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Methods"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-57446-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-57446-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-57446-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T12:56:01Z","timestamp":1743944161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-57446-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["57446"],"URL":"https:\/\/doi.org\/10.1038\/s41467-025-57446-w","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"11 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.A.S. and R.H.M. are cofounders of Vellum Biosciences and inventors on intellectual property (IP) related to the PET imaging of genetic therapies. A provisional patent related to this work has been filed with the USPTO (63\/637301) on which M.A.S., G.B., M.G.A., G.D., R.H.M., and D.W. are inventors. Y.T. is an employee of Acuitas, holds equity at Acuitas, and is cited on multiple patents for the use of lipid nanoparticles in vaccines and therapeutics. M.G.A. and D.W. are cited on multiple patents for the use of lipid nanoparticles, vaccines and therapeutics. M.G.A. serves as a scientific adviser for AfriGen Biologics, and also has an ownership stake in RNA Technologies. D.W. serves as a scientific advisor for Arcturus Therapeutics, Cabaletta Bio, and Versatope Therapeutics, and also has ownership stakes in Capstan Therapeutics, Orbital Therapeutics, Zipcode Bio, and RNA Technologies. D.W. receives royalties from CellScript and Capstan Therapeutics. All senior authors declare no conflicts of interest. In accordance with the University of Pennsylvania and Children\u2019s Hospital of Philadelphia policies and procedures and our ethical obligations as researchers, we have disclosed those interests fully to the University of Pennsylvania and the Children Hospital of Philadelphia and have in place an approved plan for managing any potential conflicts arising from licensing of the patents.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2234"}}