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In the pericentriolar material, the \u03b3-TuRC is involved in microtubule organization, while the function of the centriole lumenal pool remains unclear. The conformational landscape of the \u03b3-TuRC, which is crucial for its activity, and its centrosomal anchoring mechanisms, which determine \u03b3-TuRC activity and turnover, are not understood. Using cryo-electron tomography, we analyze \u03b3-TuRCs in human cells and purified centrosomes. Pericentriolar \u03b3-TuRCs simultaneously associate with the essential adapter NEDD1 and the microcephaly protein CDK5RAP2. NEDD1 forms a tetrameric structure at the \u03b3-TuRC base through interactions with four GCP3\/MZT1 modules and GCP5\/6-specific extensions, while multiple copies of CDK5RAP2 engage the \u03b3-TuRC in two distinct binding patterns to promote \u03b3-TuRC closure and activation. In the centriole lumen, the microtubule branching factor Augmin tethers a condensed cluster of \u03b3-TuRCs to the centriole wall with defined directional orientation. Centriole-lumenal \u03b3-TuRC-Augmin is protected from degradation during interphase and released in mitosis to aid chromosome alignment. 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