{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:29:37Z","timestamp":1794029377590,"version":"4.8.0"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-025-61346-4","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T16:36:47Z","timestamp":1751906207000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-7787","authenticated-orcid":false,"given":"Damien","family":"Restagno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Saraswat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-100X","authenticated-orcid":false,"given":"Peter V.","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-7398","authenticated-orcid":false,"given":"John","family":"Hintze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-1649","authenticated-orcid":false,"given":"Jamey D.","family":"Marth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"61346_CR1","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1189\/jlb.0512231","volume":"92","author":"L Martinez-Pomares","year":"2012","unstructured":"Martinez-Pomares, L. The mannose receptor. J. Leukoc. Biol. 92, 1177\u20131186 (2012).","journal-title":"J. Leukoc. Biol."},{"key":"61346_CR2","doi-asserted-by":"publisher","first-page":"102394","DOI":"10.1016\/j.sbi.2022.102394","volume":"75","author":"RD Cummings","year":"2022","unstructured":"Cummings, R. D. The mannose receptor ligands and the macrophage glycome. Curr. Opin. Struct. Biol. 75, 102394 (2022).","journal-title":"Curr. Opin. Struct. Biol."},{"key":"61346_CR3","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/S0021-9258(18)46005-X","volume":"267","author":"ME Taylor","year":"1992","unstructured":"Taylor, M. E., Bezouska, K. & Drickamer, K. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. J. Biol. Chem. 267, 1719\u20131726 (1992).","journal-title":"J. Biol. Chem."},{"key":"61346_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1146\/annurev.bi.54.070185.003215","volume":"54","author":"R Kornfeld","year":"1985","unstructured":"Kornfeld, R. & Kornfeld, S. Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 54, 631\u2013664 (1985).","journal-title":"Annu. Rev. Biochem."},{"key":"61346_CR5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/immu.200310024","volume":"33","author":"DG Nguyen","year":"2003","unstructured":"Nguyen, D. G. & Hildreth, J. E. K. Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages. Eur. J. Immunol. 33, 483\u2013493 (2003).","journal-title":"Eur. J. Immunol."},{"key":"61346_CR6","doi-asserted-by":"publisher","first-page":"41613","DOI":"10.1074\/jbc.M207057200","volume":"277","author":"S Zamze","year":"2002","unstructured":"Zamze, S. et al. Recognition of Bacterial Capsular Polysaccharides and Lipopolysaccharides by the Macrophage Mannose Receptor. J. Biol. Chem. 277, 41613\u201341623 (2002).","journal-title":"J. Biol. Chem."},{"key":"61346_CR7","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1128\/IAI.00095-08","volume":"76","author":"JM Dan","year":"2008","unstructured":"Dan, J. M., Kelly, R. M., Lee, C. K. & Levitz, S. M. Role of the mannose receptor in a murine model of Cryptococcus neoformans infection. Infect. Immun. 76, 2362\u20132367 (2008).","journal-title":"Infect. Immun."},{"key":"61346_CR8","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/j.ijpara.2011.08.005","volume":"41","author":"RA Paveley","year":"2011","unstructured":"Paveley, R. A. et al. The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFN\u03b3 production. Int. J. Parasitol. 41, 1335\u20131345 (2011).","journal-title":"Int. J. Parasitol."},{"key":"61346_CR9","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1084\/jem.191.7.1117","volume":"191","author":"C Leteux","year":"2000","unstructured":"Leteux, C. et al. The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates a and b and sulfated oligosaccharides of blood group lewisa and lewisx types in addition to the sulfated N -glycans of lutropin.  J. Exp. Med. 191, 1117\u20131126 (2000).","journal-title":"J. Exp. Med."},{"key":"61346_CR10","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1042\/BJ20052027","volume":"395","author":"CE Napper","year":"2006","unstructured":"Napper, C. E., Drickamer, K. & Taylor, M. E. Collagen binding by the mannose receptor mediated through the fibronectin type II domain. Biochem. J. 395, 579\u2013586 (2006).","journal-title":"Biochem. J."},{"key":"61346_CR11","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1126\/science.1069540","volume":"295","author":"SJ Lee","year":"2002","unstructured":"Lee, S. J. et al. Mannose receptor-mediated regulation of serum glycoprotein homeostasis. Science 295, 1898\u20131901 (2002).","journal-title":"Science"},{"key":"61346_CR12","doi-asserted-by":"publisher","first-page":"13931","DOI":"10.1016\/S0021-9258(18)92791-2","volume":"266","author":"M Otter","year":"1991","unstructured":"Otter, M., Barrett-Bergshoeff, M. M. & Rijken, D. C. Binding of tissue-type plasminogen activator by the mannose receptor. J. Biol. Chem. 266, 13931\u201313935 (1991).","journal-title":"J. Biol. Chem."},{"key":"61346_CR13","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1165\/ajrcmb\/2.4.335","volume":"2","author":"VL Shepherd","year":"1990","unstructured":"Shepherd, V. L. & Hoidal, J. R. Clearance of neutrophil-derived myeloperoxidase by the macrophage mannose receptor. Am. J. Respir. Cell Mol. Biol. 2, 335\u2013340 (1990).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"61346_CR14","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1002\/1521-4141(200106)31:6<1857::AID-IMMU1857>3.0.CO;2-D","volume":"31","author":"SA Linehan","year":"2001","unstructured":"Linehan, S. A., Mart\u00ednez-Pomares, L., Silva, R. P. da & Gordon, S. Endogenous ligands of carbohydrate recognition domains of the mannose receptor in murine macrophages, endothelial cells and secretory cells; potential relevance to inflammation and immunity. Eur. J. Immunol. 31, 1857\u20131866 (2001).","journal-title":"Eur. J. Immunol."},{"key":"61346_CR15","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.1182\/blood-2011-09-377754","volume":"119","author":"N Sorvillo","year":"2012","unstructured":"Sorvillo, N. et al. The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells. Blood 119, 3828\u20133835 (2012).","journal-title":"Blood"},{"key":"61346_CR16","doi-asserted-by":"publisher","first-page":"G349","DOI":"10.1152\/ajpgi.1991.261.2.G349","volume":"261","author":"DL Marks","year":"1991","unstructured":"Marks, D. L., Kost, L. J., Kuntz, S. M., Romero, J. C. & LaRusso, N. F. Hepatic processing of recombinant human renin: mechanisms of uptake and degradation. Am. J. Physiol. -Gastrointest. Liver Physiol. 261, G349\u2013G358 (1991).","journal-title":"Am. J. Physiol. -Gastrointest. Liver Physiol."},{"key":"61346_CR17","doi-asserted-by":"publisher","first-page":"13657","DOI":"10.1073\/pnas.1515464112","volume":"112","author":"WH Yang","year":"2015","unstructured":"Yang, W. H. et al. An intrinsic mechanism of secreted protein aging and turnover. Proc. Natl. Acad. Sci. USA.112, 13657\u201313662 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"61346_CR18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1042\/bj1760103","volume":"176","author":"PH Schlesinger","year":"1978","unstructured":"Schlesinger, P. H. et al. Plasma clearance of glycoproteins with terminal mannose and N -acetylglucosamine by liver non-parenchymal cells. Studies with \u03b2 -glucuronidase, N -acetyl- \u03b2 - d -glucosaminidase, ribonuclease B and agalacto-orosomucoid. Biochemical J. 176, 103\u2013109 (1978).","journal-title":"Biochemical J."},{"key":"61346_CR19","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1021\/bi00171a015","volume":"33","author":"DK Mandal","year":"1994","unstructured":"Mandal, D. K. et al. Studies of the Binding Specificity of Concanavalin A. Nature of the Extended Binding Site for Asparagine-Linked Carbohydrates. Biochemistry 33, 1157\u20131162 (1994).","journal-title":"Biochemistry"},{"key":"61346_CR20","doi-asserted-by":"publisher","first-page":"100368","DOI":"10.1016\/j.jbc.2021.100368","volume":"296","author":"H Feinberg","year":"2021","unstructured":"Feinberg, H. et al. Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J. Biol. Chem. 296, 100368 (2021).","journal-title":"J. Biol. Chem."},{"key":"61346_CR21","doi-asserted-by":"crossref","unstructured":"Miller, M. A. & Zachary, J. F. Mechanisms and Morphology of Cellular Injury, Adaptation, and Death. in Pathologic Basis of Veterinary Disease 2-43.e19 (Elsevier, 2017).","DOI":"10.1016\/B978-0-323-35775-3.00001-1"},{"key":"61346_CR22","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/s41581-023-00752-7","volume":"19","author":"S Tanaka","year":"2023","unstructured":"Tanaka, S., Portilla, D. & Okusa, M. D. Role of perivascular cells in kidney homeostasis, inflammation, repair and fibrosis. Nat. Rev. Nephrol. 19, 721\u2013732 (2023).","journal-title":"Nat. Rev. Nephrol."},{"key":"61346_CR23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2174\/1568026611313020004","volume":"13","author":"N Anatoliotakis","year":"2013","unstructured":"Anatoliotakis, N. et al. Myeloperoxidase: expressing inflammation and oxidative stress in cardiovascular disease. CTMC 13, 115\u2013138 (2013).","journal-title":"CTMC"},{"key":"61346_CR24","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1158\/1078-0432.CCR-06-2416","volume":"13","author":"LS Angelo","year":"2007","unstructured":"Angelo, L. S. & Kurzrock, R. Vascular endothelial growth factor and its relationship to inflammatory mediators. Clin. Cancer Res. 13, 2825\u20132830 (2007).","journal-title":"Clin. Cancer Res."},{"key":"61346_CR25","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1038\/s41440-023-01402-y","volume":"46","author":"AH Behnoush","year":"2023","unstructured":"Behnoush, A. H. et al. Endocan as a marker of endothelial dysfunction in hypertension: a systematic review and meta-analysis. Hypertens. Res 46, 2388\u20132399 (2023).","journal-title":"Hypertens. Res"},{"key":"61346_CR26","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1016\/j.ajpath.2018.08.005","volume":"188","author":"P Bus","year":"2018","unstructured":"Bus, P. et al. Endoglin mediates vascular endothelial growth factor-A\u2013induced endothelial cell activation by regulating Akt signaling.  Am. J. Pathol. 188, 2924\u20132935 (2018).","journal-title":"Am. J. Pathol."},{"key":"61346_CR27","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.jss.2023.10.010","volume":"295","author":"MR Baucom","year":"2024","unstructured":"Baucom, M. R. et al. Syndecan-1 as the effect or effector of the endothelial inflammatory response?. J. Surgical Res. 295, 611\u2013618 (2024).","journal-title":"J. Surgical Res."},{"key":"61346_CR28","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.jcyt.2022.02.001","volume":"24","author":"S Kobashi","year":"2022","unstructured":"Kobashi, S., Terashima, T., Katagi, M., Urushitani, M. & Kojima, H. Bone marrow-derived inducible microglia-like cells ameliorate motor function and survival in a mouse model of amyotrophic lateral sclerosis. Cytotherapy 24, 789\u2013801 (2022).","journal-title":"Cytotherapy"},{"key":"61346_CR29","doi-asserted-by":"publisher","first-page":"17513","DOI":"10.1073\/pnas.0602841103","volume":"103","author":"U Wilhelmsson","year":"2006","unstructured":"Wilhelmsson, U. et al. Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury. Proc. Natl. Acad. Sci. Usa. 103, 17513\u201317518 (2006).","journal-title":"Proc. Natl. Acad. Sci. Usa."},{"key":"61346_CR30","doi-asserted-by":"crossref","unstructured":"Facci, L., Barbierato, M. & Skaper, S. D. Astrocyte\/Microglia Cocultures as a Model to Study Neuroinflammation. in Neurotrophic Factors (ed. Skaper, S. D.) 1727, 127\u2013137 (Springer New York, New York, NY, 2018).","DOI":"10.1007\/978-1-4939-7571-6_10"},{"key":"61346_CR31","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1128\/CMR.00047-08","volume":"22","author":"I Vanlaere","year":"2009","unstructured":"Vanlaere, I. & Libert, C. Matrix Metalloproteinases as Drug Targets in Infections Caused by Gram-Negative Bacteria and in Septic Shock. Clin. Microbiol Rev. 22, 224\u2013239 (2009).","journal-title":"Clin. Microbiol Rev."},{"key":"61346_CR32","doi-asserted-by":"publisher","first-page":"23376","DOI":"10.1074\/jbc.273.36.23376","volume":"273","author":"L Mart\u0131\u0301nez-Pomares","year":"1998","unstructured":"Mart\u0131\u0301nez-Pomares, L. et al. A functional soluble form of the murine mannose receptor is produced by macrophages in vitro and is present in mouse serum. J. Biol. Chem. 273, 23376\u201323380 (1998).","journal-title":"J. Biol. Chem."},{"key":"61346_CR33","doi-asserted-by":"publisher","first-page":"964","DOI":"10.62347\/FZMM3162","volume":"16","author":"D Song","year":"2024","unstructured":"Song, D. & Zheng, X. Serum monocyte chemotactic protein 1 and soluble mannose receptor aid predictive diagnosis of pediatric sepsis. Am. J. Transl. Res 16, 964\u2013972 (2024).","journal-title":"Am. J. Transl. Res"},{"key":"61346_CR34","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1186\/s12887-021-02930-7","volume":"21","author":"NA Hassuna","year":"2021","unstructured":"Hassuna, N. A. et al. Diagnostic value of monocyte chemoattractant Protein-1, soluble mannose receptor, Presepsin, and Procalcitonin in critically ill children admitted with suspected sepsis. BMC Pediatr. 21, 458 (2021).","journal-title":"BMC Pediatr."},{"key":"61346_CR35","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.chom.2018.09.011","volume":"24","author":"WH Yang","year":"2018","unstructured":"Yang, W. H. et al. Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis. Cell Host Microbe 24, 500\u2013513.e5 (2018).","journal-title":"Cell Host Microbe"},{"key":"61346_CR36","doi-asserted-by":"publisher","first-page":"eabd6737","DOI":"10.1126\/scitranslmed.abd6737","volume":"13","author":"J Sun","year":"2021","unstructured":"Sun, J. et al. Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia. Sci. Transl. Med. 13, eabd6737 (2021).","journal-title":"Sci. Transl. Med."},{"key":"61346_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10261","volume":"7","author":"E Malmstr\u00f6m","year":"2016","unstructured":"Malmstr\u00f6m, E. et al. Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics. Nat. Commun. 7, 10261 (2016).","journal-title":"Nat. Commun."},{"key":"61346_CR38","doi-asserted-by":"publisher","first-page":"8652","DOI":"10.18632\/aging.103184","volume":"12","author":"YR Yang","year":"2020","unstructured":"Yang, Y. R. et al. Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss. Aging (Albany NY) 12, 8652\u20138668 (2020).","journal-title":"Aging (Albany NY)"},{"key":"61346_CR39","doi-asserted-by":"publisher","first-page":"100615","DOI":"10.1016\/j.mcpro.2023.100615","volume":"22","author":"M Svecla","year":"2023","unstructured":"Svecla, M. et al. Impact of asialoglycoprotein receptor and mannose receptor deficiency on murine plasma N-glycome profiles. Mol. Cell. Proteom. 22, 100615 (2023).","journal-title":"Mol. Cell. Proteom."},{"key":"61346_CR40","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/sj.jhh.1002101","volume":"21","author":"P Dandona","year":"2007","unstructured":"Dandona, P., Dhindsa, S., Ghanim, H. & Chaudhuri, A. Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade. J. Hum. Hypertens. 21, 20\u201327 (2007).","journal-title":"J. Hum. Hypertens."},{"key":"61346_CR41","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/S0735-1097(03)00846-5","volume":"42","author":"KK Koh","year":"2003","unstructured":"Koh, K. K. et al. Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients. J. Am. Coll. Cardiol. 42, 905\u2013910 (2003).","journal-title":"J. Am. Coll. Cardiol."},{"key":"61346_CR42","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1161\/01.ATV.20.3.645","volume":"20","author":"ME Pueyo","year":"2000","unstructured":"Pueyo, M. E. et al. Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-\u03bab activation induced by intracellular oxidative stress. ATVB 20, 645\u2013651 (2000).","journal-title":"ATVB"},{"key":"61346_CR43","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.coph.2010.01.006","volume":"10","author":"DG Harrison","year":"2010","unstructured":"Harrison, D. G., Vinh, A., Lob, H. & Madhur, M. S. Role of the adaptive immune system in hypertension. Curr. Opin. Pharmacol. 10, 203\u2013207 (2010).","journal-title":"Curr. Opin. Pharmacol."},{"key":"61346_CR44","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1161\/01.ATV.0000163262.83456.6d","volume":"25","author":"SJ Nicholls","year":"2005","unstructured":"Nicholls, S. J. & Hazen, S. L. Myeloperoxidase and cardiovascular disease. ATVB 25, 1102\u20131111 (2005).","journal-title":"ATVB"},{"key":"61346_CR45","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1089\/ars.2012.4783","volume":"18","author":"C Nussbaum","year":"2013","unstructured":"Nussbaum, C., Klinke, A., Adam, M., Baldus, S. & Sperandio, M. Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease. Antioxid. Redox Signal. 18, 692\u2013713 (2013).","journal-title":"Antioxid. Redox Signal."},{"key":"61346_CR46","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1126\/science.1106830","volume":"296","author":"JP Eiserich","year":"2002","unstructured":"Eiserich, J. P. et al. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science 296, 2391\u20132394 (2002).","journal-title":"Science"},{"key":"61346_CR47","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1084\/jem.20021426","volume":"197","author":"AT Askari","year":"2003","unstructured":"Askari, A. T. et al. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction.  J. Exp. Med. 197, 615\u2013624 (2003).","journal-title":"J. Exp. Med."},{"key":"61346_CR48","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/SHK.0000000000000320","volume":"43","author":"LA Cox","year":"2015","unstructured":"Cox, L. A. et al. Inflammation-induced increases in plasma endocan levels are associated with endothelial dysfunction in humans in vivo. Shock 43, 322\u2013326 (2015).","journal-title":"Shock"},{"key":"61346_CR49","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1161\/ATVBAHA.118.311143","volume":"38","author":"K Manchanda","year":"2018","unstructured":"Manchanda, K. et al. MPO (Myeloperoxidase) reduces endothelial glycocalyx thickness dependent on its cationic charge. ATVB 38, 1859\u20131867 (2018).","journal-title":"ATVB"},{"key":"61346_CR50","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1161\/01.HYP.0000138688.78906.6b","volume":"44","author":"Q Zhao","year":"2004","unstructured":"Zhao, Q. et al. Essential role of vascular endothelial growth factor in angiotensin II\u2013induced vascular inflammation and remodeling. Hypertension 44, 264\u2013270 (2004).","journal-title":"Hypertension"},{"key":"61346_CR51","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1182\/blood-2012-06-435347","volume":"121","author":"E Rossi","year":"2013","unstructured":"Rossi, E. et al. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood 121, 403\u2013415 (2013).","journal-title":"Blood"},{"key":"61346_CR52","doi-asserted-by":"crossref","unstructured":"Scott, D. W. et al. Role of endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis. ATVB 32, e51-9 (2012).","DOI":"10.1161\/ATVBAHA.112.253203"},{"key":"61346_CR53","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/glycob\/cwt014","volume":"23","author":"DW Scott","year":"2013","unstructured":"Scott, D. W. & Patel, R. P. Endothelial heterogeneity and adhesion molecules N-glycosylation: implications in leukocyte trafficking in inflammation. Glycobiology 23, 622\u2013633 (2013).","journal-title":"Glycobiology"},{"key":"61346_CR54","doi-asserted-by":"publisher","first-page":"C719","DOI":"10.1152\/ajpcell.2001.280.4.C719","volume":"280","author":"H Lum","year":"2001","unstructured":"Lum, H. & Roebuck, K. A. Oxidant stress and endothelial cell dysfunction. Am. J. Physiol. -Cell Physiol. 280, C719\u2013C741 (2001).","journal-title":"Am. J. Physiol. -Cell Physiol."},{"key":"61346_CR55","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.immuni.2017.09.010","volume":"47","author":"I Zanoni","year":"2017","unstructured":"Zanoni, I., Tan, Y., Di Gioia, M., Springstead, J. R. & Kagan, J. C. By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation. Immunity 47, 697\u2013709.e3 (2017).","journal-title":"Immunity"},{"key":"61346_CR56","doi-asserted-by":"publisher","first-page":"24748","DOI":"10.1074\/jbc.M800352200","volume":"283","author":"C Erridge","year":"2008","unstructured":"Erridge, C., Kennedy, S., Spickett, C. M. & Webb, D. J. Oxidized Phospholipid Inhibition of Toll-like Receptor (TLR) Signaling Is Restricted to TLR2 and TLR4. J. Biol. Chem. 283, 24748\u201324759 (2008).","journal-title":"J. Biol. Chem."},{"key":"61346_CR57","doi-asserted-by":"publisher","first-page":"4547","DOI":"10.1111\/jcmm.15112","volume":"24","author":"J Zhang","year":"2020","unstructured":"Zhang, J. et al. DNase I improves corneal epithelial and nerve regeneration in diabetic mice. J. Cell. Mol. Med. 24, 4547\u20134556 (2020).","journal-title":"J. Cell. Mol. Med."},{"key":"61346_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15807-6","volume":"7","author":"M Boettcher","year":"2017","unstructured":"Boettcher, M. et al. Therapeutic targeting of extracellular DNA improves the outcome of intestinal ischemic reperfusion injury in neonatal rats. Sci. Rep. 7, 15377 (2017).","journal-title":"Sci. Rep."},{"key":"61346_CR59","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","volume":"9","author":"HS Kwon","year":"2020","unstructured":"Kwon, H. S. & Koh, S.-H. Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl. Neurodegener. 9, 42 (2020).","journal-title":"Transl. Neurodegener."},{"key":"61346_CR60","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1111\/j.1460-9568.2009.06934.x","volume":"30","author":"P Vodrazka","year":"2009","unstructured":"Vodrazka, P. et al. The semaphorin 4D-plexin-B signalLing complex regulates dendritic and axonal complexity in developing neurons via diverse pathways. Eur. J. Neurosci. 30, 1193\u20131208 (2009).","journal-title":"Eur. J. Neurosci."},{"key":"61346_CR61","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.mcn.2010.09.013","volume":"46","author":"X Huang","year":"2011","unstructured":"Huang, X. et al. CHL1 negatively regulates the proliferation and neuronal differentiation of neural progenitor cells through activation of the ERK1\/2 MAPK pathway. Mol. Cell. Neurosci. 46, 296\u2013307 (2011).","journal-title":"Mol. Cell. Neurosci."},{"key":"61346_CR62","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/S0531-5565(98)00040-0","volume":"33","author":"LCB R\u00f8nn","year":"1998","unstructured":"R\u00f8nn, L. C. B., Hartz, B. P. & Bock, E. The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system. Exp. Gerontol. 33, 853\u2013864 (1998).","journal-title":"Exp. Gerontol."},{"key":"61346_CR63","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/npp.2013.274","volume":"39","author":"G Karvat","year":"2014","unstructured":"Karvat, G. & Kimchi, T. Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism. Neuropsychopharmacol 39, 831\u2013840 (2014).","journal-title":"Neuropsychopharmacol"},{"key":"61346_CR64","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1007\/s10803-020-04740-9","volume":"51","author":"MF Ceylan","year":"2021","unstructured":"Ceylan, M. F., Tural Hesapcioglu, S., Yavas, C. P., Senat, A. & Erel, O. Serum ischemia-modified albumin levels, myeloperoxidase activity and peripheral blood mononuclear cells in autism spectrum disorder (ASD). J. Autism Dev. Disord. 51, 2511\u20132517 (2021).","journal-title":"J. Autism Dev. Disord."},{"key":"61346_CR65","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1093\/glycob\/cwv042","volume":"25","author":"MK Sethi","year":"2015","unstructured":"Sethi, M. K. et al. In-depth N -glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation. Glycobiology 25, 1064\u20131078 (2015).","journal-title":"Glycobiology"},{"key":"61346_CR66","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1073\/pnas.98.3.1142","volume":"98","author":"D Chui","year":"2001","unstructured":"Chui, D. et al. Genetic remodeling of protein glycosylation in vivo induces autoimmune disease. Proc. Natl. Acad. Sci. USA. 98, 1142\u20131147 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"61346_CR67","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.immuni.2007.06.008","volume":"27","author":"RS Green","year":"2007","unstructured":"Green, R. S. et al. Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis. Immunity 27, 308\u2013320 (2007).","journal-title":"Immunity"},{"key":"61346_CR68","doi-asserted-by":"publisher","first-page":"W169","DOI":"10.1093\/nar\/gkm415","volume":"35","author":"DW Huang","year":"2007","unstructured":"Huang, D. W. et al. DAVID bioinformatics resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 35, W169\u2013W175 (2007).","journal-title":"Nucleic Acids Res."},{"key":"61346_CR69","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang, D. W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44\u201357 (2009).","journal-title":"Nat. Protoc."},{"key":"61346_CR70","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"Sherman, B. T. et al. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 50, W216\u2013W221 (2022).","journal-title":"Nucleic Acids Res."},{"key":"61346_CR71","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1093\/bioinformatics\/bty109","volume":"34","author":"JG P\u00e9rez-Silva","year":"2018","unstructured":"P\u00e9rez-Silva, J. G., Araujo-Voces, M. & Quesada, V. nVenn: generalized, quasi-proportional Venn and Euler diagrams. Bioinformatics 34, 2322\u20132324 (2018).","journal-title":"Bioinformatics"},{"key":"61346_CR72","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kr\u00e4mer","year":"2014","unstructured":"Kr\u00e4mer, A., Green, J., Pollard, J. & Tugendreich, S. Causal analysis approaches in Ingenuity Pathway Analysis. Bioinformatics 30, 523\u2013530 (2014).","journal-title":"Bioinformatics"},{"key":"61346_CR73","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1093\/clinchem\/39.3.448","volume":"39","author":"D Nadano","year":"1993","unstructured":"Nadano, D., Yasuda, T. & Kishi, K. Measurement of deoxyribonuclease I activity in human tissues and body fluids by a single radial enzyme-diffusion method. Clin. Chem. 39, 448\u2013452 (1993).","journal-title":"Clin. Chem."},{"key":"61346_CR74","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3233\/JND-150099","volume":"2","author":"J Lowe","year":"2015","unstructured":"Lowe, J. et al. The Angiotensin converting enzyme inhibitor lisinopril improves muscle histopathology but not contractile function in a mouse model of duchenne muscular dystrophy. JND 2, 257\u2013268 (2015).","journal-title":"JND"},{"key":"61346_CR75","doi-asserted-by":"crossref","unstructured":"Carter, R. J., Morton, J. & Dunnett, S. B. Motor coordination and balance in rodents. Curr. Protoc. Neurosci. 15, 12 (2001).","DOI":"10.1002\/0471142301.ns0812s15"},{"key":"61346_CR76","doi-asserted-by":"publisher","first-page":"eaay9056","DOI":"10.1126\/scitranslmed.aay9056","volume":"13","author":"AM Moreno","year":"2021","unstructured":"Moreno, A. M. et al. Long-lasting analgesia via targeted in situ repression of NaV 1.7 in mice. Sci. Transl. Med. 13, eaay9056 (2021).","journal-title":"Sci. Transl. Med."},{"key":"61346_CR77","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0023-9690(81)90020-5","volume":"12","author":"RGM Morris","year":"1981","unstructured":"Morris, R. G. M. Spatial localization does not require the presence of local cues. Learn. Motiv. 12, 239\u2013260 (1981).","journal-title":"Learn. Motiv."},{"key":"61346_CR78","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.bcp.2014.01.011","volume":"88","author":"D Puzzo","year":"2014","unstructured":"Puzzo, D., Lee, L., Palmeri, A., Calabrese, G. & Arancio, O. Behavioral assays with mouse models of Alzheimer\u2019s disease: Practical considerations and guidelines. Biochemical Pharmacol. 88, 450\u2013467 (2014).","journal-title":"Biochemical Pharmacol."},{"key":"61346_CR79","doi-asserted-by":"publisher","first-page":"ENEURO.0456-22.","DOI":"10.1523\/ENEURO.0456-22.2023","volume":"10","author":"PP Sanna","year":"2023","unstructured":"Sanna, P. P. et al. A history of repeated alcohol intoxication promotes cognitive impairment and gene expression signatures of disease progression in the 3xTg mouse model of alzheimer\u2019s disease. eNeuro 10, ENEURO.0456-22.2023 (2023).","journal-title":"eNeuro"},{"key":"61346_CR80","doi-asserted-by":"publisher","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","volume":"50","author":"Y Perez-Riverol","year":"2022","unstructured":"Perez-Riverol, Y. et al. The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences. Nucleic Acids Res 50, D543\u2013D552 (2022).","journal-title":"Nucleic Acids Res"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-61346-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-61346-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-61346-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T04:14:02Z","timestamp":1757218442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-61346-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":80,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["61346"],"URL":"https:\/\/doi.org\/10.1038\/s41467-025-61346-4","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"6 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6267"}}