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B. W. reports a research grant from REPARE Therapeutics paid to the institution, and has an immediate family member who is employed by AstraZeneca, outside the submitted work. A.L.K. is on the Scientific Advisory Board of Emendo Biotherapeutics, Karyopharm Therapeutics, Imago BioSciences, and DarwinHealth; is co-Founder and on the Scientific Advisory Board of Isabl; has equity interest in Imago BioSciences, Emendo Biotherapeutics and Isabl; is an inventor of MSK intellectual property licensed to Isabl; and receives royalty income from Labcorp. E.P. is a founder, equity holder and holds fiduciary roles in Isabl Inc. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10649"}}