{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:36:42Z","timestamp":1793320602137,"version":"4.5.0"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2022ZDZX0018"],"award-info":[{"award-number":["2022ZDZX0018"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023-YF09-00007-SN"],"award-info":[{"award-number":["2023-YF09-00007-SN"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYYC23027"],"award-info":[{"award-number":["ZYYC23027"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-024-55068-2","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T03:05:21Z","timestamp":1739156721000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5284-2889","authenticated-orcid":false,"given":"Chengdi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoufeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guonian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0985-0311","authenticated-orcid":false,"given":"Weimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"55068_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229\u2013263 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"55068_CR2","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nature25183","volume":"553","author":"RS Herbst","year":"2018","unstructured":"Herbst, R. S., Morgensztern, D. & Boshoff, C. The biology and management of non-small cell lung cancer. Nature 553, 446\u2013454 (2018).","journal-title":"Nature"},{"key":"55068_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.6004\/jnccn.2204.0023","volume":"22","author":"GJ Riely","year":"2024","unstructured":"Riely, G. J. et al. Non-small cell lung cancer, version 4.2024, NCCN clinical practice guidelines in oncology. J. Natl Compr. Canc Netw. 22, 249\u2013274 (2024).","journal-title":"J. Natl Compr. Canc Netw."},{"key":"55068_CR4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1056\/NEJMoa2212083","volume":"388","author":"N Altorki","year":"2023","unstructured":"Altorki, N. et al. Lobar or sublobar resection for peripheral stage IA non-small-cell lung cancer. N. Engl. J. Med. 388, 489\u2013498 (2023).","journal-title":"N. Engl. J. Med."},{"key":"55068_CR5","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3322\/caac.21498","volume":"68","author":"DA Mahvi","year":"2018","unstructured":"Mahvi, D. A., Liu, R., Grinstaff, M. W., Colson, Y. L. & Raut, C. P. Local cancer recurrence: the realities, challenges, and opportunities for new therapies. CA Cancer J. Clin. 68, 488\u2013505 (2018).","journal-title":"CA Cancer J. Clin."},{"key":"55068_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111047","volume":"40","author":"K Chen","year":"2022","unstructured":"Chen, K. et al. Spatiotemporal genomic analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers. Cell Rep. 40, 111047 (2022).","journal-title":"Cell Rep."},{"key":"55068_CR7","doi-asserted-by":"publisher","first-page":"e205601","DOI":"10.1001\/jamasurg.2020.5601","volume":"156","author":"GD Jones","year":"2021","unstructured":"Jones, G. D. et al. A genomic-pathologic annotated risk model to predict recurrence in early-stage lung adenocarcinoma. JAMA Surg. 156, e205601 (2021).","journal-title":"JAMA Surg."},{"key":"55068_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-6621-1","volume":"20","author":"C Wang","year":"2020","unstructured":"Wang, C., Wu, Y., Shao, J., Liu, D. & Li, W. Clinicopathological variables influencing overall survival, recurrence and post-recurrence survival in resected stage I non-small-cell lung cancer. BMC Cancer 20, 150 (2020).","journal-title":"BMC Cancer"},{"key":"55068_CR9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41571-020-0428-5","volume":"18","author":"O Ginsburg","year":"2021","unstructured":"Ginsburg, O., Ashton-Prolla, P., Cantor, A., Mariosa, D. & Brennan, P. The role of genomics in global cancer prevention. Nat. Rev. Clin. Oncol. 18, 116\u2013128 (2021).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"55068_CR10","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41568-020-0263-0","volume":"20","author":"TG Phan","year":"2020","unstructured":"Phan, T. G. & Croucher, P. I. The dormant cancer cell life cycle. Nat. Rev. Cancer 20, 398\u2013411 (2020).","journal-title":"Nat. Rev. Cancer"},{"key":"55068_CR11","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41586-023-05706-4","volume":"616","author":"C Mart\u00ednez-Ruiz","year":"2023","unstructured":"Mart\u00ednez-Ruiz, C. et al. Genomic\u2013transcriptomic evolution in lung cancer and metastasis. Nature 616, 543\u2013552 (2023).","journal-title":"Nature"},{"key":"55068_CR12","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/s41586-023-05729-x","volume":"616","author":"M Al Bakir","year":"2023","unstructured":"Al Bakir, M. et al. The evolution of non-small cell lung cancer metastases in TRACERx. Nature 616, 534\u2013542 (2023).","journal-title":"Nature"},{"key":"55068_CR13","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1056\/NEJMoa1616288","volume":"376","author":"M Jamal-Hanjani","year":"2017","unstructured":"Jamal-Hanjani, M. et al. Tracking the evolution of non-small-cell lung cancer. N. Engl. J. Med. 376, 2109\u20132121 (2017).","journal-title":"N. Engl. J. Med."},{"key":"55068_CR14","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jtho.2023.09.276","volume":"19","author":"X Wang","year":"2024","unstructured":"Wang, X. et al. Genetic intratumor heterogeneity remodels the immune microenvironment and induces immune evasion in brain metastasis of lung cancer. J. Thorac. Oncol. 19, 252\u2013272 (2024).","journal-title":"J. Thorac. Oncol."},{"key":"55068_CR15","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1056\/NEJMoa0706550","volume":"358","author":"MV Brock","year":"2008","unstructured":"Brock, M. V. et al. DNA methylation markers and early recurrence in stage I lung cancer. N. Engl. J. Med. 358, 1118\u20131128 (2008).","journal-title":"N. Engl. J. Med."},{"key":"55068_CR16","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/s41586-023-06253-8","volume":"619","author":"AM Kaiser","year":"2023","unstructured":"Kaiser, A. M. et al. p53 governs an AT1 differentiation programme in lung cancer suppression. Nature 619, 851\u2013859 (2023).","journal-title":"Nature"},{"key":"55068_CR17","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41586-022-05672-3","volume":"614","author":"M Sorin","year":"2023","unstructured":"Sorin, M. et al. Single-cell spatial landscapes of the lung tumour immune microenvironment. Nature 614, 548\u2013554 (2023).","journal-title":"Nature"},{"key":"55068_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33365-y","volume":"13","author":"Q Zhang","year":"2022","unstructured":"Zhang, Q. et al. The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis. Nat. Commun. 13, 5983 (2022).","journal-title":"Nat. Commun."},{"key":"55068_CR19","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.cell.2020.07.017","volume":"182","author":"A Maynard","year":"2020","unstructured":"Maynard, A. et al. Therapy-induced evolution of human lung cancer revealed by single-cell RNA sequencing. Cell 182, 1232\u20131251.e22 (2020).","journal-title":"Cell"},{"key":"55068_CR20","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519\u2013525 (2012).","DOI":"10.1038\/nature11404"},{"key":"55068_CR21","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511, 543\u2013550 (2014).","DOI":"10.1038\/nature13385"},{"key":"55068_CR22","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1016\/j.jtho.2020.06.001","volume":"15","author":"AL Moreira","year":"2020","unstructured":"Moreira, A. L. et al. A grading system for invasive pulmonary adenocarcinoma: a proposal from the International Association for the Study of Lung Cancer pathology committee. J. Thorac. Oncol. 15, 1599\u20131610 (2020).","journal-title":"J. Thorac. Oncol."},{"key":"55068_CR23","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1126\/science.aax3649","volume":"365","author":"S Boettcher","year":"2019","unstructured":"Boettcher, S. et al. A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science 365, 599\u2013604 (2019).","journal-title":"Science"},{"key":"55068_CR24","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","volume":"578","author":"LB Alexandrov","year":"2020","unstructured":"Alexandrov, L. B. et al. The repertoire of mutational signatures in human cancer. Nature 578, 94\u2013101 (2020).","journal-title":"Nature"},{"key":"55068_CR25","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41588-021-00865-4","volume":"53","author":"D Beyter","year":"2021","unstructured":"Beyter, D. et al. Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits. Nat. Genet. 53, 779\u2013786 (2021).","journal-title":"Nat. Genet."},{"key":"55068_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31133-6","volume":"13","author":"Y Sakamoto","year":"2022","unstructured":"Sakamoto, Y. et al. Phasing analysis of lung cancer genomes using a long read sequencer. Nat. Commun. 13, 3464 (2022).","journal-title":"Nat. Commun."},{"key":"55068_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43732-y","volume":"14","author":"Y Haga","year":"2023","unstructured":"Haga, Y. et al. Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma. Nat. Commun. 14, 8375 (2023).","journal-title":"Nat. Commun."},{"key":"55068_CR28","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3322\/caac.21765","volume":"73","author":"V Davalos","year":"2023","unstructured":"Davalos, V. & Esteller, M. Cancer epigenetics in clinical practice. CA Cancer J. Clin. 73, 376\u2013424 (2023).","journal-title":"CA Cancer J. Clin."},{"key":"55068_CR29","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41576-023-00601-0","volume":"24","author":"J Haerinck","year":"2023","unstructured":"Haerinck, J., Goossens, S. & Berx, G. The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation. Nat. Rev. Genet. 24, 590\u2013609 (2023).","journal-title":"Nat. Rev. Genet."},{"key":"55068_CR30","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/s41591-018-0323-0","volume":"25","author":"VH Teixeira","year":"2019","unstructured":"Teixeira, V. H. et al. Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions. Nat. Med 25, 517\u2013525 (2019).","journal-title":"Nat. Med"},{"key":"55068_CR31","doi-asserted-by":"publisher","first-page":"eaaj2239","DOI":"10.1126\/science.aaj2239","volume":"356","author":"Y Yin","year":"2017","unstructured":"Yin, Y. et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science 356, eaaj2239 (2017).","journal-title":"Science"},{"key":"55068_CR32","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/s41573-020-0070-z","volume":"19","author":"A Dey","year":"2020","unstructured":"Dey, A., Varelas, X. & Guan, K. L. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat. Rev. Drug Discov. 19, 480\u2013494 (2020).","journal-title":"Nat. Rev. Drug Discov."},{"key":"55068_CR33","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1038\/s41588-022-01119-7","volume":"54","author":"BK Wu","year":"2022","unstructured":"Wu, B. K., Mei, S. C., Chen, E. H., Zheng, Y. & Pan, D. YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis. Nat. Genet 54, 1202\u20131213 (2022).","journal-title":"Nat. Genet"},{"key":"55068_CR34","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.ccell.2021.06.016","volume":"39","author":"JD Pearson","year":"2021","unstructured":"Pearson, J. D. et al. Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP\/TEAD activity. Cancer Cell 39, 1115\u20131134.e12 (2021).","journal-title":"Cancer Cell"},{"key":"55068_CR35","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/s41417-021-00388-4","volume":"29","author":"S Li","year":"2022","unstructured":"Li, S., Jia, H., Zhang, Z. & Wu, D. DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP. Cancer Gene Ther. 29, 951\u2013960 (2022).","journal-title":"Cancer Gene Ther."},{"key":"55068_CR36","first-page":"64","volume":"38","author":"Y Lian","year":"2018","unstructured":"Lian, Y. et al. DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2. Cancer Commun. (Lond.) 38, 64 (2018).","journal-title":"Cancer Commun. (Lond.)"},{"key":"55068_CR37","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.ccell.2021.05.006","volume":"39","author":"A Chow","year":"2021","unstructured":"Chow, A. et al. Tim-4(+) cavity-resident macrophages impair anti-tumor CD8(+) T cell immunity. Cancer Cell 39, 973\u2013988.e9 (2021).","journal-title":"Cancer Cell"},{"key":"55068_CR38","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","volume":"166","author":"MA Nieto","year":"2016","unstructured":"Nieto, M. A., Huang, R. Y., Jackson, R. A. & Thiery, J. P. EMT: 2016. Cell 166, 21\u201345 (2016).","journal-title":"Cell"},{"key":"55068_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41568-018-0081-9","volume":"19","author":"NK Altorki","year":"2019","unstructured":"Altorki, N. K. et al. The lung microenvironment: an important regulator of tumour growth and metastasis. Nat. Rev. Cancer 19, 9\u201331 (2019).","journal-title":"Nat. Rev. Cancer"},{"key":"55068_CR40","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A Dongre","year":"2019","unstructured":"Dongre, A. & Weinberg, R. A. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat. Rev. Mol. Cell Biol. 20, 69\u201384 (2019).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"55068_CR41","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1161\/CIRCRESAHA.122.322332","volume":"132","author":"J Aman","year":"2023","unstructured":"Aman, J. & Margadant, C. Integrin-dependent cell-matrix adhesion in endothelial health and disease. Circ. Res 132, 355\u2013378 (2023).","journal-title":"Circ. Res"},{"key":"55068_CR42","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1016\/j.jtho.2016.08.120","volume":"11","author":"JL Pujol","year":"2016","unstructured":"Pujol, J. L. et al. Safety and immunogenicity of the PRAME cancer immunotherapeutic in patients with resected non-small cell lung cancer: a phase I dose escalation study. J. Thorac. Oncol. 11, 2208\u20132217 (2016).","journal-title":"J. Thorac. Oncol."},{"key":"55068_CR43","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1073\/pnas.1320383110","volume":"111","author":"S Mainardi","year":"2014","unstructured":"Mainardi, S. et al. Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proc. Natl Acad. Sci. USA 111, 255\u2013260 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"55068_CR44","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41586-020-2922-4","volume":"587","author":"KJ Travaglini","year":"2020","unstructured":"Travaglini, K. J. et al. A molecular cell atlas of the human lung from single-cell RNA sequencing. Nature 587, 619\u2013625 (2020).","journal-title":"Nature"},{"key":"55068_CR45","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/s41586-024-07113-9","volume":"627","author":"G Han","year":"2024","unstructured":"Han, G. et al. An atlas of epithelial cell states and plasticity in lung adenocarcinoma. Nature 627, 656\u2013663 (2024).","journal-title":"Nature"},{"key":"55068_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26770-2","volume":"12","author":"Z Wang","year":"2021","unstructured":"Wang, Z. et al. Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing. Nat. Commun. 12, 6500 (2021).","journal-title":"Nat. Commun."},{"key":"55068_CR47","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1016\/j.cell.2022.04.015","volume":"185","author":"D Yang","year":"2022","unstructured":"Yang, D. et al. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell 185, 1905\u20131923.e25 (2022).","journal-title":"Cell"},{"key":"55068_CR48","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41568-022-00546-2","volume":"23","author":"ST Barry","year":"2023","unstructured":"Barry, S. T., Gabrilovich, D. I., Sansom, O. J., Campbell, A. D. & Morton, J. P. Therapeutic targeting of tumour myeloid cells. Nat. Rev. Cancer 23, 216\u2013237 (2023).","journal-title":"Nat. Rev. Cancer"},{"key":"55068_CR49","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","volume":"184","author":"S Cheng","year":"2021","unstructured":"Cheng, S. et al. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell 184, 792\u2013809.e23 (2021).","journal-title":"Cell"},{"key":"55068_CR50","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41586-021-03651-8","volume":"595","author":"M Casanova-Acebes","year":"2021","unstructured":"Casanova-Acebes, M. et al. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature 595, 578\u2013584 (2021).","journal-title":"Nature"},{"key":"55068_CR51","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/s41580-023-00631-w","volume":"24","author":"L P\u00e9rez-Guti\u00e9rrez","year":"2023","unstructured":"P\u00e9rez-Guti\u00e9rrez, L. & Ferrara, N. Biology and therapeutic targeting of vascular endothelial growth factor A. Nat. Rev. Mol. Cell Biol. 24, 816\u2013834 (2023).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"55068_CR52","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41576-020-00292-x","volume":"22","author":"E Armingol","year":"2021","unstructured":"Armingol, E., Officer, A., Harismendy, O. & Lewis, N. E. Deciphering cell\u2013cell interactions and communication from gene expression. Nat. Rev. Genet. 22, 71\u201388 (2021).","journal-title":"Nat. Rev. Genet."},{"key":"55068_CR53","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","volume":"8","author":"ZL Liu","year":"2023","unstructured":"Liu, Z. L., Chen, H. H., Zheng, L. L., Sun, L. P. & Shi, L. Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduct. Target Ther. 8, 198 (2023).","journal-title":"Signal Transduct. Target Ther."},{"key":"55068_CR54","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.ccell.2024.06.009","volume":"42","author":"Y Chen","year":"2024","unstructured":"Chen, Y. et al. Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer. Cancer Cell 42, 1268\u20131285.e7 (2024).","journal-title":"Cancer Cell"},{"key":"55068_CR55","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/s41591-021-01450-2","volume":"27","author":"M Wang","year":"2021","unstructured":"Wang, M., Herbst, R. S. & Boshoff, C. Toward personalized treatment approaches for non-small-cell lung cancer. Nat. Med 27, 1345\u20131356 (2021).","journal-title":"Nat. Med"},{"key":"55068_CR56","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.ccell.2018.07.012","volume":"34","author":"E Stewart","year":"2018","unstructured":"Stewart, E. et al. Identification of therapeutic targets in rhabdomyosarcoma through integrated genomic, epigenomic, and proteomic analyses. Cancer Cell 34, 411\u2013426.e19 (2018).","journal-title":"Cancer Cell"},{"key":"55068_CR57","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nm.4107","volume":"22","author":"D Dauch","year":"2016","unstructured":"Dauch, D. et al. A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nat. Med 22, 744\u2013753 (2016).","journal-title":"Nat. Med"},{"key":"55068_CR58","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646\u2013674 (2011).","journal-title":"Cell"},{"key":"55068_CR59","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.ccell.2020.03.007","volume":"37","author":"A Marusyk","year":"2020","unstructured":"Marusyk, A., Janiszewska, M. & Polyak, K. Intratumor heterogeneity: the Rosetta Stone of therapy resistance. Cancer Cell 37, 471\u2013484 (2020).","journal-title":"Cancer Cell"},{"key":"55068_CR60","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/pcmedi\/pby007","volume":"1","author":"J Zhang","year":"2018","unstructured":"Zhang, J., Sp\u00e4th, S. S., Marjani, S. L., Zhang, W. & Pan, X. Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment. Precis Clin. Med. 1, 29\u201348 (2018).","journal-title":"Precis Clin. Med."},{"key":"55068_CR61","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.pccm.2022.11.001","volume":"1","author":"L Wang","year":"2023","unstructured":"Wang, L., Jia, Q., Chu, Q. & Zhu, B. Targeting tumor microenvironment for non-small cell lung cancer immunotherapy. Chin. Med J. Pulm. Crit. Care Med. 1, 18\u201329 (2023).","journal-title":"Chin. Med J. Pulm. Crit. Care Med."},{"key":"55068_CR62","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.cell.2017.01.018","volume":"168","author":"N McGranahan","year":"2017","unstructured":"McGranahan, N. & Swanton, C. Clonal heterogeneity and tumor evolution: past, present, and the future. Cell 168, 613\u2013628 (2017).","journal-title":"Cell"},{"key":"55068_CR63","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41571-024-00923-w","volume":"21","author":"DH Al-Rawi","year":"2024","unstructured":"Al-Rawi, D. H., Lettera, E., Li, J., DiBona, M. & Bakhoum, S. F. Targeting chromosomal instability in patients with cancer. Nat. Rev. Clin. Oncol. 21, 645\u2013659 (2024).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"55068_CR64","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/s41586-024-07177-7","volume":"627","author":"J George","year":"2024","unstructured":"George, J. et al. Evolutionary trajectories of small cell lung cancer under therapy. Nature 627, 880\u2013889 (2024).","journal-title":"Nature"},{"key":"55068_CR65","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/s43018-021-00230-8","volume":"2","author":"F Yang","year":"2021","unstructured":"Yang, F. et al. Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse. Nat. Cancer 2, 819\u2013834 (2021).","journal-title":"Nat. Cancer"},{"key":"55068_CR66","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/s41591-023-02230-w","volume":"29","author":"T Karasaki","year":"2023","unstructured":"Karasaki, T. et al. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nat. Med 29, 833\u2013845 (2023).","journal-title":"Nat. Med"},{"key":"55068_CR67","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41586-023-06303-1","volume":"620","author":"H Isozaki","year":"2023","unstructured":"Isozaki, H. et al. Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature 620, 393\u2013401 (2023).","journal-title":"Nature"},{"key":"55068_CR68","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nature14173","volume":"521","author":"F Supek","year":"2015","unstructured":"Supek, F. & Lehner, B. Differential DNA mismatch repair underlies mutation rate variation across the human genome. Nature 521, 81\u201384 (2015).","journal-title":"Nature"},{"key":"55068_CR69","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.ccell.2023.03.018","volume":"41","author":"HB Lengel","year":"2023","unstructured":"Lengel, H. B. et al. Genomic mapping of metastatic organotropism in lung adenocarcinoma. Cancer Cell 41, 970\u2013985.e3 (2023).","journal-title":"Cancer Cell"},{"key":"55068_CR70","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1016\/j.cell.2023.05.028","volume":"186","author":"H Guo","year":"2023","unstructured":"Guo, H. et al. DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs. Cell 186, 2765\u20132782.e28 (2023).","journal-title":"Cell"},{"key":"55068_CR71","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.cell.2018.11.046","volume":"176","author":"S Gkountela","year":"2019","unstructured":"Gkountela, S. et al. Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding. Cell 176, 98\u2013112.e14 (2019).","journal-title":"Cell"},{"key":"55068_CR72","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s43018-022-00361-6","volume":"3","author":"F Na","year":"2022","unstructured":"Na, F. et al. KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming. Nat. Cancer 3, 753\u2013767 (2022).","journal-title":"Nat. Cancer"},{"key":"55068_CR73","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/nature19771","volume":"538","author":"J Kim","year":"2016","unstructured":"Kim, J. et al. XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature 538, 114\u2013117 (2016).","journal-title":"Nature"},{"key":"55068_CR74","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ccell.2020.05.019","volume":"38","author":"Y Tang","year":"2020","unstructured":"Tang, Y. et al. Selective inhibition of STRN3-containing PP2A phosphatase restores Hippo tumor-suppressor activity in gastric cancer. Cancer Cell 38, 115\u2013128.e9 (2020).","journal-title":"Cancer Cell"},{"key":"55068_CR75","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.cell.2015.07.013","volume":"162","author":"HW Park","year":"2015","unstructured":"Park, H. W. et al. Alternative Wnt signaling activates YAP\/TAZ. Cell 162, 780\u2013794 (2015).","journal-title":"Cell"},{"key":"55068_CR76","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1158\/2159-8290.CD-23-1194","volume":"13","author":"YR Murciano-Goroff","year":"2023","unstructured":"Murciano-Goroff, Y. R., Suehnholz, S. P., Drilon, A. & Chakravarty, D. Precision oncology: 2023 in review. Cancer Discov. 13, 2525\u20132531 (2023).","journal-title":"Cancer Discov."},{"key":"55068_CR77","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1158\/2159-8290.CD-22-0966","volume":"13","author":"Y Pradat","year":"2023","unstructured":"Pradat, Y. et al. Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer. Cancer Discov. 13, 1116\u20131143 (2023).","journal-title":"Cancer Discov."},{"key":"55068_CR78","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-226","volume":"9","author":"F Wadelin","year":"2010","unstructured":"Wadelin, F. et al. Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia. Mol. Cancer 9, 226 (2010).","journal-title":"Mol. Cancer"},{"key":"55068_CR79","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cell.2005.07.003","volume":"122","author":"MT Epping","year":"2005","unstructured":"Epping, M. T. et al. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Cell 122, 835\u2013847 (2005).","journal-title":"Cell"},{"key":"55068_CR80","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1158\/0008-5472.CAN-17-3140","volume":"78","author":"D Orlando","year":"2018","unstructured":"Orlando, D. et al. Adoptive immunotherapy using PRAME-specific T cells in medulloblastoma. Cancer Res 78, 3337\u20133349 (2018).","journal-title":"Cancer Res"},{"key":"55068_CR81","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41994-0","volume":"14","author":"H Mumme","year":"2023","unstructured":"Mumme, H. et al. Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia. Nat. Commun. 14, 6209 (2023).","journal-title":"Nat. Commun."},{"key":"55068_CR82","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1182\/blood.2021014648","volume":"139","author":"S Naik","year":"2022","unstructured":"Naik, S. et al. Donor-derived multiple leukemia antigen-specific T-cell therapy to prevent relapse after transplant in patients with ALL. Blood 139, 2706\u20132711 (2022).","journal-title":"Blood"},{"key":"55068_CR83","volume":"3","author":"L Wen","year":"2022","unstructured":"Wen, L. et al. Single-cell technologies: from research to application. Innovation 3, 100342 (2022).","journal-title":"Innovation"},{"key":"55068_CR84","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1126\/science.aam6603","volume":"359","author":"AN Nabhan","year":"2018","unstructured":"Nabhan, A. N., Brownfield, D. G., Harbury, P. B., Krasnow, M. A. & Desai, T. J. Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells. Science 359, 1118\u20131123 (2018).","journal-title":"Science"},{"key":"55068_CR85","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj1415","volume":"383","author":"EE Gardner","year":"2024","unstructured":"Gardner, E. E. et al. Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science 383, eadj1415 (2024).","journal-title":"Science"},{"key":"55068_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33982-7","volume":"13","author":"X Ren","year":"2022","unstructured":"Ren, X. et al. Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinoma. Nat. Commun. 13, 6300 (2022).","journal-title":"Nat. Commun."},{"key":"55068_CR87","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1038\/s41591-020-1073-3","volume":"26","author":"D Cerezo-Wallis","year":"2020","unstructured":"Cerezo-Wallis, D. et al. Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nat. Med. 26, 1865\u20131877 (2020).","journal-title":"Nat. Med."},{"key":"55068_CR88","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","volume":"184","author":"Y Sun","year":"2021","unstructured":"Sun, Y. et al. Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma. Cell 184, 404\u2013421.e16 (2021).","journal-title":"Cell"},{"key":"55068_CR89","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1038\/s41591-023-02327-2","volume":"29","author":"L Sikkema","year":"2023","unstructured":"Sikkema, L. et al. An integrated cell atlas of the lung in health and disease. Nat. Med. 29, 1563\u20131577 (2023).","journal-title":"Nat. Med."},{"key":"55068_CR90","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.ccell.2022.02.013","volume":"40","author":"Y Liu","year":"2022","unstructured":"Liu, Y. et al. Immune phenotypic linkage between colorectal cancer and liver metastasis. Cancer Cell 40, 424\u2013437.e5 (2022).","journal-title":"Cancer Cell"},{"key":"55068_CR91","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.cell.2017.11.013","volume":"171","author":"RM Kortlever","year":"2017","unstructured":"Kortlever, R. M. et al. Myc cooperates with Ras by programming inflammation and immune suppression. Cell 171, 1301\u20131315.e14 (2017).","journal-title":"Cell"},{"key":"55068_CR92","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40727-7","volume":"14","author":"S Zhang","year":"2023","unstructured":"Zhang, S. et al. Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis. Nat. Commun. 14, 5123 (2023).","journal-title":"Nat. Commun."},{"key":"55068_CR93","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41571-024-00886-y","volume":"21","author":"HY Kuo","year":"2024","unstructured":"Kuo, H. Y., Khan, K. A. & Kerbel, R. S. Antiangiogenic-immune-checkpoint inhibitor combinations: lessons from phase III clinical trials. Nat. Rev. Clin. Oncol. 21, 468\u2013482 (2024).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"55068_CR94","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.cell.2023.12.004","volume":"187","author":"Q Liu","year":"2024","unstructured":"Liu, Q. et al. Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies. Cell 187, 184\u2013203.e28 (2024).","journal-title":"Cell"},{"key":"55068_CR95","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jtho.2024.02.011","volume":"19","author":"R Rami-Porta","year":"2024","unstructured":"Rami-Porta, R. et al. The International Association for the Study of Lung Cancer lung cancer staging project: proposals for revision of the TNM stage groups in the forthcoming (ninth) edition of the TNM classification for lung cancer. J. Thorac. Oncol. 19, 1007\u20131027 (2024).","journal-title":"J. Thorac. Oncol."},{"key":"55068_CR96","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1093\/bioinformatics\/btv098","volume":"31","author":"A Tarasov","year":"2015","unstructured":"Tarasov, A., Vilella, A. J., Cuppen, E., Nijman, I. J. & Prins, P. Sambamba: fast processing of NGS alignment formats. Bioinformatics 31, 2032\u20132034 (2015).","journal-title":"Bioinformatics"},{"key":"55068_CR97","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature12477","volume":"500","author":"LB Alexandrov","year":"2013","unstructured":"Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415\u2013421 (2013).","journal-title":"Nature"},{"key":"55068_CR98","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/annonc\/mdu479","volume":"26","author":"F Favero","year":"2015","unstructured":"Favero, F. et al. Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data. Ann. Oncol. 26, 64\u201370 (2015).","journal-title":"Ann. Oncol."},{"key":"55068_CR99","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nmeth.2883","volume":"11","author":"A Roth","year":"2014","unstructured":"Roth, A. et al. PyClone: statistical inference of clonal population structure in cancer. Nat. Methods 11, 396\u2013398 (2014).","journal-title":"Nat. Methods"},{"key":"55068_CR100","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-018-0066-6","volume":"4","author":"Z Sztupinszki","year":"2018","unstructured":"Sztupinszki, Z. et al. Migrating the SNP array-based homologous recombination deficiency measures to next generation sequencing data of breast cancer. npj Breast Cancer 4, 16 (2018).","journal-title":"npj Breast Cancer"},{"key":"55068_CR101","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.1093\/bioinformatics\/bty191","volume":"34","author":"H Li","year":"2018","unstructured":"Li, H. Minimap2: pairwise alignment for nucleotide sequences. Bioinformatics 34, 3094\u20133100 (2018).","journal-title":"Bioinformatics"},{"key":"55068_CR102","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nmeth.4184","volume":"14","author":"JT Simpson","year":"2017","unstructured":"Simpson, J. T. et al. Detecting DNA cytosine methylation using nanopore sequencing. Nat. Methods 14, 407\u2013410 (2017).","journal-title":"Nat. Methods"},{"key":"55068_CR103","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576\u2013589 (2010).","journal-title":"Mol. Cell"},{"key":"55068_CR104","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1093\/bioinformatics\/bty304","volume":"34","author":"V Geoffroy","year":"2018","unstructured":"Geoffroy, V. et al. AnnotSV: an integrated tool for structural variations annotation. Bioinformatics 34, 3572\u20133574 (2018).","journal-title":"Bioinformatics"},{"key":"55068_CR105","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1101\/gr.135350.111","volume":"22","author":"J Harrow","year":"2012","unstructured":"Harrow, J. et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res. 22, 1760\u20131774 (2012).","journal-title":"Genome Res."},{"key":"55068_CR106","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","volume":"8","author":"CS McGinnis","year":"2019","unstructured":"McGinnis, C. S., Murrow, L. M. & Gartner, Z. J. DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors. Cell Syst. 8, 329\u2013337.e4 (2019).","journal-title":"Cell Syst."},{"key":"55068_CR107","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky, I. et al. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat. Methods 16, 1289\u20131296 (2019).","journal-title":"Nat. Methods"},{"key":"55068_CR108","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nbt.2859","volume":"32","author":"C Trapnell","year":"2014","unstructured":"Trapnell, C. et al. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat. Biotechnol. 32, 381\u2013386 (2014).","journal-title":"Nat. Biotechnol."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-55068-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-55068-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-55068-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T03:53:41Z","timestamp":1739159621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-024-55068-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":108,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["55068"],"URL":"https:\/\/doi.org\/10.1038\/s41467-024-55068-2","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"assertion":[{"value":"27 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1477"}}