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The results revealed novel (<jats:italic>N<\/jats:italic>\u2009=\u200967) and known (<jats:italic>N<\/jats:italic>\u2009=\u200920) genome-wide significant loci associated with CBP, with 43 independent variants replicating in a non-overlapping contemporary meta-GWAS of the spinal pain dorsalgia phenotype. The most significant novel variant\u00a0was\u00a0rs12533005 (chr7:114416000, <jats:italic>p<\/jats:italic>\u2009=\u20091.61\u2009\u00d7\u200910<jats:sup>\u221220<\/jats:sup>, OR\u2009=\u20090.96 (95% CI: 0.95\u20130.97), EA\u2009=\u2009C, EAF\u2009=\u20090.39), in an intron of the <jats:italic>FOXP2<\/jats:italic> gene. In silico functional characterization revealed enrichment in brain and pituitary tissues. Mendelian randomization analysis of 62 variants for CBP-MVP revealed 48 with causal links to dorsalgia. Notably, four genes (<jats:italic>INPP5B, DRD2, HTT, SLC30A6<\/jats:italic>) associated with these variants are targets of existing drugs. Our findings more than double the number of previously reported genetic predictors across all spinal pain phenotypes.<\/jats:p>","DOI":"10.1038\/s41467-024-55326-3","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T16:25:21Z","timestamp":1739291121000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-0918","authenticated-orcid":false,"given":"Ian B.","family":"Stanaway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Suri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Afari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-5124","authenticated-orcid":false,"given":"Daniel","family":"Dochtermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Gerstenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-3762","authenticated-orcid":false,"given":"Saiju","family":"Pyarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Roseen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Million Veteran Program","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4112-5232","authenticated-orcid":false,"given":"Marianna","family":"Gasperi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"55326_CR1","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1001\/jama.2018.0158","volume":"319","author":"AH Mokdad","year":"2018","unstructured":"Mokdad, A. 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