{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:08:07Z","timestamp":1793419687167,"version":"4.5.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-025-61397-7","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:04:41Z","timestamp":1751447081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment"],"prefix":"10.1038","volume":"16","author":[{"given":"Aoran","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-1621","authenticated-orcid":false,"given":"Yuqin","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5550-3698","authenticated-orcid":false,"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-3805","authenticated-orcid":false,"given":"Zhenwei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"61397_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.pbiomolbio.2021.06.012","volume":"167","author":"T Li","year":"2021","unstructured":"Li, T., Cao, Y., Li, B. & Dai, R. The biological effects of radiation-induced liver damage and its natural protective medicine. Prog. Biophys. Mol. Biol. 167, 87\u201395 (2021).","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"61397_CR2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1097\/HP.0000000000001472","volume":"121","author":"P Kumar","year":"2021","unstructured":"Kumar, P., Wang, P., Farese, A. M., MacVittie, T. J. & Kane, M. A. Metabolomics of multiorgan radiation injury in non-human primate model reveals system-wide metabolic perturbations. Health Phys. 121, 395\u2013405 (2021).","journal-title":"Health Phys."},{"key":"61397_CR3","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ijrobp.2018.04.071","volume":"101","author":"JYC Wong","year":"2018","unstructured":"Wong, J. Y. C., Filippi, A. R., Dabaja, B. S., Yahalom, J. & Specht, L. Total body irradiation: guidelines from the international lymphoma radiation oncology group (ILROG). Int J. Radiat. Oncol. Biol. Phys. 101, 521\u2013529 (2018).","journal-title":"Int J. Radiat. Oncol. Biol. Phys."},{"key":"61397_CR4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/S1470-2045(21)00606-9","volume":"23","author":"C Le Pechoux","year":"2022","unstructured":"Le Pechoux, C. et al. Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial. Lancet Oncol. 23, 104\u2013114 (2022).","journal-title":"Lancet Oncol."},{"key":"61397_CR5","doi-asserted-by":"publisher","unstructured":"Ren H., et al. Intraoperative radiotherapy vs concurrent chemoradiotherapy in the treatment of patients with locally advanced pancreatic cancer. Pancreatology. https:\/\/doi.org\/10.1016\/j.pan.2021.04.007 (2021).","DOI":"10.1016\/j.pan.2021.04.007"},{"key":"61397_CR6","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.ygyno.2020.09.015","volume":"159","author":"J Chino","year":"2020","unstructured":"Chino, J. et al. The ASTRO clinical practice guidelines in cervical cancer: Optimizing radiation therapy for improved outcomes. Gynecol. Oncol. 159, 607\u2013610 (2020).","journal-title":"Gynecol. Oncol."},{"key":"61397_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jhep.2020.03.005","volume":"73","author":"N Kim","year":"2020","unstructured":"Kim, N. et al. Stereotactic body radiation therapy vs. radiofrequency ablation in Asian patients with hepatocellular carcinoma. J. Hepatol. 73, 121\u2013129 (2020).","journal-title":"J. Hepatol."},{"key":"61397_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.85","volume":"49","author":"J Kim","year":"2017","unstructured":"Kim, J. & Jung, Y. Radiation-induced liver disease: current understanding and future perspectives. Exp. Mol. Med 49, e359 (2017).","journal-title":"Exp. Mol. Med"},{"key":"61397_CR9","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.semradonc.2011.05.003","volume":"21","author":"C Guha","year":"2011","unstructured":"Guha, C. & Kavanagh, B. D. Hepatic radiation toxicity: avoidance and amelioration. Semin Radiat. Oncol. 21, 256\u2013263 (2011).","journal-title":"Semin Radiat. Oncol."},{"key":"61397_CR10","doi-asserted-by":"publisher","first-page":"594789","DOI":"10.3389\/fpubh.2020.594789","volume":"8","author":"M Fischietti","year":"2020","unstructured":"Fischietti, M. et al. Low Radiation environment switches the overgrowth-induced cell apoptosis toward autophagy. Front Public Health 8, 594789 (2020).","journal-title":"Front Public Health"},{"key":"61397_CR11","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.jhep.2017.11.040","volume":"68","author":"B Xu","year":"2018","unstructured":"Xu, B. et al. Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. J. Hepatol. 68, 773\u2013782 (2018).","journal-title":"J. Hepatol."},{"key":"61397_CR12","doi-asserted-by":"crossref","unstructured":"Lv X., et al. Gasdermin D-mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy. Hepatol Commun. 9, 2340\u20132353 (2022).","DOI":"10.1002\/hep4.1973"},{"key":"61397_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2437-9","volume":"11","author":"J Li","year":"2020","unstructured":"Li, J. et al. Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia-reperfusion injury. Cell Death Dis. 11, 244 (2020).","journal-title":"Cell Death Dis."},{"key":"61397_CR14","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ijrobp.2021.05.115","volume":"111","author":"G Chen","year":"2021","unstructured":"Chen, G. et al. ALKBH5-Modified HMGB1-STING Activation contributes to radiation induced liver disease via innate immune response. Int J. Radiat. Oncol. Biol. Phys. 111, 491\u2013501 (2021).","journal-title":"Int J. Radiat. Oncol. Biol. Phys."},{"key":"61397_CR15","doi-asserted-by":"publisher","first-page":"e3000807","DOI":"10.1371\/journal.pbio.3000807","volume":"18","author":"J Xiao","year":"2020","unstructured":"Xiao, J. et al. Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells. PLoS Biol. 18, e3000807 (2020).","journal-title":"PLoS Biol."},{"key":"61397_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00907-2","volume":"20","author":"DM Wu","year":"2022","unstructured":"Wu, D. M. et al. Increased susceptibility of irradiated mice to Aspergillus fumigatus infection via NLRP3\/GSDMD pathway in pulmonary bronchial epithelia. Cell Commun. Signal 20, 98 (2022).","journal-title":"Cell Commun. Signal"},{"key":"61397_CR17","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/s41556-022-00857-4","volume":"24","author":"J Lv","year":"2022","unstructured":"Lv, J. et al. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat. Cell Biol. 24, 364\u2013372 (2022).","journal-title":"Nat. Cell Biol."},{"key":"61397_CR18","doi-asserted-by":"publisher","first-page":"13132","DOI":"10.1073\/pnas.1610433113","volume":"113","author":"S Das","year":"2016","unstructured":"Das, S. et al. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc. Natl Acad. Sci. USA 113, 13132\u201313137 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"61397_CR19","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1038\/s41423-020-0395-x","volume":"18","author":"S Du","year":"2021","unstructured":"Du, S. et al. DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury. Cell Mol. Immunol. 18, 1718\u20131728 (2021).","journal-title":"Cell Mol. Immunol."},{"key":"61397_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1159\/000452543","volume":"40","author":"J Kim","year":"2016","unstructured":"Kim, J., Wang, S., Hyun, J., Guy, C. D. & Jung, Y. Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice. Cell Physiol. Biochem 40, 263\u2013276 (2016).","journal-title":"Cell Physiol. Biochem"},{"key":"61397_CR21","doi-asserted-by":"publisher","first-page":"1946369","DOI":"10.1080\/19490976.2021.1946369","volume":"13","author":"Y Shi","year":"2021","unstructured":"Shi, Y. et al. Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice. Gut Microbes Jan.13, 1946369 (2021).","journal-title":"Gut Microbes Jan."},{"key":"61397_CR22","doi-asserted-by":"publisher","first-page":"eaaz6717","DOI":"10.1126\/sciadv.aaz6717","volume":"6","author":"C Ma","year":"2020","unstructured":"Ma, C. et al. Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation. Sci. Adv. 6, eaaz6717 (2020).","journal-title":"Sci. Adv."},{"key":"61397_CR23","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1074\/mcp.M116.060145","volume":"15","author":"C Ding","year":"2016","unstructured":"Ding, C. et al. A Cell-type-resolved Liver Proteome. Mol. Cell Proteom. 15, 3190\u20133202 (2016).","journal-title":"Mol. Cell Proteom."},{"key":"61397_CR24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","volume":"547","author":"Y Wang","year":"2017","unstructured":"Wang, Y. et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547, 99\u2013103 (2017).","journal-title":"Nature"},{"key":"61397_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16043-9","volume":"11","author":"M Karmakar","year":"2020","unstructured":"Karmakar, M. et al. N-GSDMD trafficking to neutrophil organelles facilitates IL-1beta release independently of plasma membrane pores and pyroptosis. Nat. Commun. 11, 2212 (2020).","journal-title":"Nat. Commun."},{"key":"61397_CR26","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1161\/CIRCRESAHA.120.318629","volume":"129","author":"H Shi","year":"2021","unstructured":"Shi, H. et al. GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I\/R Injury. Circ. Res 129, 383\u2013396 (2021).","journal-title":"Circ. Res"},{"key":"61397_CR27","doi-asserted-by":"publisher","unstructured":"Sollberger G., et al. Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sci Immunol. https:\/\/doi.org\/10.1126\/sciimmunol.aar6689 (2018).","DOI":"10.1126\/sciimmunol.aar6689"},{"key":"61397_CR28","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/s42255-021-00389-5","volume":"3","author":"EL Mills","year":"2021","unstructured":"Mills, E. L. et al. UCP1 governs liver extracellular succinate and inflammatory pathogenesis. Nat. Metab. 3, 604\u2013617 (2021).","journal-title":"Nat. Metab."},{"key":"61397_CR29","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/hep.27921","volume":"62","author":"B Chang","year":"2015","unstructured":"Chang, B. et al. Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1. Hepatology 62, 1070\u20131085 (2015).","journal-title":"Hepatology"},{"key":"61397_CR30","doi-asserted-by":"publisher","unstructured":"Jiang K., et al. Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI151268 (2022).","DOI":"10.1172\/JCI151268"},{"key":"61397_CR31","doi-asserted-by":"crossref","unstructured":"Shi W. P., et al. CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis. Int. J. Mol. Sci. 10, 19 (2018).","DOI":"10.3390\/ijms19041145"},{"key":"61397_CR32","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1126\/science.aaf7532","volume":"354","author":"B Hu","year":"2016","unstructured":"Hu, B. et al. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 354, 765\u2013768 (2016).","journal-title":"Science"},{"key":"61397_CR33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/aps.2016.160","volume":"38","author":"AR Su","year":"2017","unstructured":"Su, A. R. et al. BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK\/p38 pathways without interfering with PDK1 activity in host cells. Acta Pharm. Sin. 38, 402\u2013414 (2017). Mar.","journal-title":"Acta Pharm. Sin."},{"key":"61397_CR34","doi-asserted-by":"publisher","first-page":"4556","DOI":"10.1111\/jcmm.17480","volume":"26","author":"M Ala","year":"2022","unstructured":"Ala, M. et al. Sildenafil improves radiation-induced oral mucositis by attenuating oxidative stress, NF-kappaB, ERK and JNK signalling pathways. J. Cell Mol. Med 26, 4556\u20134565 (2022).","journal-title":"J. Cell Mol. Med"},{"key":"61397_CR35","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/tox.23403","volume":"37","author":"J Liu","year":"2022","unstructured":"Liu, J. et al. 3,4,5-O-tricaffeoylquinic acid alleviates ionizing radiation-induced injury in vitro and in vivo through regulating ROS\/JNK\/p38 signaling. Environ. Toxicol. 37, 349\u2013361 (2022).","journal-title":"Environ. Toxicol."},{"key":"61397_CR36","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","volume":"11","author":"BE Burdette","year":"2021","unstructured":"Burdette, B. E., Esparza, A. N., Zhu, H. & Wang, S. Gasdermin D in pyroptosis. Acta Pharm. Sin. B 11, 2768\u20132782 (2021).","journal-title":"Acta Pharm. Sin. B"},{"key":"61397_CR37","doi-asserted-by":"publisher","first-page":"eabk2092","DOI":"10.1126\/sciimmunol.abk2092","volume":"7","author":"J Zhang","year":"2022","unstructured":"Zhang, J. et al. Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation. Sci. Immunol. 7, eabk2092 (2022).","journal-title":"Sci. Immunol."},{"key":"61397_CR38","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi, J. et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660\u2013665 (2015).","journal-title":"Nature"},{"key":"61397_CR39","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.it.2017.01.003","volume":"38","author":"RA Aglietti","year":"2017","unstructured":"Aglietti, R. A. & Dueber, E. C. Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions. Trends Immunol. 38, 261\u2013271 (2017).","journal-title":"Trends Immunol."},{"key":"61397_CR40","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.3389\/fimmu.2018.02201","volume":"9","author":"J Luan","year":"2018","unstructured":"Luan, J. & Ju, D. Inflammasome: a double-edged sword in liver diseases. Front Immunol. 9, 2201 (2018).","journal-title":"Front Immunol."},{"key":"61397_CR41","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1182\/blood.2021011525","volume":"138","author":"CMS Silva","year":"2021","unstructured":"Silva, C. M. S. et al. Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation. Blood 138, 2702\u20132713 (2021).","journal-title":"Blood"},{"key":"61397_CR42","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/s41590-022-01255-6","volume":"23","author":"W Chen","year":"2022","unstructured":"Chen, W. et al. Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion. Nat. Immunol. 23, 1021\u20131030 (2022).","journal-title":"Nat. Immunol."},{"key":"61397_CR43","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/ni.1960","volume":"11","author":"EA Miao","year":"2010","unstructured":"Miao, E. A. et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 11, 1136\u20131142 (2010).","journal-title":"Nat. Immunol."},{"key":"61397_CR44","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.chom.2018.05.009","volume":"24","author":"R Kang","year":"2018","unstructured":"Kang, R. et al. Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis. Cell Host Microbe 24, 97\u2013108 e4 (2018).","journal-title":"Cell Host Microbe"},{"key":"61397_CR45","doi-asserted-by":"publisher","first-page":"eaaz6717","DOI":"10.1126\/sciadv.aaz6717","volume":"6","author":"CYD Ma","year":"2020","unstructured":"Ma, C. Y. D. et al. Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation. Sci. Adv. 6, eaaz6717 (2020).","journal-title":"Sci. Adv."},{"key":"61397_CR46","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.ijrobp.2023.05.029","volume":"117","author":"Y Zhang","year":"2023","unstructured":"Zhang, Y. et al. STING-Dependent Sensing of Self-DNA Driving Pyroptosis Contributes to Radiation-Induced Lung Injury. Int J. Radiat. Oncol. Biol. Phys. 117, 928\u2013941 (2023).","journal-title":"Int J. Radiat. Oncol. Biol. Phys."},{"key":"61397_CR47","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bbrc.2022.09.073","volume":"631","author":"F Zhang","year":"2022","unstructured":"Zhang, F. et al. Activation of pyroptosis and ferroptosis is involved in radiation-induced intestinal injury in mice. Biochem Biophys. Res Commun. 631, 102\u2013109 (2022).","journal-title":"Biochem Biophys. Res Commun."},{"key":"61397_CR48","doi-asserted-by":"publisher","first-page":"C1320","DOI":"10.1152\/ajpcell.00466.2022","volume":"324","author":"J Yi","year":"2023","unstructured":"Yi, J. et al. PTPMT1 protects cardiomyocytes from necroptosis induced by gamma-ray irradiation through alleviating mitochondria injury. Am. J. Physiol. Cell Physiol. 324, C1320\u2013C1331 (2023).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"61397_CR49","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ijrobp.2018.01.035","volume":"101","author":"D Wu","year":"2018","unstructured":"Wu, D. et al. Protective Effects of Flagellin A N\/C Against Radiation-Induced NLR Pyrin Domain Containing 3 Inflammasome-Dependent Pyroptosis in Intestinal Cells. Int J. Radiat. Oncol. Biol. Phys. 101, 107\u2013117 (2018).","journal-title":"Int J. Radiat. Oncol. Biol. Phys."},{"key":"61397_CR50","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bbrc.2021.03.004","volume":"554","author":"Y Xu","year":"2021","unstructured":"Xu, Y. et al. Nrf2 alleviates radiation-induced rectal injury by inhibiting of necroptosis. Biochem Biophys. Res Commun. 554, 49\u201355 (2021).","journal-title":"Biochem Biophys. Res Commun."},{"key":"61397_CR51","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","volume":"18","author":"D Bertheloot","year":"2021","unstructured":"Bertheloot, D., Latz, E. & Franklin, B. S. Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Cell Mol. Immunol. 18, 1106\u20131121 (2021).","journal-title":"Cell Mol. Immunol."},{"key":"61397_CR52","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1093\/cei\/uxad082","volume":"214","author":"CN Ruera","year":"2023","unstructured":"Ruera, C. N. et al. Coexistence of apoptosis, pyroptosis, and necroptosis pathways in celiac disease. Clin. Exp. Immunol. 214, 328\u2013340 (2023).","journal-title":"Clin. Exp. Immunol."},{"key":"61397_CR53","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.immuni.2019.11.005","volume":"51","author":"X Yang","year":"2019","unstructured":"Yang, X. et al. Bacterial endotoxin activates the coagulation cascade through gasdermin D-dependent phosphatidylserine exposure. Immunity 51, 983\u2013996 e6 (2019).","journal-title":"Immunity"},{"key":"61397_CR54","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.immuni.2019.04.003","volume":"50","author":"C Wu","year":"2019","unstructured":"Wu, C. et al. Inflammasome activation triggers blood clotting and host death through pyroptosis. Immunity 50, 1401\u20131411 e4 (2019).","journal-title":"Immunity"},{"key":"61397_CR55","doi-asserted-by":"publisher","first-page":"825428","DOI":"10.3389\/fimmu.2022.825428","volume":"13","author":"J Wang","year":"2022","unstructured":"Wang, J. et al. Direct inhibition of GSDMD by PEITC reduces hepatocyte pyroptosis and alleviates acute liver injury in mice. Front Immunol. 13, 825428 (2022).","journal-title":"Front Immunol."},{"key":"61397_CR56","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.freeradbiomed.2020.03.007","volume":"152","author":"W Deng","year":"2020","unstructured":"Deng, W. et al. Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation. Free Radic. Biol. Med 152, 8\u201317 (2020).","journal-title":"Free Radic. Biol. Med"},{"key":"61397_CR57","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12931-022-02279-0","volume":"23","author":"S Hu","year":"2022","unstructured":"Hu, S., Wang, L., Xu, Y., Li, F. & Wang, T. Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs. Respir. Res. 23, 353 (2022).","journal-title":"Respir. Res."},{"key":"61397_CR58","doi-asserted-by":"publisher","first-page":"780142","DOI":"10.3389\/fcell.2021.780142","volume":"9","author":"J Wu","year":"2021","unstructured":"Wu, J. et al. Treatment of Severe Acute Pancreatitis and Related Lung Injury by Targeting Gasdermin D-Mediated Pyroptosis. Front Cell Dev. Biol. 9, 780142 (2021).","journal-title":"Front Cell Dev. Biol."},{"key":"61397_CR59","doi-asserted-by":"publisher","first-page":"e255","DOI":"10.1002\/mco2.255","volume":"4","author":"M Liu","year":"2023","unstructured":"Liu, M. et al. Caffeic acid, but not ferulic acid, inhibits macrophage pyroptosis by directly blocking gasdermin D activation. MedComm (2020) 4, e255 (2023).","journal-title":"MedComm (2020)"},{"key":"61397_CR60","doi-asserted-by":"publisher","first-page":"F96","DOI":"10.1152\/ajprenal.00351.2019","volume":"318","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. Activation of GSDMD contributes to acute kidney injury induced by cisplatin. Am. J. Physiol. Ren. Physiol. 318, F96\u2013F106 (2020).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"61397_CR61","doi-asserted-by":"publisher","first-page":"H460","DOI":"10.1152\/ajpheart.00056.2019","volume":"317","author":"Z Tavakoli Dargani","year":"2019","unstructured":"Tavakoli Dargani, Z. & Singla, D. K. Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis. Am. J. Physiol. Heart Circ. Physiol. 317, H460\u2013H471 (2019).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"61397_CR62","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nature25016","volume":"552","author":"Z Skrott","year":"2017","unstructured":"Skrott, Z. et al. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature 552, 194\u2013199 (2017).","journal-title":"Nature"},{"key":"61397_CR63","doi-asserted-by":"publisher","first-page":"6070","DOI":"10.1158\/1078-0432.CCR-09-1035","volume":"15","author":"K Iljin","year":"2009","unstructured":"Iljin, K. et al. High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin. Cancer Res. 15, 6070\u20136078 (2009).","journal-title":"Clin. Cancer Res."},{"key":"61397_CR64","doi-asserted-by":"publisher","first-page":"10425","DOI":"10.1158\/0008-5472.CAN-06-2126","volume":"66","author":"D Chen","year":"2006","unstructured":"Chen, D., Cui, Q. C., Yang, H. & Dou, Q. P. Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res 66, 10425\u201310433 (2006).","journal-title":"Cancer Res"},{"key":"61397_CR65","doi-asserted-by":"publisher","first-page":"4721","DOI":"10.1182\/blood-2009-04-216390","volume":"114","author":"A Kimura","year":"2009","unstructured":"Kimura, A. et al. The transcription factors STAT5A\/B regulate GM-CSF-mediated granulopoiesis. Blood 114, 4721\u20134728 (2009).","journal-title":"Blood"},{"key":"61397_CR66","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/imr.12198","volume":"261","author":"HS Li","year":"2014","unstructured":"Li, H. S. & Watowich, S. S. Innate immune regulation by STAT-mediated transcriptional mechanisms. Immunol. Rev. 261, 84\u2013101 (2014).","journal-title":"Immunol. Rev."},{"key":"61397_CR67","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1182\/blood-2009-08-240317","volume":"115","author":"H Nguyen-Jackson","year":"2010","unstructured":"Nguyen-Jackson, H., Panopoulos, A. D., Zhang, H., Li, H. S. & Watowich, S. S. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 115, 3354\u20133363 (2010).","journal-title":"Blood"},{"key":"61397_CR68","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16596-9","volume":"11","author":"G Boivin","year":"2020","unstructured":"Boivin, G. et al. Durable and controlled depletion of neutrophils in mice. Nat. Commun. 11, 2762 (2020).","journal-title":"Nat. Commun."},{"key":"61397_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0377-4","volume":"9","author":"L Su","year":"2018","unstructured":"Su, L. et al. Kupffer cell-derived TNF-alpha promotes hepatocytes to produce CXCL1 and mobilize neutrophils in response to necrotic cells. Cell Death Dis. 9, 323 (2018).","journal-title":"Cell Death Dis."},{"key":"61397_CR70","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1016\/j.jhep.2020.12.010","volume":"74","author":"G Wei","year":"2021","unstructured":"Wei, G. et al. Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB\/c.Abcb4(-\/-) mouse model of PFIC3. J. Hepatol. 74, 1416\u20131428 (2021).","journal-title":"J. Hepatol."},{"key":"61397_CR71","doi-asserted-by":"publisher","first-page":"1000s86","DOI":"10.1016\/j.xpro.2020.100086","volume":"1","author":"M Charni-Natan","year":"2020","unstructured":"Charni-Natan, M. & Goldstein, I. Protocol for primary mouse hepatocyte Isolation. STAR Protoc. 1, 1000s86 (2020).","journal-title":"STAR Protoc."},{"key":"61397_CR72","first-page":"e50586","volume":"10","author":"M Swamydas","year":"2013","unstructured":"Swamydas, M. & Lionakis, M. S. Isolation, purification and labeling of mouse bone marrow neutrophils for functional studies and adoptive transfer experiments. J. Vis. Exp. 10, e50586 (2013).","journal-title":"J. Vis. Exp."},{"key":"61397_CR73","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.jhep.2019.02.003","volume":"70","author":"R Manco","year":"2019","unstructured":"Manco, R. et al. Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury. J. Hepatol. 70, 1180\u20131191 (2019).","journal-title":"J. Hepatol."},{"key":"61397_CR74","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41586-019-1340-y","volume":"571","author":"X Wang","year":"2019","unstructured":"Wang, X. et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature 571, 127\u2013131 (2019).","journal-title":"Nature"},{"key":"61397_CR75","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29186-8","volume":"13","author":"J Lee","year":"2022","unstructured":"Lee, J., Byun, J., Shim, G. & Oh, Y. K. Fibroblast activation protein activated antifibrotic peptide delivery attenuates fibrosis in mouse models of liver fibrosis. Nat. Commun. 13, 1516 (2022).","journal-title":"Nat. Commun."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-61397-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-61397-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-61397-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T10:03:00Z","timestamp":1751450580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-61397-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["61397"],"URL":"https:\/\/doi.org\/10.1038\/s41467-025-61397-7","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"23 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6064"}}