.2009.265","volume":"24","author":"S Abbas","year":"2010","unstructured":"Abbas, S., Erpelinck-Verschueren, C. A., Goudswaard, C. S., Lowenberg, B. & Valk, P. J. Mutant Wilms\u2019 tumor 1 (WT1) mRNA with premature termination codons in acute myeloid leukemia (AML) is sensitive to nonsense-mediated RNA decay (NMD). Leukemia 24, 660\u2013663 (2010).","journal-title":"Leukemia"},{"key":"55047_CR46","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nature10725","volume":"481","author":"J Zhang","year":"2012","unstructured":"Zhang, J. et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481, 157\u2013163 (2012).","journal-title":"Nature"},{"key":"55047_CR47","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1182\/blood-2018-03-837468","volume":"132","author":"E Pronier","year":"2018","unstructured":"Pronier, E. et al. Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis. Blood 132, 1265\u20131278 (2018).","journal-title":"Blood"},{"key":"55047_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).","journal-title":"Genome Biol."},{"key":"55047_CR49","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3389\/fgene.2015.00169","volume":"6","author":"DY Wu","year":"2015","unstructured":"Wu, D. Y., Bittencourt, D., Stallcup, M. R. & Siegmund, K. D. Identifying differential transcription factor binding in ChIP-seq. Front. Genet. 6, 169 (2015).","journal-title":"Front. Genet."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-55047-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-55047-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-55047-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T21:40:16Z","timestamp":1736804416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-55047-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["55047"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-55047-7","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"17 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"617"}}