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To gain insights into the phenotype and possible platelet-subgroups in the context of type III inflammation, high-parametric single cell spectral\u00a0flow cytometry was applied to a prospectively followed cohort of psoriasis patients undergoing systemic therapy. By focusing on the activation profile of platelets and their interaction with immune cells, we identify cell-surface proteins CD32\n                    <jats:sup>+<\/jats:sup>\n                    CD154\n                    <jats:sup>+<\/jats:sup>\n                    and TLR2\n                    <jats:sup>+<\/jats:sup>\n                    TLR4\n                    <jats:sup>+<\/jats:sup>\n                    , distinguishing unique platelet subsets in psoriasis patients. These subsets demonstrate regression over the course of systemic therapy. Notably, these platelet phenotypes and frequencies differ from those of healthy controls, and patients with atopic dermatitis (AD), a type II inflammation-driven disease. Our data highlight a specific platelet phenotype responding acutely to the respective inflammatory context. This finding warrants further investigation into platelets as a diagnostic tool in inflammatory conditions, necessitating future insight into the function of these subsets across disease etiologies.\n                  <\/jats:p>","DOI":"10.1038\/s41467-025-65894-7","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T10:03:25Z","timestamp":1764929005000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammation"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-2658","authenticated-orcid":false,"given":"Katharina S.","family":"Kommoss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-1751","authenticated-orcid":false,"given":"Sinduya","family":"Krishnarajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3611-9305","authenticated-orcid":false,"given":"Tabea","family":"Bieler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-2376","authenticated-orcid":false,"given":"Ekaterina","family":"Friebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Rindlisbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-9648","authenticated-orcid":false,"given":"Pierluigi","family":"Ramadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5197-3338","authenticated-orcid":false,"given":"Philipp","family":"H\u00e4ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing","family":"Kam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Prokosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Rothermel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1396-2252","authenticated-orcid":false,"given":"Francesca","family":"Barletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-286X","authenticated-orcid":false,"given":"Stefan","family":"Czemmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-0691","authenticated-orcid":false,"given":"Sven","family":"Nahnsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9321-2069","authenticated-orcid":false,"given":"Dominic","family":"Helm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-7799","authenticated-orcid":false,"given":"Knut","family":"Sch\u00e4kel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-421X","authenticated-orcid":false,"given":"Alexander","family":"Enk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-7867","authenticated-orcid":false,"given":"Burkhard","family":"Becher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-2274","authenticated-orcid":false,"given":"Mathias","family":"Heikenw\u00e4lder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"65894_CR1","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s41577-019-0202-z","volume":"19","author":"F Gaertner","year":"2019","unstructured":"Gaertner, F. & Massberg, S. 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K.S. discloses that he was an advisor and\/or received speakers\u2019 honoraria and\/or received grants and\/or participated in clinical trials of the following companies: AbbVie, Almirall, Boehringer Ingelheim, Celgene, Eli Lilly, Galderma, Janssen-Cilag GmbH, LEO Pharma, Novartis, Pfizer and UCB. A.E. discloses speakers\u2019 honoraria\/travel grants for Janssen-Cilag GmbH, Abbvie, and Eli Lilly. The authors declare that these conflicts are not associated with this work. The other authors have no competing interests to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10881"}}