{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T04:59:21Z","timestamp":1794200361898,"version":"4.8.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-025-66596-w","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:54:48Z","timestamp":1764680088000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The gut methanotroph Methylocystis intestini modulates intestinal peristalsis and fat metabolism via reducing methane levels"],"prefix":"10.1038","volume":"17","author":[{"given":"Yiming","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Chistoserdova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-3946","authenticated-orcid":false,"given":"Zheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"66596_CR1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.freeradbiomed.2006.06.020","volume":"41","author":"T Sobko","year":"2006","unstructured":"Sobko, T. et al. Generation of NO by probiotic bacteria in the gastrointestinal tract. Free Radic. Biol. Med. 41, 985\u2013991 (2006).","journal-title":"Free Radic. Biol. Med."},{"key":"66596_CR2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41575-019-0193-z","volume":"16","author":"K Kalantar-Zadeh","year":"2019","unstructured":"Kalantar-Zadeh, K., Berean, K. J., Burgell, R. E., Muir, J. G. & Gibson, P. R. Intestinal gases: influence on gut disorders and the role of dietary manipulations. Nat. Rev. Gastroenterol. Hepatol. 16, 733\u2013747 (2019).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"66596_CR3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5056\/jnm.2014.20.1.31","volume":"20","author":"K Triantafyllou","year":"2014","unstructured":"Triantafyllou, K., Chang, C. & Pimentel, M. Methanogens, methane and gastrointestinal motility. J. Neurogastroenterol. Motil. 20, 31 (2014).","journal-title":"J. Neurogastroenterol. Motil."},{"key":"66596_CR4","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/ajg.2009.744","volume":"105","author":"D Roccarina","year":"2010","unstructured":"Roccarina, D. et al. The role of methane in intestinal diseases. Off. J. Am. Coll. Gastroenterol. 105, 1250\u20131256 (2010).","journal-title":"Off. J. Am. Coll. Gastroenterol."},{"key":"66596_CR5","unstructured":"Waqar, S. H. B. & Rehan, A. Methane and constipation-predominant irritable bowel syndrome: entwining pillars of emerging neurogastroenterology. Cureus 11, e4764 (2019)."},{"key":"66596_CR6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ajgsup.2012.6","volume":"1","author":"M Pimentel","year":"2012","unstructured":"Pimentel, M., Gunsalus, R. P., Rao, S. S. & Zhang, H. Methanogens in human health and disease. Am. J. Gastroenterol. 1, 28 (2012).","journal-title":"Am. J. Gastroenterol."},{"key":"66596_CR7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/oby.20277","volume":"21","author":"R Mathur","year":"2013","unstructured":"Mathur, R. et al. Intestinal Methanobrevibacter smithii but not total bacteria is related to diet-induced weight gain in rats. Obesity 21, 748\u2013754 (2013).","journal-title":"Obesity"},{"key":"66596_CR8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.orcp.2016.06.006","volume":"10","author":"R Mathur","year":"2016","unstructured":"Mathur, R. et al. Intestinal methane production is associated with decreased weight loss following bariatric surgery. Obes. Res. Clin. Pract. 10, 728\u2013733 (2016).","journal-title":"Obes. Res. Clin. Pract."},{"key":"66596_CR9","first-page":"22","volume":"8","author":"RJ Basseri","year":"2012","unstructured":"Basseri, R. J. et al. Intestinal methane production in obese individuals is associated with a higher body mass index. Gastroenterol. Hepatol. 8, 22 (2012).","journal-title":"Gastroenterol. Hepatol."},{"key":"66596_CR10","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1007\/s10620-011-1590-5","volume":"56","author":"D Kunkel","year":"2011","unstructured":"Kunkel, D. et al. Methane on breath testing is associated with constipation: a systematic review and meta-analysis. Dig. Dis. Sci. 56, 1612\u20131618 (2011).","journal-title":"Dig. Dis. Sci."},{"key":"66596_CR11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s11695-019-04307-3","volume":"30","author":"H You","year":"2020","unstructured":"You, H. et al. Serum FABP1 levels correlate positively with obesity in Chinese patients after laparoscopic sleeve gastrectomy: a 12-month follow-up study. Obes. Surg. 30, 931\u2013940 (2020).","journal-title":"Obes. Surg."},{"key":"66596_CR12","doi-asserted-by":"crossref","first-page":"G1089","DOI":"10.1152\/ajpgi.00574.2004","volume":"290","author":"M Pimentel","year":"2006","unstructured":"Pimentel, M. et al. Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity. Am. J. Physiol.-Gastrointest. Liver Physiol. 290, G1089\u2013G1095 (2006).","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"66596_CR13","volume":"29","author":"Y Park","year":"2017","unstructured":"Park, Y., Lee, Y., Hussain, Z., Lee, Y. & Park, H. The effects and mechanism of action of methane on ileal motor function. Neurogastroenterol. Motil. 29, e13077 (2017).","journal-title":"Neurogastroenterol. Motil."},{"key":"66596_CR14","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41467-021-21408-9","volume":"12","author":"BA Jensen","year":"2021","unstructured":"Jensen, B. A. et al. Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+ ROR\u03b3t+ IL-17+ Tregs and improve metabolism. Nat. Commun. 12, 1093 (2021).","journal-title":"Nat. Commun."},{"key":"66596_CR15","first-page":"2384","volume":"57","author":"P Pecora","year":"1981","unstructured":"Pecora, P., Suraci, C., Antonelli, M., De Maria, S. & Marrocco, W. Constipation and obesity: a statistical analysis. J. Biol. Res.-Boll. Soc. Biol. Sper. 57, 2384\u20132388 (1981).","journal-title":"J. Biol. Res.-Boll. Soc. Biol. Sper."},{"key":"66596_CR16","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1186\/s12889-024-18647-y","volume":"24","author":"N Xiang","year":"2024","unstructured":"Xiang, N., Xu, L., Qian, H. & Zhang, D. Multiple obesity indices suggest a close relationship between obesity and constipation: evidence from NHANES. BMC Public Health 24, 1273 (2024).","journal-title":"BMC Public Health"},{"key":"66596_CR17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/oby.21385","volume":"24","author":"R Mathur","year":"2016","unstructured":"Mathur, R. et al. Metabolic effects of eradicating breath methane using antibiotics in prediabetic subjects with obesity. Obesity 24, 576\u2013582 (2016).","journal-title":"Obesity"},{"key":"66596_CR18","first-page":"527","volume":"14","author":"L Love-Gregory","year":"2011","unstructured":"Love-Gregory, L. & Abumrad, N. A. CD36 genetics and the metabolic complications of obesity. Curr. Opin. Clin. Nutr. Metab. Care\u00a014, 527\u2013534 (2011).","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"66596_CR19","doi-asserted-by":"crossref","unstructured":"Qu, J. et al. Low-density lipoprotein receptor-related protein 1 (LRP1) is a v receptor for apolipoprotein A4 (APOA4) in adipose tissue. Sci Rep. 11, 13289 (2021).","DOI":"10.1038\/s41598-021-92711-0"},{"key":"66596_CR20","doi-asserted-by":"crossref","unstructured":"Bae, Y. J. et al. Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon. Genes Nutr. 11, 30 (2016).","DOI":"10.1186\/s12263-016-0547-x"},{"key":"66596_CR21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ni.2612","volume":"14","author":"P Starkl","year":"2013","unstructured":"Starkl, P., Marichal, T. & Galli, S. J. PLA2G3 promotes mast cell maturation and function. Nat. Immunol. 14, 527\u2013529 (2013).","journal-title":"Nat. Immunol."},{"key":"66596_CR22","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1091\/mbc.E14-10-1472","volume":"26","author":"HL Gijs","year":"2015","unstructured":"Gijs, H. L. et al. Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3. Mol. Biol. Cell 26, 2321\u20132332 (2015).","journal-title":"Mol. Biol. Cell"},{"key":"66596_CR23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejim.2017.10.005","volume":"48","author":"MC Dao","year":"2018","unstructured":"Dao, M. C. & Cl\u00e9ment, K. Gut microbiota and obesity: Concepts relevant to clinical care. Eur. J. Intern. Med. 48, 18\u201324 (2018).","journal-title":"Eur. J. Intern. Med."},{"key":"66596_CR24","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1038\/s41467-019-10068-5","volume":"10","author":"P Lap\u00e9bie","year":"2019","unstructured":"Lap\u00e9bie, P., Lombard, V., Drula, E., Terrapon, N. & Henrissat, B. Bacteroidetes use thousands of enzyme combinations to break down glycans. Nat. Commun. 10, 2043 (2019).","journal-title":"Nat. Commun."},{"key":"66596_CR25","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3390\/nu15071779","volume":"15","author":"J Wang","year":"2023","unstructured":"Wang, J. et al. Characteristics of the gut microbiome and serum metabolome in patients with functional constipation. Nutrients 15, 1779 (2023).","journal-title":"Nutrients"},{"key":"66596_CR26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.soilbio.2018.08.014","volume":"127","author":"L Nazaries","year":"2018","unstructured":"Nazaries, L. et al. Environmental drivers of the geographical distribution of methanotrophs: Insights from a national survey. Soil Biol. Biochem. 127, 264\u2013279 (2018).","journal-title":"Soil Biol. Biochem."},{"key":"66596_CR27","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41575-022-00673-z","volume":"19","author":"C Hoegenauer","year":"2022","unstructured":"Hoegenauer, C., Hammer, H. F., Mahnert, A. & Moissl-Eichinger, C. Methanogenic archaea in the human gastrointestinal tract. Nat. Rev. Gastroenterol. Hepatol.\u00a019, 805\u2013813 (2022).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"66596_CR28","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3389\/fmicb.2019.01277","volume":"10","author":"J Pereira-Marques","year":"2019","unstructured":"Pereira-Marques, J. et al. Impact of host DNA and sequencing depth on the taxonomic resolution of whole metagenome sequencing for microbiome analysis. Front. Microbiol. 10, 1277 (2019).","journal-title":"Front. Microbiol."},{"key":"66596_CR29","doi-asserted-by":"crossref","unstructured":"Rodriguez-R, L. M. & Konstantinidis, K. T. Estimating coverage in metagenomic data sets and why it matters. ISME J. 8, 2349\u20132351 (2014).","DOI":"10.1038\/ismej.2014.76"},{"key":"66596_CR30","doi-asserted-by":"crossref","unstructured":"Albenberg, L. et al. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology 147, 1055\u20131063.e1058 (2014).","DOI":"10.1053\/j.gastro.2014.07.020"},{"key":"66596_CR31","doi-asserted-by":"crossref","unstructured":"Dedysh, S. N. & Dunfield, P. F. Cultivation of methanotrophs. in Hydrocarbon and Lipid Microbiology Protocols: Isolation and Cultivation, 231\u2013247 (Springer, 2014).","DOI":"10.1007\/8623_2014_14"},{"key":"66596_CR32","volume":"120","author":"L He","year":"2023","unstructured":"He, L. et al. A methanotrophic bacterium to enable methane removal for climate mitigation. Proc. Natl. Acad. Sci. USA 120, e2310046120 (2023).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"66596_CR33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.micres.2015.06.003","volume":"179","author":"J Reu\u00df","year":"2015","unstructured":"Reu\u00df, J. et al. Isolation of methanotrophic bacteria from termite gut. Microbiol. Res. 179, 29\u201337 (2015).","journal-title":"Microbiol. Res."},{"key":"66596_CR34","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","volume":"34","author":"S Chen","year":"2018","unstructured":"Chen, S., Zhou, Y., Chen, Y. & Gu, J. fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34, i884\u2013i890 (2018).","journal-title":"Bioinformatics"},{"key":"66596_CR35","doi-asserted-by":"crossref","first-page":"D741","DOI":"10.1093\/nar\/gkab961","volume":"50","author":"LC Reimer","year":"2022","unstructured":"Reimer, L. C. et al. Bac Dive in 2022: the knowledge base for standardized bacterial and archaeal data. Nucleic Acids Res. 50, D741\u2013D746 (2022).","journal-title":"Nucleic Acids Res."},{"key":"66596_CR36","volume":"10","author":"JP Meier-Kolthoff","year":"2019","unstructured":"Meier-Kolthoff, J. P. & G\u00f6ker, M. TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. Nat. Commun. 10, 2182 (2019).","journal-title":"Nat. Commun."},{"key":"66596_CR37","volume":"9","author":"C Jain","year":"2018","unstructured":"Jain, C., Rodriguez-R, L. M., Phillippy, A. M., Konstantinidis, K. T. & Aluru, S. High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries. Nat. Commun. 9, 5114 (2018).","journal-title":"Nat. Commun."},{"key":"66596_CR38","doi-asserted-by":"crossref","first-page":"e52249","DOI":"10.1371\/journal.pone.0052249","volume":"7","author":"H Xu","year":"2012","unstructured":"Xu, H. et al. FastUniq: a fast de novo duplicates removal tool for paired short reads. PLoS ONE 7, e52249 (2012).","journal-title":"PLoS ONE"},{"key":"66596_CR39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357\u2013359 (2012).","journal-title":"Nat. Methods"},{"key":"66596_CR40","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","volume":"31","author":"D Li","year":"2015","unstructured":"Li, D., Liu, C. M., Luo, R., Sadakane, K. & Lam, T. W. MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. Bioinformatics 31, 1674\u20131676 (2015).","journal-title":"Bioinformatics"},{"key":"66596_CR41","volume":"7","author":"DD Kang","year":"2019","unstructured":"Kang, D. D. et al. MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies. PeerJ 7, e7359 (2019).","journal-title":"PeerJ"},{"key":"66596_CR42","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/s41592-023-01940-w","volume":"20","author":"A Chklovski","year":"2023","unstructured":"Chklovski, A., Parks, D. H., Woodcroft, B. J. & Tyson, G. W. CheckM2: a rapid, scalable and accurate tool for assessing microbial genome quality using machine learning. Nat. Methods 20, 1203\u20131212 (2023).","journal-title":"Nat. Methods"},{"key":"66596_CR43","doi-asserted-by":"crossref","unstructured":"Chaumeil, P.-A., Mussig, A. J., Hugenholtz, P. & Parks, D. H. GTDB-Tk: a toolkit to classify genomes with the Genome Taxonomy Database. Bioinformatics 36, 1925\u20131927 (2020).","DOI":"10.1093\/bioinformatics\/btz848"},{"key":"66596_CR44","first-page":"000685","volume":"7","author":"O Schwengers","year":"2021","unstructured":"Schwengers, O. et al. Bakta: rapid and standardized annotation of bacterial genomes via alignment-free sequence identification. Microb. Genomics 7, 000685 (2021).","journal-title":"Microb. Genomics"},{"key":"66596_CR45","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3389\/fmicb.2015.01346","volume":"6","author":"C Knief","year":"2015","unstructured":"Knief, C. Diversity and habitat preferences of cultivated and uncultivated aerobic methanotrophic bacteria evaluated based on pmoA as molecular marker. Front. Microbiol. 6, 1346 (2015).","journal-title":"Front. Microbiol."},{"key":"66596_CR46","doi-asserted-by":"crossref","unstructured":"Rachel, R. et al. Methods in Cell Biology, Vol. 96, 47\u201369 (Elsevier, 2010).","DOI":"10.1002\/0471143030.cb2700s47"},{"key":"66596_CR47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cell.2015.08.059","volume":"163","author":"N Dey","year":"2015","unstructured":"Dey, N. et al. Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel. Cell 163, 95\u2013107 (2015).","journal-title":"Cell"},{"key":"66596_CR48","doi-asserted-by":"publisher","unstructured":"Zhang, C. C. et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe 31, https:\/\/doi.org\/10.1016\/j.chom.2023.10.011 (2023).","DOI":"10.1016\/j.chom.2023.10.011"},{"key":"66596_CR49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0160-5402(78)90022-0","volume":"1","author":"LE Bailey","year":"1978","unstructured":"Bailey, L. E. & Ong, S. D. Krebs-Henseleit solution as a physiological buffer in perfused and superfused preparations. J. Pharmacol. Methods 1, 171\u2013175 (1978).","journal-title":"J. Pharmacol. Methods"},{"key":"66596_CR50","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2982.2011.01819.x","volume":"24","author":"J Jahng","year":"2012","unstructured":"Jahng, J., Jung, I., Choi, E., Conklin, J. & Park, H. The effects of methane and hydrogen gases produced by enteric bacteria on ileal motility and colonic transit time. Neurogastroenterol. Motil. 24, 185\u2013e192 (2012).","journal-title":"Neurogastroenterol. Motil."},{"key":"66596_CR51","first-page":"e922248","volume":"26","author":"N Shen","year":"2020","unstructured":"Shen, N., Wang, Z., Wang, C., Zhang, J. & Liu, C. Methane alleviates inflammation and apoptosis of dextran sulfate sodium-induced inflammatory bowel diseases by inhibiting toll-like receptor 4 (TLR4)\/Myeloid differentiation factor 88 (MyD88)\/Nuclear translocation of nuclear factor-\u03bab (NF-\u03baB) and endoplasmic reticulum stress pathways in mice. Med. Sci. Monit. 26, e922248\u2013922241 (2020).","journal-title":"Med. Sci. Monit."},{"key":"66596_CR52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim, D., Langmead, B. & Salzberg, S. L. HISAT: a fast spliced aligner with low memory requirements. Nat. Methods 12, 357\u2013360 (2015).","journal-title":"Nat. Methods"},{"key":"66596_CR53","doi-asserted-by":"crossref","unstructured":"Korotkevich, G. et al. Fast gene set enrichment analysis. Preprint at biorxiv https:\/\/www.biorxiv.org\/content\/10.1101\/060012v3 (2016).","DOI":"10.1101\/060012"},{"key":"66596_CR54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2014-15-1-r1","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 1\u201321 (2014).","journal-title":"Genome Biol."},{"key":"66596_CR55","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/nbt.3988","volume":"35","author":"M Steinegger","year":"2017","unstructured":"Steinegger, M. & S\u00f6ding, J. MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Nat. Biotechnol. 35, 1026\u20131028 (2017).","journal-title":"Nat. Biotechnol."},{"key":"66596_CR56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","volume":"12","author":"B Buchfink","year":"2015","unstructured":"Buchfink, B., Xie, C. & Huson, D. H. Fast and sensitive protein alignment using DIAMOND. Nat. Methods 12, 59\u201360 (2015).","journal-title":"Nat. Methods"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-66596-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-66596-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-66596-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T21:02:56Z","timestamp":1767474176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-66596-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["66596"],"URL":"https:\/\/doi.org\/10.1038\/s41467-025-66596-w","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"12 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2"}}