{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:29:23Z","timestamp":1790144963416,"version":"4.0.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070713"],"award-info":[{"award-number":["82070713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300767"],"award-info":[{"award-number":["82300767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100705"],"award-info":[{"award-number":["82100705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970631"],"award-info":[{"award-number":["81970631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-025-66850-1","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T07:49:35Z","timestamp":1764834575000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impaired glycolysis-derived serine metabolism as a key driver of podocyte injury with senescence"],"prefix":"10.1038","volume":"17","author":[{"given":"Hongtu","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-225X","authenticated-orcid":false,"given":"Lanlan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1098-5662","authenticated-orcid":false,"given":"Wei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4325","authenticated-orcid":false,"given":"Zhaowei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7477-5798","authenticated-orcid":false,"given":"Guohua","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"66850_CR1","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/s41581-024-00843-z","volume":"20","author":"K Meliambro","year":"2024","unstructured":"Meliambro, K., He, J. C. & Campbell, K. N. Podocyte-targeted therapies\u2014progress and future directions. Nat. Rev. Nephrol. 20, 643\u2013658 (2024).","journal-title":"Nat. Rev. Nephrol."},{"key":"66850_CR2","doi-asserted-by":"publisher","first-page":"5523","DOI":"10.1172\/JCI140155","volume":"130","author":"A Chen","year":"2020","unstructured":"Chen, A. et al. Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression. J. Clin. Invest. 130, 5523\u20135535 (2020).","journal-title":"J. Clin. Invest."},{"key":"66850_CR3","doi-asserted-by":"publisher","first-page":"F120","DOI":"10.1152\/ajprenal.00261.2023","volume":"326","author":"BM Veloso Pereira","year":"2024","unstructured":"Veloso Pereira, B. M. et al. Podocyte injury at young age causes premature senescence and worsens glomerular aging. Am. J. Physiol. Ren. Physiol. 326, F120\u2013F134 (2024).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"66850_CR4","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1681\/ASN.2021050614","volume":"32","author":"SJ Shankland","year":"2021","unstructured":"Shankland, S. J. et al. Podocyte aging: why and how getting old matters. J. Am. Soc. Nephrol. 32, 2697\u20132713 (2021).","journal-title":"J. Am. Soc. Nephrol."},{"key":"66850_CR5","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2398712","volume":"46","author":"Q Zhao","year":"2024","unstructured":"Zhao, Q. et al. Podocyte senescence: from molecular mechanisms to therapeutics. Ren. Fail 46, 2398712 (2024).","journal-title":"Ren. Fail"},{"key":"66850_CR6","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","volume":"98","author":"SJ Forrester","year":"2018","unstructured":"Forrester, S. J. et al. Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology. Physiol. Rev. 98, 1627\u20131738 (2018).","journal-title":"Physiol. Rev."},{"key":"66850_CR7","doi-asserted-by":"crossref","unstructured":"Mohandes, S. et al. Molecular pathways that drive diabetic kidney disease. J. Clin. Invest. 133, e165654 (2023).","DOI":"10.1172\/JCI165654"},{"key":"66850_CR8","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.kint.2023.01.007","volume":"103","author":"Z Chen","year":"2023","unstructured":"Chen, Z. et al. Reduction of anaerobic glycolysis contributes to angiotensin II-induced podocyte injury with foot process effacement. Kidney Int. 103, 735\u2013748 (2023).","journal-title":"Kidney Int."},{"key":"66850_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101151","volume":"63","author":"Y Fang","year":"2020","unstructured":"Fang, Y. et al. The ageing kidney: molecular mechanisms and clinical implications. Ageing Res. Rev. 63, 101151 (2020).","journal-title":"Ageing Res. Rev."},{"key":"66850_CR10","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/nm.4328","volume":"23","author":"W Qi","year":"2017","unstructured":"Qi, W. et al. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat. Med. 23, 753\u2013762 (2017).","journal-title":"Nat. Med."},{"key":"66850_CR11","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.semcancer.2022.09.007","volume":"86","author":"S Paul","year":"2022","unstructured":"Paul, S., Ghosh, S. & Kumar, S. Tumor glycolysis, an essential sweet tooth of tumor cells. Semin. Cancer Biol. 86, 1216\u20131230 (2022).","journal-title":"Semin. Cancer Biol."},{"key":"66850_CR12","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.tem.2023.03.001","volume":"34","author":"L He","year":"2023","unstructured":"He, L., Ding, Y., Zhou, X., Li, T. & Yin, Y. Serine signaling governs metabolic homeostasis and health. Trends Endocrinol. Metab. 34, 361\u2013372 (2023).","journal-title":"Trends Endocrinol. Metab."},{"key":"66850_CR13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-nutr-061021-022648","volume":"43","author":"MK Handzlik","year":"2023","unstructured":"Handzlik, M. K. & Metallo, C. M. Sources and sinks of serine in nutrition, health, and disease. Annu. Rev. Nutr. 43, 123\u2013151 (2023).","journal-title":"Annu. Rev. Nutr."},{"key":"66850_CR14","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.apsb.2021.09.019","volume":"12","author":"D Du","year":"2022","unstructured":"Du, D. et al. Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. Acta Pharm. Sin. B 12, 558\u2013580 (2022).","journal-title":"Acta Pharm. Sin. B"},{"key":"66850_CR15","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.cmet.2020.02.004","volume":"31","author":"J Le Douce","year":"2020","unstructured":"Le Douce, J. et al. Impairment of glycolysis-derived l-serine production in astrocytes contributes to cognitive deficits in Alzheimer\u2019s disease. Cell Metab. 31, 503\u2013517.e508 (2020).","journal-title":"Cell Metab."},{"key":"66850_CR16","doi-asserted-by":"crossref","unstructured":"Holecek, M. Serine metabolism in health and disease and as a conditionally essential amino acid. Nutrients 14, 1987 (2022).","DOI":"10.3390\/nu14091987"},{"key":"66850_CR17","unstructured":"Braun, F. et al. Accumulation of alpha-synuclein mediates podocyte injury in Fabry nephropathy. J. Clin. Invest. 133, e157782 (2023)."},{"key":"66850_CR18","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41586-022-05637-6","volume":"614","author":"MK Handzlik","year":"2023","unstructured":"Handzlik, M. K. et al. Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. Nature 614, 118\u2013124 (2023).","journal-title":"Nature"},{"key":"66850_CR19","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.bbalip.2018.12.013","volume":"1864","author":"MA Lone","year":"2019","unstructured":"Lone, M. A., Santos, T., Alecu, I., Silva, L. C. & Hornemann, T. 1-Deoxysphingolipids. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 512\u2013521 (2019).","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"66850_CR20","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41586-020-2609-x","volume":"586","author":"T Muthusamy","year":"2020","unstructured":"Muthusamy, T. et al. Serine restriction alters sphingolipid diversity to constrain tumour growth. Nature 586, 790\u2013795 (2020).","journal-title":"Nature"},{"key":"66850_CR21","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ade6509","volume":"15","author":"TI Lima","year":"2023","unstructured":"Lima, T. I. et al. Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging. Sci. Transl. Med. 15, eade6509 (2023).","journal-title":"Sci. Transl. Med."},{"key":"66850_CR22","doi-asserted-by":"publisher","first-page":"6128","DOI":"10.1074\/jbc.M110.166991","volume":"286","author":"I Tato","year":"2011","unstructured":"Tato, I., Bartrons, R., Ventura, F. & Rosa, J. L. Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K\/Akt signaling. J. Biol. Chem. 286, 6128\u20136142 (2011).","journal-title":"J. Biol. Chem."},{"key":"66850_CR23","doi-asserted-by":"publisher","first-page":"916","DOI":"10.2174\/0118715206296355240325113920","volume":"24","author":"N Bani","year":"2024","unstructured":"Bani, N. et al. Wortmannin inhibits cell growth and induces apoptosis in colorectal cancer cells by suppressing the PI3K\/AKT pathway. Anticancer Agents Med. Chem. 24, 916\u2013927 (2024).","journal-title":"Anticancer Agents Med. Chem."},{"key":"66850_CR24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s13046-022-02377-3","volume":"41","author":"M Chi","year":"2022","unstructured":"Chi, M. et al. TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K\/AKT pathway in bladder cancer. J. Exp. Clin. Cancer Res. 41, 175 (2022).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"66850_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04576-4","volume":"13","author":"Y He","year":"2022","unstructured":"He, Y. et al. PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4\/ERK signaling pathway and accelerating glycolysis. Cell Death Dis. 13, 118 (2022).","journal-title":"Cell Death Dis."},{"key":"66850_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51232-w","volume":"15","author":"Z Guo","year":"2024","unstructured":"Guo, Z. et al. Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle. Nat. Commun. 15, 6915 (2024).","journal-title":"Nat. Commun."},{"key":"66850_CR27","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.molcel.2017.01.027","volume":"65","author":"X Qian","year":"2017","unstructured":"Qian, X. et al. Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy. Mol. Cell 65, 917\u2013931.e916 (2017).","journal-title":"Mol. Cell"},{"key":"66850_CR28","doi-asserted-by":"crossref","unstructured":"Wang, J. TFTF: an R-based integrative tool for decoding human transcription factor-target interactions. Biomolecules 14, 749 (2024).","DOI":"10.3390\/biom14070749"},{"key":"66850_CR29","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/ki.2015.178","volume":"88","author":"K Hayashi","year":"2015","unstructured":"Hayashi, K. et al. Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria. Kidney Int. 88, 745\u2013753 (2015).","journal-title":"Kidney Int."},{"key":"66850_CR30","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/hr.2016.166","volume":"40","author":"N Ohashi","year":"2017","unstructured":"Ohashi, N., Isobe, S., Ishigaki, S. & Yasuda, H. Circadian rhythm of blood pressure and the renin-angiotensin system in the kidney. Hypertens. Res. 40, 413\u2013422 (2017).","journal-title":"Hypertens. Res."},{"key":"66850_CR31","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1042\/CS20190765","volume":"134","author":"LF Almeida","year":"2020","unstructured":"Almeida, L. F., Tofteng, S. S., Madsen, K. & Jensen, B. L. Role of the renin-angiotensin system in kidney development and programming of adult blood pressure. Clin. Sci. 134, 641\u2013656 (2020).","journal-title":"Clin. Sci."},{"key":"66850_CR32","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2023.2230318","volume":"45","author":"X Huang","year":"2023","unstructured":"Huang, X. et al. PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment. Ren. Fail 45, 2230318 (2023).","journal-title":"Ren. Fail"},{"key":"66850_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155718","volume":"150","author":"Z Luo","year":"2024","unstructured":"Luo, Z., Chen, Z., Hu, J. & Ding, G. Interplay of lipid metabolism and inflammation in podocyte injury. Metabolism 150, 155718 (2024).","journal-title":"Metabolism"},{"key":"66850_CR34","doi-asserted-by":"crossref","unstructured":"Miwa, S., Kashyap, S., Chini, E. & von Zglinicki, T. Mitochondrial dysfunction in cell senescence and aging. J. Clin. Invest. 132, e158447 (2022).","DOI":"10.1172\/JCI158447"},{"key":"66850_CR35","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1124\/pharmrev.122.000622","volume":"75","author":"V Lucas","year":"2023","unstructured":"Lucas, V., Cavadas, C. & Aveleira, C. A. Cellular senescence: from mechanisms to current biomarkers and senotherapies. Pharm. Rev. 75, 675\u2013713 (2023).","journal-title":"Pharm. Rev."},{"key":"66850_CR36","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41586-023-06621-4","volume":"622","author":"S Victorelli","year":"2023","unstructured":"Victorelli, S. et al. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature 622, 627\u2013636 (2023).","journal-title":"Nature"},{"key":"66850_CR37","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1101\/gad.343129.120","volume":"34","author":"J Birch","year":"2020","unstructured":"Birch, J. & Gil, J. Senescence and the SASP: many therapeutic avenues. Genes Dev. 34, 1565\u20131576 (2020).","journal-title":"Genes Dev."},{"key":"66850_CR38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s42255-020-00329-9","volume":"3","author":"SL Geeraerts","year":"2021","unstructured":"Geeraerts, S. L., Heylen, E., De Keersmaecker, K. & Kampen, K. R. The ins and outs of serine and glycine metabolism in cancer. Nat. Metab. 3, 131\u2013141 (2021).","journal-title":"Nat. Metab."},{"key":"66850_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101896","volume":"197","author":"M Maugard","year":"2021","unstructured":"Maugard, M., Vigneron, P. A., Bolanos, J. P. & Bonvento, G. l-Serine links metabolism with neurotransmission. Prog. Neurobiol. 197, 101896 (2021).","journal-title":"Prog. Neurobiol."},{"key":"66850_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2021.107852","volume":"35","author":"V Fridman","year":"2021","unstructured":"Fridman, V. et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J. Diabetes Complications 35, 107852 (2021).","journal-title":"J. Diabetes Complications"},{"key":"66850_CR41","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1159\/000527798","volume":"9","author":"Y Iwata","year":"2023","unstructured":"Iwata, Y. et al. Intra-brain and plasma levels of L-serine are associated with cognitive status in patients with chronic kidney disease. Kidney Dis. 9, 118\u2013129 (2023).","journal-title":"Kidney Dis."},{"key":"66850_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2024.116240","volume":"247","author":"JR Lucio-Gutierrez","year":"2024","unstructured":"Lucio-Gutierrez, J. R. et al. Targeted and untargeted serum NMR metabolomics to reveal initial kidney disease in diabetes mellitus. J. Pharm. Biomed. Anal. 247, 116240 (2024).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"66850_CR43","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s00726-024-03400-x","volume":"56","author":"T Morishita","year":"2024","unstructured":"Morishita, T. et al. Plasma D-asparagine and the D\/L-serine ratio reflect chronic kidney diseases in children regardless of physique. Amino Acids 56, 38 (2024).","journal-title":"Amino Acids"},{"key":"66850_CR44","doi-asserted-by":"crossref","unstructured":"Mallela, S. K., Merscher, S. & Fornoni, A. Implications of sphingolipid metabolites in kidney diseases. Int. J. Mol. Sci. 23, 4244 (2022).","DOI":"10.3390\/ijms23084244"},{"key":"66850_CR45","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nrm.2017.107","volume":"19","author":"YA Hannun","year":"2018","unstructured":"Hannun, Y. A. & Obeid, L. M. Sphingolipids and their metabolism in physiology and disease. Nat. Rev. Mol. Cell Biol. 19, 175\u2013191 (2018).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"66850_CR46","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1016\/j.bpj.2014.10.010","volume":"107","author":"N Jimenez-Rojo","year":"2014","unstructured":"Jimenez-Rojo, N. et al. Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells. Biophys. J. 107, 2850\u20132859 (2014).","journal-title":"Biophys. J."},{"key":"66850_CR47","doi-asserted-by":"crossref","unstructured":"Xiang, Y., Zhao, K., Tang, Y. Q., Dai, R. & Miao, H. Modulating serine palmitoyltransferase-deoxysphingolipid axis in cancer therapy. MedComm 2, 117\u2013119 (2021).","DOI":"10.1002\/mco2.44"},{"key":"66850_CR48","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.prostaglandins.2019.02.005","volume":"141","author":"NU Schwartz","year":"2019","unstructured":"Schwartz, N. U. et al. Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins Other Lipid Mediat. 141, 40\u201348 (2019).","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"66850_CR49","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411002109","volume":"14","author":"SM Schultze","year":"2012","unstructured":"Schultze, S. M., Hemmings, B. A., Niessen, M. & Tschopp, O. PI3K\/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. Expert Rev. Mol. Med. 14, e1 (2012).","journal-title":"Expert Rev. Mol. Med."},{"key":"66850_CR50","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1007\/s11255-024-03989-8","volume":"56","author":"H Wang","year":"2024","unstructured":"Wang, H. et al. The role of PI3K\/Akt signaling pathway in chronic kidney disease. Int. Urol. Nephrol. 56, 2623\u20132633 (2024).","journal-title":"Int. Urol. Nephrol."},{"key":"66850_CR51","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.molcel.2016.02.009","volume":"61","author":"X Li","year":"2016","unstructured":"Li, X. et al. Mitochondria-translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in tumorigenesis. Mol. Cell 61, 705\u2013719 (2016).","journal-title":"Mol. Cell"},{"key":"66850_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36708-5","volume":"14","author":"K Wang","year":"2023","unstructured":"Wang, K. et al. PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. Nat. Commun. 14, 1011 (2023).","journal-title":"Nat. Commun."},{"key":"66850_CR53","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.cmet.2022.04.002","volume":"34","author":"G Bonvento","year":"2022","unstructured":"Bonvento, G., Oliet, S. H. R. & Panatier, A. Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer\u2019s disease. Cell Metab. 34, 654\u2013655 (2022).","journal-title":"Cell Metab."},{"key":"66850_CR54","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fonc.2014.00096","volume":"4","author":"U Knippschild","year":"2014","unstructured":"Knippschild, U. et al. The CK1 family: contribution to cellular stress response and its role in carcinogenesis. Front. Oncol. 4, 96 (2014).","journal-title":"Front. Oncol."},{"key":"66850_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00498-4","volume":"8","author":"M Liu","year":"2017","unstructured":"Liu, M. et al. Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling. Nat. Commun. 8, 413 (2017).","journal-title":"Nat. Commun."},{"key":"66850_CR56","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202405153","volume":"11","author":"H Hu","year":"2024","unstructured":"Hu, H. et al. RBBP6-mediated ERRalpha degradation contributes to mitochondrial injury in renal tubular cells in diabetic kidney disease. Adv. Sci. 11, e2405153 (2024).","journal-title":"Adv. Sci."},{"key":"66850_CR57","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s00726-023-03270-9","volume":"55","author":"FE Langroudi","year":"2023","unstructured":"Langroudi, F. E. et al. Effect of L-serine on oxidative stress markers in the kidney of streptozotocin-induced diabetic mice. Amino Acids 55, 799\u2013806 (2023).","journal-title":"Amino Acids"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-66850-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-66850-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-66850-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T04:39:46Z","timestamp":1767760786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-025-66850-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["66850"],"URL":"https:\/\/doi.org\/10.1038\/s41467-025-66850-1","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,4]]},"assertion":[{"value":"11 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"138"}}